Interpretation of the 2015 guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism by the European Thyroid Association

亚临床甲状腺功能亢进症在临床中很常见,但对其危害及处理有很大的争议。欧洲甲状腺学会根据现有的临床证据,公布了内因性亚临床甲状腺功能亢进症诊治指南; 。指南强调,要确立持续性亚临床甲状腺功能亢进症的诊断,明确其病因,按照其进展为临床甲亢、发生不良心血管事件及骨质疏松风险进行危险分层,以指导临床; 处理。Endogenous subclinical hyperthyroidism (Endo SHyper) is a common form of; thyroid diseases. Currently controversy exists in the management of Endo; SHyper. Based on the existing clinical evidence, the European Thyroid; Association (ETA) published a guideline on diagnosis and treatment of; Endo SHyper in 2015. The guidelines recommend that clinicians establish; the diagnosis of persisted Endo SHyper, then clarify its etiology, and; guide treatment by the risk stratification according to the development; of overt hyperthyroidism, adverse cardiovascular events and; osteoporosis

Determination of Pseudostellarin B in Pseudostellaria heterophylla by HPCE and Study on Its Fingerprints Analysis

建立了测定太子参中环肽Pseudostellarin B含量的高效毛细管电泳(HPCE)分析方法,对10种不同产地太子参中环肽Pseudostellarin B的含量进行了测定。HPCE工作条件:采用未涂层熔融石英毛细管(内径75μm,有效长度50cm),分离电压为15kV,柱温20℃,二极管阵列检测器(DAD)检测波长为203nm,缓冲液为20mmol/L硼砂(pH=9.3)溶液。在选定的工作条件下,环肽Pseudostellarin B浓度与其响应信号值之间具有较好的线性相关性(Y=0.6357X+2.546,R=0.9985),加标回收率在93.8%~105.6%之间。在此基础上进行了太子参HPCE指纹图谱研究,采用中药指纹图谱相似度计算软件对不同太子参样品的HPCE指纹图谱进行相似度计算,以系统生成的对照指纹图谱为对照模板,10份样品中有8份的相似度在0.90以上,说明该方法可用于太子参质量控制。A modern HPCE analysis method was developed for determinating cyclic peptide Pseudostellarin B in Pseudostellaria heterophylla(Miq.) Pax.Separation and determination were carried out by HPCE under the following conditions: bared fused silica capillary (50 cm×75 μm i.d.),20 mmol/L borate (pH=9.3)as buffer,the run voltage is +15 kV,detection length of UV at 203 nm,and column temperature of 20 ℃.The results indicated that the developed method was simple,accurate and reliable for the determination of Pseudostellarin B with a good linearity(Y=0.6357X+2.546,R=0.9985),and the recovery ranges of 93.8%～105.6%.Based on this method,the HPCE fingerprints of Pseudostellaria heterophylla (Miq.) Pax were established.The fingerprints were compared by the software of the similarity evaluation system for chromatographic fingerprint.The fingerprint congruence coefficients of 8 electropherograms in 10 were above 0.90.The method of HPCE fingerprint is reliable and accurate.国家自然科学基金项目(20235020);; 国家科技部攻关项目(2003BA759C

Progress on Fucoxanthin and Fucoxanthin-chlorophyll Protein （ FCP） Complexes

岩藻黄素又称岩藻黄质,是广泛存在于海洋藻类中的一种光合色素,为类胡萝卜素的含氧衍生物。岩藻黄素-叶绿素蛋白复合体(FCP)是由岩藻黄素和叶绿素共同组成的高效捕光蛋白复合物。主要综述了岩藻黄素的理化性质、生物活性、和提取方法以及FCP的功能、结构和提取方法

Mirk/Dyrk1b在上皮性卵巢癌组织中的表达及意义

目的:探讨Mirk/Dryk1b(Minibrain-related kinase/Dual specificity tyrosine-phosphorylation-regulated kinase1B)在卵巢组织中的表达及其临床意义。方法:利用免疫组化检测Mirk/Dyrk1b在30例上皮性卵巢癌、20例上皮性卵巢囊腺瘤、10例正常卵巢组织中的表达。结果:Dyrk1b在上皮性卵巢癌中的表达明显高于上皮性卵巢囊腺瘤及正常卵巢组织(P0.05)。结论:Dyrk1b在上皮性卵巢癌中高表达,提示其可能参与了肿瘤的发生和发展,并有望成为临床早期诊断的肿瘤标志物和新的卵巢癌治疗的靶基因

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

3D-printed integrative probeheads for magnetic resonance

射频探头前端作为核磁共振设备的核心部件之一，极大程度的决定着系统实验性能的优劣。探头前端通常由射频线圈、射频电路及样品检测管道等部分组成。现有的射频线圈制作技术主要是通过手工或机械手段按照所需的线圈形状进行绕制。但是，当线圈结构较为复杂、不规则，或体积尺寸较小时，常规绕制方法便难以满足结构设计和制造的精度需求，因此造成线圈性能的劣化，增大检测区域的射频场不均匀性，对核磁共振检测产生负面影响。本研究中，利用3D打印熔融沉积制造或光敏树脂选择性固化技术精确加工出一体化磁共振探头前端，使用常温液态金属填充线圈模型管路形成射频线圈，搭建出稳定的一体化磁共振射频探头。利用高精度3D打印和液态金属灌注技术制备出包含有射频线圈和定制化样品管道结构在内的一体化磁共振射频探头前端，克服了传统磁共振三维微型线圈成型困难、与样品腔匹配程度差等问题，提高了探头的信噪比，为定制化的磁共振检测提供了新思路。 该工作由厦门大学电子科学与技术学院陈忠教授、游学秋副研究员和孙惠军高级工程师共同指导完成，博士研究生谢君尧为论文第一作者。厦门大学电子科学与技术学院黄玉清高级工程师、王忻昌副教授、倪祖荣助理教授、硕士研究生张德超，化学化工学院杨朝勇教授、博士研究生李星锐，萨本栋微米纳米科学技术研究院陈宏教授为合作作者。【Abstract】Magnetic resonance (MR) technology has been widely employed in scientific research, clinical diagnosis and geological survey. However, the fabrication of MR radio frequency probeheads still face difficulties in integration, customization and miniaturization. Here, we utilized 3D printing and liquid metal filling techniques to fabricate integrative radio frequency probeheads for MR experiments. The 3D-printed probehead with micrometer precision generally consists of liquid metal coils, customized sample chambers and radio frequency circuit interfaces. We screened different 3D printing materials and optimized the liquid metals by incorporating metal microparticles. The 3D-printed probeheads are capable of performing both routine and nonconventional MR experiments, including in situ electrochemical analysis, in situ reaction monitoring with continues-flow paramagnetic particles and ions separation, and small-sample MR imaging. Due to the flexibility and accuracy of 3D printing techniques, we can accurately obtain complicated coil geometries at the micrometer scale, shortening the fabrication timescale and extending the application scenarios.The work is supported by the National Natural Science Foundation of China (Grants U1632274, 11761141010, U1805261, 11475142, 22073078, and 61801411), and China Postdoctoral Science Foundation (2017M622075).研究工作得到国家自然科学基金、中国博士后科学基金等项目支持

Research on the Characteristics of Athletics Ability Displayed in Big Games by the World' s Elite Male Long Jumpers

本研究运用了文献资料法、数理统计法、逻辑分析法等研究方法,对1928年～2008年共17届奥运会男子跳远决赛运动员的各跳成绩、试跳情况与免跳情况等指标进行统计分析,力求揭示世界最高水平跳远运动员的竞技能力表现特征与规律,为我国跳远比赛、训练提供理论依据与数据支撑。研究表明:(1)奥运会男子跳远比赛最佳成绩跳次分布特征为:前三跳创造最佳成绩的比例高;除第六跳外,后三跳其余跳次创造最佳成绩的比例不高。(2)免跳分布特征为:89.3%的免跳分布于后三跳,10.7%的免跳分布于前三跳;冠军选手的免跳申请占总免跳申请的50.0%,且免跳申请集中分布在后三跳。(3)试跳成功率、犯规率分布特征为:前三跳成功率高于后三跳;犯规率反之。This thesis uses documentation method, mathematical statistics and logical analysis, etc to statistically study the results of all jumps, the status of trial jumps and passed jumps of all the players who made to men＇s long jump final during the 17 Olympiads from 1928 to 2008. It is aimed at revealing the characteristics and patterns of the world＇s top-level players＇ athletics a- bility, as well as providing theoretical and data support for the cause of our long jump competition and training. The study shows： 1. The distribution features of best jump for the Olympics men＇ s long jump： the first 3 jumps have a high rate to create the best result; the 6th jump not counted, the other two jumps of the last 3 have a low rate to produce the best result. 2. The distribution features of passed jump： 89.3% of passed jumps fall in the last 3 jumps and 10.7% in the first 3; the passed jump requests of champion players account for 50% of the total and concentrate on the last 3 jumps. 3. The distribution features of trial jump success rate and foul rate： The success rate of the first 3 trial jumps is higher than the last 3 and with foul rate it is the other way round. But there isn＇t a marked difference between the first 3 jumps and the last 3 in terms of the two rates

基于涡合成方法的 可压缩入口湍流条件的生成

为了给大涡模拟LES计算提供合适的湍流入口信息，本文采用了一种改进的涡合成方法(synthetic eddy methods)来生成指定速度和雷诺应力分布下的湍流入口条件。该方法根据可压缩平板边界层内的湍流结构特征将入口截面沿壁面法向方向分为若干区域，并为它们指定不同的形状函数、特征迁移速度与流动尺度来描述相应的湍流结构，并最终生成含有特定湍流脉动信息的入口条件。但由于涡合成方法生成的湍流脉动量无法满足连续性条件，流场下游会出现较强的虚假压力脉动，海绵边界条件(sponge layer)的引入很好地抑制了此种现象。计算结果表明：在满足必要的网格分辨率下，采用涡合成方法的来流马赫数为2的可压缩平板边界层可以在8&delta;的过渡距离内形成完全发展的湍流流场；数值模拟得到的时均统计量结果（壁面摩擦系数、速度型、雷诺应力、湍动能能量谱密度）与可压缩流动的理论结果以及DNS模拟结果符合良好，进一步验证了涡合成方法在可压缩湍流边界层入口条件生成上的应用前景。</p