Data science, analytics and artificial intelligence in e-health : trends, applications and challenges

Acknowledgments. This work has been partially supported by the Divina Pastora Seguros company.More than ever, healthcare systems can use data, predictive models, and intelligent algorithms to optimize their operations and the service they provide. This paper reviews the existing literature regarding the use of data science/analytics methods and artificial intelligence algorithms in healthcare. The paper also discusses how healthcare organizations can benefit from these tools to efficiently deal with a myriad of new possibilities and strategies. Examples of real applications are discussed to illustrate the potential of these methods. Finally, the paper highlights the main challenges regarding the use of these methods in healthcare, as well as some open research lines

Monitoring and Detection Platform to Prevent Anomalous Situations in Home Care

Monitoring and tracking people at home usually requires high cost hardware installations, which implies they are not affordable in many situations. This study/paper proposes a monitoring and tracking system for people with medical problems. A virtual organization of agents based on the PANGEA platform, which allows the easy integration of different devices, was created for this study. In this case, a virtual organization was implemented to track and monitor patients carrying a Holter monitor. The system includes the hardware and software required to perform: ECG measurements, monitoring through accelerometers and WiFi networks. Furthermore, the use of interactive television can moderate interactivity with the user. The system makes it possible to merge the information and facilitates patient tracking efficiently with low cost

New platform for intelligent context-based distributed information fusion

Tesis por compendio de publicaciones[ES]Durante las últimas décadas, las redes de sensores se han vuelto cada vez más importantes y hoy en día están presentes en prácticamente todos los sectores de nuestra sociedad. Su gran capacidad para adquirir datos y actuar sobre el entorno, puede facilitar la construcción de sistemas sensibles al contexto, que permitan un análisis detallado y flexible de los procesos que ocurren y los servicios que se pueden proporcionar a los usuarios. Esta tesis doctoral se presenta en el formato de “Compendio de Artículos”, de tal forma que las principales características de la arquitectura multi-agente distribuida propuesta para facilitar la interconexión de redes de sensores se presentan en tres artículos bien diferenciados. Se ha planteado una arquitectura modular y ligera para dispositivos limitados computacionalmente, diseñando un mecanismo de comunicación flexible que permite la interacción entre diferentes agentes embebidos, desplegados en dispositivos de tamaño reducido. Se propone un nuevo modelo de agente embebido, como mecanismo de extensión para la plataforma PANGEA. Además, se diseña un nuevo modelo de organización virtual de agentes especializada en la fusión de información. De esta forma, los agentes inteligentes tienen en cuenta las características de las organizaciones existentes en el entorno a la hora de proporcionar servicios. El modelo de fusión de información presenta una arquitectura claramente diferenciada en 4 niveles, siendo capaz de obtener la información proporcionada por las redes de sensores (capas inferiores) para ser integrada con organizaciones virtuales de agentes (capas superiores). El filtrado de señales, minería de datos, sistemas de razonamiento basados en casos y otras técnicas de Inteligencia Artificial han sido aplicadas para la consecución exitosa de esta investigación. Una de las principales innovaciones que pretendo con mi estudio, es investigar acerca de nuevos mecanismos que permitan la adición dinámica de redes de sensores combinando diferentes tecnologías con el propósito final de exponer un conjunto de servicios de usuario de forma distribuida. En este sentido, se propondrá una arquitectura multiagente basada en organizaciones virtuales que gestione de forma autónoma la infraestructura subyacente constituida por el hardware y los diferentes sensores

Identifying HRV patterns in ECG signals as early markers of dementia

The appearance of Artificial Intelligence (IA) has improved our ability to process large amount of data. These tools are particularly interesting in medical contexts, in order to evaluate the variables from patients’ screening analysis and disentangle the information that they contain. We propose in this work a novel method for evaluating the role of electrocardiogram (ECG) signals in the human cognitive decline. This framework offers a complete solution for all the steps in the classification pipeline, from the preprocessing of the raw signals to the final classification stage. Numerous metrics are computed from the original data in terms of different domains (time, frequency, etc.), and dimensionality is reduced through a Principal Component Analysis (PCA). The resulting characteristics are used as inputs of different classifiers (linear/non-linear Support Vector Machines, Random Forest, etc.) to determine the amount of information that they contain. Our system yielded an area under the Receiver Operating Characteristic (ROC) curve of 0.80 identifying Mild Cognitive Impairment (MCI) patients, showing that ECG contain crucial information for predicting the appearance of this pathology. These results are specially relevant given the fact that ECG acquisition is much more affordable and less invasive than brain imaging used in most of these intelligent systems, allowing our method to be used in environments of any socioeconomic range.Funding for open access charge: Universidad de Málaga/CBUA. This work was supported by projects PID2022-137461NB-C32 (Spanish “Ministerio de Ciencia e Innovación, /AEI /10.13039/501100011033/ FEDER, UE), UMA20-FEDERJA-086 European Regional Development Funds (ERDF) “Una manera de hacer Europa”, and by Spanish “Ministerio de Universidades” (Next Generation EU funds) through Margarita-Salas grant to J.E. Arco

Distributed Computing and Monitoring Technologies for Older Patients

This book summarizes various approaches for the automatic detection of health threats to older patients at home living alone. The text begins by briefly describing those who would most benefit from healthcare supervision. The book then summarizes possible scenarios for monitoring an older patient at home, deriving the common functional requirements for monitoring technology. Next, the work identifies the state of the art of technological monitoring approaches that are practically applicable to geriatric patients. A survey is presented on a range of such interdisciplinary fields as smart homes, telemonitoring, ambient intelligence, ambient assisted living, gerontechnology, and aging-in-place technology. The book discusses relevant experimental studies, highlighting the application of sensor fusion, signal processing and machine learning techniques. Finally, the text discusses future challenges, offering a number of suggestions for further research directions

Mobile Health Technologies

Mobile Health Technologies, also known as mHealth technologies, have emerged, amongst healthcare providers, as the ultimate Technologies-of-Choice for the 21st century in delivering not only transformative change in healthcare delivery, but also critical health information to different communities of practice in integrated healthcare information systems. mHealth technologies nurture seamless platforms and pragmatic tools for managing pertinent health information across the continuum of different healthcare providers. mHealth technologies commonly utilize mobile medical devices, monitoring and wireless devices, and/or telemedicine in healthcare delivery and health research. Today, mHealth technologies provide opportunities to record and monitor conditions of patients with chronic diseases such as asthma, Chronic Obstructive Pulmonary Diseases (COPD) and diabetes mellitus. The intent of this book is to enlighten readers about the theories and applications of mHealth technologies in the healthcare domain

Cardiovascular data analytics for real time patient monitoring

Improvements in wearable sensor devices make it possible to constantly monitor physiological parameters such as electrocardiograph (ECG) signals for long periods. Remote patient monitoring with wearable sensors has an important role to play in health care, particularly given the prevalence of chronic conditions such as cardiovascular disease (CVD)—one of the prominent causes of morbidity and mortality worldwide. Approximately 4.2 million Australians suffer from long-term CVD with approximately one death every 12 minutes. The assessment of ECG features, especially heart rate variability (HRV), represents a non-invasive technique which provides an indication of the autonomic nervous system (ANS) function. Conditions such as sudden cardiac death, hypertension, heart failure, myocardial infarction, ischaemia, and coronary heart disease can be detected from HRV analysis. In addition, the analysis of ECG features can also be used to diagnose many types of life-threatening arrhythmias, including ventricular fibrillation and ventricular tachycardia. Non-cardiac conditions, such as diabetes, obesity, metabolic syndrome, insulin resistance, irritable bowel syndrome, dyspepsia, anorexia nervosa, anxiety, and major depressive disorder have also been shown to be associated with HRV. The analysis of ECG features from real time ECG signals generated from wearable sensors provides distinctive challenges. The sensors that receive and process the signals have limited power, storage and processing capacity. Consequently, algorithms that process ECG signals need to be lightweight, use minimal storage resources and accurately detect abnormalities so that alarms can be raised. The existing literature details only a few algorithms which operate within the constraints of wearable sensor networks. This research presents four novel techniques that enable ECG signals to be processed within the limitations of resource constraints on devices to detect some key abnormalities in heart function. - The first technique is a novel real-time ECG data reduction algorithm, which detects and transmits only those key points that are critical for the generation of ECG features for diagnoses. - The second technique accurately predicts the five-minute HRV measure using only three minutes of data with an algorithm that executes in real-time using minimal computational resources. - The third technique introduces a real-time ECG feature recognition system that can be applied to diagnose life threatening conditions such as premature ventricular contractions (PVCs). - The fourth technique advances a classification algorithm to enhance the performance of automated ECG classification to determine arrhythmic heart beats based on noisy ECG signals. The four novel techniques are evaluated in comparison with benchmark algorithms for each task on the standard MIT-BIH Arrhythmia Database and with data generated from patients in a major hospital using Shimmer3 wearable ECG sensors. The four techniques are integrated to demonstrate that remote patient monitoring of ECG using HRV and ECG features is feasible in real time using minimal computational resources. The evaluation show that the ECG reduction algorithm is significantly better than existing algorithms that can be applied within sensor nodes, such as time-domain methods, transformation methods and compressed sensing methods. Furthermore, the proposed ECG reduction is found to be computationally less complex for resource constrained sensors and achieves higher compression ratios than existing algorithms. The prediction of a common HRV measure, the five-minute standard deviation of inter-beat variations (SDNN) and the accurate detection of PVC beats was achieved using a Count Data Model, combined with a Poisson-generated function from three-minute ECG recordings. This was achieved with minimal computational resources and was well suited to remote patient monitoring with wearable sensors. The PVC beats detection was implemented using the same count data model together with knowledge-based rules derived from clinical knowledge. A real-time cardiac patient monitoring system was implemented using an ECG sensor and smartphone to detect PVC beats within a few seconds using artificial neural networks (ANN), and it was proven to provide highly accurate results. The automated detection and classification were implemented using a new wrapper-based hybrid approach that utilized t-distributed stochastic neighbour embedding (t-SNE) in combination with self-organizing maps (SOM) to improve classification performance. The t-SNE-SOM hybrid resulted in improved sensitivity, specificity and accuracy compared to most common hybrid methods in the presence of noise. It also provided a better, more accurate identification for the presence of many types of arrhythmias from the ECG recordings, leading to a more timely diagnosis and treatment outcome.Doctor of Philosoph

A scalable cloud Platform for Active healthcare monitoring applications

Continuous, remote monitoring of patients using wearable sensors can facilitate early detection of many conditions and can help to manage the growing healthcare crisis worldwide. A remote patient monitoring application consists of many emerging services such as wireless wearable sensor configuration, patient registration and authentication, collaborative consultation of doctors, storage and maintenance of electronic health record. The provision of these services requires the development and maintenance of a remote healthcare monitoring application (HMA) that includes a body area wireless sensor network (BASWN) and Health Applications (HA) to detect specific health issues. In addition, the deployment of HMAs for different hospitals is not easily scalable owing to the heterogeneous nature of hardware and software involved. Cloud computing overcomes this aspect by allowing simple and easy maintenance of ICT infrastructure. In this work, we report a real-time-like cloud based architecture known as Assistive Patient monitoring cloud Platform for Active healthcare applications (AppA) using a delegate pattern. The built AppA is highly scalable and capable of spawning new instances based on monitoring requirements from the health care providers, and are aligned with scalable economic models. © 2014 IEEE