Kinetics pathway of precipitation in model Co-Al-W superalloy

International audienc

Application de la méthode LSPIV pour la mesure de champs de vitesse et de débits de crue sur modèle réduit et en rivière

International audienceLSPIV technique enables the measurement of surface flow velocities using image sequence analysis. EDF and Irstea partnership made possible the development of Fudaa‑LSPIV freeware by DeltaCAD Company. Two software applications at flume and field scales are detailed: (i) bed shear stresses were calculated owing to LSPIV velocities, water depth and bathymetry for a physical model of the Old Rhine; (ii) the software was used to optimize the calculation parameters of LSPIV flood discharge measurement stations in Mediterranean rivers.La technique LSPIV (Large Scale Particle Image Velocimetry) permet de mesurer les vitesses de surface d'un écoulement par analyse de séquence d'images. Pour faciliter l'application opérationnelle de la méthode, un logiciel, Fudaa-LSPIV, a été développé par la société DeltaCAD dans le cadre d'une collaboration entre EDF et Irstea. Deux applications en laboratoire et en rivière sont présentées : (i) couplée avec des mesures de hauteur d'eau et de bathymétries, la LSPIV a permis d'estimer des paramètres de Shields sur le modèle physique à fond mobile du Vieux-Rhin ; (ii) le logiciel a été utilisé pour procéder à des analyses de sensibilité pour paramétrer ainsi au mieux les stations LSPIV de mesure de débit en crue de rivières cévenoles

Morphodynamics of the exit of a cutoff meander: experimental findings from field and laboratory studies

The morphological evolution of the entrances and exits of abandoned river channels governs their hydrological connectivity. The study focusses on flow and sediment dynamics in the exit of a cut-off meander where the downstream entrance is still connected to the main channel, but the upstream entrance is closed. Two similar field and laboratory cases were investigated using innovative velocimetry techniques (acoustic Doppler profiling, image analysis). Laboratory experiments were conducted with a mobile-bed physical model of the Morava river (Slovakia). Field measurements were performed in the exit of the Port-Galland cut-off meander, Ain river (France). Both cases yielded consistent and complementary results from which a generic scheme for flow patterns and morphological evolution was derived. A simple analogy with flows in rectangular side cavities was used to explain the recirculating flow patterns which developed in the exit. A decelerating inflow deposits bedload in the downstream part of the cavity, while the upstream part is eroded by an accelerating outflow, leading to the retreat of the upstream bank. In the field, strong secondary currents were observed, especially in the inflow, which may enhance the scouring of the downstream corner of the cavity. Also, fine sediment deposits constituted a silt layer in a transitional zone, located between the mouth of the abandoned channel and the oxbow-lake within the cut-off meander. Attempts at morphological prediction should consider not only the flow and sediment conditions in the cavity, but also the dynamics of the main channel

Magnetic Behavior of Co/Pt and TbCo Nanocaps Assembly for Bit Pattern Media

Large area patterning of self-assembled alumina nanobumps, with hexagonally close-packed order, has been used to create ordered array of bit pattern magnetic media. We have studied the magnetic properties of perpendicular magnetic TbCo alloy and Co/Pt multilayers deposited on self assembled alumina nanobumps. Measurement of reversal field as a function of field intensity, as well as magnetic force microscopy images confirm the weakness of exchange coupling between bits in the case of Co/Pt multilayer while stronger coupling is observed in the case of TbCo alloys. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3535

Magnetic Behavior of Co/Pt and TbCo Nanocaps Assembly for Bit Pattern Media

Large area patterning of self-assembled alumina nanobumps, with hexagonally close-packed order, has been used to create ordered array of bit pattern magnetic media. We have studied the magnetic properties of perpendicular magnetic TbCo alloy and Co/Pt multilayers deposited on self assembled alumina nanobumps. Measurement of reversal field as a function of field intensity, as well as magnetic force microscopy images confirm the weakness of exchange coupling between bits in the case of Co/Pt multilayer while stronger coupling is observed in the case of TbCo alloys. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3535

Impact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion

Background. Normothermic machine perfusion (NMP) protocols using blood-based solutions are commonly used in the assessment of kidneys before transplantation. This procedure is, nevertheless, limited by blood availability and warrants the search for alternatives. We compared a blood-based solution with a serum-like preservation solution (Aqix) enriched with colloids with and without red blood cells (RBCs). Methods. Porcine kidneys retrieved from an abattoir were subjected to 30min of warm ischemia, followed by 3h of hypothermic oxygenated machine perfusion at 4 degrees C. Subsequently, kidneys (n=6 per group) were evaluated with NMP for 4h with 5 different solutions: diluted blood, Aqix with BSARBCs, or Aqix with dextran 40RBCs. Results. Throughout NMP, markers of renal function and tubular metabolism were favorable in groups with RBCs. The addition of RBCs resulted in 4- to 6-fold higher oxygen consumption rates. Controls had significantly higher ATP levels post-NMP, exhibited decreased production of oxidative stress markers, and had the highest creatinine clearance. In conclusion, this study shows that the addition of RBCs during NMP reduced renal injury, improved function, and was associated with increased renal metabolism. Conclusions. Although the RBC-BSA-supplemented Aqix solution was also able to support metabolism and renal function, a blood-based perfusion solution remains superior

Quantifier l'effet de choix du site dans l'incertitude des jaugeages ADCP par transects

HMEM, Durham, New Hampshire, USA, 09-/07/2017 - 12/07/2017International audienceStage-discharge rating curves are used to relate streamflow discharge to continuously measured river stage readings to create a continuous record of streamflow discharge. The stage-discharge relationship is estimated and refined using discrete streamflow measurements over time, during which both the discharge and stage are measured. There is uncertainty in the resulting rating curve due to multiple factors including the curve-fitting process, assumptions on the form of the model used, fluvial geomorphology of natural channels, and the approaches used to extrapolate the rating equation beyond available observations. This rating curve uncertainty leads to uncertainty in the streamflow timeseries, and therefore to uncertainty in predictive models that use the streamflow data. Many different methods have been proposed in the literature for estimating rating curve uncertainty, differing in mathematical rigor, in the assumptions made about the component errors, and in the information required to implement the method at any given site. This study describes the results of an international experiment to test and compare streamflow uncertainty estimation methods from 7 research groups across 9 institutions. The methods range from simple LOWESS fits to more complicated Bayesian methods that consider hydraulic principles directly. We evaluate these different methods when applied to three diverse gauging stations using standardized information (channel characteristics, hydrographs, and streamflow measurements). Our results quantify the resultant spread of the stage-discharge Quantifying the uncertainty of discharge measurements (or "gaugings") is a challenge in the hydrometric community. A useful tool to empirically estimate the uncertainty of a gauging method is the field inter-laboratory experiment (Le Coz et al., 2016). Previous inter-laboratory experiments conducted in France (in 2009, 2010, 2011 and 2012) showed that the expanded uncertainty (with a probability level of 95%) of an ADCP gauging made of six successive transects is typically around 5% under optimum site conditions (straight reach, uniform and smooth streambed cross-section, homogeneous flow, etc.) and may be twice higher under poorer site conditions. In practice, the selected cross-section does not always match all quality requirements which may result in larger uncertainty. However, the uncertainty due to site selection is very difficult to estimate with predictive equations. From 9 to 10 November 2016, 50 teams from 8 different countries, using 50 ADCPs simultaneously, conducted more than 600 discharge measurements in steady flow conditions (~14 m3/s released by a dam). 26 cross-sections with various shapes and flow conditions were distributed over 500 meters along the Taurion River at Saint-Priest-de-Taurion, France. A specific experiment protocol, which consisted of circulating every team over half of the cross-sections, was implemented in order to quantify the impact of site selection on the discharge measurement uncertainty. Beyond the description of the experiments, uncertainty estimates are presented. The overall expanded uncertainty of a 6-transect ADCP gaugings (duration around 720 seconds) is estimated to be around 6%.The uncertainty of the discharge measurements varies among the cross-sections. These variations are well correlated to the expert judgment on the cross-section quality made by each team. First results seem to highlight a relation between uncertainty computed for each cross-section and criteria such as flow shallowness and measured discharge ratio. Further investigations are necessary to identify the criteria related to error sources that are possibly meaningful for categorizing measurement conditions and site selection. Moreover, experimental uncertainty and the uncertainty predicted by analytical methods such as QRev, QUant, OURSIN, RiverFlowUA or QMSys software will be compared

Controlled oxygenated rewarming up to normothermia for pretransplant reconditioning of liver grafts

Controlled oxygenated rewarming (COR) up to 20 degrees C during ex vivo machine perfusion limits reperfusion-induced tissue injury upon graft implantation. Rewarming up to normothermia might add further benefits and provide better prediction of post-transplantation organ function. The effect of 90 minutes of oxygenated machine perfusion with Aqix RS-I after cold storage combined with gentle rewarming up to 20 degrees C (COR20) or 35 degrees C (COR35) was studied in rat livers and compared with cold storage alone (CS, n = 6, resp). Postpreservation recovery was evaluated upon warm reperfusion using an established in vitro system. COR generally resulted in significantly improved energetic recovery, increased bile flow, less activities alanine aminotransferase (ALT) release, and improved histopathology upon reperfusion as compared to only cold-stored livers, without significant differences between COR20 and COR35. Parameters obtained during COR, especially during COR35, also allowed for prediction of hepatic recovery upon reperfusion. For instance, ulterior bile production upon reperfusion was found closely correlated to bile flow observed already during COR35 (R-2=0.91). COR significantly improved liver quality after static cold storage. Elevation of machine perfusion temperature up to 35 degrees C may prove promising to refine ex vivo evaluation of the graft prior to transplantation

IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation

Injury due to cold ischemia reperfusion (I/R) is a major cause of primary graft non-function following liver transplantation. We postulated that I/R-induced cellular damage during liver transplantation might affect the secretory pathway, particularly at the endoplasmic reticulum (ER). We examined the involvement of ER stress in organ preservation, and compared cold storage in University of Wisconsin (UW) solution and in Institute Georges Lopez-1 (IGL-1) solution. In one group of rats, livers were preserved in UW solution for 8 h at 4 °C, and then orthotopic liver transplantation was performed according to Kamada's cuff technique. In another group, livers were preserved in IGL-1 solution. The effect of each preservation solution on the induction of ER stress, hepatic injury, mitochondrial damage and cell death was evaluated. As expected, we found increased ER stress after liver transplantation. IGL-1 solution significantly attenuated ER damage by reducing the activation of three pathways of unfolded protein response and their effector molecules caspase-12, C/EBP homologous protein-10, X-box-binding protein 1, tumor necrosis factor-associated factor 2 and eukaryotic translation initiation factor 2. This attenuation of ER stress was associated with a reduction in hepatic injury and cell death. Our results show that IGL-1 solution may be a useful means to circumvent excessive ER stress reactions associated with liver transplantation, and may optimize graft quality