12,549 research outputs found
Combining Bayesian Approaches and Evolutionary Techniques for the Inference of Breast Cancer Networks
Gene and protein networks are very important to model complex large-scale
systems in molecular biology. Inferring or reverseengineering such networks can
be defined as the process of identifying gene/protein interactions from
experimental data through computational analysis. However, this task is
typically complicated by the enormously large scale of the unknowns in a rather
small sample size. Furthermore, when the goal is to study causal relationships
within the network, tools capable of overcoming the limitations of correlation
networks are required. In this work, we make use of Bayesian Graphical Models
to attach this problem and, specifically, we perform a comparative study of
different state-of-the-art heuristics, analyzing their performance in inferring
the structure of the Bayesian Network from breast cancer data
Bayesian regularization of non-homogeneous dynamic Bayesian networks by globally coupling interaction parameters
To relax the homogeneity assumption of classical dynamic Bayesian networks (DBNs), various recent studies have combined DBNs with multiple changepoint processes. The underlying assumption is that the parameters associated with time series segments delimited by multiple changepoints are a priori independent. Under weak regularity conditions, the parameters can be integrated out in the likelihood, leading to a closed-form expression of the marginal likelihood. However, the assumption of prior independence is unrealistic in many real-world applications, where the segment-specific regulatory relationships among the interdependent quantities tend to undergo gradual evolutionary adaptations. We therefore propose a Bayesian coupling scheme to introduce systematic information sharing among the segment-specific interaction parameters. We investigate the effect this model improvement has on the network reconstruction accuracy in a reverse engineering context, where the objective is to learn the structure of a gene regulatory network from temporal gene expression profiles
Tree-guided group lasso for multi-response regression with structured sparsity, with an application to eQTL mapping
We consider the problem of estimating a sparse multi-response regression
function, with an application to expression quantitative trait locus (eQTL)
mapping, where the goal is to discover genetic variations that influence
gene-expression levels. In particular, we investigate a shrinkage technique
capable of capturing a given hierarchical structure over the responses, such as
a hierarchical clustering tree with leaf nodes for responses and internal nodes
for clusters of related responses at multiple granularity, and we seek to
leverage this structure to recover covariates relevant to each
hierarchically-defined cluster of responses. We propose a tree-guided group
lasso, or tree lasso, for estimating such structured sparsity under
multi-response regression by employing a novel penalty function constructed
from the tree. We describe a systematic weighting scheme for the overlapping
groups in the tree-penalty such that each regression coefficient is penalized
in a balanced manner despite the inhomogeneous multiplicity of group
memberships of the regression coefficients due to overlaps among groups. For
efficient optimization, we employ a smoothing proximal gradient method that was
originally developed for a general class of structured-sparsity-inducing
penalties. Using simulated and yeast data sets, we demonstrate that our method
shows a superior performance in terms of both prediction errors and recovery of
true sparsity patterns, compared to other methods for learning a
multivariate-response regression.Comment: Published in at http://dx.doi.org/10.1214/12-AOAS549 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Bioinformatics tools in predictive ecology: Applications to fisheries
This article is made available throught the Brunel Open Access Publishing Fund - Copygith @ 2012 Tucker et al.There has been a huge effort in the advancement of analytical techniques for molecular biological data over the past decade. This has led to many novel algorithms that are specialized to deal with data associated with biological phenomena, such as gene expression and protein interactions. In contrast, ecological data analysis has remained focused to some degree on off-the-shelf statistical techniques though this is starting to change with the adoption of state-of-the-art methods, where few assumptions can be made about the data and a more explorative approach is required, for example, through the use of Bayesian networks. In this paper, some novel bioinformatics tools for microarray data are discussed along with their ‘crossover potential’ with an application to fisheries data. In particular, a focus is made on the development of models that identify functionally equivalent species in different fish communities with the aim of predicting functional collapse
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Inferring spatial and signaling relationships between cells from single cell transcriptomic data.
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by utilizing spatial measurements of a relatively small number of genes. A spatial metric for individual cells in scRNA-seq data is first established based on a map connecting it with the spatial measurements. The cell-cell communications are then obtained by "optimally transporting" signal senders to target signal receivers in space. Using partial information decomposition, we next compute the intercellular gene-gene information flow to estimate the spatial regulations between genes across cells. Four datasets are employed for cross-validation of spatial gene expression prediction and comparison to known cell-cell communications. SpaOTsc has broader applications, both in integrating non-spatial single-cell measurements with spatial data, and directly in spatial single-cell transcriptomics data to reconstruct spatial cellular dynamics in tissues
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