自动复位通配型安全手术刀柄的设计

目的克服普通手术刀柄所装载的刀片裸露易误刺、术中必须采取被动防护措施等缺欠,并提高依从性、适配性及经济性。方法参照并遵从国标,借鉴课题组昔研的滑移护刃鞘、卡簧定位钮及闭式自动复位等相关专利设计了安全便捷的\"内藏式自动复位捷卸式通配型并置刀架\",益于直接安全传递。结果通过外科医生及手术室护士实际装卸刀片并进行问卷调查统计,结果显示自动刀柄装卸用时更短(P<0.05),医护的使用满意率更高(P<0.05)。结论自动刀柄保险御刺、舒握抗损、简骤增效、降耗环保、以一代多、人机和谐、便携易储。福建省医学创新课题(2017-CXB-21

Thermal performance testing for high power light-emitting diode based on voltage-current characteristics with pulse injection

热学特性是影响功率型lEd光学和电学特性的主要因素之一,设计了一套基于脉冲式u-I特性的功率型lEd热学特性测试系统,可以测试在不同结温下lEd工作电流与正向电压的关系,从而获得lEd的热学特性参数。该系统通过产生窄脉冲电流来驱动lEd,对其峰值时的电压电流进行采样,同时控制和采集lEd的热沉温度,从而获得不同温度下lEd的u-I特性曲线。与其他u-I测试系统相比,文中采用了窄脉冲(1μS)工作电流,lEd器件Pn结区处于发热与散热的交替过程,不会造成大的热积累,大大提高了测量精度。实验中,对某功率型lEd进行了测试,获得了该器件的电压、电流和结温特性曲线,并利用b样条建立该器件的u-I-T模型,进而实现了对其结温的实时在线检测。Thermal performance is one of the main factors which affect the optical and electrical performance of high power LED.The thermal performance testing system for high power LEDs based on voltage-current characteristics with pulse injection was designed in this paper, which can test the relationship between the operating current and forward voltage of LED under different junction temperatures, thereby obtaining LED thermal characteristics parameters.The system worked by generating a controlled narrow pulse current to drive the LED, and sampling the peaks of voltage and current of LEDs with LED heat sink temperature control and acquisition, thereby obtaining the voltage-current characteristic curve in different junction temperatures.Compared with other voltage-current testing systems, the designed system adapts the narrow pulse duty cycle(1 μs), so the PN junction of LED devices is always in the process of alternately heating and cooling, which can avoid large heat accumulation and greatly improve the accuracy of measurement.In the experiment, a power LED device was tested by the system and the voltage-current-temperature curve was obtained.Then the B-spline based U-I-T model of the LED was established, so the real-time online detection of LED device was achieved.国家自然科学基金(61102030

Curcumin-induced Apoptosis Affects the Expression and Localization of hnRNP A2/B1 in Human Osteosarcoma MG-63 Cells

姜黄素(CurCuMIn)诱导处理的人成骨肉瘤Mg-63细胞,在光镜和电镜观察细胞凋亡的基础上,对HnrnP A2/b1在核基质中存在、分布及其与凋亡相关基因产物在Mg-63细胞中的共定位关系进行了研究.经姜黄素处理后,细胞出现染色质凝聚、细胞核固缩、凋亡小体等典型的细胞凋亡形态特征;双向凝胶电泳和质谱鉴定结果显示,HnrnP A2/b1存在于Mg-63细胞核基质蛋白组分中,在姜黄素处理后细胞核基质蛋白中表达下调.蛋白质印迹杂交结果,证实HnrnP A2/b1在姜黄素处理前后的Mg-63细胞核基质蛋白中的存在及其表达下调变化.免疫荧光显微镜观察显示,HnrnP A2/b1定位于Mg-63细胞核基质纤维上,经姜黄素处理后出现分布位置与表达水平变化.激光扫描共聚焦显微镜的观察结果显示,HnrnP A2/b1在Mg-63细胞凋亡过程中与bAX、bCl-2、fAS和P53等基因产物具有共定位关系,且其共定位区域发生了变化.研究结果证实了HnrnP A2/b1定位于核基质纤维上,是一种核基质蛋白,在姜黄素诱导人成骨肉瘤Mg-63凋亡过程中的表达与分布变化及其与凋亡相关基因的关系显然对Mg-63细胞凋亡具有重要影响,这为深入揭示肿瘤细胞凋亡的机制提供了重要科学依据和深入探索的新方向.The morphology of human osteosarcoma MG-63 cells under light microscopy and transmission election microscopy was altered when treated with curcumin.The distribution of heterogeneous nuclear ribonucleoprotein (hnRNP)A2 /B1 in the nuclear matrix and its colocalization with the apoptosis-related gene products were examined.The results demonstrated that curcumin induced typical apoptotic responses,such as chromatin agglutination,nuclei condensation,and apoptotic body formation.Twodimentional PAGE and mass spectrum analyses showed that hnRNP A2 /B1 was complexed with the nuclear matrix.Confirmed by Western blotting,curcumin treatment resulted in a down-regulation of hnRNP A2 /B1 expression.An altered distribution of hnRNP A2 /B1 with the nuclear matrix was observed in immunofluorescence assays.Laser confocal microscopy showed that hnRNP A2 /B1 colocalized with apoptosis-related molecules,including Bax,Bcl-2,Fas and p53,with different patterns before and after curcumin treatments.Our study showed that expression level and the distribution of hnRNP A2 /B1,a nuclear matrix protein,were altered by curcumin treatments and mought be involved in the process of apoptosis in MG-63 cells.国家自然科学基金项目(No.30871241)---

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In order to obtain clear salivary gland images, subtraction scintigraphy was attempted in the mouse neck. The purpose of this attempt was to eliminate the unwanted thyroid gland image which appeared overlapped with the salivary gland image. The subtraction procedures were carried out photographically using a thyroid gland scintigram with Na^I and a salivary gland scintigram with ^TcO^-_4. Thyroid gland scintigram was used as a scout image, which was used to make a subtraction mask. Salivary gland scintigram was used as the original image. These two images were superimposed exactly, and were exposed with a spotlight. Subtraction scintigram was obtained as a negative image, which demonstrated only the salivary gland structure

The Morphology of the Primary Dental Arch of Chinese Children in Shijiazhuang-City Part-I: Research concerning the size of the primary tooth crown, primary dental arch and the condition of primary occlusion

The purpose of this study was to investigate the size of the primary tooth crowns, primary dental arches, standard values and frequency distribution of primary occlusion in Chinese children. With the cooperation of a kindergarten in Shijiazhuang-city, China, the dental plasters from 55 children (36 boys and 19 girls, age range from 3-6 years old) with normal primary occlusion were collected. Because of different growth rates of the children, these children were divided into two groups, one comprising children less than 5 years old and the other of 5 years old or older. According to the method that the Japanese Society of Pediatric Dentistry reported, the data were statistically analyzed and compared to Japanese children. The results were summarized as follows: 1. Except lower primary lateral incisors, the values of the mesio-distal width of primary crowns of each tooth were significantly larger for boys than for girls in all tooth types. Also the Chinese children were inclined to show smaller mesio-distal tooth crown width than those of the Japanese children in all types of teeth. 2. Compared with the Japanese children, the Chinese children were inclined to show smaller primary dental arch length both in the maxilla and the mandible. But in the senior group, the Chinese girls were inclined to show smaller primary dental arch width than their Japanese female counterparts. On the contrary, the Chinese children tended to show larger dimensioned primary dental arch height than those of the Japanese children. 3. Though spaces between teeth (primate and growth spaces) were found in the Chinese children, the frequency was lower than that of the Japanese children. 4. The frequency of terminal plans in the Chinese children was 41.8% in the vertical type, 6.4% in the distal-step type and 51.8% in the mesial step type. 5. The primary canines occlusal relationship in the Chinese children was 63.1% in type I, 13.6% in type II and 23.7 in type III