New Method of Nanosilicon Preparation by Pulsed-laser Deposition

采用高强度激光灼蚀沉积(PLD)的方式,在流动N2做为保护气体的情况下,成功制备出Si纳米结构,并利用扫描电镜(SEM)、光致发光(PL)进行表征。结果表明,该方法制备的纳米Si尺寸在几nm到几10nm之间,同时它具有较强的发光,发光强度比同等测量条件下的多孔Si(PS)样品高10倍以上,而且方法比较简单。The photo-luminescence of Si-based material is one of the most interesting and difficult subjects in research field.Nano-silicon will be a useful way to realize silicon-based photoluminescence.A new pulsed-laser-deposition(PLD) method to produce nano silicon is reported then according to SEM and photo-luminescence(PL) it′s characters are expressed.The results show that n-Si produced by the new pulsed-laser deposition(PLD) style has a great PL intensity.For the simpleness of new PLD style,it will be of some reference value for silicon-based PL rereach.国家自然科学重点基金资助项目(60336010

A Study on the Photoluminescence Spectroscopy of Silicon Nanocrystal Formed by Pulse-laser Deposition

在激光灼蚀(PLD)系统中,采用流动的N2作为环境气体成功制备了尺寸从2纳米到几纳米之间的纳米硅,并在1.60～1.75eV之间观测到了较强的光致发光谱:结合Raman散射和光致发光谱的分析,推断强光致发光来源于纳米硅的量子效应。It has been successful to fabricate silicon nanocrystal from 2 nm to several nanometers by pulse-laser deposition using flowing N_2 as atmosphere gas.Strong photoluminescence between 1.6 eV and 1.75 eV has been observed.The origin of the photoluminescence was investigated by Raman scattering spectroscopy and photoluminescence spectroscopy.It was deduced that the strong pholuminescence stems from quantum effect.国家自然科学重点基金(批准号:60336010)资助项

Study on the Kinetics of L-Tryptophan Adsorption by Ion Exchange Resin

通过静态吸附实验,研究了l-色氨酸在001x7型阳离子交换树脂上的等温吸附和吸附动力学特性。采用动边界模型描述l-色氨酸在该树脂上的交换行为,考察了料液浓度、树脂粒径和温度对交换过程的影响。结果表明,l-色氨酸在001x7型阳离子交换树脂上的吸附等温线符合lAngMuIr等温方程,且随PH降低,树脂的最大平衡吸附量逐渐增大;交换过程的吸附速率随l-色氨酸浓度和温度的升高而增大,但随树脂粒径的增大而减小;离子交换过程的速度控制步骤为颗粒扩散控制。交换过程的反应速率常数k0为1.199x10 5,反应级数为1.7,表观活化能EA为19.94kJ MOl 1,并得到了动力学总方程式。The isothermal adsorption and adsorption kinetics of L-tryptophan by 001×7 cation-exchange resin were studied by static experiments.The Moving Boundary Model was applied to describe the kinetics of the ion exchange process.The effects of experimental conditions including the concentration of L-tryptophan,resin particle diameter and adsorption temperature on the ion exchange process were investigated.The results show that the maximum L-tryptophan adsorption capacity of 001×7 cation-exchange resin increases with decreasing solution pH.It was found that the Langmuir equation fits the adsorption isotherm data best,and the particle diffusion is the rate-limiting step of the adsorption process.The adsorption ratio increases with the increase of L-tryptophan concentration and adsorption temperature,but decreases with the increase of the resin particle diameter.The rate constant of exchange(k0),reaction order() and the apparent activation energy of reaction(Ea) were obtained as follows: k0=1.199×10 5,Ea=19.94 kJ mol 1,and the kinetics equation was obtained too.国家自然科学基金(3107488);福建省自然科学基金(2011J01058);中央高校基本科研专项基金(2011121017

Raman Analysis of Silicon Nanocrystal Formed by Pulse-laser Deposition

以流动气体(N2,Ar2)作为反应环境,利用开放式激光熔蒸系统,通过改变制备参数:熔蒸激光强度,流动气体种类及其流速,激光熔蒸时间,制备出一系列纳米硅样品.利用Raman光谱对在不同参数下所得到的样品表面形貌进行分析,可以看出,激光强度对生成的样品表面形貌有最直接的影响,并决定生成粒子的大小,而流动气体的种类则影响着沉积粒子的分布及其大小.流动的气体防止生成的纳米硅在开放系统中被氧化,而激光熔蒸时间对样品表面形貌的作用则表现的不是很明显.国家自然科学重点基金(60336010); 福建省自然科学基金(A0410008)资

靶向调控非小细胞肺癌的作用机制

【目的】探究miR-204-3p 靶向EphB2 基因对非小细胞肺癌增殖、凋亡、侵袭的调控机制。【方法】培养将非小细胞肺癌A549 细胞系分为 5 组 NC mimic 组（miR-204-3p 过表达阴性对照组）、miR-204-3p mimic 组（miR-204-3p 过表达组）、oe-NC 组（EphB2 过表达阴性对照组）、oe-EphB2 组（EphB2 过表达组）、miR-204-3p mimic+oe-EphB2 组（miR-204-3p 与EphB2 均过表达组）。MTT、流式细胞术、Transwell、划痕实验分别检测细胞增殖、周期、凋亡、侵袭、迁移情况。双荧光素酶报告分析 miR-204-3p 与 EphB2 靶向关系。qPCR 和Western Blot 检测miR-204-3p、EphB2 mRNA 和蛋白表达情况。【结果】在A549 细胞系中，miR-204-3p 与EphB2 3′UTR 区存在结合位点，miR-204-3p 高表达明显抑制 EphB2 mRNA 和蛋白的表达（P<0.01）；与阴性对照组相比，miR-204-3p mimic组A549细胞增殖能力明显下降（P<0.05），凋亡率明显增加（P<0.05），细胞迁移及侵袭能力明显下降（P<0.05），共转染EphB2 后逆转上述变化；此外，在非小细胞肺癌中，miR-204-3p 与EphB2 表达呈负相关（r=0.636， P<0.001），且 EphB2 高表达较低表达的总生存期短（logrank χ2=3.899，P=0.049）。【结论】miR-204-3p 可通过靶向下调EphB2 来抑制非小细胞肺癌的增殖、侵袭、迁移，诱导细胞凋亡

Expert consensus on the management of dermatogenic chronic pruritus in children

瘙痒见于多种疾病,在儿童多由皮肤疾病导致,即皮肤源性瘙痒.持续存在的慢性瘙痒治疗困难,可对患儿的睡眠、情绪、认知、学校表现及社会家庭功能等方面产生负面影响,严重影响患儿及其家庭成员的生活质量.临床上迫切需要对儿童慢性瘙痒进行规范化管理,而目前国内外缺乏独立的儿童慢性瘙痒诊疗指南或共识.该共识根据循证医学证据及专家意见,制定了一套针对0～18岁儿童皮肤源性慢性瘙痒的管理方案,供临床医生参考.</p

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel