Dise?o e implementaci?n del mundo caim?n del videojuego jaguares, que da a conocer la morfolog?a, uso y significado de la cer?mica de los ancestros del Tolima.

98 p. Recurso Electr?nicoDurante d?cadas, el Museo Antropol?gico de la Universidad del Tolima y el grupo GRAPA (Grupo de Investigaci?n en Arqueolog?a y Patrimonio Regional) han realizado investigaciones arqueol?gicas a lo largo del territorio tolimense, logrando hallazgos f?siles de animales y vegetales, adem?s de elementos cer?micos que datan desde 10.000 a.C. hasta la conquista y colonia espa?ola. Sin embargo, las nuevas generaciones se muestran indiferentes ante los conocimientos obtenidos. Este proyecto busca crear un videojuego para ense?ar de manera novedosa, a ni?os con edades entre ocho a catorce a?os sobre las cer?micas tolimenses. Se implementa sobre Unity v5.5.1f1, aplicando la metodolog?a de desarrollo ?gil SUM que se adapta para la creaci?n de videojuegos utilizando roles de SCRUM, e incorpora seis fases consecutivas que son: concepto, planificaci?n, elaboraci?n, beta, cierre y gesti?n de riesgos que se realiza de manera continua durante la ejecuci?n del desarrollo. Durante la fase de concepto se realiza una investigaci?n amplia sobre la cer?mica tolimense, que posteriormente sirve como insumo para crear una propuesta detallada y s?lida en la etapa de planificaci?n. En la fase de elaboraci?n se aplica la metodolog?a de Arquitectura Dirigida por Modelos (MDA) orientada a la elaboraci?n de videojuegos. Esta fase se realiza de manera iterativa y en conjunto con las pruebas Beta que permiten evaluar el cumplimiento de los objetivos planteados a medida que se avanza en el desarrollo. Por ?ltimo en la fase de cierre se generan los productos finales y se eval?an las lecciones aprendidas. Palabras claves: Unity, Videojuego 2D, Videojuego Educativo, Metodolog?a SUM, Museo Antropol?gico, Cer?mica tolimense.For decades, the Anthropological Museum of the University of Tolima and the group GRAPA (Research Group in Archeology and Regional Heritage) have carried out archaeological research throughout the territory of Tolima, finding fossil of animals and plants, as well as ceramic elements dating back to from 10,000 BC until the Spanish conquest and colony. However, the new generations are indifferent to the knowledge obtained. This project seeks to create a video game to teach in a novel way, to children aged between eight and fourteen years old, about the ceramics of Tolima. It is implemented on Unity v5.5.1f1, applying the agile development methodology SUM that is adapted for the creation of video games using SCRUM roles, and incorporates six consecutive phases that are: concept, planning, preparation, beta, closure and risk management that is done continuously during the execution of the development. During the concept phase, a comprehensive investigation is carried out on ceramic of Tolima, which later serves as an input to create a detailed and solid proposal in the planning stage. In the elaboration phase, the methodology of Model-Directed Architecture (MDA), oriented to the elaboration of videogames is applied. This phase is carried out iteratively and in conjunction with Beta tests that allow evaluating compliance with the objectives set as progress is made in development. Finally, in the closing phase, the final products are generated and the lessons learned are evaluated. Keywords: Unity, 2D Videogame, Educational Videogame, SUM Methodology, Anthropological Museum, Tolima?s Ceramics

Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

The enzyme Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), is a positive genetic predictor of diabetes type 2 and obesity. As increased TST activity protects against the development of diabetic symptoms in mice, an activating compound for TST may provide therapeutic benefits in diabetes and obesity. We identified a small molecule activator of human TST through screening of an inhouse small molecule library. Kinetic studies in vitro suggest that two distinct isomers of the compound are required for full activation as well as an allosteric mode of activation. Additionally, we studied the effect of TST protein and the activator on TST activity through mitochondrial respiration. Molecular docking and molecular dynamics (MD) approaches supports an allosteric site for the binding of the activator, which is supported by the lack of activation in the E. coli. mercaptopyruvate sulfurtransferase. Finally, we show that increasing TST activity in isolated mitochondria increases mitochondrial oxygen consumption. This article is protected by copyright. All rights reserved.</p

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care

Tourists, prices and exchange rates

Tourists travelling to foreign destinations commonly have to face a complex and new decision environment where new prices, new goods and new services are suddenly being evaluated. However destination prices are not necessarily straightforward as tourists need to "translate" destination prices via the exchange rate into their own currency. This study explored the difficulties that tourists may face in working out what prices they are paying in terms that they can understand, usually their home currency. A two phase study was conducted with a qualitative phase where travellers were observed while travelling in South America, and a quantitative phase where a simulation was conducted. The study found ample evidence of tourists making errors and finding difficulties as destination prices were being evaluated. It is suggested that these difficulties are related to situational (context) characteristics as well as personal characteristics (mainly mathematical ability). This study suggests that difficulties found in the context, and that may lead to errors, may, in the case of some tourists, be better dealt with by giving this responsibility to a third party, such as a prepaid package, credit card or tour guide

Restablecimiento de derechos de niños, niñas y adolescentes en el sistema nacional de bienestar familiar

De acuerdo con los estándares internacionales, los Estados deben actuar oportuna y eficazmente ante las situaciones de vulneración de derechos. En este artículo presentamos los hallazgos de un estudio de caso sobre el funcionamiento del Sistema Nacional de Bienestar Familiar de Colombia, en el restablecimiento de derechos vulnerados. Analizamos los logros, dificultades y problemas, así como el nivel de cumplimiento y aplicación del Código de la Infancia y la Adolescencia, concluyendo que aún en la capital del país, donde hay una alta concentración de recursos y programas, falta bastante para llegar a una protección integral efectiva y a una respuesta contundente en el restablecimiento de los derechos.-1. Introducción. 2. Metodología del estudio. 3. Estudios sobre el tema. 4. El Sistema Nacional de Bienestar Familiar. -5. El Proceso de Restablecimiento de Derechos 6. Conclusiones y reflexiones finales. Lista de referencias

Puro mercadeo: reestructuración de una empresa en crisis

El desarrollo del presente trabajo tuvo en cuenta tres aspectos básicos del modelo de gerencia estratégica: formulación, ejecución y evaluación de estrategias en la primera parte presenta la formulación, la investigación en la análisis de las diferentes áreas de la empresa. Dentro de esta misma etapa se desarrolló la matriz DOFA que sirvió para proponer el plan estratégico a la compañía, estos aspectos se contemplan un Segundo capítulo. La ejecución de la estrategia se desarrollará en el tercer capítulo presentando las diferentes acciones que se implementaron en la empresa con el fin de alcanzar la estrategia inicialmente propuesta y finalmente en el último capítulo se realice la donación de las estrategias diseñadas para Puro Mercadeo Ltda.Situación actual de la empresa. Planteamiento del problema y estrategias para su solución. Ejecución del plan estratégico nuevos conceptos para la empresa. Evaluación de l a estrategia y sus efectos en la proyección de los estados financieros.Especialista en finanzas corporativasEspecializaciónEMM

Oficina de Enlace : Cooperacion Universidad-Empresa para el Desarrollo : ALFA EuropeAID co-operation office

(Indice sintetico della pubblicazione) Introducci\uf3n 1. - Presentaci\uf3n de las Universidades 1.h - Tabla comparativa de las Universidades 1.i - Comentarios al cap\uedtulo 2. - Presentaci\uf3n de las Oficinas de Enlace (OdEs) 2.a - Industrial Liaison Office (I.L.O.) \u201cUETP ALMA MATER" - Universidad de Bologna 2.b - Direcci\uf3n de Convenios y Transferencia de Tecnolog\ueda (DCTT) - Universidad de Buenos Aires 2.c - N\ufacleo de Extens\ue3o UFSCar - Empresa (NUEMP) - Universidad Federal de S\ue3o Carlos 2.d - Technologie Transferstelle (uni-transfer) - Universidad de Hannover 2.e - Centro para la Transferencia de los Resultados de Investigaci\uf3n (CETRI - Litoral) - Universidad Nacional del Litoral 2.f - Unidad de Enlance Universidad-Empresa - Universidad Tecnol\uf3gica de Panam\ue1 2.g - Oficina de Transferencia de Resultados de Investigaci\uf3n (OTRI) - Universidad de Zaragoza 2.h - Comentarios al cap\uedtulo 2 3. - Detalle sobre las actividades desarrolladas por la OdE 3.a - Universidad de Bologna: Industrial Liaison Office \u201cUETP Alma Mater\u201d 3.b - Universidad de Buenos Aires: Direcci\uf3n de Convenios y Transferencia de Tecnolog\ueda (DCTT) 3.c - Universidad de S\ue3o Carlos: N\ufacleo de Extens\ue3o UFSCar-Empresa (NUEMP) 3.d - Universidad de Hannover: Technologie Transfertelle (uni-transfer) 3.e - Universidad Nacional del Litoral: Centro para la Transferencia de los Resultados de Investigaci\uf3n (CETRI - Litoral) 3.f - Universidad Tecnol\uf3gica de Panam\ue1: Unidad de Enlace Universidad-Empresa 3.g - Universidad de Zaragoza: Oficina de transferencia de resultados de investigaci\uf3n (OTRI) 3.h Tabla comparativa de las actividades desarrolladas en cada universidad 3.i - Comentarios al cap\uedtulo 3 4. - Rol de la Oficina de Enlace en los contratos con empresas 4.a - Rol de la I.L.O. \u201cUETP Alma Mater\u201d (Universidad de Bologna) 4.b - Rol de la DCTT (Universidad de Buenos Aires) 4.c - Rol del NUEMP (Universidad de S\ue3o Carlos) 4.d - Rol de Uni-transfer (Universidad de Hannover) 4.e - Rol del CETRI - Litoral (Universidad Nacional del Litoral) 4.f - Rol de la Unidad de Enlace Universidad-Empresa (Universidad Tecnol\uf3gica de Panam\ue1) 4.g - Rol de la OTRI (Universidad de Zaragoza) 4.h - Comentarios al cap\uedtulo 4 5. - Aspectos financieros 5.a - Universidad de Bologna 5.b - Universidad de Buenos Aires 5.c - Universidad de S\ue3o Carlos 5.d - Universidad de Hannover 5.e - Universidad Nacional del Litoral 5.f - Universidad Tecnol\uf3gica de Panam\ue1 5.g - Universidad de Zaragoza 5.h - Comentarios al cap\uedtulo 5 6 - Conclusiones 7 - Anexo

Taming Mammon:Corporate Social Responsibility &amp; the Global Regulation of Conflict Trade

NoUnethical business practices, the conduct of corrupt rulers and conflict entrepreneurs in conflict-prone societies have provoked genuine humanitarian concern from NGOs and activists who constitute the main driving force behind calls for ethical markets. However, powerful players, such as western multinational corporations and OECD governments, have been able to undercut campaigns for compulsory legal regulatory codes by promoting industry self-regulation and voluntary codes of conduct. This article assesses a number of these initiatives to control the trade in conflict goods and promote good resource governance. It concludes that current mechanisms constitute a weak attempt to control the negative impacts of the market and, by failing to tackle the real causes of instability, are inadequate for building a political economy of peace

Estudio comparativo de enfermedad diarreica en infantes humanos y animales con la enterotoxina de Clostridium perfringens (etapa II)

IP 10000-3-33-76Contiene listado de publicaciones, presentaciones, resúmenes y artículos de ponencias en relación al tema Rollo No. 24perfringens type A a enterotoxin / Manuel J. Torres A. --Enterotoxin clostridium perfringens typa A in select;humans II a cohort study / Manuel J. Torres A., Hans P. Riemanny Paolo Brant -- The possible welchicin;activity of clostridium perfringens type A enterotoxin / ManuelJ. TorresA., Hans P. Riemann -- La monta;forzada en la cria de conejos / Manuel J. Torres A. -- Unnuevoenfoque para la evaluacion de la potencia;germicida de desinfectantes quimicos aplicada al cloruro de Benzalconio /Victor Cotrino Badillo, Manuel Jose;ARTICULOS DE REVISTA : Diez años de vida cientifica / Manuel Jose Torres Angel -- Investigacion serologica;de deptospira en perros de Bogotá / Manuel Jose Torres Angel --Aislamiento de Shigelia flexineriproteus;murganni, providence y otras enterobacteriaceas de lechesde consumo en Bogotá / Manuel Jose Torres Angel --;Estudio inicial de la igiene de las leches pasteurizadas en laciudad de Bogotá / Manuel Jose Torres Angel ...;[et al.] -- Bactofugation as a presterilizacion treatment/ Manuel Jose Torres Angel -- Estudio de la;contaminacion con enterobacteriaceas en concentrados paraanimales: segundo recuento y aislamiento de;bacterias coliformes / Manuel J. Torres Angel ... [et al.]--Spore removal by centrifugation and its effect;on ultrahigh temperature commercial sterilization of milk/ Manuel J. Torres Angel, T. I. Hedrick -- The use;of phase contrast microscopy in the diagnoses of dermatomycoses/ Manuel J. Torres A., a. Guevara y R. Sandino;'-- Mass screening for dermatomycosis / M. J. Torres Angel-- Caracteristics of enterotoxigenic clostridium;perfringns type A isolated form cattle and chickens / CheChungTsai, M. J. Torres y Hans P. Riemann --;Fluorescent antibody inhibition for determination of serumantibodies against the enterotoxin of clostridium;perfringens type A / Manuel J. Torres, Hans P. Riemann --Improved culturetechniques and sporulation medium;for enterotoxin production by clostridium perfringens typaA /Che Chung Tsai, M. J. Torres Angel y Hans P.;Riemann -- A new criterion for implicating clostridium perfringens as thecase of food poisoning / V. R.;Dowell ... [et al.] -- El complejo respiratorio en cunicultura/Manuel Jose Torres Angel -- Las diarreas del;conejo: coccidiosis / Manuel J. Torres Angel -- Las diferentesrazas de conejos y sus pesos / Manuel J. Torres;A. -- Los genes recesivos / Manuel J. Torres Angel -- Theuseofsucking micen assaying clostridium;Torres A. y Nestor E. Peña Echeverri -- The use of a double gel(6-25/DEAEsephadex) for one step separation;of fluorescein tagged gammaglobulins / Manuel J. Torres A,JaimeHuger y H. P. Riemann -- Protective;immunization of breeding rabbits agains the respiratory complexand its complications / Manuel J. Torres A.,;Victor Cotrino B. -- La nutricion del conejo / Manuel J. TorresA. -- Humans as carriers of enterotoxing;clostridium perfringens (Welchii) / Manuel J. Torres A. --Prevalencia declostridium perfringens /Welchii) en;la ubre bovina / Manuel J. Torres A., Alvaro Guaqueta Rincon yJohnny Melani Martinez -- El uso de la;inmunofluorescencia en el analisis microbiologico de los alimentos con especial referencia a la comparacion de;esta prueba con pruebas de cultivo / Manuel J. Torres A.,MariaT. Brigardy H. P. Riemann;TESIS : Respuesta electroenterografica del conejo a la acciondela enterotoxina de Clostridium perfringens /;Nelson Rafael Rueda Alejo -- Accion de la Esporo (entero)toxinadel clostridium perfringens en el intestino;aislado del conejo / Rosana Vargas de Berna