11,731 research outputs found
P-248 Futility and utility of two-stage hepatectomy
Meeting abstract in the European-Society-for-Medical-Oncology (ESMO) 21st World Congress on Gastrointestinal Cancer.info:eu-repo/semantics/publishedVersio
Heterotrophy as a tool to overcome the long and costly autotrophic scale-up process for large scale production of microalgae
Industrial scale-up of microalgal cultures is often a protracted step prone to culture collapse and the occurrence of unwanted contaminants. To solve this problem, a two-stage scale-up process was developed - heterotrophically Chlorella vulgaris cells grown in fermenters (1st stage) were used to directly inoculate an outdoor industrial autotrophic microalgal production unit (2nd stage). A preliminary pilot-scale trial revealed that C. vulgaris cells grown heterotrophically adapted readily to outdoor autotrophic growth conditions (1-m3 photobioreactors) without any measurable difference as compared to conventional autotrophic inocula. Biomass concentration of 174.5 g L-1, the highest value ever reported for this microalga, was achieved in a 5-L fermenter during scale-up using the heterotrophic route. Inocula grown in 0.2- and 5-m3 industrial fermenters with mean productivity of 27.54 ± 5.07 and 31.86 ± 2.87 g L-1 d-1, respectively, were later used to seed several outdoor 100-m3 tubular photobioreactors. Overall, all photobioreactor cultures seeded from the heterotrophic route reached standard protein and chlorophyll contents of 52.18 ± 1.30% of DW and 23.98 ± 1.57 mg g-1 DW, respectively. In addition to providing reproducible, high-quality inocula, this two-stage approach led to a 5-fold and 12-fold decrease in scale-up time and occupancy area used for industrial scale-up, respectively.Agência financiadora
project FERMALG
017608
Fundacao para a Ciencia e a Tecnologia (FCT)
UID/Multi/04326/2019
project FERMALG (AVISO)
32/SI/2015info:eu-repo/semantics/publishedVersio
Ab-initio angle and energy resolved photoelectron spectroscopy with time-dependent density-functional theory
We present a time-dependent density-functional method able to describe the
photoelectron spectrum of atoms and molecules when excited by laser pulses.
This computationally feasible scheme is based on a geometrical partitioning
that efficiently gives access to photoelectron spectroscopy in time-dependent
density-functional calculations. By using a geometrical approach, we provide a
simple description of momentum-resolved photoe- mission including multi-photon
effects. The approach is validated by comparison with results in the literature
and exact calculations. Furthermore, we present numerical photoelectron angular
distributions for randomly oriented nitrogen molecules in a short near infrared
intense laser pulse and helium-(I) angular spectra for aligned carbon monoxide
and benzene.Comment: Accepted for publication on Phys. Rev.
Phase transition of a two dimensional binary spreading model
We investigated the phase transition behavior of a binary spreading process
in two dimensions for different particle diffusion strengths (). We found
that cluster mean-field approximations must be considered to get
consistent singular behavior. The approximations result in a continuous
phase transition belonging to a single universality class along the phase transition line. Large scale simulations of the particle density
confirmed mean-field scaling behavior with logarithmic corrections. This is
interpreted as numerical evidence supporting that the upper critical dimension
in this model is .The pair density scales in a similar way but with an
additional logarithmic factor to the order parameter. At the D=0 endpoint of
the transition line we found DP criticality.Comment: 8 pages, 10 figure
Bone growth as the main determinant of mouse digit tip regeneration after amputation
Regeneration is classically demonstrated in mammals using mice digit tip. In this study, we compared different amputation plans and show that distally amputated digits regrow with morphology close to normal but fail to regrow the fat pad. Proximally amputated digits do not regrow the phalangeal bone, but the remaining structures (nail, skin and connective tissue), all with intrinsic regenerative capacity, re-establishing integrity indistinguishably in distally and proximally amputated digits. Thus, we suggest that the bone growth promoted by signals and progenitor cells not removed by distal amputations is responsible for the re-establishment of a drastically different final morphology after distal or proximal digit tip amputations. Despite challenging the use of mouse digit tip as a model system for limb regeneration in mammals, these findings evidence a main role of bone growth in digit tip regeneration and suggest that mechanisms that promote joint structures formation should be the main goal of regenerative medicine for limb and digit regrowth9CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP460664/2014-02012/09602-0; 2019/09870-
Final Analysis and Results of the Phase II SIMPLE Dark Matter Search
We report the final results of the Phase II SIMPLE measurements, comprising
two run stages of 15 superheated droplet detectors each, the second stage
including an improved neutron shielding. The analyses includes a refined signal
analysis, and revised nucleation efficiency based on reanalysis of
previously-reported monochromatic neutron irradiations. The combined results
yield a contour minimum of \sigma_{p} = 4.2 x 10^-3 pb at 35 GeV/c^2 on the
spin-dependent sector of WIMP-proton interactions, the most restrictive to date
from a direct search experiment and overlapping for the first time results
previously obtained only indirectly. In the spin-independent sector, a minimum
of 3.6 x 10^-6 pb at 35 GeV/c^2 is achieved, with the exclusion contour
challenging the recent CoGeNT region of current interest.Comment: revised, PRL-accepted version with slightly weakened limit contour
Poliomielite associada à vacina: descrição de caso por transmissão domiciliar
Poliomyelitis associated with live strain vaccine is defined as the paralytic form of the acute anterior poliomyelitis related to the vaccine strain. Since these strains behave similarly to the wild-type virus, we can differentiate, epidemiologically, two types of vaccine-associated poliomyelitis: cases in which the patient was vaccinated and cases in which the patient had had contact with vaccinated individuals. We herein present the case of an unvaccinated child, with a clinical picture of an acute anterior poliomyelitis associated with the live strain vaccine, whose brother received the Sabin vaccine 20 days before the onset of the symptoms. Vaccine strain of the type 3 poliovirus was isolated in fecal culture and a presented mutation in nucleotide 472 (C;®;U) in the 5' non-coding region, which is strongly related to the higher strain virulence.A poliomielite associada à vacina oral é definida como a forma paralítica da poliomielite anterior aguda decorrente da cepa vacinal. Uma vez que o comportamento da cepa vacinal é semelhante ao do vírus selvagem, epidemiologicamente podemos distinguir dois tipos de poliomielite associada à vacina, os casos em que o paciente foi vacinado e os casos em que o paciente teve contato com pessoas que receberam a vacina. Apresentamos o caso de um lactente não vacinado, que apresentou quadro de poliomielite anterior aguda associada à vacina oral, cujo irmão havia recebido a vacina Sabin 20 dias antes do início do quadro clínico. Na cultura de fezes do paciente foi isolado o poliovírus tipo 3, cepa vacinal, que apresentava mutação do nucleotídeo 472 (C;®;U) na região 5' não codificadora, a qual está significativamente relacionada com a maior virulência da cepa
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