The zinc finger protein ZFP106 is a novel positive regulator of the p53 tumor suppressor

肿瘤抑制因子p53能够感知并应答各种细胞胁迫，包括DNA损伤、原癌基因激活、缺氧以及其他刺激。在正常生长条件下E3泛素连接酶Mdm2泛素化降解p53使p53维持在非常低的水平。当细胞受到胁迫时p53被大量诱导并活化。活化的p53通过诱导细胞周期阻滞、衰老或凋亡抑制损伤细胞的分裂和增殖。越来越多的研究表明各种细胞胁迫能够通过活化不同的信号通路抑制Mdm2的E3泛素连接酶活性从而活化p53。许多蛋白能够作用于Mdm2-p53调节通路增强或者抑制Mdm2的E3泛素连接酶的活性。 本文发现含WD40结构域的锌指蛋白ZFP106（zincfingerprotein106）能够结合p53并通过抑制Mdm...The tumor suppressor p53 serves as a cellular stress sentinel, responding to diverse cellular stresses, including DNA damage, oncogenic stress, hypoxia, and other stimuli. p53 is kept at very low levels in normal cells by mouse double minute 2(Mdm2), which functions primarily as an E3 ubiquitin ligase and promotes proteasomal-dependent degradation of p53. p53 is stabilized and activated in respons...学位：理学博士院系专业：生命科学学院_生物学学号：2162010015393

基于加密图像的可逆信息隐藏

加密图像的可逆信息隐藏对于数据处理过程中的信息安全可以起到双重保险的作用,加密对数据信息进行保护,而嵌入的秘密数据可以起到在解密后监视多媒体数据的传输中是否被篡改,验证其完整性和原始载体的无损恢复。本文阐述了信息隐藏技术,介绍可逆信息隐藏技术的研究现状,分析了基于加法同态的直方图多峰值平移的可逆信息隐藏算法与基于Paillier同态公钥加密与预测误差的可逆信息隐藏算法。课题项目:2018福建省中青年教师教育科研项目“科技类”课题,项目编号:JT180830;;课题项目:2018年泉州市科协资助项目,批准文号:泉科协【2018】65

我国数字文化产业之发展障碍与路径选择

数字文化产业是文化产业发展的未来方向,是基于数字技术的发展和创意产业的融合催生出的文化产业新趋势。我国应当利用区域优势,将数字文化产业作为经济发展的重要组成部分,结合我国文化产业优势与\"一带一路\"的重要机遇,利用数字技术,将文化场馆的文化资源进行跨场馆整合,并从文化保护的视角出发,运用虚拟现实与可视化技术,进行文化遗产的重现与推广,建立特色文化数据库。此外,还应当从技术、资本、人力资源、知识产权等多方面进行市场构建和政策支持,将数字文化产业打造成我国的优势产业,并使之具有国际影响力。福建省社科青年项目“自贸协定视角下知识产权交易税制研究”(FJ2017C005

公司董事会特征与绩效研究综述

本文系统地回顾了国内外有关董事会特征与公司绩效之间关系的理论和实证研究成果。董事会特征主要包括董事会规模、董事会构成、董事会会议频率和董事会领导结构。迄今的研究成果在一定程度上支持了小规模董事会的作用,却无法确定外部董事是否能提高公司的绩效。董事会会议是一种企业的被动行为,高频率的董事会会议可能是对公司业绩下滑的一种反应。虽然许多团体大力提倡两职分离,但是两职分离能否提高公司绩效仍是个未知数

Remarks on the Efficiency of Principal Component Cluster Analysis

本文针对经典聚类分析和普通主成分聚类分析极端情形下的失效问题展开讨论,通过定义客观赋权的主成分距离为分类统计量,并以实证检验取得良好效果为依据,有效地解决了主成分聚类分析在极端情形下所不能揭示的问题。A discussion about the invalidations of canonical cluster analysis and ordinary principal component cluster analysis under extreme situations is presented in this paper,by defining an objective weighted principal component distance as classification statistic,this paper solves the problems effectively which can't be revealed by principal component cluster analysis under extreme situations,and the empirical test proves its validation.国家社会科学基金项目“金融高频数据挖掘方法及应用研究”(11BTJ001)资

基于银行数据仓库的元数据管理系统

元数据在银行数据仓库中具有重要意义。讨论元数据的分类和作用,分析元数据的管理功能,给出一种基于银行数据仓库的元数据管理系统,对其结构进行分析和说明。实践结果表明,该系统可以加強对数据的分析和管理能力,提高银行数据仓库等决策系统的灵活性和可扩展性

Hartree-Fock量子MonteCarlo方法

量子MOnTECArlO(QMC)方法已成功地应用于量子化学领域,对QMC的评述请参考

Ultrastructural Characteristics of Heterotype Tapetum Development in Lycium barbarum L.

采用半薄和超薄切片技术对宁夏枸杞(lyCIuM bArbAruM l.)异型绒毡层的来源、结构及发育特点进行了研究,结果表明:(1)枸杞异型绒毡层由药隔绒毡层和药壁绒毡层组成,两种绒毡层除了来源、形态及分布位置不同外,其分化、成熟和降解时间,以及细胞质组成、分泌物成分等均有差异。(2)小孢子母细胞期间,药隔绒毡层细胞电子密度大,具有很强的脂质性质,光滑内质网和脂质小泡很丰富;而药壁绒毡层细胞中的核糖体和粗糙内质网较多。四分体后期,两种绒毡层细胞均含有很丰富的核糖体、粗糙内质网和分泌团。减数分裂前,两种绒毡层的细胞壁出现松散并呈絮状。之后,由于不同发育时期绒毡层细胞的不同分泌物在絮状细胞壁中的分布,致使二者的细胞壁都出现了一系列变化。(3)从小孢子早期开始,两种绒毡层细胞的质膜都发生了局部解体。分析推测,在母细胞期间药隔绒毡层具有较高的糖和脂类合成率,药壁绒毡层具有较高的蛋白质类合成率;在四分体后期,药隔绒毡层具有加强胼胝质酶合成和分泌的功能;而两种绒毡层絮状松散的细胞壁和局部解体的质膜有利于绒毡层的较大颗粒分泌物大量、顺利地分泌出绒毡层细胞。To understand the discrepancy of the heterotypic tapetum of Lycium barbarum L.,we investigated the origin,morphology and ultrastructural characteristics using light and electron microscopy.Besides the origin,form,and the location are different,the time of differentiation,mature and degradation,the cytoplasm composition,and secretion components are not the same in the two tapeta.During the microspore mother cell phase the electronic density is higher and having very strong lipid properties,while smooth ER and lipid vesicles are very rich in C-tapeta,but ribosomes and rough ER are very abundant in P-tapeta.At the late of tetrad there are lots of ribosomes,rough ER and secretory groups in the two tapeta.Before Meiosis the wall of two tapeta appears to loose and with the cottony.Following that during the distribution of different secretions at cottony wall in developmental stages,the walls of the both tapeta have gone through a series of special changes.Moreover,from the early stage of microspore the plasma membranes of the both tapeta disaggregate partially.It is presumed that the P-tapeta possess own a higher rate of protein synthesis,and C-tapeta having a higher rate of sugar and lipid synthesis during the microspore mother cell stage.At the late stage of tetrad C-tapeta have strengthening the functions of synthesis and secretion of callose enzyme.The cottony wall and the partial disintegrated plasma membrane of two tapeta facilitate to secrete greater nutrient granules out of the tapetacells with large quantity and smoothly.宁夏大学自然科学基金(ZR200839);宁夏科技攻关重大专项(KGZ-09-07-04)资

Application of Ionic Liquids in Extraction and Separation

室温离子液体是由正负离子组成的室温为液体的熔融盐,因其具有极低的蒸汽压、可设计性和特殊的选择溶解能力等独特的性质,使得其在萃取分离有机物及金属离子、液相微萃取和汽油柴油中脱硫及碱性氮化物等领域都有着广泛应用。综述了离子液体在萃取分离上的应用进展。Ionic substances with melting points close to room temperature were referred as room-temperature ionic liquids,which showed lots of unique properties,e.g.environmentally benign,nonvolatile,designable and were good solvents for a wide range of both organic and inorganic materials.Ionic liquids are widely used in extraction and separation processes,e.g.extraction and separation of metal ions and organic compounds,headspace liquid-phase micro extraction,removal of basic nitrogen compound from distilled diesel and desulphurization of gasoline.In this paper,the recent application of ionic liquids in extraction and separation were reviewed.教育部科学技术研究基金重点资助项目(207108

The clinical significance of KAI1 /CD82 expression in colon tumor

目的　KAI1是一种特异性抑制肿瘤转移的基因,其蛋白产物为KAI1/CD82。通过检测 6 4例结肠腺癌石蜡切片的KAI1/CD82蛋白表达,探讨其与预后等临床因素的相关性。方法　肿瘤经福尔马林固定 ,石蜡包埋。免疫组化方法检测石蜡切片中KAI1/CD82蛋白表达水平。生物学统计采用 χ2 检验法。生存曲线采用Kaplan Meier软件绘制。结果　KAI1/CD82蛋白呈现棕褐色、细颗粒状物 ,弥漫性分布结肠腺癌细胞膜上。KAI1/CD82蛋白在结肠腺癌组织中表达阳性率为 5 1.5 6 %。生物学统计结果表明 ,KAI1/CD82蛋白表达与淋巴结转移、远处转移及肿瘤临床分期等密切相关 ,有统计学意义 ;而与肿瘤患者的年龄和性别、肿瘤大小、分化程度及肿瘤部位等无关。KAI1/CD82蛋白阳性结肠腺癌患者的术后生存期明显高于阴性患者 ,前者平均术后生存期为 5 4 .2 7± 2 1.5 1月 ,而后者仅为 37.5 5± 15 .17月 ,具有统计学意义。结论　KAI1/CD82表达水平与结肠腺癌分期、淋巴结转移及远处转移关系密切 ,可能和其它指标一起作为判断结肠腺癌预后的指标之一 ,对术后进一步治疗具... 【英文摘要】 Objective KAI1 gene is a specific metastasis suppressor gene, and its protein product is KAI1 /CD82. The relationship between KAI1 /CD82 expression and colon cancer patient prognosis was investigated. Methods 64 colon tumor specimens were detected and analyzed for their KAI1 /CD82 protein expression level with immunohistochemical method, the paraffin embedded tissue sections were incubated with anti KAI1 antibody. The Student s t test and the Kaplan Meier method were used. Results The KAI1 /CD82 pro...教育部科学技术重点项目(00073)；教育部访问学者专项基金(2000年度