12,027 research outputs found
Learning and comparing functional connectomes across subjects
Functional connectomes capture brain interactions via synchronized
fluctuations in the functional magnetic resonance imaging signal. If measured
during rest, they map the intrinsic functional architecture of the brain. With
task-driven experiments they represent integration mechanisms between
specialized brain areas. Analyzing their variability across subjects and
conditions can reveal markers of brain pathologies and mechanisms underlying
cognition. Methods of estimating functional connectomes from the imaging signal
have undergone rapid developments and the literature is full of diverse
strategies for comparing them. This review aims to clarify links across
functional-connectivity methods as well as to expose different steps to perform
a group study of functional connectomes
Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia.
Cognitive control deficits have been consistently documented in patients with schizophrenia. Recent work in cognitive neuroscience has hypothesized a distinction between two theoretically separable modes of cognitive control-reactive and proactive. However, it remains unclear the extent to which these processes are uniquely associated with dysfunctional neural recruitment in individuals with schizophrenia. This functional magnetic resonance imaging (fMRI) study utilized the color word Stroop task and AX Continuous Performance Task (AX-CPT) to tap reactive and proactive control processes, respectively, in a sample of 54 healthy controls and 43 patients with first episode schizophrenia. Healthy controls demonstrated robust dorsolateral prefrontal, anterior cingulate, and parietal cortex activity on both tasks. In contrast, patients with schizophrenia did not show any significant activation during proactive control, while showing activation similar to control subjects during reactive control. Critically, an interaction analysis showed that the degree to which prefrontal activity was reduced in patients versus controls depended on the type of control process engaged. Controls showed increased dorsolateral prefrontal cortex (DLPFC) and parietal activity in the proactive compared to the reactive control task, whereas patients with schizophrenia did not demonstrate this increase. Additionally, patients' DLPFC activity and performance during proactive control was associated with disorganization symptoms, while no reactive control measures showed this association. Proactive control processes and concomitant dysfunctional recruitment of DLPFC represent robust features of schizophrenia that are also directly associated with symptoms of disorganization
Investigating the Evidence of Behavioral, Cognitive, and Psychiatric Endophenotypes in Autism: A Systematic Review
Substantial evidence indicates that parents of autistic individuals often display milder forms of autistic traits referred to as the broader autism phenotype (BAP). To determine if discrete endophenotypes of autism can be identified, we reviewed the literature to assess the evidence of behavioral, cognitive, and psychiatric profiles of the BAP. A systematic review was conducted using EMBASE, MEDLINE, PsycINFO, PsycEXTRA, and Global Health. Sixty papers met our inclusion criteria and results are discussed according to the proportion of studies that yield significant deficits per domain. The behavioral, cognitive, and psychiatric endophenotypes in parents of autistic probands are still not clarified; however, evidence suggests mild social/communication deficits, rigid/aloof personality traits, and pragmatic language difficulties as the most useful sociobehavioral candidate endophenotype traits. The existence of deficits in the cognitive domain does suggest familial vulnerability for autism. Furthermore, increased depressed mood and anxiety can also be useful markers; however, findings should be interpreted with caution because of the small number of studies in such heterogeneously broad domains and several methodological limitations
Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction.
Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functional magnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomarkers and predictors of TBI outcome. This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties at the level of the connectome. In this context, our present review summarizes recent developments on the roles of these two techniques in the search for novel structural neuroimaging biomarkers that have TBI outcome prognostication value. The themes being explored cover notable trends in this area of research, including (1) the role of advanced MRI processing methods in the analysis of structural pathology, (2) the use of brain connectomics and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics. The goal of the review is to draw the community's attention to these recent advances on TBI outcome prediction methods and to encourage the development of new methodologies whereby structural neuroimaging can be used to identify biomarkers of TBI outcome
RNNs Implicitly Implement Tensor Product Representations
Recurrent neural networks (RNNs) can learn continuous vector representations
of symbolic structures such as sequences and sentences; these representations
often exhibit linear regularities (analogies). Such regularities motivate our
hypothesis that RNNs that show such regularities implicitly compile symbolic
structures into tensor product representations (TPRs; Smolensky, 1990), which
additively combine tensor products of vectors representing roles (e.g.,
sequence positions) and vectors representing fillers (e.g., particular words).
To test this hypothesis, we introduce Tensor Product Decomposition Networks
(TPDNs), which use TPRs to approximate existing vector representations. We
demonstrate using synthetic data that TPDNs can successfully approximate linear
and tree-based RNN autoencoder representations, suggesting that these
representations exhibit interpretable compositional structure; we explore the
settings that lead RNNs to induce such structure-sensitive representations. By
contrast, further TPDN experiments show that the representations of four models
trained to encode naturally-occurring sentences can be largely approximated
with a bag of words, with only marginal improvements from more sophisticated
structures. We conclude that TPDNs provide a powerful method for interpreting
vector representations, and that standard RNNs can induce compositional
sequence representations that are remarkably well approximated by TPRs; at the
same time, existing training tasks for sentence representation learning may not
be sufficient for inducing robust structural representations.Comment: Accepted to ICLR 201
Emotion Recognition from Acted and Spontaneous Speech
DizertaÄnĂ prĂĄce se zabĂœvĂĄ rozpoznĂĄnĂm emoÄnĂho stavu mluvÄĂch z ĆeÄovĂ©ho signĂĄlu. PrĂĄce je rozdÄlena do dvou hlavnĂch ÄastĂ, prvnĂ ÄĂĄst popisuju navrĆŸenĂ© metody pro rozpoznĂĄnĂ emoÄnĂho stavu z hranĂœch databĂĄzĂ. V rĂĄmci tĂ©to ÄĂĄsti jsou pĆedstaveny vĂœsledky rozpoznĂĄnĂ pouĆŸitĂm dvou rĆŻznĂœch databĂĄzĂ s rĆŻznĂœmi jazyky. HlavnĂmi pĆĂnosy tĂ©to ÄĂĄsti je detailnĂ analĂœza rozsĂĄhlĂ© ĆĄkĂĄly rĆŻznĂœch pĆĂznakĆŻ zĂskanĂœch z ĆeÄovĂ©ho signĂĄlu, nĂĄvrh novĂœch klasifikaÄnĂch architektur jako je napĆĂklad âemoÄnĂ pĂĄrovĂĄnĂâ a nĂĄvrh novĂ© metody pro mapovĂĄnĂ diskrĂ©tnĂch emoÄnĂch stavĆŻ do dvou dimenzionĂĄlnĂho prostoru. DruhĂĄ ÄĂĄst se zabĂœvĂĄ rozpoznĂĄnĂm emoÄnĂch stavĆŻ z databĂĄze spontĂĄnnĂ ĆeÄi, kterĂĄ byla zĂskĂĄna ze zĂĄznamĆŻ hovorĆŻ z reĂĄlnĂœch call center. Poznatky z analĂœzy a nĂĄvrhu metod rozpoznĂĄnĂ z hranĂ© ĆeÄi byly vyuĆŸity pro nĂĄvrh novĂ©ho systĂ©mu pro rozpoznĂĄnĂ sedmi spontĂĄnnĂch emoÄnĂch stavĆŻ. JĂĄdrem navrĆŸenĂ©ho pĆĂstupu je komplexnĂ klasifikaÄnĂ architektura zaloĆŸena na fĂșzi rĆŻznĂœch systĂ©mĆŻ. PrĂĄce se dĂĄle zabĂœvĂĄ vlivem emoÄnĂho stavu mluvÄĂho na ĂșspÄĆĄnosti rozpoznĂĄnĂ pohlavĂ a nĂĄvrhem systĂ©mu pro automatickou detekci ĂșspÄĆĄnĂœch hovorĆŻ v call centrech na zĂĄkladÄ analĂœzy parametrĆŻ dialogu mezi ĂșÄastnĂky telefonnĂch hovorĆŻ.Doctoral thesis deals with emotion recognition from speech signals. The thesis is divided into two main parts; the first part describes proposed approaches for emotion recognition using two different multilingual databases of acted emotional speech. The main contributions of this part are detailed analysis of a big set of acoustic features, new classification schemes for vocal emotion recognition such as âemotion couplingâ and new method for mapping discrete emotions into two-dimensional space. The second part of this thesis is devoted to emotion recognition using multilingual databases of spontaneous emotional speech, which is based on telephone records obtained from real call centers. The knowledge gained from experiments with emotion recognition from acted speech was exploited to design a new approach for classifying seven emotional states. The core of the proposed approach is a complex classification architecture based on the fusion of different systems. The thesis also examines the influence of speakerâs emotional state on gender recognition performance and proposes system for automatic identification of successful phone calls in call center by means of dialogue features.
Effective connectivity reveals strategy differences in an expert calculator
Mathematical reasoning is a core component of cognition and the study of experts defines the upper limits of human cognitive abilities, which is why we are fascinated by peak performers, such as chess masters and mental calculators. Here, we investigated the neural bases of calendrical skills, i.e. the ability to rapidly identify the weekday of a particular date, in a gifted mental calculator who does not fall in the autistic spectrum, using functional MRI. Graph-based mapping of effective connectivity, but not univariate analysis, revealed distinct anatomical location of âcortical hubsâ supporting the processing of well-practiced close dates and less-practiced remote dates: the former engaged predominantly occipital and medial temporal areas, whereas the latter were associated mainly with prefrontal, orbitofrontal and anterior cingulate connectivity. These results point to the effect of extensive practice on the development of expertise and long term working memory, and demonstrate the role of frontal networks in supporting performance on less practiced calculations, which incur additional processing demands. Through the example of calendrical skills, our results demonstrate that the ability to perform complex calculations is initially supported by extensive attentional and strategic resources, which, as expertise develops, are gradually replaced by access to long term working memory for familiar material
Statistical Inferences for Polarity Identification in Natural Language
Information forms the basis for all human behavior, including the ubiquitous
decision-making that people constantly perform in their every day lives. It is
thus the mission of researchers to understand how humans process information to
reach decisions. In order to facilitate this task, this work proposes a novel
method of studying the reception of granular expressions in natural language.
The approach utilizes LASSO regularization as a statistical tool to extract
decisive words from textual content and draw statistical inferences based on
the correspondence between the occurrences of words and an exogenous response
variable. Accordingly, the method immediately suggests significant implications
for social sciences and Information Systems research: everyone can now identify
text segments and word choices that are statistically relevant to authors or
readers and, based on this knowledge, test hypotheses from behavioral research.
We demonstrate the contribution of our method by examining how authors
communicate subjective information through narrative materials. This allows us
to answer the question of which words to choose when communicating negative
information. On the other hand, we show that investors trade not only upon
facts in financial disclosures but are distracted by filler words and
non-informative language. Practitioners - for example those in the fields of
investor communications or marketing - can exploit our insights to enhance
their writings based on the true perception of word choice
Differences in fMRI intersubject correlation while viewing unedited and edited videos of dance performance
Intersubject Correlation (ISC) analysis of fMRI data provides insight into how continuous streams of sensory stimulation are processed by groups of observers. Although edited movies are frequently used as stimuli in ISC studies, there has been little direct examination of the effect of edits on the resulting ISC maps. In this study we showed 16 observers two audiovisual movie versions of the same dance. In one experimental condition there was a continuous view from a single camera (Unedited condition) and in the other condition there were views from different cameras (Edited condition) that provided close up views of the feet or face and upper body. We computed ISC maps for each condition, as well as created a map that showed the difference between the conditions. The results from the Unedited and Edited maps largely overlapped in the occipital and temporal cortices, although more voxels were found for the Edited map. The difference map revealed greater ISC for the Edited condition in the Postcentral Gyrus, Lingual Gyrus, Precentral Gyrus and Medial Frontal Gyrus, while the Unedited condition showed greater ISC in only the Superior Temporal Gyrus. These findings suggest that the visual changes associated with editing provide a source of correlation in maps obtained from edited film, and highlight the utility of using maps to evaluate the difference in ISC between conditions
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