Prevalencia de delirium en adultos mayores con fractura de cadera

Objetivo: Establecer la prevalencia de delirium en pacientes adultos mayores con fractura de cadera en el Servicio de Traumatología del Hospital Universitario Dr. José E. González de octubre del 2008 a mayo del 2009. Métodos: se realizó estudio descriptivo, transversal y prospectivo en la población de pacientes mayores de 60 años con diagnóstico de fractura de cadera en un periodo de ocho meses. Se evaluó delirium mediante el método del estado confusional agudo (CAM) y criterios DSM IV, durante el internamiento y al mes del egreso por vía telefónica. Resultados: Se analizó una población de 74 pacientes con una edad promedio de 79.47 años y primordialmente femenina (74.3%), el promedio de días de estancia fue de 14.68 días, observando prevalencia de delirium del 37.8% y una mortalidad final del 17.6%. No se encontraron diferencias entre ambos grupos, la edad es mayor en los pacientes con delirium y esta correlaciona con la patología (edad promedio: delirium= 84 años / sin delirium= 77 años / p = 0.0016; Rho= 0.347 / p = 0.002). Conclusiones: La prevalencia de delirium encontrada es similar a la reportada en otros estudios. Se observó menor tiempo de estancia hospitalaria, así como una mayor mortalidad en ambos grupos durante su hospitalización, de igual manera, un mes después del ingreso, en el grupo de pacientes que desarrollaron delirium

Diagnosis and Management of Iliac Artery Endofibrosis: Results of a Delphi Consensus Study

Objective Iliac endofibrosis is a rare condition that may result in a reduction of blood flow to the lower extremity in young, otherwise healthy individuals. The data to inform everyday clinical management are weak and therefore a Delphi consensus methodology was used to explore areas of consensus and disagreement concerning the diagnosis and management of patients with suspected iliac endofibrosis. Methods A three-round Delphi questionnaire approach was used among vascular surgeons, sports physicians, sports scientists, radiologists, and clinical vascular scientists with experience of treating this condition to explore diagnosis and clinical management issues for patients with suspected iliac artery endofibrosis. Analysis is based on 18 responses to round 2 and 14 responses to round 3, with agreement reported when 70% of respondents were in agreement. Results Initially there was agreement on the typical symptoms at presentation and the need for an exercise test in the diagnosis. Round 3 clarified that duplex ultrasound was a useful tool in the diagnosis of endofibrosis. There was consensus on the most appropriate type of surgery (endarterectomy and vein patch) and that endovascular interventions were inadvisable. The final round helped to inform aspects of the natural history and post-operative surveillance. Progression of the disease was likely with continued exercise but cessation may prevent progression. Surveillance after surgery is generally recommended yearly with at least a clinical assessment. Conclusions There is broad agreement about the presenting symptoms and the investigations required to confirm (or exclude) the diagnosis of iliac endofibrosis. There was consensus on the surgical approach to repair. Disagreement existed about the specific diagnostic criteria that should be applied during non-invasive testing and about post-operative care and resumption of exercise

Modelado de la interacción de albúmina de suero de bovino (BSA) con diferentes combinatorias en la estructura de pirrol sintetizado por plasma (PPPy)

Se ha estudiado la interacción entre el polipirrol sintetizado por plasma (PPPy) con la proteína albúmina de suero bovino (BSA). Esta interacción es importante debido a que el PPPy presenta neuroprotección y mejora la actividad motora en lesiones traumáticas de médula espinal en roedores. Se realizaron estudios de acoplamiento molecular (docking) alrededor de la superficie de BSA con diferentes combinaciones de PPPy generados a partir de la estructura reportada por Kumar et al., (2003) y se evaluó la energía de unión de estos complejos. Los resultados obtenidos indicaron una clara contribución electrostática en los sitios de reconocimiento sobre la superficie de BSA debido a la combinación de tres grupos funcionales (CH3, OH y NH2) presentes en los confórmeros de PPPy. Es importante mencionar que estos resultados complementan evidencias experimentales y computacionales de nuestro grupo de investigación.The interaction between plasma synthesized polypyrrol (PPPy) with bovine serum albumin protein (BSA) has been studied. This interaction is important because PPPy exhibits neuroprotection and improves motor activity in traumatic spinal cord lesions in rodents. Docking studies were made around of surface of BSA with different combinations of PPPy generated from the structure reported by Kumar et al., (2003) and the binding energy of these complexes was evaluated. The results indicated a clear electrostatic contribution at the recognition sites on the surface of BSA due to the combination of three functional groups (CH3, OH and NH2) present in the PPPy conformers. It is important to mention that these results complement the experimental and computational evidence obtained in our research group

Measurement of the CKM angle γ using B ± → DK ± with D → K0S π + π −, K0S K + K − decays

A binned Dalitz plot analysis of B± → DK± decays, with D → K0S + − and D → K0S K+K−, is performed to measure the CP-violating observables x± and y±, which are sensitive to the Cabibbo-Kobayashi-Maskawa angle . The analysis exploits a sample of proton-proton collision data corresponding to 3.0 fb−1 collected by the LHCb experiment. Measurements from CLEO-c of the variation of the strong-interaction phase of the D decay over the Dalitz plot are used as inputs. The values of the parameters are found to be x+ = (−7.7 ± 2.4 ± 1.0 ± 0.4) × 10−2, x− = (2.5 ± 2.5 ± 1.0 ± 0.5) × 10−2, y+ = (−2.2 ± 2.5 ± 0.4 ± 1.0) × 10−2, and y− = (7.5 ± 2.9 ± 0.5 ± 1.4) × 10−2. The first, second, and third uncertainties are the statistical, the experimental systematic, and that associated with the precision of the strong-phase parameters. These are the most precise measurements of these observables and correspond to = (62 +15 −14) , with a second solution at γ → γ  + 180 , and rB = 0.080+0.019 −0.021, where rB is the ratio between the suppressed and favoured B decay amplitudesS

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1). This step turns off the IKK/NF-kappa B/SOD2 antioxidant pathway. Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-kappa B/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. Our results indicate that PKD1 inactivation underlies excitotoxicity-induced neuronal death and suggest that PKD1 inactivation may be critical for the accumulation of oxidation-induced neuronal damage during aging and in neurodegenerative disorders

Search for long-lived particles decaying to jet pairs

A search is presented for long-lived particles with a mass between 25 and 50 GeV/c2 and a lifetime between 1 and 200ps in a sample of proton–proton collisions at a centre-of-mass energy of s√=7 TeV, corresponding to an integrated luminosity of 0.62 fb −1, collected by the LHCb detector. The particles are assumed to be pair-produced by the decay of a standard model-like Higgs boson. The experimental signature of the long-lived particle is a displaced vertex with two associated jets. No excess above the background is observed and limits are set on the production cross-section as a function of the long-lived particle mass and lifetimeS

Measurement of the ηc(1S) production cross-section in proton–proton collisions via the decay ηc(1S)→pp

The production of the ηc(1S) state in proton-proton collisions is probed via its decay to the pp final state with the LHCb detector, in the rapidity range 2.06.5GeV/c. The cross-section for prompt production of ηc(1S) mesons relative to the prompt J/ψ cross-section is measured, for the first time, to be σηc(1S)/σJ/ψ=1.74±0.29±0.28±0.18B at a centre-of-mass energy s√=7 TeV using data corresponding to an integrated luminosity of 0.7 fb−1, and σηc(1S)/σJ/ψ=1.60±0.29±0.25±0.17B at s√=8 TeV using 2.0 fb−1. The uncertainties quoted are, in order, statistical, systematic, and that on the ratio of branching fractions of the ηc(1S) and J/ψ decays to the pp final state. In addition, the inclusive branching fraction of b-hadron decays into ηc(1S) mesons is measured, for the first time, to be B(b→ηcX)=(4.88±0.64±0.29±0.67B)×10−3, where the third uncertainty includes also the uncertainty on the J/ψ inclusive branching fraction from b-hadron decays. The difference between the J/ψ and ηc(1S) meson masses is determined to be 114.7±1.5±0.1MeV/c2.S

Study of χb meson production in p p collisions at √s=7 and 8TeV and observation of the decay χb(3P)→Υ(3S)γ

A study of χb meson production at LHCb is performed on proton–proton collision data, corresponding to 3.0 fb−1of integrated luminosity collected at centre-of-mass energies √s= 7 and 8 TeV. The fraction of Υ(nS) mesons originating from χb decays is measured as a function of the Υ transverse momentum in the rapidity range 2.0<yΥ<4.5. The radiative transition of the χb(3P) meson to Υ(3S) is observed for the first time. The χb1(3P) mass is determined to be mχb1(3P)=10511.3±1.7±2.5MeV/c2, where the first uncertainty is statistical and the second is systematic.We acknowledge support from CERN and from the national agencies: CAPES, CNPq, FAPERJ and FINEP (Brazil); NSFC (China); CNRS/IN2P3 (France); BMBF, DFG, HGF and MPG (Germany); SFI (Ireland); INFN (Italy); FOM and NWO (The Netherlands); MNiSW and NCN (Poland); MEN/IFA (Romania); MinES and FANO (Russia); MinECo (Spain); SNSF and SER (Switzerland); NASU (Ukraine); STFC (United Kingdom); NSF (USA). The Tier1 computing centres are supported by IN2P3 (France), KIT and BMBF (Germany), INFN (Italy), NWO and SURF (The Netherlands), PIC (Spain), GridPP (United Kingdom). We are indebted to the communities behind the multiple open source software packages on which we depend. We are also thankful for the computing resources and the access to software R&D tools provided by Yandex LLC (Russia). Individual groups or members have received support from EPLANET, Marie Skłodowska-Curie Actions and ERC (European Union), Conseil général de Haute-Savoie, Labex ENIGMASS and OCEVU, Région Auvergne (France), RFBR (Russia), XuntaGal and GENCAT (Spain), Royal Society and Royal Commission for the Exhibition of 1851 (United Kingdom)S

Measurement of the forward W boson cross-section in pp collisions at √s=7 TeV

A measurement of the inclusive W → μν production cross-section using data from pp collisions at a centre-of-mass energy of √s=7 TeV is presented. The analysis is based on an integrated luminosity of about 1.0 fb−1 recorded with the LHCb detector. Results are reported for muons with a transverse momentum greater than 20 GeV/c and pseudorapidity between 2.0 and 4.5. The W + and W − production cross-sections are measured to be σW+→μ+ν=861.0±2.0±11.2±14.7pb, σW−→μ−ν¯=675.8±1.9±8.8±11.6pb, where the first uncertainty is statistical, the second is systematic and the third is due to the luminosity determination. Cross-section ratios and differential distributions as functions of the muon pseudorapidity are also presented. The ratio of W + to W − cross-sections in the same fiducial kinematic region is determined to be σW+→μ+νσW−→μ−ν¯=1.274±0.005±0.009, where the uncertainties are statistical and systematic, respectively. Results are in good agreement with theoretical predictions at next-to-next-to-leading order in perturbative quantum chromodynamics.S