Research and Design of Intelligent Elevator Group Control System

随着建筑物向大型化和高层化方向发展，在一幢大楼内往往需要配置几台或多台电梯，如果这些数台电梯各自单独运行，电梯群的整体运行效率将会不高，也会极大地浪费能源，因此在电梯群的电气控制系统中必须考虑到如何合理调度分配电梯的问题。本文正是以厦门一家公司的项目开发为应用背景，对电梯群控系统进行了研究与设计。 电梯群控系统所要解决的是一个复杂的、具有非线性和不确定性的多目标随机决策问题。在现代建筑中，电梯群控技术多被采用来调度电梯群的运行，在提高系统的服务质量和运营效率的同时降低能耗。 本文在借鉴国内外电梯群控相关技术及研究成果的基础上，首先对电梯群控系统的特性进行了分析，对电梯群控系统进行了多目标规...With the buildings becoming larger and higher, it’s necessary to equip several elevators in the building. Operating efficiency of the elevator group system is low if each elevator runs independently, and which leads to great waste of energy. Therefore, how to reasonably dispatch elevators must be considered in Elevator Group Control System (EGCS). In this paper, research and design of EGCS is made...学位：工学硕士院系专业：信息科学与技术学院自动化系_检测技术与自动化装置学号：2005130246

Optimization of β lactam antibiotics regimens against bloodstream infection caused by Pseudomonas aeruginosa

目的制定某院B内酰胺类在铜绿假单胞菌（PA）血流感染中的治疗方案。方法收集某院2015年至2016年血培养中铜绿假单胞菌共64株，测定B内酰胺类（哌拉西林／他唑巴坦，头孢他啶，头孢吡肟，亚胺培南，美罗培南）对铜绿假单胞菌的最低抑菌浓度（MIC）。用蒙特卡洛模拟计算多种治疗方案的达标率（PrA）和累积反应分数（CFR）。结果经验治疗时，哌拉西彬他唑巴坦4．5g（q6h），头孢他啶2g（q8h），头孢吡肟2g（q8h），亚胺培南1g（q6h），美罗培南1g（q8h，q6h），共6种方案的CFR值〉90％；目标治疗时，当MIC≥16μg·mL^-1时，模拟的所有方案达标概率值均（90％。结论铜绿假单胞菌血流感染经验治疗时可选哌拉西林／他唑巴坦4．5g（q6h），头孢他啶2g（q8h），头孢吡肟2g（q8h），亚胺培南1g（q6h），美罗培南1g（q8h，q6h）；目标治疗当MIC≥16μg·mL^-1时需要联合用药。Objective To develop the regimens of β lactam antibiotics against bloodstream infection caused by Pseudomonas aeruginosa （PA）. Methods A total of 64 strains of PA cultured by blood from 2015 to 2016, the minimum inhibitory concentration （MIC）of piperacillin/ tazobactam （ TZP ）, ceflazidine （ CAZ ）, cefepime （ FEP ）, imipenem （IPM）, meropenem（MEM） against PA were determined, probability of talget attainment （ PTA ） and cumulative fraction of response （CFR） were calculated by monte carlo simulation. Results CFRs of TZP4. 5 g （q6 h）, CAZ 2 g（q8 h）, FEP2 g（q8 h）, IPM 1 g（q6 h） and MEM 1 g （q8 h, q6 h） were 〉 90% at experiential therapy, when MIC ≥16 μg · mL-1 at target therapy, PTA of all regimens 〈 90%. Conclusion when the patient was PA bloodstream infection, we suggest TZP 4. 5 g （q6 h）, CAZ2 g（q8 h）, FEP2 g（q8 h）, IPM 1 g（q6 h） and MEM 1 g（q8 h, q6 h） regimens at experiential therapy, and combined with other antibiotics at target therapy when MIC ≥ 16 μg · mL-1

Optimization of beta lactam antibiotics regimens against bloodstream infection caused by Pseudomonas aeruginosa

目的制定某院beta内酰胺类在铜绿假单胞菌(PA)血流感染中的治疗方案。方法收集某院2015年至2016年血培养中铜绿假单胞菌共64株,测定; beta内酰胺类(哌拉西林/他唑巴坦,头孢他啶,头孢吡肟,亚胺培南,美罗培南)对铜绿假单胞菌的最低抑菌浓度(MIC)。用蒙特卡洛模拟计算多种治疗; 方案的达标率(PTA)和累积反应分数(CFR)。结果经验治疗时,哌拉西林/他唑巴坦4.5 g(q6 h),头孢他啶2 g(q8 h),头孢吡肟2; g(q8 h),亚胺培南1 g(q6 h),美罗培南1 g(q8 h, q6 h),共6种方案的CFR值> 90%;目标治疗时,当MIC≥16; mug·mL~(-1)时,模拟的所有方案达标概率值均 90% at; experiential therapy,when MIC≥16 mug·mL~(-1) at target therapy,PTA of; all regimens < 90%. Conclusion when the patient was PA bloodstream; infection,we suggest TZP 4.5 g (q6 h),CAZ 2 g(q8 h),FEP 2 g(q8 h),IPM 1; g(q6 h) and MEM 1 g(q8 h,q6 h) regimens at experiential therapy,and; combined with other antibiotics at target therapy when MIC≥16; mug·mL~(-1)

Investigation of behaviour of particle impact on material by impinging jet

颗粒冲击材料现象广泛存在于自然界以及工业领域中。应用实验测量与数值计算相结合的方法研究了颗粒射流冲击材料(304不锈钢)的磨损行为。考虑了颗粒粒; 径、运动轨迹、颗粒-壁面撞击点分布以及所导致材料物相结构变化。实验测试包括材料质量损耗、材料元素X射线衍射(XRD)分析、表面微观结构扫描电镜(; SEM)观察。对相应的颗粒射流冲击材料行为进行了数值计算,获得流场,颗粒场以及相应材料磨损。结果表明:颗粒射流冲击下颗粒运动轨迹与撞击点的分布不; 同,造成了材料样品表面磨损区域明显不同。颗粒-壁面碰撞不仅会导致材料损失而且会造成材料物相结构的变化。Particle-material impact is popular in the nature and industries. In; this work, experimental measurement and numerical calculation were; carried out to investigate the particle impinging jet effect on the; behaviour of material (304 stainless steel). Herein, particle diameter,; particle tracking trajectories, particle-wall collision point; distribution were considered to study material loss and the phase change; of material structure. In the experimental work, the measurements were; carried out for material mass loss, material element X-ray; diffractometry (XRD) analysis, surface micro-structure scanning electron; microscopy (SEM) observation and so on. In addition, the behaviour of; particle impinging jet impact on wall material was studied by numerical; simulations. Particularly, flow fields, particle trajectories and wall; material loss were obtained. The results show that particle collision; point distribution is quite different from their tracking trajectories; under particle impinging jet impact, which causes the wear zones on; sample surface different from each other obviously. It is concluded that; particle-wall impact will not only lead to material loss but also cause; the phase change of material structure.国家自然科学基

Experimental research state of preventive and therapeutic effect of traditional Chinses medicine on gastrointestinal injury after stress

应激会破坏胃肠道的自稳态,引起胃肠道功能紊乱,轻则出现恶心、呕吐、厌食、腹泻、腹胀,甚则可致应激性溃疡,影响人们的工作生活和健康。单药、经方、自; 拟方和针灸等中医药干预可通过抗胃肠黏膜损伤、调整紊乱的胃肠激素等途径有效改善各种应激后胃肠损伤,文章对此作一综述,并发现迄今为止在中医药预防应激; 后胃肠损伤的抗应激相关机制研究尚显不足,值得进一步研究。Various kinds of stress would destroy gastrointestinal homeostasis and; lead to functional disturbances of gastrointestinal tract, such as; nausea, vomiting, anorexia, diarrhea, abdominal distention and even; stress ulcer, which could influence the work, life and health of people; suffered from stress. Classical prescription, self-made prescription and; acupuncture could ameliorate symptoms and signs of gastrointestinal; stress reaction effectively by protecting from gastrointestinal mucosa; injury and regulating gastrointestinal hormones. This article reviewed; those researches and found that, so far, there were shortages of TCM in; prevention effect and mechanism of anti-stress, which deserved further; study.国家自然科学基金项目; 福建省自然科学基金项

暹罗鳄多肽粉提高机体免疫力及抗疲劳的效应

为研究暹罗鳄多肽粉对小鼠免疫力及抗疲劳效应的影响,对小鼠的免疫能力和相关血清指标进行了测定,同时也对小鼠的运动能力及疲劳代谢指标进行了测定.实验结果显示:暹罗鳄多肽粉可以促进小鼠胸腺和脾脏的生长,免疫力得到提高.相对于对照组小鼠,暹罗鳄多肽粉组小鼠血清中的总蛋白、血钙、白蛋白含量升高(p<0.05),谷丙转氨酶(ALT)的活力和血糖浓度下降(p<0.05).小鼠爬绳及负重游泳实验发现服用了暹罗鳄多肽粉的小鼠垂直爬绳时间和负重游泳时间均高于对照组的(p<0.01),小鼠的耐力增强.进一步通过建立抗疲劳小鼠力竭游泳模型研究了暹罗鳄多肽粉的抗疲劳动物学功效,结果显示相对于对照组,暹罗鳄多肽粉组小鼠血液中尿素氮(BUN)和乳酸(LA)的含量以及乳酸脱氢酶(LDH)的酶活力均降低(p<0.05),而超氧化物歧化酶(SOD)的酶活力升高(p<0.05).综上结果表明暹罗鳄多肽粉可能有保肝护肝,提高肌体免疫力以及抗疲劳等功效.福建省自然科学基金项目(2016J05105);;广东省自然科学基金博士启动项目(2016A030310374);;厦门大学生命科学学院-福建鼍龙鳄鱼生物制品研发协同创新中心项目(XDHT2017004C

各种应激源对胃肠相关功能影响的研究进展

应激源指对机体构成任何威胁的刺激,包括物理（低温、高温等）、化学、机械、心理、社会等各种刺激。应激源作用于人体产生的非特异性应答反应称为应激。适当的应激可以促进机体逐步适应环境,而过度的应激则使机体正常稳态被破坏,发生一系列非特异性损害。胃肠道是机体与外界接触面积最大的器官,且由于其黏膜血管的解剖特点,在应激状态下更容易受影响,其中,肠道为多器官功能障碍的始动器官。国家自然科学基金项目（No.81302876）; 福建省自然科学基金项目（2013J05123

暹罗鳄多肽粉的营养成分分析

以暹罗鳄(Crocodylus siamensis)肉为原料,采用胰蛋白酶酶解,通过喷雾干燥工艺得到暹罗鳄多肽粉.分析该多肽粉对实验小鼠无不良反应,表明暹罗鳄多肽粉是无毒的.暹罗鳄多肽粉的成分分析结果显示,其蛋白质质量分数达74.3%,总糖和脂肪质量分数分别仅为1.24%和1.89%,氨基酸种类齐全,其人体需要量最大的赖氨酸和亮氨酸含量较多.同时其对人体有益元素含量从高到低依次为K、Na、Ca、Mg、Fe、Zn、Cu.应用基质辅助激光解吸附飞行时间质谱法(MALDI-TOF-MS)分析了暹罗鳄多肽粉分子质量的分布范围,结果显示,暹罗鳄多肽粉分子质量主要集中在1 000~1 300 u.这些结果显示暹罗鳄多肽粉是一种高蛋白、低糖、低脂的功能性保健食品,具有很高的开发潜力

Experience of professor WANG Yan-hui's in treating tumor based on ‘tumor is the pathologic products'

王彦晖教授在多年的肿瘤诊疗过程中发现肿瘤与中医学之“病理产物“在病因、病位、病症方面有诸多共性,从而提出“肿瘤都是病理产物“的观点以指导治疗,强调治疗当以“祛除病理产物“为法,并且具体处方用药有4个特点:1祛邪贯穿治疗始终;2理气、化痰、祛瘀并用;3大剂量用药,功效突出;4持法守方。王教授以此治疗各种恶性肿瘤,验之有效,值得推广。Professor WANG Yan-hui has found that tumor and pathologic products have some qualities in common such as pathogenesis, location and symptom, so he proposes that tumor is the pathologic products.He emphasizes on the law of ‘eliminating pathologic products' in tumor's treatment.There are four characteristics in his prescription and medication as follows: 1eliminating pathology has always been throughout in the treatment, 2combination of regulation qi, dissolving phlegm and removing blood stasis, 3large dose medication, 4keeping the same law and prescription.This theory has been proved by professor WANG in his practices which is worth for learning

Influence of Helicobacter pylori infection on autologous DC-CIK maintenance therapy in the advanced gastric cancer patients

目的:对比幽门螺杆菌(HElICObACTEr PylOrI,HP)感染阴性和阳性的晚期胃癌患者接受自体树突状细胞联合细胞因子诱导的杀伤(dEndrITIC CEllS-CyTOkInE InduCEd kIllEr,dC-CIk)细胞维持治疗的疗效差异。方法:收集2010年6月至2012年6月中国人民解放军第174医院肿瘤中心收治的72例晚期胃癌患者,年龄29~90岁,中位年龄56岁,通过胃镜检查进行胃癌确诊并检测HP,分为HP阳性组(45例)及HP阴性组(27例),在接受手术或/和放化疗后,接受2疗程自体dC-CIk维持治疗,比较两组外周血培养的dC分化成熟情况及临床疗效差异。结果:两组dC成熟过程形态变化无差异;HP阳性组dC表面分子Cd83、Cd86表达显著高于HP阴性组(P0.05)。HP阳性组治疗后生活质量评分(kPS)、外周血T细胞亚群(Cd3+、Cd4+、Cd8+)比例较治疗前显著提高(P0.05)。HP阳性组治疗后kPS评分、CEA和CA199表达以及Cd3+和Cd4+T细胞数量等的改善均优于HP阴性组(P0.05)。共随访2年,阳性组患者中位生存期为12.64个月,长于阴性组的11.42个月(P 0.05).Levels of CD83 and CD86 on the surface of DCs were significantly higher in the Hp-positive group than those in the Hp-negative group( P 0.05).In the Hp-positive group,the quality of life KPS score and levels of T lymphocyte markers( CD3+,CD4+and CD8+) were significantly increased( P 0.05).Hp-positive patients had better KPS score,higher levels of CEA and CA199,and more abundant CD3+CD4+T cells than Hp-negative patients( P 0.05).At the end of 2-years follow-up,the median survival time was 12.64 months in the HP-positive group and 11.42 months in the HP-negative group( P < 0.05).Conclusion: Hp infection may help stabilize the tumor size,improve the quality of life,and prolong the survival time in patients with advanced gastric cancer undergoing maintenance therapy with DC-CIK cells.南京军区医学科技创新课题资助(No.10MA068); 厦门市科技计划创新项目资助(No.3502z20134026;No.3502z20144034)~