Pore scale 3D modelling of heat and mass transfer in the gas diffusion layer and cathode channel of a PEM fuel cell

Flooding of the gas diffusion layer (GDL) of proton exchange membrane (PEM) fuel cells can be a bottleneck to the system’s efficiency and even durability under certain operating conditions. Due to the small scale and complex geometry of the materials involved, detailed insight into the pore scale phenomena that take place are difficult to measure or simulate. In the present effort, a direct 3D microscale model of a portion of the PEM cathode channel and carbon cloth GDL is used to parametrically investigate local heat and fluid flow at the GDL’s pore scale and their effects on condensation of water vapour that leads to flooding. The 3D simulation through the microscale geometry is among the first appearing in the international literature. The Navier–Stokes, energy and water vapour transport equations are solved at steady state and in three-dimensional space for a range of inlet velocities and cloth fibre material properties, using a conjugate heat transfer approach to calculate the temperature field within the solid fibres. Psychrometric calculations are applied to provide indications of the conditions and areas most prone to condensation based on the calculated local temperatures and water vapour concentration

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules

IGF-IR is highly associated with the behaviour of breast cancer cells. In ERα-positive breast cancer, IGF-IR is present at high levels. In clinical practice, prolonged treatment with anti-estrogen agents results in resistance to the therapy with activation of alternative signaling pathways. Receptor Tyrosine Kinases, and especially IGF-IR, have crucial roles in these processes. Here, we report a nodal role of IGF-IR in the regulation of ERα-positive breast cancer cell aggressiveness and the regulation of expression levels of several extracellular matrix molecules. In particular, activation of IGF-IR, but not EGFR, in MCF-7 breast cancer cells results in the reduction of specific matrix metalloproteinases and their inhibitors. In contrast, IGF-IR inhibition leads to the depletion by endocytosis of syndecan-4. Global important changes in cell adhesion receptors, which include integrins and syndecan-4 triggered by IGF-IR inhibition, regulate adhesion and invasion. Cell function assays that were performed in MCF-7 cells as well as their ERα-suppressed counterparts indicate that ER status is a major determinant of IGF-IR regulatory role on cell adhesion and invasion. The strong inhibitory role of IGF-IR on breast cancer cells aggressiveness for which E2-ERα signaling pathway seems to be essential, highlights IGF-IR as a major molecular target for novel therapeutic strategies

Mothering Here and Mothering There: International Migration and Postbirth Mental Health

Over 125,000 women immigrate to Canada yearly—most in their childbearing years and many having given birth before immigrating. We sought to (1) examine the background characteristics and mental health profile of women separated from their children due to migration and subsequently giving birth in Canada (“dual-country (DC) mothers”) and (2) contrast these with those of “non-dual-country” migrant mothers. Of 514 multiparous migrant women giving birth, one-fifth (18%) reported being separated from their children due to migration. Over one-third of DC mothers were living in poverty (36.0% versus 18.6%, P=0.001), and one in seven was experiencing household food insecurity (16.3% versus 7.6%, P=0.01). Over one-third had no partner (40.2% versus 11.4%, P=0.00), and nearly one-quarter reported no available support (23.1% versus 12.2%, P=0.007). Over three-quarters were asylum seekers or refugees (83.7% versus 51%, P=0.00). More DC than non-DC mothers had symptoms of postpartum depression (28.3% versus 18.6%, P=0.04), symptoms of clinical depression (23.1% versus 13.5%, P=0.02), and anxiety related to trauma (16.5% versus 9.4%, P=0.04). Results suggest that identifying DC mothers is a rapid approach to enable clinicians to target a subgroup of women needing special attention

Deconstructing the lesbian, gay, bisexual, transgender victim of sex trafficking: Harm, exceptionality and religion–sexuality tensions

Contrary to widespread belief, sex trafficking also targets lesbian, gay, bisexual, transgender (LGBT) communities. Contemporary social and political constructions of victimhood lie at the heart of regulatory policies on sex trafficking. Led by the US Department of State, knowledge about LGBT victims of trafficking constitutes the newest frontier in the expansion of criminalization measures. These measures represent a crucial shift. From a burgeoning range of preemptive measures enacted to protect an amorphous class of ‘all potential victims’, now policies are heavily premised on the risk posed by traffickers to ‘victims of special interest’. These constructed identities, however, are at odds with established structures. Drawing on a range of literatures, the core task of this article is to confront some of the complexities and tensions surrounding constructions of LGBT trafficking victims. Specifically, the article argues that discourses of ‘exceptional vulnerability’ and the polarized notions of ‘innocence’ and ‘guilt’ inform hierarchies of victimhood. Based on these insights, the article argues for the need to move beyond monolithic understandings of victims, by reframing the politics of harm accordingly

"Here is your mission, now own it!" The rhetoric and practice of local ownership in EU interventions

One of the core principles of EU interventions under the Common Security and Defence Policy (CSDP) has been local ownership. While the EU takes pride in fully respecting this principle, the existing research suggests that the implementation has been far from smooth. However, we still know very little how this principle is conceptualised and operationalised, let alone why its implementation has been so difficult. Drawing on document analysis and 27 in-depth interviews, the article makes 3 arguments. First, ownership is increasingly construed in the EU policy rhetoric as a middle ground between imposition and restraint. Second, in practice, ownership is operationalised as an externally driven, top-down endeavour, resulting in the low degree of local participation. Third, in addition to the obstacles normally faced by other peace-builders, the EU's efforts to implement ownership are constrained by the politics and policy-making of CSDP. The arguments are illustrated in a case study of the European Union Mission on Regional Maritime Capacity Building in the Horn of Africa (EUCAP Nestor)

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd