Target concept learning from ambiguously labeled data

The multiple instance learning problem addresses the case where training data comes with label ambiguity, i.e., the learner has access only to inaccurately labeled data. For example, in target detection from remotely sensed hyperspectral imagery, targets are usually sub-pixel and the ground truthing of the targets according to GPS coordinates could drift across several meters. Thus the locations of the targets corresponding to the hyperspectral image are inaccurate. Training a supervised algorithm or extracting target signatures from this kind of labels is intractable. This dissertation investigates the topic target concept learning from ambiguously labeled data comprehensively; reviews and proposes several methods that either learn a set of representative or discriminative target concepts. The multiple instance hybrid estimator (MI-HE) maximizes the response of the hybrid detector under a generalized mean framework and estimates a set of discriminative target concepts. MI-HE adopts a linear mixture model and iterates between estimating a set of discriminative target and non-target signatures and solving a sparse unmixing problem. MI-HE preserves bag-level label information for each positive bag and is able to estimate a target concept that is commonly shared among positive bags. Furthermore, MI-HE has the potential to learn multiple signatures to address signature variability. After learning target concept, signature based detector could be applied for target detection. The presented algorithms were tested in many applications including simulated and real hyperspectral target detection, heartbeat characterization from ballistocardiogram signals and tree species classification from remotely sensed data. The presented algorithms were proven to be effective in learning high-quality target signatures and consistently achieved superior performance over the state-of-the-art comparison algorithms.Includes biblographical reference

Acoustic sensing as a novel approach for cardiovascular monitoring at the wrist

Cardiovascular diseases are the number one cause of deaths globally. An increased cardiovascular risk can be detected by a regular monitoring of the vital signs including the heart rate, the heart rate variability (HRV) and the blood pressure. For a user to undergo continuous vital sign monitoring, wearable systems prove to be very useful as the device can be integrated into the user's lifestyle without affecting the daily activities. However, the main challenge associated with the monitoring of these cardiovascular parameters is the requirement of different sensing mechanisms at different measurement sites. There is not a single wearable device that can provide sufficient physiological information to track the vital signs from a single site on the body. This thesis proposes a novel concept of using acoustic sensing over the radial artery to extract cardiac parameters for vital sign monitoring. A wearable system consisting of a microphone is designed to allow the detection of the heart sounds together with the pulse wave, an attribute not possible with existing wrist-based sensing methods. Methods: The acoustic signals recorded from the radial artery are a continuous reflection of the instantaneous cardiac activity. These signals are studied and characterised using different algorithms to extract cardiovascular parameters. The validity of the proposed principle is firstly demonstrated using a novel algorithm to extract the heart rate from these signals. The algorithm utilises the power spectral analysis of the acoustic pulse signal to detect the S1 sounds and additionally, the K-means method to remove motion artifacts for an accurate heartbeat detection. The HRV in the short-term acoustic recordings is found by extracting the S1 events using the relative information between the short- and long-term energies of the signal. The S1 events are localised using three different characteristic points and the best representation is found by comparing the instantaneous heart rate profiles. The possibility of measuring the blood pressure using the wearable device is shown by recording the acoustic signal under the influence of external pressure applied on the arterial branch. The temporal and spectral characteristics of the acoustic signal are utilised to extract the feature signals and obtain a relationship with the systolic blood pressure (SBP) and diastolic blood pressure (DBP) respectively. Results: This thesis proposes three different algorithms to find the heart rate, the HRV and the SBP/ DBP readings from the acoustic signals recorded at the wrist. The results obtained by each algorithm are as follows: 1. The heart rate algorithm is validated on a dataset consisting of 12 subjects with a data length of 6 hours. The results demonstrate an accuracy of 98.78%, mean absolute error of 0.28 bpm, limits of agreement between -1.68 and 1.69 bpm, and a correlation coefficient of 0.998 with reference to a state-of-the-art PPG-based commercial device. A high statistical agreement between the heart rate obtained from the acoustic signal and the photoplethysmography (PPG) signal is observed. 2. The HRV algorithm is validated on the short-term acoustic signals of 5-minutes duration recorded from each of the 12 subjects. A comparison is established with the simultaneously recorded electrocardiography (ECG) and PPG signals respectively. The instantaneous heart rate for all the subjects combined together achieves an accuracy of 98.50% and 98.96% with respect to the ECG and PPG signals respectively. The results for the time-domain and frequency-domain HRV parameters also demonstrate high statistical agreement with the ECG and PPG signals respectively. 3. The algorithm proposed for the SBP/ DBP determination is validated on 104 acoustic signals recorded from 40 adult subjects. The experimental outputs when compared with the reference arm- and wrist-based monitors produce a mean error of less than 2 mmHg and a standard deviation of error around 6 mmHg. Based on these results, this thesis shows the potential of this new sensing modality to be used as an alternative, or to complement existing methods, for the continuous monitoring of heart rate and HRV, and spot measurement of the blood pressure at the wrist.Open Acces

Emotional State Recognition Based on Physiological Signals

Emotsionaalsete seisundite tuvastamine on väga tähtis inimese ja arvuti vahelise suhtlemise (Human-Computer Interaction, HCI) jaoks. Tänapäeval leiavad masinõppe meetodid ühe enam rakendust paljudes inimtegevuse valdkondades. Viimased uuringud näitavad, et füsioloogiliste signaalide analüüs masinõppe meetoditega võiks võimaldada inimese emotsionaalse seisundi tuvastamist hea täpsusega. Vaadates emotsionaalse sisuga videosid, või kuulates helisid, tekib inimesel spetsifiline füsiloogiline vastus. Antud uuringus me kasutame masinõpet ja heuristilist lähenemist, et tuvastada emotsionaalseid seisundeid füsioloogiliste signaalide põhjal. Meetodite võrdlus näitas, et kõrgeim täpsus saavutati juhuslike metsade (Random Forest) meetodiga rakendades seda EEG signaalile, mis teisendati sagedusintervallideks. Ka kombineerides EEG-d teiste füsioloogiliste signaalidega oli tuvastamise täpsus suhteliselt kõrge. Samas heuristilised meetodid ja EEG signaali klassifitseerimise rekurrentse närvivõrkude abil ebaõnnestusid. Andmeallikaks oli MAHNOB-HCI mitmemodaalne andmestik, mis koosneb 27 isikult kogutud füsioloogilistest signaalidest, kus igaüks neist vaatas 20 emotsionaalset videolõiku. Ootamatu tulemusena saime teada, et klassikaline Eckman'i emotsionaalsete seisundite nimekiri oli parem emotsioonide kirjeldamiseks ja klassifitseerimiseks kui kaasaegne mudel, mis esitab emotsioone valentsuse ja ärrituse teljestikul. Meie töö näitab, et emotsiooni märgistamise meetod on väga tähtis hea klassifitseerimismudeli loomiseks, ning et kasutatav andmestik peab sobima masinõppe meetodite jaoks. Saadud tulemused võivad aidata valida õigeid füsioloogilisi signaale ja emotsioonide märkimise meetodeid uue andmestiku loomisel ja töötlemisel.Emotional state recognition is a crucial task for achieving a new level of Human-Computer Interaction (HCI). Machine Learning applications penetrate more and more spheres of everyday life. Recent studies are showing promising results in analyzing physiological signals (EEG, ECG, GSR) using Machine Learning for accessing emotional state. Commonly, specific emotion is invoked by playing affective videos or sounds. However, there is no canonical way for emotional state interpretation. In this study, we classified affective physiological signals with labels obtained from two emotional state estimation approaches using machine learning algorithms and heuristic formulas. Comparison of the method has shown that the highest accuracy was achieved using Random Forest classifier on spectral features from the EEG records, a combination of features for the peripheral physiological signal also shown relatively high classification performance. However, heuristic formulas and novel approach for ECG signal classification using recurrent neural network ultimately failed. Data was taken from the MAHNOB-HCI dataset which is a multimodal database collected on 27 subjects by showing 20 emotional movie fragment`s. We obtained an unexpected result, that description of emotional states using discrete Eckman's paradigm provides better classification results comparing to the contemporary dimensional model which represents emotions by matching them onto the Cartesian plane with valence and arousal axis. Our study shows the importance of label selection in emotion recognition task. Moreover, obtained dataset have to be suitable for Machine Learning algorithms. Acquired results may help to select proper physiological signals and emotional labels for further dataset creation and post-processing

Blind Source Separation for the Processing of Contact-Less Biosignals

(Spatio-temporale) Blind Source Separation (BSS) eignet sich für die Verarbeitung von Multikanal-Messungen im Bereich der kontaktlosen Biosignalerfassung. Ziel der BSS ist dabei die Trennung von (z.B. kardialen) Nutzsignalen und Störsignalen typisch für die kontaktlosen Messtechniken. Das Potential der BSS kann praktisch nur ausgeschöpft werden, wenn (1) ein geeignetes BSS-Modell verwendet wird, welches der Komplexität der Multikanal-Messung gerecht wird und (2) die unbestimmte Permutation unter den BSS-Ausgangssignalen gelöst wird, d.h. das Nutzsignal praktisch automatisiert identifiziert werden kann. Die vorliegende Arbeit entwirft ein Framework, mit dessen Hilfe die Effizienz von BSS-Algorithmen im Kontext des kamera-basierten Photoplethysmogramms bewertet werden kann. Empfehlungen zur Auswahl bestimmter Algorithmen im Zusammenhang mit spezifischen Signal-Charakteristiken werden abgeleitet. Außerdem werden im Rahmen der Arbeit Konzepte für die automatisierte Kanalauswahl nach BSS im Bereich der kontaktlosen Messung des Elektrokardiogramms entwickelt und bewertet. Neuartige Algorithmen basierend auf Sparse Coding erwiesen sich dabei als besonders effizient im Vergleich zu Standard-Methoden.(Spatio-temporal) Blind Source Separation (BSS) provides a large potential to process distorted multichannel biosignal measurements in the context of novel contact-less recording techniques for separating distortions from the cardiac signal of interest. This potential can only be practically utilized (1) if a BSS model is applied that matches the complexity of the measurement, i.e. the signal mixture and (2) if permutation indeterminacy is solved among the BSS output components, i.e the component of interest can be practically selected. The present work, first, designs a framework to assess the efficacy of BSS algorithms in the context of the camera-based photoplethysmogram (cbPPG) and characterizes multiple BSS algorithms, accordingly. Algorithm selection recommendations for certain mixture characteristics are derived. Second, the present work develops and evaluates concepts to solve permutation indeterminacy for BSS outputs of contact-less electrocardiogram (ECG) recordings. The novel approach based on sparse coding is shown to outperform the existing concepts of higher order moments and frequency-domain features

Digital phenotyping through multimodal, unobtrusive sensing

The growing adoption of multimodal wearable and mobile devices, such as smartphones and wrist-worn watches has generated an increase in the collection of physiological and behavioural data at scale. This digital phenotyping data enables researchers to make inferences regarding users’ physical and mental health at scale, for the first time. However, translating this data into actionable insights requires computational approaches that turn unlabelled, multimodal time-series sensor data into validated measures that can be interpreted at scale. This thesis describes the derivation of novel computational methods that leverage digital phenotyping data from wearable devices in large-scale populations to infer physical behaviours. These methods combine insights from signal processing, data mining and machine learning alongside domain knowledge in physical activity and sleep epidemiology. First, the inference of sleeping windows in free-living conditions through a heart rate sensing approach is explored. This algorithm is particularly valuable in the absence of ground truth or sleep diaries given its simplicity, adaptability and capacity for personalization. I then explore multistage sleep classification through combined movement and cardiac wearable sensing and machine learning. Further, I demonstrate that postural changes detected through wrist accelerometers can inform habitual behaviours and are valuable complements to traditional, intensity-based physical activity metrics. I then leverage the concomitant responses of heart rate to physical activity that can be captured through multimodal wearable sensors through a self-supervised training task. The resulting embeddings from this task are shown to be useful for the downstream classification of demographic factors, BMI, energy expenditure and cardiorespiratory fitness. Finally, I describe a deep learning model for the adaptive inference of cardiorespiratory fitness (VO2max) using wearable data in free living conditions. I demonstrate the robustness of the model in a large UK population and show the models’ adaptability by evaluating its performance in a subset of the population with repeated measures ~6 years after the original recordings. Together, this work increases the potential of multimodal wearable and mobile sensors for physical activity and behavioural inferences in population studies. In particular, this thesis showcases the potential of using wearable devices to make valuable physical activity, sleep and fitness inferences in large cohort studies. Given the nature of the data collected and the fact that most of this data is currently generated by commercial providers and not research institutes, laying the foundations for responsible data governance and ethical use of these technologies will be critical to building trust and enabling the development of the field of digital phenotyping.I was funded by GlaxoSmithKline and the Engineering and Physical Sciences Research Council. I was also supported by the Alan Turing Institute through their Enrichment Scheme

Biomedical and Human Factors Requirements for a Manned Earth Orbiting Station

This report is the result of a study conducted by Republic Aviation Corporation in conjunction with Spacelabs, Inc.,in a team effort in which Republic Aviation Corporation was prime contractor. In order to determine the realistic engineering design requirements associated with the medical and human factors problems of a manned space station, an interdisciplinary team of personnel from the Research and Space Divisions was organized. This team included engineers, physicians, physiologists, psychologists, and physicists. Recognizing that the value of the study is dependent upon medical judgments as well as more quantifiable factors (such as design parameters) a group of highly qualified medical consultants participated in working sessions to determine which medical measurements are required to meet the objectives of the study. In addition, various Life Sciences personnel from NASA (Headquarters, Langley, MSC) participated in monthly review sessions. The organization, team members, consultants, and some of the part-time contributors are shown in Figure 1. This final report embodies contributions from all of these participants

Aerospace medicine and biology - a continuing bibliography

Aerospace medicine and biology - bibliograph