Magnetic Field Uniformity Across the GF 9-2 YSO, L1082C Dense Core, and GF 9 Filamentary Dark Cloud

The orientation of the magnetic field (B-field) in the filamentary dark cloud GF 9 was traced from the periphery of the cloud into the L1082C dense core that contains the low-mass, low-luminosity Class 0 young stellar object (YSO) GF 9-2 (IRAS 20503+6006). This was done using SOFIA HAWC+ dust thermal emission polarimetry (TEP) at 216 um in combination with Mimir near-infrared background starlight polarimetry (BSP) conducted at H-band (1.6 um) and K-band (2.2 um). These observations were augmented with published I-band (0.77 um) BSP and Planck 850 um TEP to probe B-field orientations with offset from the YSO in a range spanning 6000 AU to 3 pc. No strong B-field orientation change with offset was found, indicating remarkable uniformity of the B-field from the cloud edge to the YSO environs. This finding disagrees with weak-field models of cloud core and YSO formation. The continuity of inferred B-field orientations for both TEP and BSP probes is strong evidence that both are sampling a common B-field that uniformly threads the cloud, core, and YSO region. Bayesian analysis of Gaia DR2 stars matched to the Mimir BSP stars finds a distance to GF 9 of 270 +/- 10 pc. No strong wavelength dependence of B-field orientation angle was found, contrary to previous claims.Comment: 18 pages, 6 figures ApJ, accepte

Crawling in Rogue's dungeons with (partitioned) A3C

Rogue is a famous dungeon-crawling video-game of the 80ies, the ancestor of its gender. Rogue-like games are known for the necessity to explore partially observable and always different randomly-generated labyrinths, preventing any form of level replay. As such, they serve as a very natural and challenging task for reinforcement learning, requiring the acquisition of complex, non-reactive behaviors involving memory and planning. In this article we show how, exploiting a version of A3C partitioned on different situations, the agent is able to reach the stairs and descend to the next level in 98% of cases.Comment: Accepted at the Fourth International Conference on Machine Learning, Optimization, and Data Science (LOD 2018

Free-form lens model and mass estimation of the high redshift galaxy cluster ACT-CL J0102-4915, "El Gordo"

We examine the massive colliding cluster El Gordo, one of the most massive clusters at high redshift. We use a free-form lensing reconstruction method that avoids making assumptions about the mass distribution. We use data from the RELICS program and identify new multiply lensed system candidates. The new set of constraints and free-form method provides a new independent mass estimate of this intriguing colliding cluster. Our results are found to be consistent with earlier parametric models, indirectly confirming the assumptions made in earlier work. By fitting a double gNFW profile to the lens model, and extrapolating to the virial radius, we infer a total mass for the cluster of $M_{200c}=(1.08^{+0.65}_{-0.12})\times10^{15}$M$_{\odot}$. We estimate the uncertainty in the mass due to errors in the photometric redshifts, and discuss the uncertainty in the inferred virial mass due to the extrapolation from the lens model. We also find in our lens map a mass overdensity corresponding to the large cometary tail of hot gas, reinforcing its interpretation as a large tidal feature predicted by hydrodynamical simulations that mimic El Gordo. Finally, we discuss the observed relation between the plasma and the mass map, finding that the peak in the projected mass map may be associated with a large concentration of colder gas, exhibiting possible star formation. El Gordo is one of the first clusters that will be observed with JWST, which is expected to unveil new high redshift lensed galaxies around this interesting cluster, and provide a more accurate estimation of its mass.Comment: 19 pages, 10 figures. Updated figure

Hepatitis C: an update.

Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. While current therapeutic options for hepatitis C are limited, recent progress in the understanding of the biology of HCV led to the identification of novel targets for antiviral intervention. In addition, molecular and immunotherapeutic strategies to inhibit HCV replication or gene expression and to enhance the cellular immune response against HCV are being explored. These and other novel antiviral strategies may eventually complement existing therapeutic modalities. Here, we briefly review current concepts of the epidemiology, molecular virology, pathogenesis, natural history, diagnosis, therapy, and prevention of hepatitis C

Phase I multicenter study of combined high-dose ifosfamide and doxorubicin in the treatment of advanced sarcomas

Ifosfamide and doxorubicin are the most active agents in the treatment of sarcomas and are characterized by a marked dose-response relationship. The objective of this study was to determine the maximum tolerated dose (MTD) of both agents in combination under granulocyte-macrophage colony-stimulating factor (GM-CSF) cover. Patients and methods: Thirty-three patients with untreated sarcomas (soft tissue: n = 20; gynecological: n = 11; bone: n = 2) were treated with ifosfamide 12 g/m2 by continuous i.v. infusion over five days and doxorubicin with dose escalation from 50 mg/m2 i.v. bolus divided on two days, then to 60 mg/m2bolus divided on three days. Ifosfamide was reduced to 10 g/m2 and doxorubicin was further escalated up to 90 mg/m2. GM-CSF (5 μg/kg/day subcutaneously) was started 24 hours after chemotherapy and continued for 10 days. Results: The MTD was reached with the combination of ifosfamide at 12 g/m2 and doxorubicin at 60 mg/m2. But with ifosfamide 10 g/m2 and doxorubicin 90 mg/m2 the MTD was not obtained. While severe leukopenia and granulopenia were observed at all-dose levels, severe anemia was more frequently related to the highest dose of ifosfamide. Severe thrombopenia and mucositis were more commonly observed at the highest dose of doxorubicin. Ifosfamide 10 g/m2 and doxorubicin 90 mg/m2 induced WHO grade 4 leukopenia in 58%, grade 3-4 thrombopenia in 42%, and anemia in 31% of cycles. Mucositis was minor in 50% of cycles. The overall response rate among 31 evaluable patients was 55% (95 confidence interval (CI): 36%-73%), with four (13%) complete responders and 13 (42%) partial responders. Response rates based on soft-tissue sarcomas or gynecological sarcomas alone were similar. Ten patients could be treated by elective surgery and/or radiotherapy. The total group of patients reached a median survival of two years, with 25% (SE 8%) survivors after three years. Conclusions: The dose level of ifosfamide 10 g/m2 and doxorubicin 90 mg/m2 with supportive GM-CSF is manageable in a multicenter setting and should be further tested in regular phase II trials, including patients with gynecological and soft-tissue sarcomas. Transient toxicity with myelosup-pression should be accepted in order to obtain a high anti-tumor activity of this regimen and a potential improvement in surviva

Generating Levels That Teach Mechanics

The automatic generation of game tutorials is a challenging AI problem. While it is possible to generate annotations and instructions that explain to the player how the game is played, this paper focuses on generating a gameplay experience that introduces the player to a game mechanic. It evolves small levels for the Mario AI Framework that can only be beaten by an agent that knows how to perform specific actions in the game. It uses variations of a perfect A* agent that are limited in various ways, such as not being able to jump high or see enemies, to test how failing to do certain actions can stop the player from beating the level.Comment: 8 pages, 7 figures, PCG Workshop at FDG 2018, 9th International Workshop on Procedural Content Generation (PCG2018

Discovery of the Vanadium Isotopes

Twenty-four vanadium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.Comment: to be published in At. Data. Nucl. Data Table

Assessment of processing technologies which may improve the nutritional composition of dairy products – Overview of progress

Among consumers there is a growing demand for food products with a natural nutritional-physiological advantage over comparable conventional products. As part of an EU funded project, ALP is examining the possible impact of processing on nutritionally valuable milk components, using the example of conjugated linoleic acids (CLA). The extent to which processing influences the CLA content of the end product was determined by literature research and own investigations of organic and conventional butter. Furthermore, new chemical, sensory-based and bio crystallization methods were evaluated by ALP and the University of Kassel to determine the oxidation stability of butter. In a further step the storage stability of CLA enriched and conventional butter was examined and the different methods will be compared. As a third objective a process for low-input CLA enrichment of milk fat (with a focus on alpine butter) has been developed. Since the process selected for the work is a physical enrichment process, it is accepted by international organic farming and food groups. Among the many benefits ascribed to CLA, it is believed to be an effective agent against cancer. The demand for foods with properties that promote human health is growing. The dairy industry has the opportunity to meet this demand by developing new dairy products with a nutritional-physiological function for the functional food market

Adiabatic times for Markov chains and applications

We state and prove a generalized adiabatic theorem for Markov chains and provide examples and applications related to Glauber dynamics of Ising model over Z^d/nZ^d. The theorems derived in this paper describe a type of adiabatic dynamics for l^1(R_+^n) norm preserving, time inhomogeneous Markov transformations, while quantum adiabatic theorems deal with l^2(C^n) norm preserving ones, i.e. gradually changing unitary dynamics in C^n