Research on Methods of Modeling and Fault Diagnosis for Micro Direct-Current Motors

直流微电机以体积小、重量轻、便于控制等优点被广泛应用于生产消费领域，在微型精密仪器中尤为重要。为了保证产品出厂品质，生产过程必须对直流微电机进行100%检测。目前检测主要依靠人工的经验来判断电机的好坏，其工作量大，生产效率低，漏检现象严重，导致电机出厂质量不稳定。因此有必要寻找一种简便和可靠的直流微电机在生产线上的故障检测技术。该技术即可以对出厂前的直流微电机进行自动在线检测，以保证直流微电机的出厂合格率；又可以推广应用于其他永磁直流电机的故障检测与诊断。 通过分析空载下直流电机的动态数学模型，假设稳态下dω⁄dt=0，推导出永磁直流电机稳态电枢电流的解析式，其揭示了电枢电流与电...Micro direct-current motors (MDCMs) are increasingly used in industry fields and consumption fields, especially in micro precision instruments. Compared to other motors, smaller size and simpler control scheme are achieved. MDCMs must be screened at 100% detection efficiency on the production line to ensure the quality of outgoing products. Currently, fault detection of motor is mainly based on th...学位：工学博士院系专业：物理与机电工程学院_机械电子工程学号：1992012015387

Study on properties of armature current for micro DC motors and multiple features of fault diagnosis

针对直流微电机生产线上故障检测环节难以自动化的问题,提出一种基于故障多特征量的直流微电机故障诊断模型。通过分析空载和稳态下直流微电机的动态数学模型,推导出电枢电流的时域解析式,确定基于电枢电流的频域故障多特征量。以数台直流微电机为实验样本,分析其电枢电流时频域特征,对典型故障直流微电机运用定义的故障多特征量进行故障分析。实验结果表明不同故障电机的多特征量变化率明显不同,该故障多特征量可以被用来诊断直流微电机。A fault diagnostic model for the micro direct-current motor( MDCM) was presented,which is used to solve the problem that MDCMs can't be automatically inspected on the production line.The method was based on multiple features of the armature current.The analytical expression for the armature current was obtained from the dynamic model of MDCM under no-load and steady-state operation conditions.The multiple features based on the armature current were confirmed.The experiments on several motors with the representative failures were studied.The time-frequency domain features of the current for the MDCM were analyzed.The fault mechanism were analyzed by using the multiple features mentioned above.The experimental results show that the relative changes of the multiple features in different fault cases are different and the multiple features can be utilized as the fault diagnostic indices.福建省科技厅重大项目(2014H6026); 贵州教育厅自然科学研究项目(黔教合KY字(2012)075号

Establishment of a method to quantitatively detect FLT3 internal tandem duplication in acute myeloid leukemia with denaturing high-performance liquid chromatography

目的:建立一种应用变性高效液相色谱技术(dHPlC)相对定量检测急性髓细胞白血病(AMl)患者fMS样酪氨酸激酶3(flT3)基因的内部串联重复(ITd)突变的方法。方法:根据flT3-ITd突变基因多位于14外显子而设计引物,用聚合酶链反应(PCr)方法特异性扩增121例AMl患者flT3-ITd突变基因,再用dH-PlC技术相对定量检测flT3-ITd等位基因突变的情况;与毛细管电泳法(CE)检测突变的结果对比进行该方法的有效性检验;最后与121例样品PCr扩增产物的测序结果进行对比。结果:经dHPlC分析后均能得到特征性的洗脱峰。121例样本中检测到flT3-ITd突变阳性的样本13例,总阳性率为10.7%,阳性突变等位基因的比例不一,分布范围中位数为34.5%(11.4%-80.2%),为21-87 bP单个插入片段。阳性率和突变比例与CE方法检测结果相比较均无显著差异(P>0.05),并与121例样本flT3-ITd扩增PCr产物基因测序结果一致。结论:成功建立了一种应用dHPlC相对定量检测AMl患者flT3-ITd基因突变的方法。AIM: To establish a relatively-quantitative method to detect the internal tandem duplication(ITD) mutation of Fms-like tyrosine kinase 3(FLT3)gene in acute myeloid leukemia(AML) patients using denaturing high-performance liquid chromatography(DHPLC).METHODS: According to the fact that much more FLT3-ITD mutations are located in exon 14,we designed the primers,and use the method of polymerase chain reaction(PCR) to specifically amplify FLT3-ITD mutation gene in 121 cases of AML,and relatively quantified the situation of mutant allelic gene of FLT3-ITD by the method of DHPLC.The effectiveness of DHPLC was verified by the method of capillary electrophoresis(CE).The sequenced results from PCR amplified products of 121 samples were compared.RESULTS: A characteristic of elution peak was detected by DHPLC with 10.7% overall positive rate(13/121) and varied in the proportion of mutant alleles,with a single duplicated insert fragment from 21 bp to 87 bp.The median range of mutant alleles was 34.5%(11.4%-80.2%).No significant difference of the positive rates and mutation proportions between the results with DHPLC and the results with CE method was observed.The results of FLT3-ITD mutant gene of 121 samples were consistent with the results using sequencing method.CONCLUSION: A relatively-quantitative method to analyze AML patients with FLT3-ITD mutation by DHPLC is successfully established

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

闽南文化研究国际笔谈会论点选载

2013年12月21日,由闽南师范大学闽南文化研究院主办的“2013闽南文化研究国际笔谈会“在国际学术交流中心召开。来自海峡两岸及日本、新加坡等国家的闽南文化研究方面的专家、学者二十余人出席了会议。会议围绕着闽南文化的内涵、外延及特征,闽南文化的当代价值与社会功能,闽南文化研究的理论与方法,闽南文化的跨文化阐释,闽南文化的世界性及其意义,闽南文化与两岸交流,闽南文化的生态保护,闽南文化学科建设与人才培养等议题展开了深入的研讨,言简意赅,探幽发微,对当下闽南文化理论研究势必产生积极的影响。本期节录专家们的精彩发言,以飨读者,也希望由此来带动和促进闽南文化研究的进一步升华

南海中深层动力格局与演变机制研究进展

南海是连接印度洋-太平洋的最大边缘海,在季风、海峡水交换以及复杂地形影响下,南海环流呈现出独特的三层结构以及远强于大洋的混合特征.理论与观测表明,南海内潮、内孤立波以及强风等过程是强混合的动力来源.在南海强混合作用下,南海发育了活跃的中深层动力系统,一方面促进了南海与大洋之间的水体交换,另一方面调控上层风生环流,使得南海环流显著区别于其他热带与副热带海盆.南海活跃的中深层环流所具有的物质搬运能力又显著影响着南海的地质沉积、生物地球化学循环等过程.中国对深海研究持续投入,在南海中深层环流动力学研究方面取得了显著的成果,文章就该方面进行总结,并对南海深海环流未来研究设想进行初步探讨

中国超大城市空气污染和人体健康 (APHH-Beijing) 中英联合研究计划 最终报告

Chinese versio

中国物理海洋学研究70年：发展历程、学术成就概览

本文概略评述新中国成立70年来物理海洋学各分支研究领域的发展历程和若干学术成就。中国物理海洋学研究起步于海浪、潮汐、近海环流与水团,以及以风暴潮为主的海洋气象灾害的研究。随着国力的增强,研究领域不断拓展,涌现了大量具有广泛影响力的研究成果,其中包括:提出了被国际广泛采用的"普遍风浪谱"和"涌浪谱",发展了第三代海浪数值模式;提出了"准调和分析方法"和"潮汐潮流永久预报"等潮汐潮流的分析和预报方法;发现并命名了"棉兰老潜流",揭示了东海黑潮的多核结构及其多尺度变异机理等,系统描述了太平洋西边界流系;提出了印度尼西亚贯穿流的南海分支(或称南海贯穿流);不断完善了中国近海陆架环流系统,在南海环流、黑潮及其分支、台湾暖流、闽浙沿岸流、黄海冷水团环流、黄海暖流、渤海环流,以及陆架波方面均取得了深刻的认识;从大气桥和海洋桥两个方面对太平洋–印度洋–大西洋洋际相互作用进行了系统的总结;发展了浅海水团的研究方法,基本摸清了中国近海水团的分布和消长特征与机制,在大洋和极地水团分布及运动研究方面也做出了重要贡献;阐明了南海中尺度涡的宏观特征和生成机制,揭示了中尺度涡的三维结构,定量评估了其全球物质与能量输运能力;基本摸清了中国近海海洋锋的空间分布和季节变化特征,提出了地形、正压不稳定和斜压不稳定等锋面动力学机制;构建了"南海内波潜标观测网",实现了对内波生成–演变–消亡全过程机理的系统认识;发展了湍流的剪切不稳定理论,提出了海流"边缘不稳定"的概念,开发了海洋湍流模式,提出了湍流混合参数化的新方法等;在海洋内部混合机制和能量来源方面取得了新的认识,并阐述了混合对海洋深层环流、营养物质输运等过程的影响;研发了全球浪–潮–流耦合模式,推出一系列海洋与气候模式;发展了可同化主要海洋观测数据的海洋数据同化系统和用于ENSO预报的耦合同化系统;建立了达到国际水准的非地转(水槽/水池)和地转(旋转平台)物理模型实验平台;发展了ENSO预报的误差分析方法,建立了海洋和气候系统年代际变化的理论体系,揭示了中深层海洋对全球气候变化的响应;初步建成了中国近海海洋观测网;持续开展南北极调查研究;建立了台风、风暴潮、巨浪和海啸的业务化预报系统,为中国气象减灾提供保障;突破了国外的海洋技术封锁,研发了万米水深的深水水听器和海洋光学特性系列测量仪器;建立了溢油、危险化学品漂移扩散等预测模型,为伴随海洋资源开发所带来的风险事故的应急处理和预警预报提供科学支撑。文中引用的大量学术成果文献(每位第一作者优选不超过3篇)显示,经过70年的发展,中国物理海洋学研究培养了一支实力雄厚的科研队伍,这是最宝贵的成果。这支队伍必将成为中国物理海洋学研究攀登新高峰的主力军

Musical composition, interpretation and listening : a semioethic approach to teaching music in primary school

Orientador: Guilherme do Val Toledo PradoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de EducaçãoResumo: Composições musicais e co-envolvimento dos alunos, em atividade didática musical, se configuram em textos e contextos intrigantes e conflituosos, levando uma professora de música à investigação da própria prática. Crianças de 4º ano e jovens de 7° ano, do Ensino Fundamental, respectivamente em escola confessional (atendendo, em geral, classe econômica média) e em organização não governamental (atendendo, exclusivamente, classe econômica baixa), pertencentes à rede privada de ensino, localizadas em dois grandes centros urbanos do estado de São Paulo, são produtores das composições, "textos sem os quais não há pesquisa nas ciências humanas" (M. M. Bakhtin). Como percurso metodológico, a pesquisa se baseia na narrativa docente (G. V. T. Prado) em três movimentos: registro do cotidiano escolar; instrumento de (auto)formação; gênero textual da pesquisa. O locus privilegiado de formação e investigação é a escola básica, onde o ensino e a música, áreas diversas e específicas de estudo, constituem e se constituem de intertextualidades, simultaneidades em experiências verbais e musicais, desde sua interferência e ressonâncias mútuas nos sujeitos: alunos e professora. Na pesquisa, a opção por um estudo dos signos que aí surge impõe, como "ato responsável, sem álibi" (M. M. Bakhtin) da professora e pesquisadora de música, o firme posicionamento semioético (A. Ponzio e S. Petrilli) da divulgação da capacidade humana de modelização, que nos permite criar "infinitos mundos possíveis" (T. A. Sebeok) nas mais diversas linguagens e da iconicidade, tida como a principal estratégia representacional humana. Considerando a expressão semiótica como produtora de pensamento (M. M. Bakhtin) e tendo no signo musical um dos mais característicos signos de espécie icônica, além de ser o mais refratário à tradução (A. Ponzio, C. Caputo, S. Petrilli), de signo em signo, numa semiose infinita (C. S. Peirce), chega-se ao enorme potencial formativo da atividade didática de composição musical, para a criança e jovem. Não se pode deixar de assinalar que na base da interpretação semioética estão os princípios bakhtinianos de escuta responsiva, alteridade e, portanto, de não indiferença e confiança em cada criança/jovem aprendiz, como seres cognitivo-estético-éticos, compositores de músicas e de relações humanas, na cultura escolar. Dentre as lições mais marcantes da pesquisa, está a compreensão de que o trabalho de composição no ensino de música pode iniciar-se precocemente na escola, desde que não se espere da criança/jovem um conhecimento simbólico/teórico convencional anterior ao próprio trabalho de criação; a descoberta do outro enquanto alteridade, que se dá no processo de criação e escuta da composição musical e da relação da criança/jovem compositora, com a outra criança/jovem no processo de criação e escuta de sua composição musical e no coletivo de crianças/jovens compositoras e a professora, também aprendendo a escutar e a criar, a criar e a escutar, em seu ensino de música para crianças/jovensAbstract: On a musical teaching activity, musical compositions and the co-involvement of the students with each other configure on intriguing and conflicting texts and contexts, leading a teacher of music to her own teaching practice research. The "texts without which there is no research in the human sciences" (M. M. Bakhtin) are the compositions whose authors are the 5th and 7th grades of the elementary school, respectively, in confessional school (average economy class) and NGO school (exclusively low economic class), that belong to the private education iniciative located in two large urban centers of the state of São Paulo. The research methodological approach is based upon the teacher narrative (G. V. T. Prado) in three movements: daily school record; (self) educating tool; literary of the research genre. The elementary school is the privileged research locus for the research, where education, teaching music and diverse and specific fields of study constitute and are constituted of intertextualities and simultaneities in both individual verbal and musical experiences, having mutual interference and resonance on both students and teacher. The option that arises in this research and imposes one "responsible act without excuse" (M. M. Bakhtin) a steady semioethics positioning of the music teacher and researcher (A. Ponzio and S. Petrilli): the modeling human capacity which allows us to create "infinite possible worlds" (T. A. Sebeok) in several languages and the music signs iconicity, which is the main human representational strategy. Considering the semiotic expression as a producer of the thought (M. M. Bakhtin) and having in the musical sign one of the most characteristic signs of the iconic species, as much as being the most refractory sign to translation (A.Ponzio, C.Caputo, S.Petrilli), from sign to sign, in an infinite semiosis (C. S. Peirce), one reaches the enormous formation potential of the didactic activity of musical composition, for children and teenagers. One cannot fail to notice that in the base of semioethics interpretation are the bakhtinian concepts of responsiveness listening and otherness, therefore, of "not indifference" and confidence in each child/young apprentice, as cognitive-aesthetic-ethical beings, music and human relations composers in the school culture. Among the most important lessons of this study is the understanding that the composition work in music education can be initiated early in the school, as long as no one expects a previous conventional theoretical/symbolic knowledge of the child/teenager prior to the proper creation work; the discovery of the other while alterity, which happens in process of creating and listening to the music composition and the relationship of the child/teenager composer with other children/teenageres in the creative process and listening to his/her music composition and in collective children/teenagers composers and the teacher, also learning to listen and to create, to create and to listen, in the process of teaching music education for children/teenagersDoutoradoEnsino e Práticas CulturaisDoutora em Educaçã

武汉东湖湖球蚬种群动态及生产力的研究

1999年 6月至 2 0 0 0年 5月对武汉东湖湖球蚬进行了周年研究。湖球蚬年均密度和生物量分别为 10 0 2ind /m2 和12 1g/m2 ,密度和生物量的高峰分别出现在 4月 (2 97ind /m2 )和 3月 (4 3 8g/m2 ) ;湖球蚬为一年一代 ,其种群含有 3个年龄组 ,其中 1999年龄组占绝对优势。利用瞬时增长率法和体长频率法计算湖球蚬的周年生产量为带壳湿重4 2 79g/m2 ,去壳干重 2 4 4g/m2 ,P/B系数为 3 5 5。同时湖球蚬的生产力动态也被研究