Clinical pharmacist intervention effects on analgesic treatment of outpatients with terminal cancer

目的探讨临床药师在门诊晚期癌症患者疼痛治疗中的作用。方法采用随机对照法,收集病例为2012年12月至2013年5月,在我院门诊建立麻醉药品取用卡的晚期癌痛患者101例,分为实验组和对照组。实验组实施技术干预,对照组不予技术干预。每位患者随访1个月后,分别评估其疼痛强度、生活质量、用药依从性和回顾监测Adr,并对结果进行比较研究。结果两组患者在疼痛强度、用药依从性方面差异有统计学意义,部分生活质量指标(疼痛、认知、情绪、疲倦、恶心、呕吐、便秘及总体健康状况)和部分不良反应(恶心、呕吐、便秘)差异也有统计学意义;而阿片类药物使用剂量和部分生活质量指标(躯体功能、角色功能、社会功能、气促、失眠、食欲、腹泻、经济困难)差异无统计学意义。结论临床药师对门诊晚期癌症患者疼痛治疗的干预,能提高患者用药合理性、用药安全性和用药依从性,能有效缓解患者癌痛,改善其生活质量。AIM To explore the role of clinical pharmacists in the analgesic treatment of cancer outpatients.METHODS This was a randomized and controlled study.A total of 101 cases of terminal cancer outpatients in our hospital with a card about narcotic drugs from December 2012 to May 2013,were divided into the trial group and the control group.The trial group was given technological intervention treatment while the control group was not.After one-month follow-up,clinical pharmacists respectively evaluated terminal cancer patients' pain relief,quality of life,medication compliance,and monitoring review of adverse drug reactions,and compared the results.RESULTS There was statistic significance between 2 groups in pain relief,medication compliance,some quality of life indexes( pain,cognition,emotion,fatigue,nausea,vomiting,constipation and overall health status) and some indexes of adverse drug reactions( nausea,vomiting and constipation)( P < 0.05),whereas there was no significant difference in using doses about opioid drugs as well as some quality of life indexes( somatic function,role function,social function,polypnea,insomnia,appetite,diarrhea and economic difficulties).CONCLUSION Through the intervention treatment of outpatients with terminal cancer pain,clinical pharmacists could not only significantly improve patients' medication safety,medication compliance and the quality of life but also effectively alleviate the cancer patients' pain,and quality of life

大熊猫粪便皮质醇激素分布与取样对策

粪便皮质醇激素对衡量动物应激强度具有较好的指示作用,但其检测准确性受诸多因素影响。为了评估不同取样方式对大熊猫(Ailuropoda melanoleuca)粪便皮质醇测定产生的影响,将粪便横向纵向四等分分割,采用冻干研筛法与酶联免疫吸附法(ELISA)处理每部分粪便和测定激素含量,旨在分析粪便激素分布情况以进一步探讨取样对策。结果显示:每部分粪便的皮质醇含量无显著差异(df=3,F=0.033,P=0.992),粪便在四等分处理下的激素分布比较均匀,即每部分粪便激素均能在一定程度上代表整体水平。1/2取样所产生的变异系数小于1/4取样,前者的检测准确性更高。粪便湿重与尺寸大小存在显著正相关性(r=0.897,Py=2.3x-29.3(y为粪便湿重,x为粪便大小,R2=0.804,F=418.846,P<0.001)。粪便干重由粪便类型、尺寸和含水率决定。在野外工作中,建议采用纵向1/2的取样对策

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

Measurement of integrated luminosity of data collected at 3.773 GeV by BESIII from 2021 to 2024

We present a measurement of the integrated luminosity e+e- of collision data collected by the BESIII detector at the BEPCII collider at a center-of-mass energy of Ecm = 3.773 GeV. The integrated luminosities of the datasets taken from December 2021 to June 2022, from November 2022 to June 2023, and from October 2023 to February 2024 were determined to be 4.995±0.019 fb-1, 8.157±0.031 fb-1, and 4.191±0.016 fb-1, respectively, by analyzing large angle Bhabha scattering events. The uncertainties are dominated by systematic effects, and the statistical uncertainties are negligible. Our results provide essential input for future analyses and precision measurements

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies

Determination of the number of ψ(3686) events taken at BESIII

The number of ψ(3686) events collected by the BESIII detector during the 2021 run period is determined to be (2259.3±11.1)×106 by counting inclusive ψ(3686) hadronic events. The uncertainty is systematic and the statistical uncertainty is negligible. Meanwhile, the numbers of ψ(3686) events collected during the 2009 and 2012 run periods are updated to be (107.7±0.6)×106 and (345.4±2.6)×106, respectively. Both numbers are consistent with the previous measurements within one standard deviation. The total number of ψ(3686) events in the three data samples is (2712.4±14.3)×10^