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<p>Cell scratch test and Transwell were used to measure the migration abilities of HSVSMCs. NC = Negative control group, only control siRNA transfected; GAS5(-) = lncRNA-GAS5 knockdown group transfected with silence siRNA. <b>A:</b>Cell scratch test was used to measure the migration abilities of HSVSMCs. The results showed that the HSVSMCs have the best migration abilities in the first 24 hours. Values are mean±SE, N = 4. <b>B:</b> The migration abilities of HSVSMCs measured by Transwell. After transfected by lncRNA-GAS5 siRNA for 48 hours, the HSVSMCs were passage into the Transwell Inserts. Then 4 hours, 7 hours, 10 hours later, the migration HSVSMCs were photographed and counted, respectively. Knockdown of lncRNA-GAS5 expression promotes migration of HSVSMCs. Optical microscope images under 200x magnification. <b>C:</b> The migration abilities of HSVSMCs were reflected indirectly by the new migration cells counting with Transwell. Silencing of lncRNA-GAS5 expression increses migration ability of HSVSMCs. Values are mean±SE, N = 10; *, P<0.05.</p

Randomised controlled trial using smartphone website vs leaflet\\nto support antenatal perineal massage practice for pregnant women

journal articl

ダニエル・リベスキンドの初期ドローイング : 《マイクロメガス》と《チェンバー・ワークス》を中心に

departmental bulletin pape

スラッジからジクロンの直接合成

Articledepartmental bulletin pape

実験計画法を用いたナノ粒子製剤製造における重要工程パラメータの解明

静岡県立大学博士（生命薬科学）2018application/pdfdoctoral thesi

Joining the Global Research Community : Japanese High School Students and Scientific Networks of Collaboration = グローバルな研究コミュニティへの参加 : 国際交流、日本の高校生、科学的協力ネットワーク

Scientific knowledge is discovered by teams of researchers, often working across the globe. Researchers need to master the social dynamics of forming collaborative networks. The current study examines the use of social network analysis to train Japanese and European high school students to form collaborative networks with intentionality. While collaborating on science projects, the students were taught how to utilise social media tools from a network perspective to form collaborative networks. After the students met in Europe, a corpus analysis of the Japanese participants’ learning diaries and recollections were compared to a control sample of another group who participated in a similar program but without the network workshop. Analysis confirmed that the group who received the training demonstrated a higher level of understanding of the project, greater feelings of competency, and a deeper insight into how to interact in a multicultural environment than did the control sample.科学的知識は、多くの場合世界中で活動する研究者のチームによって発見されます。 研究者は、協力的なネットワークを形成する社会的力学を習得する必要があります。 現在の研究では、日本とヨーロッパの高校生が意図性を持って協力的なネットワークを形成できるように訓練するためのソーシャル ネットワーク分析の使用を検討しています。 学生たちは科学プロジェクトで共同作業をしながら、ネットワークの観点からソーシャル メディア ツールを活用して共同ネットワークを形成する方法を学びました。 学生たちがヨーロッパで出会った後、日本人参加者の学習日記と回想のコーパス分析が、ネットワークワークショップなしで同様のプログラムに参加した別のグループの対照サンプルと比較された。 分析の結果、トレーニングを受けたグループは、対照サンプルよりもプロジェクトに対するより高いレベルの理解、より高い有能感、そして多文化環境でどのように交流するかについてより深い洞察を示していることが確認されました。departmental bulletin pape

編集後記・投稿規定・奥付

othe

ぞう × 高原誠吉商店

application/pdf主催：絵本のちからプロジェクト（代表：上杉和大）　協賛：尾道市商店街連合会　おやこのためのゆかいなコンサート実行委員会　協力：九州大学ユーザー感性学専攻子どもプロジェクト・尾道市・本町センター街・Yuri・尾道学研究会・子育て情報局おのみちしるべ・おはなしのこみちの会・尾道大学生有志　 開催期間：2010年11月22日（月）～11月28日（日）othe

Proximity-Induced Nucleic Acid Degrader (PINAD) approach to targeted RNA degradation using small molecules

Nature has evolved intricate machinery to target and degrade RNA, and some of these molecular mechanisms can be adapted for therapeutic use. Small interfering RNAs and RNase H-inducing oligonucleotides have yielded therapeutic agents against diseases that cannot be tackled using protein-centered approaches. Because these therapeutic agents are nucleic acid-based, they have several inherent drawbacks which include poor cellular uptake and stability. Here we report a new approach to target and degrade RNA using small molecules, proximity-induced nucleic acid degrader (PINAD). We have utilized this strategy to design two families of RNA degraders which target two different RNA structures within the genome of SARS-CoV-2: G-quadruplexes and the betacoronaviral pseudoknot. We demonstrate that these novel molecules degrade their targets using in vitro, in cellulo, and in vivo SARS-CoV-2 infection models. Our strategy allows any RNA binding small molecule to be converted into a degrader, empowering RNA binders that are not potent enough to exert a phenotypic effect on their own. PINAD raises the possibility of targeting and destroying any disease-related RNA species, which can greatly expand the space of druggable targets and diseases.info:eu-repo/semantics/publishedVersio

金峯神社周辺地盤の安定性評価

特集2　里山基盤科学技術の社会実装モデルプロジェクト2016departmental bulletin pape