Modeling Diffusion Directions of Corpus Callosum

Diffusion Tensor Imaging (DTI) has been used to study the characteristics of Multiple Sclerosis (MS) in the brain. The von Mises- Fisher distribution (vmf) is a probability distribution for modeling directional data on the unit hypersphere. In this paper we modeled the diffusion directions of the Corpus Callosum (CC) as a mixture of vmf distributions for both MS subjects and healthy controls. Higher diffusion concentration around the mean directions and smaller sum of angles between the mean directions are observed on the normal-appearing CC of the MS subjects as compared to the healthy controls

k-Nearest Neighbor Based Consistent Entropy Estimation for Hyperspherical Distributions

A consistent entropy estimator for hyperspherical data is proposed based on the k-nearest neighbor (knn) approach. The asymptotic unbiasedness and consistency of the estimator are proved. Moreover, cross entropy and Kullback-Leibler (KL) divergence estimators are also discussed. Simulation studies are conducted to assess the performance of the estimators for models including uniform and von Mises-Fisher distributions. The proposed knn entropy estimator is compared with the moment based counterpart via simulations. The results show that these two methods are comparable

Isotropic Multiple Scattering Processes on Hyperspheres

This paper presents several results about isotropic random walks and multiple scattering processes on hyperspheres ${\mathbb S}^{p-1}$. It allows one to derive the Fourier expansions on ${\mathbb S}^{p-1}$ of these processes. A result of unimodality for the multiconvolution of symmetrical probability density functions (pdf) on ${\mathbb S}^{p-1}$ is also introduced. Such processes are then studied in the case where the scattering distribution is von Mises Fisher (vMF). Asymptotic distributions for the multiconvolution of vMFs on ${\mathbb S}^{p-1}$ are obtained. Both Fourier expansion and asymptotic approximation allows us to compute estimation bounds for the parameters of Compound Cox Processes (CCP) on ${\mathbb S}^{p-1}$.Comment: 16 pages, 4 figure

Hyperspherical von mises-fisher mixture (HvMF) modelling of high angular resolution diffusion MRI

A mapping of unit vectors onto a 5D hypersphere is used to model and partition ODFs from HARDI data. This mapping has a number of useful and interesting properties and we make a link to interpretation of the second order spherical harmonic decompositions of HARDI data. The paper presents the working theory and experiments of using a von Mises-Fisher mixture model for directional samples. The MLE of the second moment of the HvMF pdf can also be related to fractional anisotropy. We perform error analysis of the estimation scheme in single and multi-fibre regions and then show how a penalised-likelihood model selection method can be employed to differentiate single and multiple fibre regions

Directional Estimation for Robotic Beating Heart Surgery

In robotic beating heart surgery, a remote-controlled robot can be used to carry out the operation while automatically canceling out the heart motion. The surgeon controlling the robot is shown a stabilized view of the heart. First, we consider the use of directional statistics for estimation of the phase of the heartbeat. Second, we deal with reconstruction of a moving and deformable surface. Third, we address the question of obtaining a stabilized image of the heart