Learning Hybrid Neuro-Fuzzy Classifier Models From Data: To Combine or Not to Combine?

To combine or not to combine? Though not a question of the same gravity as the Shakespeare’s to be or not to be, it is examined in this paper in the context of a hybrid neuro-fuzzy pattern classifier design process. A general fuzzy min-max neural network with its basic learning procedure is used within six different algorithm independent learning schemes. Various versions of cross-validation, resampling techniques and data editing approaches, leading to a generation of a single classifier or a multiple classifier system, are scrutinised and compared. The classification performance on unseen data, commonly used as a criterion for comparing different competing designs, is augmented by further four criteria attempting to capture various additional characteristics of classifier generation schemes. These include: the ability to estimate the true classification error rate, the classifier transparency, the computational complexity of the learning scheme and the potential for adaptation to changing environments and new classes of data. One of the main questions examined is whether and when to use a single classifier or a combination of a number of component classifiers within a multiple classifier system

A Multiple Classifier System Identifies Novel Cannabinoid CB2 Receptor Ligands

open access articleDrugs have become an essential part of our lives due to their ability to improve people’s health and quality of life. However, for many diseases, approved drugs are not yet available or existing drugs have undesirable side effects, making the pharmaceutical industry strive to discover new drugs and active compounds. The development of drugs is an expensive process, which typically starts with the detection of candidate molecules (screening) for an identified protein target. To this end, the use of high-performance screening techniques has become a critical issue in order to palliate the high costs. Therefore, the popularity of computer-based screening (often called virtual screening or in-silico screening) has rapidly increased during the last decade. A wide variety of Machine Learning (ML) techniques has been used in conjunction with chemical structure and physicochemical properties for screening purposes including (i) simple classifiers, (ii) ensemble methods, and more recently (iii) Multiple Classifier Systems (MCS). In this work, we apply an MCS for virtual screening (D2-MCS) using circular fingerprints. We applied our technique to a dataset of cannabinoid CB2 ligands obtained from the ChEMBL database. The HTS collection of Enamine (1.834.362 compounds), was virtually screened to identify 48.432 potential active molecules using D2-MCS. This list was subsequently clustered based on circular fingerprints and from each cluster, the most active compound was maintained. From these, the top 60 were kept, and 21 novel compounds were purchased. Experimental validation confirmed six highly active hits (>50% displacement at 10 μM and subsequent Ki determination) and an additional five medium active hits (>25% displacement at 10 μM). D2-MCS hence provided a hit rate of 29% for highly active compounds and an overall hit rate of 52%

A fuzzy random forest

AbstractWhen individual classifiers are combined appropriately, a statistically significant increase in classification accuracy is usually obtained. Multiple classifier systems are the result of combining several individual classifiers. Following Breiman’s methodology, in this paper a multiple classifier system based on a “forest” of fuzzy decision trees, i.e., a fuzzy random forest, is proposed. This approach combines the robustness of multiple classifier systems, the power of the randomness to increase the diversity of the trees, and the flexibility of fuzzy logic and fuzzy sets for imperfect data management. Various combination methods to obtain the final decision of the multiple classifier system are proposed and compared. Some of them are weighted combination methods which make a weighting of the decisions of the different elements of the multiple classifier system (leaves or trees). A comparative study with several datasets is made to show the efficiency of the proposed multiple classifier system and the various combination methods. The proposed multiple classifier system exhibits a good accuracy classification, comparable to that of the best classifiers when tested with conventional data sets. However, unlike other classifiers, the proposed classifier provides a similar accuracy when tested with imperfect datasets (with missing and fuzzy values) and with datasets with noise

Combining Parametric and Non-parametric Algorithms for a Partially Unsupervised Classification of Multitemporal Remote-Sensing Images

In this paper, we propose a classification system based on a multiple-classifier architecture, which is aimed at updating land-cover maps by using multisensor and/or multisource remote-sensing images. The proposed system is composed of an ensemble of classifiers that, once trained in a supervised way on a specific image of a given area, can be retrained in an unsupervised way to classify a new image of the considered site. In this context, two techniques are presented for the unsupervised updating of the parameters of a maximum-likelihood (ML) classifier and a radial basis function (RBF) neural-network classifier, on the basis of the distribution of the new image to be classified. Experimental results carried out on a multitemporal and multisource remote-sensing data set confirm the effectiveness of the proposed system

Symmetric RBF classifier for nonlinear detection in multiple-antenna aided systems

In this paper, we propose a powerful symmetric radial basis function (RBF) classifier for nonlinear detection in the so-called “overloaded” multiple-antenna-aided communication systems. By exploiting the inherent symmetry property of the optimal Bayesian detector, the proposed symmetric RBF classifier is capable of approaching the optimal classification performance using noisy training data. The classifier construction process is robust to the choice of the RBF width and is computationally efficient. The proposed solution is capable of providing a signal-to-noise ratio (SNR) gain in excess of 8 dB against the powerful linear minimum bit error rate (BER) benchmark, when supporting four users with the aid of two receive antennas or seven users with four receive antenna elements. Index Terms—Classification, multiple-antenna system, orthogonal forward selection, radial basis function (RBF), symmetry

Applying feature reduction analysis to a PPRLM-multiple Gaussian language identification system

This paper presents the application of a feature selection technique such as LDA to a language identification (LID) system. The baseline system consists of a PPRLM module followed by a multiple-Gaussian classifier. This classifier makes use of acoustic scores and duration features of each input utterance. We applied a dimension reduction of the feature space in order to achieve a faster and easier-trainable system. We imputed missing values of our vectors before projecting them on the new space. Our experiments show a very low performance reduction due to the dimension reduction approach. Using a single dimension projection the error rates we have obtained are about 8.73% taking into account the 22 most significant features

Using spatio-temporal continuity constraints to enhance visual tracking of moving objects

We present a framework for annotating dynamic scenes involving occlusion and other uncertainties. Our system comprises an object tracker, an object classifier and an algorithm for reasoning about spatio-temporal continuity. The principle behind the object tracking and classifier modules is to reduce error by increasing ambiguity (by merging objects in close proximity and presenting multiple hypotheses). The reasoning engine resolves error, ambiguity and occlusion to produce a most likely hypothesis, which is consistent with global spatio-temporal continuity constraints. The system results in improved annotation over frame-by-frame methods. It has been implemented and applied to the analysis of a team sports video

Combat Identification with Sequential Observations, Rejection Option, and Out-of-Library Targets

This research extends a mathematical framework to select the optimal sensor ensemble and fusion method across multiple decision thresholds subject to warfighter constraints for a combat identification (CID) system. The formulation includes treatment of exemplars from target classes on which the CID system classifiers are not trained (out-of-library classes) and enables the warfighter to optimize a CID system without explicit enumeration of classifier error costs. A time-series classifier design methodology is developed and applied, yielding a multi-variate Gaussian hidden Markov model (HMM). The extended CID framework is used to compete the HMM-based CID system against a template-based CID system. The framework evaluates competing classifier systems that have multiple fusion methods, varied prior probabilities of targets and non-targets, varied correlation between multiple sensor looks, and varied levels of target pose estimation error. Assessment using the extended framework reveals larger feasible operating regions for the HMM-based classifier across experimental settings. In some cases the HMM-based classifier yields a feasible region that is 25\% of the threshold operating space versus 1\% for the template-based classifier