Influence of Wood Properties and Building Construction on Energy Demand, Thermal Comfort and Start-Up Lag Time of Radiant Floor Heating Systems

Radiant floor heating is becoming increasingly popular in cold climates because it delivers higher comfort levels more efficiently than conventional systems. Wood is one of the surface coverings most frequently used in radiant flooring, despite the widely held belief that in terms of thermal performance it is no match for higher conductivity materials if a high energy performance is intended. Given that the highest admissible thermal resistance for flooring finishes or coverings is generally accepted to be 0.15 m(2)K/W, wood would appear to be a scantly appropriate choice. Nonetheless, the evaluation of the thermal performance of wooden radiant floor heating systems in conjunction with the building in terms of energy demand, thermal comfort, and start-up period, has been insufficiently explored in research. This has led to the present knowledge gap around its potential to deliver lower energy consumption and higher thermal comfort than high-thermal-conductivity materials, depending on building characteristics. This article studies the thermal performance of wood radiant floors in terms of three parameters: energy demand, thermal comfort, and start-up lag time, analysing the effect of wood properties in conjunction with building construction on each. An experimentally validated radiant floor model was coupled to a simplified building thermal model to simulate the performance of 60 wood coverings and one reference granite covering in 216 urban dwellings differing in construction features. The average energy demand was observed to be lower in the wood than in the granite coverings in 25% of the dwellings simulated. Similarly, on average, wood lagged behind granite in thermal comfort by less than 1 h/day in 50% of the dwellings. The energy demand was minimised in a significant 18% and thermal comfort maximised in 14% of the simulations at the lowest thermal conductivity value. The vast majority of the wooden floors lengthened the start-up lag time relative to granite in only 30 min or less in all the dwellings. Wood flooring with the highest thermal resistance (even over the 0.15 m(2)K/W cited in standard EN 1264-2) did not significantly affect the energy demand or thermal comfort. On average, wood flooring lowered energy demand by 6.4% and daily hours of thermal comfort by a mere 1.6% relative to granite coverings. The findings showed that wood-finished flooring may deliver comparable or, in some cases, higher thermal performance than high-conductivity material coverings, even when their thermal resistance is over 0.15 m(2)K/W. The suggestion is that the aforementioned value, presently deemed the maximum admissible thermal resistance, may need to be revised

A Methodology for Buildings Access to Solar Radiation in Sustainable Cities

The growing need to improve the environmental and energy sustainability of buildings involves the use of solar radiation incident on their surfaces. However, in cities, this task is complicated due to the constructive geometry that leads to shading between buildings. In this context, this work presents a study of solar access to the façades of buildings in cities. The methodology is based on the determination of the incident annual solar radiation in 121 significant points of each façade considering the twelve representative days of the year. To characterize the influence of the different city typologies on solar access, the urban solar coefficient is proposed. A study of two neighborhoods in Cordoba (Spain) with different urban settings have been analyzed. Specifically, two typologies of neighborhoods have been compared: one with “L-shaped” and “U-shaped blocks” and another with “Grouped blocks”. For both of them, the Urban Solar Coefficient has been calculated, obtaining a higher mean value for the neighborhood with “L-shaped” and “U-shaped blocks” (0.317) than for the one with “Grouped blocks” (0.260). Accordingly, the results show that urban morphology can influence the Urban Solar Coefficient and solar access. Finally, a regression model for each neighborhood has been obtained in order to determine the dependence of the Urban Solar Coefficient on neighborhood geometry factors

Snail1 induces IL-17 expression to inhibit adipogenesis

44 p.-7 fig.-1 tab. Peláez-García, Alberto et al.Adipogenesis requires a differentiation program driven by multiple transcription factors, where PPARγ and C/EBPα play a central role. Recent findings indicate that Snail inhibits adipocyte differentiation in 3T3-L1 and murine mesenchymal stem cells (mMSC). An in-depth quantitative SILAC analysis of the nuclear fraction of Snail-induced alterations of 3T3-L1 cells was carried out. In total, 2251 overlapping proteins were simultaneously quantified in forward and reverse experiments. We observed 574 proteins deregulated by Snail1 using a fold-change ≥1.5, with 111 up- and 463 down-regulated proteins, respectively. Among other proteins, multiple transcription factors such as Trip4, OsmR, Nr2f6, Cbx6, and Prrx1 were down-regulated. Results were validated in 3T3-L1 cells and mMSC cells by Western blot and quantitative PCR. Knock-down experiments in 3T3-L1 cells demonstrated that only Nr2f6 (and Trip4 at minor extent) was required for adipocyte differentiation. Ectopic expression of Nr2f6 reversed the effects of Snail1 and promoted adipogenesis. Because Nr2f6 inhibits the expression of IL-17, we tested the effect of Snail on IL-17 expression. IL-17 and TNFα were among the most up-regulated pro-inflammatory cytokines in Snail-transfected 3T3-L1 and mMSC cells. Furthermore, the blocking of IL-17 activity in Snail-transfected cells promoted adipocyte differentiation, reverting Snail inhibition. In summary, Snail inhibits adipogenesis through a down-regulation of Nr2f6, which in turn facilitates the expression of IL-17, an anti-adipogenic cytokine. These results would support a novel and important role for Snail and Nr2f6 in obesity control.This research was supported by a grant to established research groups (AECC), grant BIO2012-31023 from the Ministry of Economy and Competitiveness, grant S2011/BMD-2344/ (Colomics2) from Comunidad de Madrid and ProteoRed-ISCIII support. Work at AGH’s lab was supported by a grant from the Ministry of Economy and Competitiveness (SAF2010-16089)Peer reviewe

Ectomycorrhizal fungal communities and their functional traits mediate plant–soil interactions in trace element contaminated soils

There is an increasing consensus that microbial communities have an important role in mediating ecosystem processes. Trait-based ecology predicts that the impact of the microbial communities on ecosystem functions will be mediated by the expression of their traits at community level. The link between the response of microbial community traits to environmental conditions and its effect on plant functioning is a gap in most current microbial ecology studies. In this study, we analyzed functional traits of ectomycorrhizal fungal species in order to understand the importance of their community assembly for the soil–plant relationships in holm oak trees (Quercus ilex subsp. ballota) growing in a gradient of exposure to anthropogenic trace element (TE) contamination after a metalliferous tailings spill. Particularly, we addressed how the ectomycorrhizal composition and morphological traits at community level mediate plant response to TE contamination and its capacity for phytoremediation. Ectomycorrhizal fungal taxonomy and functional diversity explained a high proportion of variance of tree functional traits, both in roots and leaves. Trees where ectomycorrhizal fungal communities were dominated by the abundant taxa Hebeloma cavipes and Thelephora terrestris showed a conservative root economics spectrum, while trees colonized by rare taxa presented a resource acquisition strategy. Conservative roots presented ectomycorrhizal functional traits characterized by high rhizomorphs formation and low melanization which may be driven by resource limitation. Soil-to-root transfer of TEs was explained substantially by the ectomycorrhizal fungal species composition, with the highest transfer found in trees whose roots were colonized by Hebeloma cavipes. Leaf phosphorus was related to ectomycorrhizal species composition, specifically higher leaf phosphorus was related to the root colonization by Thelephora terrestris. These findings support that ectomycorrhizal fungal community composition and their functional traits mediate plant performance in metal-contaminated soils, and have a high influence on plant capacity for phytoremediation of contaminants. The study also corroborates the overall effects of ectomycorrhizal fungi on ecosystem functioning through their mediation over the plant economics spectrum

A fully automatic method for vascular tortuosity feature extraction in the supra-aortic region: unraveling possibilities in stroke treatment planning

Vascular tortuosity of supra-aortic vessels is widely considered one of the main reasons for failure and delays in endovascular treatment of large vessel occlusion in patients with acute ischemic stroke. Characterization of tortuosity is a challenging task due to the lack of objective, robust and effective analysis tools. We present a fully automatic method for arterial segmentation, vessel labelling and tortuosity feature extraction applied to the supra-aortic region. A sample of 566 computed tomography angiography scans from acute ischemic stroke patients (aged 74.8 ± 12.9, 51.0% females) were used for training, validation and testing of a segmentation module based on a U-Net architecture (162 cases) and a vessel labelling module powered by a graph U-Net (566 cases). Successively, 30 cases were processed for testing of a tortuosity feature extraction module. Measurements obtained through automatic processing were compared to manual annotations from two observers for a thorough validation of the method. The proposed feature extraction method presented similar performance to the inter-rater variability observed in the measurement of 33 geometrical and morphological features of the arterial anatomy in the supra-aortic region. This system will contribute to the development of more complex models to advance the treatment of stroke by adding immediate automation, objectivity, repeatability and robustness to the vascular tortuosity characterization of patients

Digital ulcerative lichenoid dermatitis in a patient receiving anti-PD-1 therapy

Programmed cell death receptor 1 inhibitors (anti-PD-1) constitute a form of immunotherapy for the treatment of several cancers. They are associated with cutaneous immune-related adverse events (irAE), occurring in up to 50% of patients. Lichenoid dermatitis is frequent and several presentations have been described. Although attempts have been made to study these reactions, they are yet to be fully characterized and the relationship with tumor response is unclear. We describe a case of digital ulcerative lichenoid dermatitis resembling ulcerative cutaneous lichen planus that occurred during pembrolizumab therapy for oral squamous cell carcinoma. The patient developed a painful ulcer on his index finger 18 months into therapy. Biopsy revealed epidermal ulceration with intense lichenoid dermatitis. Immunohistochemical study revealed intense CD8 positivity at the ulcer's edges and marked CD163 positivity at its base. Although idiopathic forms of this type of lichenoid dermatitis are particularly recalcitrant, our case was successfully managed with topical therapy and oncologic treatment did not require modification. One year after ending treatment the patient remains free of disease progression. It is unclear if this reaction is associated with his favorable oncologic response. This report adds an undescribed reaction to the increasing diversity of cutaneous irAE associated with anti-PD-1 therapy

Default mode network components and its relationship with anomalous self-experiences in schizophrenia: A rs-fMRI exploratory study

Producción CientíficaAnomalous self-experiences (ASEs) in schizophrenia have been under research for the last 20 years. However, no neuroimage studies have provided insight of the possible biological underpinning of ASEs. In this novel approach, the connectivity within the default mode network, calculated through a ROI-based analysis of functional magnetic resonance imaging data, was correlated to the ASEs scores assessed by the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) in a sample of 22 schizophrenia patients. The Pearson's correlation coefficients between IPASE scores and intrahemispheric connectivity of the parahippocampal gyrus with the isthmus cingulate cortex in both hemispheres, and right parahippocampal gyrus with the right rostral anterior cingulate cortex were positive and significant suggesting a relation between hyperactive functional connectivity and anomalous self-experiences intensity. Prior literature reported these areas to have a role in self-processing and consciousness as well as being anatomically connected. Further research with larger sample size and comparison with controls are needed to confirm the relationship of this connectivity with anomalous self-experiences.Instituto de Salud Carlos III (beca ID PI18/00178)Junta de Castilla y León (Dirección Regional de Salud de Castilla y León - grant ID GRS 2121/A/20)Junta de Castilla y León” and the European Social Fund (grant IDs VA-183-18 to IFL, VA-223-19 to RMBR