Parkinson's Disease Classification and Clinical Score Regression via United Embedding and Sparse Learning From Longitudinal Data

Parkinson's disease (PD) is known as an irreversible neurodegenerative disease that mainly affects the patient's motor system. Early classification and regression of PD are essential to slow down this degenerative process from its onset. In this article, a novel adaptive unsupervised feature selection approach is proposed by exploiting manifold learning from longitudinal multimodal data. Classification and clinical score prediction are performed jointly to facilitate early PD diagnosis. Specifically, the proposed approach performs united embedding and sparse regression, which can determine the similarity matrices and discriminative features adaptively. Meanwhile, we constrain the similarity matrix among subjects and exploit the l2,p norm to conduct sparse adaptive control for obtaining the intrinsic information of the multimodal data structure. An effective iterative optimization algorithm is proposed to solve this problem. We perform abundant experiments on the Parkinson's Progression Markers Initiative (PPMI) data set to verify the validity of the proposed approach. The results show that our approach boosts the performance on the classification and clinical score regression of longitudinal data and surpasses the state-of-the-art approaches

Automatic Autism Spectrum Disorder Detection Using Artificial Intelligence Methods with MRI Neuroimaging: A Review

Autism spectrum disorder (ASD) is a brain condition characterized by diverse signs and symptoms that appear in early childhood. ASD is also associated with communication deficits and repetitive behavior in affected individuals. Various ASD detection methods have been developed, including neuroimaging modalities and psychological tests. Among these methods, magnetic resonance imaging (MRI) imaging modalities are of paramount importance to physicians. Clinicians rely on MRI modalities to diagnose ASD accurately. The MRI modalities are non-invasive methods that include functional (fMRI) and structural (sMRI) neuroimaging methods. However, the process of diagnosing ASD with fMRI and sMRI for specialists is often laborious and time-consuming; therefore, several computer-aided design systems (CADS) based on artificial intelligence (AI) have been developed to assist the specialist physicians. Conventional machine learning (ML) and deep learning (DL) are the most popular schemes of AI used for diagnosing ASD. This study aims to review the automated detection of ASD using AI. We review several CADS that have been developed using ML techniques for the automated diagnosis of ASD using MRI modalities. There has been very limited work on the use of DL techniques to develop automated diagnostic models for ASD. A summary of the studies developed using DL is provided in the appendix. Then, the challenges encountered during the automated diagnosis of ASD using MRI and AI techniques are described in detail. Additionally, a graphical comparison of studies using ML and DL to diagnose ASD automatically is discussed. We conclude by suggesting future approaches to detecting ASDs using AI techniques and MRI neuroimaging

A new Stack Autoencoder: Neighbouring Sample Envelope Embedded Stack Autoencoder Ensemble Model

Stack autoencoder (SAE), as a representative deep network, has unique and excellent performance in feature learning, and has received extensive attention from researchers. However, existing deep SAEs focus on original samples without considering the hierarchical structural information between samples. To address this limitation, this paper proposes a new SAE model-neighbouring envelope embedded stack autoencoder ensemble (NE_ESAE). Firstly, the neighbouring sample envelope learning mechanism (NSELM) is proposed for preprocessing of input of SAE. NSELM constructs sample pairs by combining neighbouring samples. Besides, the NSELM constructs a multilayer sample spaces by multilayer iterative mean clustering, which considers the similar samples and generates layers of envelope samples with hierarchical structural information. Second, an embedded stack autoencoder (ESAE) is proposed and trained in each layer of sample space to consider the original samples during training and in the network structure, thereby better finding the relationship between original feature samples and deep feature samples. Third, feature reduction and base classifiers are conducted on the layers of envelope samples respectively, and output classification results of every layer of samples. Finally, the classification results of the layers of envelope sample space are fused through the ensemble mechanism. In the experimental section, the proposed algorithm is validated with over ten representative public datasets. The results show that our method significantly has better performance than existing traditional feature learning methods and the representative deep autoencoders.Comment: 17 pages,6 figure

Application of deep learning techniques for biomedical data analysis

Deep learning and machine learning methods have been used for addressing the problems in the biomedical applications, such as diabetic retinopathy assessment and Parkinson's disease diagnosis. The severity of diabetic retinopathy is estimated by the expert's examination of fundus images based on the amount and location of three diabetic retinopathy signs (i.e., exudates, hemorrhages, and microaneurysms). An automatic and accurate system for detection of these signs can significantly help clinicians to make the best possible prognosis can result in reducing the risk of vision loss. For Parkinson's disease diagnosis, analysis of a speech voice is considered as the earliest symptom with the advantage of being non-intrusive and suitable for online applications. While some reported outcomes of the developed techniques have shown the good results and ongoing progress for these two applications, designing new algorithms is a thriving research field to overcome the poor sensitivity and specificity of the outcomes as well as the limitations such as dataset size and heuristic selection of the network parameters. This thesis has comprehensively studied and developed various deep learning frameworks for detection of diabetic retinopathy signs and diagnosis of Parkinson's disease. To improve the performance of the current systems, this work has had an investigation on different techniques: (i) color space investigation, (ii) examination of various deep learning methods, (iii) development of suitable pre/post-processing algorithms and (iv) appropriate selection of deep learning architectures and parameters. For diabetic retinopathy assessment, this thesis has proposed the new color space as the input for the deep learning models that obtained better replicability compared with the conventional color spaces. This has also shown the pre-trained model can extract more relevant features compared to the models which were trained from scratch. This has also presented a deep learning framework combined with the suitable pre and post-processing algorithms that increased the performance of the system. By investigation different architectures and parameters, the suitable deep learning model has been presented to distinguish between Parkinson's disease and healthy speech signal

Cancer prediction using graph-based gene selection and explainable classifier

Several Artificial Intelligence-based models have been developed for cancer prediction. In spite of the promise of artificial intelligence, there are very few models which bridge the gap between traditional human-centered prediction and the potential future of machine-centered cancer prediction. In this study, an efficient and effective model is developed for gene selection and cancer prediction. Moreover, this study proposes an artificial intelligence decision system to provide physicians with a simple and human-interpretable set of rules for cancer prediction. In contrast to previous deep learning-based cancer prediction models, which are difficult to explain to physicians due to their black-box nature, the proposed prediction model is based on a transparent and explainable decision forest model. The performance of the developed approach is compared to three state-of-the-art cancer prediction including TAGA, HPSO and LL. The reported results on five cancer datasets indicate that the developed model can improve the accuracy of cancer prediction and reduce the execution time

Machine Learning for Multiclass Classification and Prediction of Alzheimer\u27s Disease

Alzheimer\u27s disease (AD) is an irreversible neurodegenerative disorder and a common form of dementia. This research aims to develop machine learning algorithms that diagnose and predict the progression of AD from multimodal heterogonous biomarkers with a focus placed on the early diagnosis. To meet this goal, several machine learning-based methods with their unique characteristics for feature extraction and automated classification, prediction, and visualization have been developed to discern subtle progression trends and predict the trajectory of disease progression. The methodology envisioned aims to enhance both the multiclass classification accuracy and prediction outcomes by effectively modeling the interplay between the multimodal biomarkers, handle the missing data challenge, and adequately extract all the relevant features that will be fed into the machine learning framework, all in order to understand the subtle changes that happen in the different stages of the disease. This research will also investigate the notion of multitasking to discover how the two processes of multiclass classification and prediction relate to one another in terms of the features they share and whether they could learn from one another for optimizing multiclass classification and prediction accuracy. This research work also delves into predicting cognitive scores of specific tests over time, using multimodal longitudinal data. The intent is to augment our prospects for analyzing the interplay between the different multimodal features used in the input space to the predicted cognitive scores. Moreover, the power of modality fusion, kernelization, and tensorization have also been investigated to efficiently extract important features hidden in the lower-dimensional feature space without being distracted by those deemed as irrelevant. With the adage that a picture is worth a thousand words, this dissertation introduces a unique color-coded visualization system with a fully integrated machine learning model for the enhanced diagnosis and prognosis of Alzheimer\u27s disease. The incentive here is to show that through visualization, the challenges imposed by both the variability and interrelatedness of the multimodal features could be overcome. Ultimately, this form of visualization via machine learning informs on the challenges faced with multiclass classification and adds insight into the decision-making process for a diagnosis and prognosis

A methodology to compare dimensionality reduction algorithms in terms of loss of quality

Dimensionality Reduction (DR) is attracting more attention these days as a result of the increasing need to handle huge amounts of data effectively. DR methods allow the number of initial features to be reduced considerably until a set of them is found that allows the original properties of the data to be kept. However, their use entails an inherent loss of quality that is likely to affect the understanding of the data, in terms of data analysis. This loss of quality could be determinant when selecting a DR method, because of the nature of each method. In this paper, we propose a methodology that allows different DR methods to be analyzed and compared as regards the loss of quality produced by them. This methodology makes use of the concept of preservation of geometry (quality assessment criteria) to assess the loss of quality. Experiments have been carried out by using the most well-known DR algorithms and quality assessment criteria, based on the literature. These experiments have been applied on 12 real-world datasets. Results obtained so far show that it is possible to establish a method to select the most appropriate DR method, in terms of minimum loss of quality. Experiments have also highlighted some interesting relationships between the quality assessment criteria. Finally, the methodology allows the appropriate choice of dimensionality for reducing data to be established, whilst giving rise to a minimum loss of quality