双腔气管插管患者术后咽喉痛的危险因素分析

目的探讨拔管力等因素是否是双腔气管插管术后咽喉痛的危险因素。方法这是一项随机对照试验的事后分析。本研究收集18~65岁，ASAI-Ⅲ级的双腔气管插管患者围术期资料，记录性别、年龄、吸烟史、导管直径、导管留置时间、舒芬太尼用量、是否使用氟比洛芬酯、是否拔管时呛咳等。拔管时使用测力计测量拔除导管所需的力。根据术后是否发生咽喉痛分为咽喉痛组和无咽喉痛组。对两组资料进行组间比较和多因素logistic回归分析，筛选术后咽喉痛的危险因素。使用ROC曲线预测危险因素的预测效应。结果最终纳入163例患者，拔管后30 min有74例（45.4%）患者发生术后咽喉痛，89例（54.6%）患者未发生术后咽喉痛。多因素logistic回归分析结果显示女性［OR95%CI=3.83（1.73，8.50），P=0.000 1］和拔管力增大［OR95%CI=1.78（1.45，2.20），P＜0.001］是术后咽喉痛的独立危险因素。拔管力预测术后咽喉痛的AUC曲线为0.773［95%CI（0.701，0.846），P＜0.001］ ；当约登指数为0.447时，拔管力的最佳临界点是13N。结论女性和拔管力是双腔气管插管全身麻醉术后咽喉痛的独立危险因素

Typing the genes of hepatitis C virus by reverse dot blot

目的:分析厦门地区及肝病患者不同临床类型丙型肝炎病毒(HCV)感染株的基因型。方法:用反向点杂交技术(RDB)对109例HCVRNA阳性的血清进行基因分型。结果:109例HCVRNA阳性血清中,其中单一型感染者98例(89.91%),混合型感染11例(10.09%),单一型感染者中以1b型占绝对优势,共90例(82.57%),2a/2c及6a型分别为2例和3例,另有3例1b+2a/2c和8例1b+6a混合型;HCV1b型在急、慢性肝炎、肝硬化及肝癌患者中均占绝对优势,其余有少量2a/2c、6a及某些混合感染型。结论:厦门地区HCV感染者中,以HCV1b基因型为主,其次为HCV6a,另有少数2a/2c型。不同基因型在不同临床类型中的分布无明显差异。Objective To analyze the genotypes of isolates of HCV from different clinical styles of liver disease in the Xiamen area. Methods 109 cases of HCV-RNA serum samples were typed by reverse dot blot (RDB). Results Of 109 cases,98 were single genotype (89.91%) and 11 were multi-genotypes (10.09%). There were 90 cases of HCV-1b (82.57%),2 HCV-2a/2c and 3 HCV-6a in the single genotype and 3 HCV genotype 1b+2a/2c,and 8 HCV genotype 1b+6a in the hybrid genotype. The isolates of HCV-1b were prominent in acute hepatitis,chronic hepatitis,hepatocirrhosis and hepatocellular carcinoma and the remaining was the isolates of HCV-2a/2c,HCV-6a and other genotypes. Conclusions HCV-1b is the main genotype in the individuals infected by HCV in the Xiamen area and followed by HCV-6a.A few infected individuals are HCV-2a/2c. There is no significant difference in the distribution of HCV genotypes in various types of liver disease

多酸基纳米复合材料的制备及性能研究进展

杂多酸基纳米复合材料在光电催化、生物传感器件等方面有较好的应用前景,其合成方法简单、环保,催化性能良好。利用杂多酸同时作为包覆剂、还原剂和链接剂制备银纳米粒子@多酸-碳纳米管三元纳米复合材料,该材料可以提高修饰电极的抗甲醇干扰性,且具有很高的电催化氧气还原反应(ORR)活性。利用原位还原方法同时还原金属离子与氧化石墨,制备出包括金、铂、钯纳米粒子等贵金属纳米粒子@多酸-石墨烯以及银纳米网@多酸-石墨烯三元纳米复合材料,可作为良好的生物传感材料和燃料电池电极材料。利用高温NH3处理制备银纳米粒子@多酸-氮掺杂石墨炔三元纳米复合材料,可实现无金属高活性ORR电催化。</p

新疆塔里木盆地沉积特征与储集条件研究

该项目属于为油气普查、勘探与开发服务的层序地层学、沉积与储盖层地质学领域。主要内容为塔里木盆地沉积特征与油气储盖条件的系统研究总结，包括应用层序地层学理论研究全盆地震层序划分与层序地层格架的最新进展，生物地层与岩石地层研究的新发现与认识。展示综合盆缘主干露头剖面研测、区域地震剖面解释与石油深钻井资料，重新编制的震旦系－第三系岩相古地理图，介绍各层系沉积相展布、相模式及其变迁，突出了与烃类生聚密切相关的凝缩段深水缺氧沉、地史上三次大规模碳酸盐台地建造与相关沉积、各类重力流沉积、陆源碎屑海岸沉积、湖泊、三角洲与风成沉积等。探讨把地球动力学背景与沉积类型结合恢复的沉积盆地原型及其复合叠加关系。进而在具体分析储盖条件下组合基础上，划分油气远景区带，强调克拉通内盆地长期发育的古隆起与斜坡带、叠合前陆盆地稳定翼在全盆油气勘探中的重要地位。项目特点是基础研究与应用研究结合，从而为全盆油气勘探选区评价，提供了科学依据，成果已实际应用于生产。研究方法在其他大型含油气盆地得到推广

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors