台湾地区莎士比亚戏剧研究的主体性回归

莎士比亚戏剧在20世纪初日本对台湾实行殖民统治时期传入台湾。1945年以后,台湾莎剧研究回归到以中华传统文化为背景的中文语境。然而,自莎士比亚戏剧进入台湾一百多年来,莎剧研究作为台...国家社科基金艺术学重大项目“当代欧美戏剧理论前沿问题研究”(18ZD06)阶段性成

海洋中药蛎昆一号制剂对5-Fu化疗后所致动物骨髓抑制的功效研究

目的研究蛎昆一号制剂对5-氟尿嘧啶(5-Fu)致小鼠骨髓抑制外周血中白细胞、血小板、淋巴细胞、单核细胞计数的影响。方法纯系雄性BALB/c种小鼠60只,随机分为对照组、5-Fu、5-Fu联用重组人粒细胞集落刺激因子(rhG-CSF)、蛎昆一号制剂低、中、高剂量6个组。经腹腔注射肿瘤化疗药5-Fu建立小鼠骨髓抑制模型,对照组注射等量生理盐水;注射后第1天上午使用不同剂量的蛎昆一号制剂灌胃,对照组等量生理盐水灌胃;给药7 d后上午取眼球血进行血常规分析。结果小鼠在注射5-Fu造模后,外周血白细胞、血小板、淋巴细胞与对照组相比均有明显降低(P<0.05),单核细胞比率与对照组相比明显升高(P<0.05);不同剂量的蛎昆一号制剂及阳性对照(rhG-CSF)均有效地升高小鼠外周血白细胞、血小板、淋巴细胞数值,且单核细胞比率也较模型组明显降低,但以蛎昆一号制剂中剂量组的效果最为明显,复方制剂高剂量组次之。结论蛎昆一号制剂能够明显改善5-Fu化疗药物所引起的小鼠骨髓抑制现象,增加骨髓抑制小鼠外周血白细胞、血小板、淋巴细胞数目;降低外周血中单核细胞比率,表明蛎昆一号制剂能够有效的恢复骨髓抑制小鼠造血系统,提高造血活性。厦门市海洋经济发展专项资金(编号:17GYY001NF01

Influence of Chaotic IIR Filter on Nonlinear Dynamic Characteristic of Underwater Acoustic Signal

本文探讨了混沌滤波器在水声信号处理中的一种新的应用.混沌蔡氏电路产生的信号进行频带调制和高通IIr滤波后,由水声换能器发射并经过水池传播和接收.实验结果表明混沌滤波器实现了频带搬移,且接收到的水声信号具有与原始的混沌发射信号相似的宽频带特性.进一步,运用非线性动力学方法对原始混沌电路信号和接收水声信号进行时间序列分析比较.发现接收的水声信号具有比发射的原始混沌信号更为不规则的重建相空间和更高的分形维数.混沌滤波器运用于水声信道提高了接收信号的非线性复杂特性.A new application of chaotic filter in underwater acoustic signal processing is described.After frequency modulation and high-pass IIR filtering,the chaotic signal generated by the Chua's circuit was transmitted through a underwater sound channel.The received acoustic signal shows similar frequency band characteristic with chaotic circuit.Furthermore,nonlinear dynamic analysis is applied to compare the underwater acoustic signal and the original circuit signals.The results show that the acoustic signal has more irregular phase space and higher fractal dimension than chaotic circuit signals.Chaotic filter increases the complexity of the underwater signal

金属苯的亲核加成和芳香亲核取代反应

近年来有关金属苯亲核反应的研究工作为证实金属苯的芳香性提供了有力的实验证据,发展了经典有机化学的芳香亲核取代反应理论.同时,借助金属苯亲核反应的研究还可获得一系列结构新颖的金属有机化合物.本文就迄今为止已报道的金属苯的亲核加成和芳香亲核取代反应进行了全面的总结

AHPN衍生物的合成及其与RARγ的结合活性研究

目的本实验以6-{3’-(1-金刚烷基)-4’-羟基苯基}-2-萘甲酸(AHPN)母核为结构基础,设计、合成一系列AHPN衍生物,并对这些衍生物做初步的活性筛选,期望找到活性显著的衍生物。方法以对溴苯酚和1-金刚烷醇为原料经取代、缩合、氧化、还原等反应合成AHPN衍生物,经过1H-NMR、13C-NMR、HR-MS表征,并利用Biacore技术检测衍生物与蛋白质之间的结合能力。结果衍生物7c、6c、6e、6h显示出了显著优于先导化合物AHPN与视黄酸核受体γ(RARγ)的结合能力,亚磷酸二甲酯基与氮杂环的引入提高了该类化合物的活性。结论该类AHPN衍生物与RARγ结合能力显著,有进一步研究的价值。扬州市邗江区科技计划项目资助;;福建省基金项目资助(2014Y0044);;国家海洋局第三海洋研究所基本科研业务费专项资金资助项目(海三科2016044

Synthesis and Characterization of Lanthanide Complexes Involving Cyclopentadienyl and N-phenylzohydroxamic Acid

合成了以茂基和 N-苯基苯甲异羟肟酸为配体的一系列新型稀土金属有机配合物 Cp2 Ln L( Cp=η5-C5H5;Ln=Sm,Nd,Gd,Dy,Ho,Er,Yb Pr;L=C6H5CONOC6H5)。产物经元素分析、IR和 MS表征A series of new mixed-ligand organolanthanide complexes involving cyclopentadienyl and N-phenylbenzohydroxamic acid ligands Cp 2LnL(Cp=η 5-C 5H 5; Ln=Nd,Sm,Gd,Dy,Ho,Er,Yb Pr; L=C 6H 5CONOC 6H 5) have been synthesized. All the complexes were characterized by elemental analysis, IR and MS spectra.安徽省自然科学基金 ( 0 0 0 46 5 0 9);; 安徽省教育厅项目基金 ( 2 0 0 0 j10 90

Effects of four typical brominated flame retardants on hepatic antioxidant system of Mossambica tilapia in vitro

以罗非鱼(MOSSAMbICA TIlAPIA)为实验生物,研究了离体条件下其肝脏抗氧化系统中谷胱甘肽(gSH)含量、谷胱甘肽硫转移酶(gST)和超氧化物歧化酶(SOd)活性对4种溴代阻燃剂(brOMInATEd flAME rETArdAnTS,bfrS)——四溴联苯醚(bdE-47)、十溴联苯醚(bdE-209)、六溴环十二烷(HbCd)和四溴双酚A(TbbPA)的响应.研究结果表明:离体暴露于4种bfrS 1 H后,罗非鱼肝脏上清液中gSH含量和SOd活性随暴露剂量升高均呈现先升高后回落的趋势,但总体均高于对照组水平;gST活性则被抑制.上述3种抗氧化参数中,同一参数对4种bfrS响应均呈现一致的变化趋势,其中gST和SOd活性响应更为灵敏.gST活性对bdE-47、bdE-209和HbCd的最低响应浓度均低于1 ng·l-1,且与TbbPA和bdE-209在一定浓度范围内存在较好的剂量-效应关系;SOd活性对4种bfrS暴露较为敏感,最低响应浓度均低于10 ng·l-1,并且与除bdE-209外的上述3种污染物在一定的浓度范围内具有良好的剂量-效应关系.因此,gST和SOd活性指标是值得进一步研究的溴代阻燃剂污染候选生物标志物.The present work aims to investigate the responses of glutathione(GSH),glutathione S-transferase(GST) and superoxide dismutase(SOD)in Mossambica tilapia liver supernatant exposed in vitro to four kinds of brominated flame retardants(BFRs)(BDE-47,BDE-209,HBCD and TBBPA)for 1 h at different doses.The results showed that hepatic GSH content and SOD activity increased at lower concentrations,and then decreased at higher concentrations,while GSH content and SOD activity in the exposed groups were higher than that in the control at all mentioned concentrations.The GST activity was inhibited by the four types of BFRs.The results indicated that the same antioxidant parameter had the similar response trend to the 4 BFRs.Moreover,the responses of the activity of GST and SOD to the BFRs were more sensitive than that of GSH content.The lowest observed effect concentration(LOEC) of GST activity to BDE-47,BDE-209 and HBCD was less than 1 ng·L-1and GST activity values had a good linear relationship with the certain concentrations of TBBPA and BDE-209.The SOD activity was sensitive to all four types of BFRs and the LOEC was less than 10 ng·L-1.The values of SOD activity had a good linear relationship with the certain concentrations of BDE-47,HBCD and TBBPA.Our results suggested that the parameters of GST and SOD in Mossambica tilapia liver antioxidant system had the potential to serve as biomarkers to evaluate the adverse effects of BFRs pollution.海洋公益性项目(No.201105013); 国家海洋局第三海洋研究所基本科研业务费专项基金项目(No.201221); 福建省重大专项/专题项目(No.2011YZ0001-1); 福建省自然科学基金项目(No.2013J01386)~

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

探讨蛎昆一号制剂对小鼠骨髓抑制的保护作用及其分子机制

目的探讨蛎昆一号制剂对小鼠骨髓抑制损伤的保护作用及机制。方法 60只♂BALB/c小鼠,随机分为正常对照组、5-氟尿嘧啶(5-Fu)模型组、阳性对照组(rh G-CSF)、蛎昆一号制剂低、中、高剂量组。除正常组外,其余各组腹腔注射5-Fu 1次,建立骨髓抑制模型,给药7 d后血常规分析,ELISA检测血清TNF-α、IL-2水平,Western blot测定脾脏组织中p-JAK2、p-STAT5磷酸化水平。结果给予蛎昆一号制剂后,小鼠腹泻症状减轻,体质量升高(P <0. 05),白细胞、血小板和淋巴细胞均升高(P <0. 05); ELISA检测显示,蛎昆一号制剂中、高剂量组血清IL-2含量高于模型组(P <0. 05),TNF-α含量低于模型组(P <0. 05); Western blot检测显示,与模型组比较,蛎昆一号制剂各剂量组小鼠脾脏组织JAK2、STAT5磷酸化水平上调(P <0. 05)。结论蛎昆一号制剂对5-Fu致小鼠骨髓抑制损伤有保护作用,其分子机制可能与蛎昆一号制剂增加JAK2、STAT5磷酸化水平,促进IL-2产生,减少TNF-α分泌有关。厦门市海洋经济发展专项资金(No 17GYY001NF01);;\n黔科合字J字[2008]228