46,548 research outputs found
Modularity from Fluctuations in Random Graphs and Complex Networks
The mechanisms by which modularity emerges in complex networks are not well
understood but recent reports have suggested that modularity may arise from
evolutionary selection. We show that finding the modularity of a network is
analogous to finding the ground-state energy of a spin system. Moreover, we
demonstrate that, due to fluctuations, stochastic network models give rise to
modular networks. Specifically, we show both numerically and analytically that
random graphs and scale-free networks have modularity. We argue that this fact
must be taken into consideration to define statistically-significant modularity
in complex networks.Comment: 4 page
Community detection in temporal multilayer networks, with an application to correlation networks
Networks are a convenient way to represent complex systems of interacting
entities. Many networks contain "communities" of nodes that are more densely
connected to each other than to nodes in the rest of the network. In this
paper, we investigate the detection of communities in temporal networks
represented as multilayer networks. As a focal example, we study time-dependent
financial-asset correlation networks. We first argue that the use of the
"modularity" quality function---which is defined by comparing edge weights in
an observed network to expected edge weights in a "null network"---is
application-dependent. We differentiate between "null networks" and "null
models" in our discussion of modularity maximization, and we highlight that the
same null network can correspond to different null models. We then investigate
a multilayer modularity-maximization problem to identify communities in
temporal networks. Our multilayer analysis only depends on the form of the
maximization problem and not on the specific quality function that one chooses.
We introduce a diagnostic to measure \emph{persistence} of community structure
in a multilayer network partition. We prove several results that describe how
the multilayer maximization problem measures a trade-off between static
community structure within layers and larger values of persistence across
layers. We also discuss some computational issues that the popular "Louvain"
heuristic faces with temporal multilayer networks and suggest ways to mitigate
them.Comment: 42 pages, many figures, final accepted version before typesettin
On functional module detection in metabolic networks
Functional modules of metabolic networks are essential for understanding the metabolism of an organism as a whole. With the vast amount of experimental data and the construction of complex and large-scale, often genome-wide, models, the computer-aided identification of functional modules becomes more and more important. Since steady states play a key role in biology, many methods have been developed in that context, for example, elementary flux modes, extreme pathways, transition invariants and place invariants. Metabolic networks can be studied also from the point of view of graph theory, and algorithms for graph decomposition have been applied for the identification of functional modules. A prominent and currently intensively discussed field of methods in graph theory addresses the Q-modularity. In this paper, we recall known concepts of module detection based on the steady-state assumption, focusing on transition-invariants (elementary modes) and their computation as minimal solutions of systems of Diophantine equations. We present the Fourier-Motzkin algorithm in detail. Afterwards, we introduce the Q-modularity as an example for a useful non-steady-state method and its application to metabolic networks. To illustrate and discuss the concepts of invariants and Q-modularity, we apply a part of the central carbon metabolism in potato tubers (Solanum tuberosum) as running example. The intention of the paper is to give a compact presentation of known steady-state concepts from a graph-theoretical viewpoint in the context of network decomposition and reduction and to introduce the application of Q-modularity to metabolic Petri net models
Analysis of group evolution prediction in complex networks
In the world, in which acceptance and the identification with social
communities are highly desired, the ability to predict evolution of groups over
time appears to be a vital but very complex research problem. Therefore, we
propose a new, adaptable, generic and mutli-stage method for Group Evolution
Prediction (GEP) in complex networks, that facilitates reasoning about the
future states of the recently discovered groups. The precise GEP modularity
enabled us to carry out extensive and versatile empirical studies on many
real-world complex / social networks to analyze the impact of numerous setups
and parameters like time window type and size, group detection method,
evolution chain length, prediction models, etc. Additionally, many new
predictive features reflecting the group state at a given time have been
identified and tested. Some other research problems like enriching learning
evolution chains with external data have been analyzed as well
Module detection in complex networks using integer optimisation
<p>Abstract</p> <p>Background</p> <p>The detection of <it>modules or community structure </it>is widely used to reveal the underlying properties of complex networks in biology, as well as physical and social sciences. Since the adoption of modularity as a measure of network topological properties, several methodologies for the discovery of community structure based on modularity maximisation have been developed. However, satisfactory partitions of large graphs with modest computational resources are particularly challenging due to the NP-hard nature of the related optimisation problem. Furthermore, it has been suggested that optimising the modularity metric can reach a resolution limit whereby the algorithm fails to detect smaller communities than a specific size in large networks.</p> <p>Results</p> <p>We present a novel solution approach to identify community structure in large complex networks and address resolution limitations in module detection. The proposed algorithm employs modularity to express network community structure and it is based on mixed integer optimisation models. The solution procedure is extended through an iterative procedure to diminish effects that tend to agglomerate smaller modules (resolution limitations).</p> <p>Conclusions</p> <p>A comprehensive comparative analysis of methodologies for module detection based on modularity maximisation shows that our approach outperforms previously reported methods. Furthermore, in contrast to previous reports, we propose a strategy to handle resolution limitations in modularity maximisation. Overall, we illustrate ways to improve existing methodologies for community structure identification so as to increase its efficiency and applicability.</p
Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks
Topological network motifs represent functional relationships within and
between regulatory and protein-protein interaction networks. Enriched motifs
often aggregate into self-contained units forming functional modules.
Theoretical models for network evolution by duplication-divergence mechanisms
and for network topology by hierarchical scale-free networks have suggested a
one-to-one relation between network motif enrichment and aggregation, but this
relation has never been tested quantitatively in real biological interaction
networks. Here we introduce a novel method for assessing the statistical
significance of network motif aggregation and for identifying clusters of
overlapping network motifs. Using an integrated network of transcriptional,
posttranslational and protein-protein interactions in yeast we show that
network motif aggregation reflects a local modularity property which is
independent of network motif enrichment. In particular our method identified
novel functional network themes for a set of motifs which are not enriched yet
aggregate significantly and challenges the conventional view that network motif
enrichment is the most basic organizational principle of complex networks.Comment: 12 pages, 5 figure
- …