Web application of physiological data based on FHIR

This paper works toward implementing a prototype demonstrating some of the capabilities of the FHIR specification. The specification requires a clear understanding of its different components in order to be successfully implemented, therefore the primary concern of this work is to understand and analyse FHIR’s concepts. The research conducted in this work revealed that FHIR is a well-designed specification, based on a powerful data model and technologies. Therefore, it sould help solving the interoperability issues of the healthcare eco-system. It has also been pointed that since FHIR is a recent standard, many of its uses and benefits are still to be discovered. Moreover, FHIR integrates well in the current health information technology context since it can be used in addition to existing standards

Why digital medicine depends on interoperability

Digital data are anticipated to transform medicine. However, most of today's medical data lack interoperability: hidden in isolated databases, incompatible systems and proprietary software, the data are difficult to exchange, analyze, and interpret. This slows down medical progress, as technologies that rely on these data - artificial intelligence, big data or mobile applications - cannot be used to their full potential. In this article, we argue that interoperability is a prerequisite for the digital innovations envisioned for future medicine. We focus on four areas where interoperable data and IT systems are particularly important: (1) artificial intelligence and big data; (2) medical communication; (3) research; and (4) international cooperation. We discuss how interoperability can facilitate digital transformation in these areas to improve the health and well-being of patients worldwide

BIRS Course: RNA Vaccine Manufacture and Assessment of Regulatory Documents for RNA Vaccines

This paper is in three segments: (A) Segment on Vaccine Manufacture; (B) Segment on Ready to Use (RTU) Fluid Path for Compounded Sterile Preparations, mRNA Vaccines, and Phage Therapy, (C) Segment on Competency Framework for Addressing Regulatory Review These segments can be used separately or in combination. Additionally, they can be presented in any order. The time devoted to each segment depends on the depth of the course coverage. These segments are interrelated and describe how to make vaccines, how to manufacture vaccines with a point-of-care system built from ready-to-use parts; and how to regulate vaccines. This is a timely review because of the importance of vaccines for the treatment of diseases. It is hoped that it will lead to new approaches to vaccine manufacture and regulation

Architecture and Information Requirements to Assess and Predict Flight Safety Risks During Highly Autonomous Urban Flight Operations

As aviation adopts new and increasingly complex operational paradigms, vehicle types, and technologies to broaden airspace capability and efficiency, maintaining a safe system will require recognition and timely mitigation of new safety issues as they emerge and before significant consequences occur. A shift toward a more predictive risk mitigation capability becomes critical to meet this challenge. In-time safety assurance comprises monitoring, assessment, and mitigation functions that proactively reduce risk in complex operational environments where the interplay of hazards may not be known (and therefore not accounted for) during design. These functions can also help to understand and predict emergent effects caused by the increased use of automation or autonomous functions that may exhibit unexpected non-deterministic behaviors. The envisioned monitoring and assessment functions can look for precursors, anomalies, and trends (PATs) by applying model-based and data-driven methods. Outputs would then drive downstream mitigation(s) if needed to reduce risk. These mitigations may be accomplished using traditional design revision processes or via operational (and sometimes automated) mechanisms. The latter refers to the in-time aspect of the system concept. This report comprises architecture and information requirements and considerations toward enabling such a capability within the domain of low altitude highly autonomous urban flight operations. This domain may span, for example, public-use surveillance missions flown by small unmanned aircraft (e.g., infrastructure inspection, facility management, emergency response, law enforcement, and/or security) to transportation missions flown by larger aircraft that may carry passengers or deliver products. Caveat: Any stated requirements in this report should be considered initial requirements that are intended to drive research and development (R&D). These initial requirements are likely to evolve based on R&D findings, refinement of operational concepts, industry advances, and new industry or regulatory policies or standards related to safety assurance

Defining Security Requirements with the Common Criteria: Applications, Adoptions, and Challenges

Advances of emerging Information and Communications Technology (ICT) technologies push the boundaries of what is possible and open up new markets for innovative ICT products and services. The adoption of ICT products and systems with security properties depends on consumers' confidence and markets' trust in the security functionalities and whether the assurance measures applied to these products meet the inherent security requirements. Such confidence and trust are primarily gained through the rigorous development of security requirements, validation criteria, evaluation, and certification. Common Criteria for Information Technology Security Evaluation (often referred to as Common Criteria or CC) is an international standard (ISO/IEC 15408) for cyber security certification. In this paper, we conduct a systematic review of the CC standards and its adoptions. Adoption barriers of the CC are also investigated based on the analysis of current trends in security evaluation. Specifically, we share the experiences and lessons gained through the recent Development of Australian Cyber Criteria Assessment (DACCA) project that promotes the CC among stakeholders in ICT security products related to specification, development, evaluation, certification and approval, procurement, and deployment. Best practices on developing Protection Profiles, recommendations, and future directions for trusted cybersecurity advancement are presented

A conformance test framework for the DeviceNet fieldbus

The DeviceNet fieldbus technology is introduced and discussed. DeviceNet is an open standard fieldbus which uses the proven Controller Area Network technology. As an open standard fieldbus, the device conformance is extremely important to ensure smooth operation. The error management in DeviceNet protocol is highlighted and an error injection technique is devised to test the implementation under test for the correct error-recovery conformance. The designed Error Frame Generator prototype allows the error management and recovery of DeviceNet implementations to be conformance tested. The Error Frame Generator can also be used in other Controller Area Network based protocols. In addition, an automated Conformance Test Engine framework has been defined for realising the conformance testing of DeviceNet implementations. Automated conformance test is used to achieve consistent and reliable test results, apart from the benefits in time and personnel savings. This involves the investigations and feasibility studies in adapting the ISO 9646 conformance test standards for use in DeviceNet fieldbus. The Unique Input/Output sequences method is used for the generation of DeviceNet conformance tests. The Unique Input/Output method does not require a fully specified protocol specification and gives shorter test sequences, since only specific state information is needed. As conformance testing addresses only the protocol verification, it is foreseen that formal method validation of the DeviceNet protocol must be performed at some stage to validate the DeviceNet specification

Automation, Protection and Control of Substation Based on IEC 61850

Reliability of power system protection system has been a key issue in the substation operation due to the use of multi-vendor equipment of proprietary features, environmental issues, and complex fault diagnosis. Failure to address these issues could have a significant effect on the performance of the entire electricity grid. With the introduction of IEC 61850 standard, substation automation system (SAS) has significantly altered the scenario in utilities and industries as indicated in this thesis

Building the Future Internet through FIRE

The Internet as we know it today is the result of a continuous activity for improving network communications, end user services, computational processes and also information technology infrastructures. The Internet has become a critical infrastructure for the human-being by offering complex networking services and end-user applications that all together have transformed all aspects, mainly economical, of our lives. Recently, with the advent of new paradigms and the progress in wireless technology, sensor networks and information systems and also the inexorable shift towards everything connected paradigm, first as known as the Internet of Things and lately envisioning into the Internet of Everything, a data-driven society has been created. In a data-driven society, productivity, knowledge, and experience are dependent on increasingly open, dynamic, interdependent and complex Internet services. The challenge for the Internet of the Future design is to build robust enabling technologies, implement and deploy adaptive systems, to create business opportunities considering increasing uncertainties and emergent systemic behaviors where humans and machines seamlessly cooperate