Hepatoprotective effect of Fufang-Huanglu oral liquid on α- naphthylisothiocyanate-induced hepatitis jaundice in mice

Purpose: To investigate the effect of Fufang-Huanglu Oral Liquid (HOL) on hepatitis jaundice in mice.Methods: A total of 72 mice were divided into 6 groups (n = 12): normal group,  control group (model group), positive-treated group, and 3 HOL treatment groups (7.5, 15 and 30 mL/kg). Mice in normal and control groups received normal saline (20 mL/kg) orally, while positive and HOL-treated mice were orally administered Huganning tablets (1.0 g/kg) and HOL (7.5, 15 and 30 mL/kg), respectively. After 8 days, all mice (except normal group) were orally administered  α-naphthylisothiocyanate (ANIT, 100 mg/kg) to induce hepatitis jaundice, and sacrificed 2 days after drug administration. Serum GPT, GOT and TNF-α, as well as liver index, MDA, SOD and lipid profiles were determined.Results: The results showed that HOL, at all doses, significantly decreased liver index, serum GPT, serum SGOT and serum  TNF-α (p < 0.01). HOL also significantly decreased MDA, total cholesterol, TC and triglycerides, TG (p < 0.01), but increased  liver SOD (p < 0.01). Histological results indicate that HOL ameliorated liver injury induced by ANIT.Conclusion: These results showed that HOL possesses significant hepatoprotective effects against liver injury.Keywords: Fufang-Huanglu Oral Liquid, Hepatoprotective, Mice, Hepatitis, Jaundice, α-Naphthylisothiocyanate, Liver inde

Mechanical analysis of finite idempotent relations

We use the technique of interactive theorem proving to develop the theory and anenumeration technique for finite idempotent relations. Starting from a short mathematical characterization of finite idempotents defined and proved in Isabelle/HOL, we derive first an iterative procedure to generate all instances of idempotents over a finite set. From there, we develop a more precise theo- retical characterization giving rise to an efficient predicate that can be executed in the programming language ML. Idempotent relations represent a very basic, general mathematical concept but the steps taken to develop their theory with the help of Isabelle/HOL are representative for developing algorithms from a mathematical specification

Nano JSON: Working with JSON formatted data in Isabelle/HOL and Isabelle/ML

This is the final version. Available from AFP via the link in this recordJSON (JavaScript Object Notation) is a common format for exchanging data, based on a collection of key/value-pairs (the JSON objects) and lists. Its syntax is inspired by JavaScript with the aim of being easy to read and write for humans and easy to parse and generate for machines. Despite its origin in the JavaScript world, JSON is language-independent and many programming languages support working with JSON-encoded data. This makes JSON an interesting format for exchanging data with Isabelle/HOL. This AFP entry provides a JSON-like import-expert format for both Isabelle/ML and Isabelle/HOL. On the one hand, this AFP entry provides means for Isabelle/HOL users to work with JSON encoded data without the need using Isabelle/ML. On the other and, the provided Isabelle/ML interfaces allow additional extensions or integration into Isabelle extensions written in Isabelle/ML. While format is not fully JSON compliant (e.g., due to limitations in the range of supported Unicode characters), it works in most situations: the provided implementation in Isabelle/ML and its representation in Isabelle/HOL have been used successfully in several projects for exchanging data sets of several hundredths of megabyte between Isabelle and external tools

Code Generation for a Simple First-Order Prover

We present Standard ML code generation in Isabelle/HOL of a sound and complete prover for first-order logic, taking formalizations by Tom Ridge and others as the starting point. We also define a set of so-called unfolding rules and show how to use these as a simple prover, with the aim of using the approach for teaching logic and verification to computer science students at the bachelor level

Towards a Verified Enumeration of All Tame Plane Graphs

In his proof of the Kepler conjecture, Thomas Hales introduced the notion of tame graphs and provided a Java program for enumerating all tame plane graphs. We have translated his Java program into an executable function in HOL ("the generator"), have formalized the notions of tameness and planarity in HOL, and have partially proved that the generator returns all tame plane graphs. Running the generator in ML has shows that the list of plane tame graphs ("the archive") that Thomas Hales also provides is complete. Once we have finished the completeness proof for the generator. In addition we checked the redundancy of the archive by formalising an executable notion of isomorphism between plane graphs, and checking if the archive contains only graphs produced by the generator. It turned out that 2257 of the 5128 graphs in the archive are either not tame or isomorphic to another graph in the archive

Generating Verified LLVM from Isabelle/HOL

We present a framework to generate verified LLVM programs from Isabelle/HOL. It is based on a code generator that generates LLVM text from a simplified fragment of LLVM, shallowly embedded into Isabelle/HOL. On top, we have developed a separation logic, a verification condition generator, and an LLVM backend to the Isabelle Refinement Framework. As case studies, we have produced verified LLVM implementations of binary search and the Knuth-Morris-Pratt string search algorithm. These are one order of magnitude faster than the Standard-ML implementations produced with the original Refinement Framework, and on par with unverified C implementations. Adoption of the original correctness proofs to the new LLVM backend was straightforward. The trusted code base of our approach is the shallow embedding of the LLVM fragment and the code generator, which is a pretty printer combined with some straightforward compilation steps

Isabelle/PIDE as Platform for Educational Tools

The Isabelle/PIDE platform addresses the question whether proof assistants of the LCF family are suitable as technological basis for educational tools. The traditionally strong logical foundations of systems like HOL, Coq, or Isabelle have so far been counter-balanced by somewhat inaccessible interaction via the TTY (or minor variations like the well-known Proof General / Emacs interface). Thus the fundamental question of math education tools with fully-formal background theories has often been answered negatively due to accidental weaknesses of existing proof engines. The idea of "PIDE" (which means "Prover IDE") is to integrate existing provers like Isabelle into a larger environment, that facilitates access by end-users and other tools. We use Scala to expose the proof engine in ML to the JVM world, where many user-interfaces, editor frameworks, and educational tools already exist. This shall ultimately lead to combined mathematical assistants, where the logical engine is in the background, without obstructing the view on applications of formal methods, formalized mathematics, and math education in particular.Comment: In Proceedings THedu'11, arXiv:1202.453

A Comparative Study of Coq and HOL

This paper illustrates the differences between the style of theory mechanisation of Coq and of HOL. This comparative study is based on the mechanisation of fragments of the theory of computation in these systems. Examples from these implementations are given to support some of the arguments discussed in this paper. The mechanisms for specifying definitions and for theorem proving are discussed separately, building in parallel two pictures of the different approaches of mechanisation given by these systems

The Common HOL Platform

The Common HOL project aims to facilitate porting source code and proofs between members of the HOL family of theorem provers. At the heart of the project is the Common HOL Platform, which defines a standard HOL theory and API that aims to be compatible with all HOL systems. So far, HOL Light and hol90 have been adapted for conformance, and HOL Zero was originally developed to conform. In this paper we provide motivation for a platform, give an overview of the Common HOL Platform's theory and API components, and show how to adapt legacy systems. We also report on the platform's successful application in the hand-translation of a few thousand lines of source code from HOL Light to HOL Zero.Comment: In Proceedings PxTP 2015, arXiv:1507.0837