Late Cenozoic Geodynamic Evolution of Simav (Kutahya) and Surroundings

The Late Cenozoic geodynamic evolution of Simav (Kutahya) and surroundings was determined by dating active tectonic structures in the region (Simav Fault and Simav Detachment Fault) and granitic and volcanic rocks of the Egrigoz Magmatic Complex. Additionally it was revealed that the currently normal Simav Fault, in previous periods acted as a strike-slip fault according to dating studies of fault planes and field observations. Dating of the fault planes along the Simav Fault determined that initiation of the Simav Fault occurred in the interval between 19.3-26.1 Ma. In this period the Simav Fault demonstrated strike-slip fault behavior in a compressional regime. The results of dating studies of the Egrigoz and Koyunoba Plutons (21.9-26.3 Ma) reveal that the unroofing of these plutons was related to the Simav Detachment Fault (20.0-27.4 Ma). Additionally the presence of volcanism in the time period was identified (7.1-21.3 Ma). The Simav Fault which displayed previous strike-slip character currently has listric normal fault behavior after a tectonic regime change in the Plio-Quaternary. The transition from extensional-compressional regime to a regional extensional regime and cause of the tectonic regime change is thought to be related to the complex subduction process (slab-pull and and roll-back) between the African Plate and Anatolian Plate in the Eastern Mediterranean

Implications of 2007's Earthquake Activity in Egirdir Lake (SW Anatolia) Based on Moment Tensor Solutions and Inversion of Stress State

We analyzed the waveforms of the small- to moderate-sized earthquakes that took place in the northern part of the inner Isparta Angle (IA) to retrieve their source parameters and combine these results with the focal mechanism solutions of the larger events that occurred in 2007 in Egirdir Lake at the apex of IA. In total, source mechanisms of 20 earthquakes within the magnitude range 3.5 < M < 5.0 were calculated using a regional moment tensor inversion technique. The inversion of the focal mechanisms yields an extensional regime with a NNE-SSW (N38A degrees E) trending sigma (3) axis. Inversion results are related to a mainly WNW-ESE oriented normal fault beneath Egirdir Lake. The R value of a NNE-SSW extensional regime is 0.562 showing a triaxial stress state in the region. The current stress regime results from complex subduction processes such as slab pull, slab break-off, roll-back and/or retreating mechanism along the Hellenic and Cyprus arcs and the southwestward extrusion of the Anatolian block since the early Pliocene

Late cenozoic stress field in the Cameli Basin, SW Turkey

A history of deformation has been determined for the Cameli Basin located in the western part of the major Fethiye-Burdur Fault Zone, interpreted as the on-land continuation of Pliny-Strabo fault system (e.g., eastern boundary of the Hellenic Arc). Inversion of fault slip vectors affecting Mio-Pliocene to Quaternary formations in the Cameli Basin, in the southwestern segment of the transtensional Fethiye-Burdur Fault Zone, yields two different normal faulting stress regimes characterized by a roughly orthogonal set of extensional axes; a NW-SE (N129 +/- 19 degrees E) sigma(3) axis and a NE-SW (N50 +/- 16 degrees E) sigma(3) axis. The orientation of fault sets is predominantly around the NE-SW direction in the major Fethiye-Burdur Fault Zone, making the extension NW-SE. The mean R values are 0.74 and 0.69 for both extensions indicating a triaxial stress state, which is clearly different from radial extension and from transitional to strike-slip stress state. The NW-SE extension is probably responsible for the formation of the Cameli Basin during Mio-Pliocene time. In contrast, the inversion of focal mechanism solutions of shallow earthquakes occurring within the Cameli basin identifies a present-day, predominantly extensional stress regime, characterized by an approximately N-S (N184 degrees E) sigma(3) axis, which has an R value of 0.637 indicating a triaxial stress state. The nearly orthogonal extensional stress regimes seem to have been acting contemporaneously with each other at different intensities from the Mio-Pliocene onwards in SW Turkey. This may be attributed to the geodynamic effects related to the subduction of the African plate beneath Anatolia, diffusing along Hellenic and Cyprus arcs and in the west-southwestward extrusion of Anatolia

Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE)

Background/aim: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs. Materials and methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch. The observation period included three key assessment time points (before the switch, at switch, and after the switch). Data were collected from the MS patients’ database by neurologists between January 2018 and June 2019. The longest follow-up period of the patients was determined as 24 months after the switch. Results: In 462 MS patients that were included in the study, both treatments significantly decreased the number of relapses during the postswitch 12 months versus preswitch one year while patients in the FNG group experienced significantly fewer relapses compared to iDMT cohort in the postswitch 12 months period. FNG cohort experienced fewer relapses than in the iDMT cohort within the postswitch 2 year. The mean time to first relapse after the switch was significantly longer in the FNG group. Conclusion: The present study revealed superior effectiveness of vertical switch over lateral switch regarding the improvement in relapse outcomes. Patients in the FNG cohort experienced sustainably fewer relapses during the follow-up period after the switch compared the iDMT cohort. Importantly, switching to FNG was more effective in delaying time to first relapse when compared with iDMTs