An ontology for formal representation of medication adherence-related knowledge : case study in breast cancer

Indiana University-Purdue University Indianapolis (IUPUI)Medication non-adherence is a major healthcare problem that negatively impacts the health and productivity of individuals and society as a whole. Reasons for medication non-adherence are multi-faced, with no clear-cut solution. Adherence to medication remains a difficult area to study, due to inconsistencies in representing medicationadherence behavior data that poses a challenge to humans and today’s computer technology related to interpreting and synthesizing such complex information. Developing a consistent conceptual framework to medication adherence is needed to facilitate domain understanding, sharing, and communicating, as well as enabling researchers to formally compare the findings of studies in systematic reviews. The goal of this research is to create a common language that bridges human and computer technology by developing a controlled structured vocabulary of medication adherence behavior—“Medication Adherence Behavior Ontology” (MAB-Ontology) using breast cancer as a case study to inform and evaluate the proposed ontology and demonstrating its application to real-world situation. The intention is for MAB-Ontology to be developed against the background of a philosophical analysis of terms, such as belief, and desire to be human, computer-understandable, and interoperable with other systems that support scientific research. The design process for MAB-Ontology carried out using the METHONTOLOGY method incorporated with the Basic Formal Ontology (BFO) principles of best practice. This approach introduces a novel knowledge acquisition step that guides capturing medication-adherence-related data from different knowledge sources, including adherence assessment, adherence determinants, adherence theories, adherence taxonomies, and tacit knowledge source types. These sources were analyzed using a systematic approach that involved some questions applied to all source types to guide data extraction and inform domain conceptualization. A set of intermediate representations involving tables and graphs was used to allow for domain evaluation before implementation. The resulting ontology included 629 classes, 529 individuals, 51 object property, and 2 data property. The intermediate representation was formalized into OWL using Protégé. The MAB-Ontology was evaluated through competency questions, use-case scenario, face validity and was found to satisfy the requirement specification. This study provides a unified method for developing a computerized-based adherence model that can be applied among various disease groups and different drug categories

Process Mining Concepts for Discovering User Behavioral Patterns in Instrumented Software

Process Mining is a technique for discovering “in-use” processes from traces emitted to event logs. Researchers have recently explored applying this technique to documenting processes discovered in software applications. However, the requirements for emitting events to support Process Mining against software applications have not been well documented. Furthermore, the linking of end-user intentional behavior to software quality as demonstrated in the discovered processes has not been well articulated. After evaluating the literature, this thesis suggested focusing on user goals and actual, in-use processes as an input to an Agile software development life cycle in order to improve software quality. It also provided suggestions for instrumenting software applications to support Process Mining techniques

Grounding event references in news

Events are frequently discussed in natural language, and their accurate identification is central to language understanding. Yet they are diverse and complex in ontology and reference; computational processing hence proves challenging. News provides a shared basis for communication by reporting events. We perform several studies into news event reference. One annotation study characterises each news report in terms of its update and topic events, but finds that topic is better consider through explicit references to background events. In this context, we propose the event linking task which—analogous to named entity linking or disambiguation—models the grounding of references to notable events. It defines the disambiguation of an event reference as a link to the archival article that first reports it. When two references are linked to the same article, they need not be references to the same event. Event linking hopes to provide an intuitive approximation to coreference, erring on the side of over-generation in contrast with the literature. The task is also distinguished in considering event references from multiple perspectives over time. We diagnostically evaluate the task by first linking references to past, newsworthy events in news and opinion pieces to an archive of the Sydney Morning Herald. The intensive annotation results in only a small corpus of 229 distinct links. However, we observe that a number of hyperlinks targeting online news correspond to event links. We thus acquire two large corpora of hyperlinks at very low cost. From these we learn weights for temporal and term overlap features in a retrieval system. These noisy data lead to significant performance gains over a bag-of-words baseline. While our initial system can accurately predict many event links, most will require deep linguistic processing for their disambiguation

Simple identification tools in FishBase

Simple identification tools for fish species were included in the FishBase information system from its inception. Early tools made use of the relational model and characters like fin ray meristics. Soon pictures and drawings were added as a further help, similar to a field guide. Later came the computerization of existing dichotomous keys, again in combination with pictures and other information, and the ability to restrict possible species by country, area, or taxonomic group. Today, www.FishBase.org offers four different ways to identify species. This paper describes these tools with their advantages and disadvantages, and suggests various options for further development. It explores the possibility of a holistic and integrated computeraided strategy

Exemplar-Based Image and Video Stylization Using Fully Convolutional Semantic Features

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Semantic technologies: from niche to the mainstream of Web 3? A comprehensive framework for web Information modelling and semantic annotation

Context: Web information technologies developed and applied in the last decade have considerably changed the way web applications operate and have revolutionised information management and knowledge discovery. Social technologies, user-generated classification schemes and formal semantics have a far-reaching sphere of influence. They promote collective intelligence, support interoperability, enhance sustainability and instigate innovation. Contribution: The research carried out and consequent publications follow the various paradigms of semantic technologies, assess each approach, evaluate its efficiency, identify the challenges involved and propose a comprehensive framework for web information modelling and semantic annotation, which is the thesis’ original contribution to knowledge. The proposed framework assists web information modelling, facilitates semantic annotation and information retrieval, enables system interoperability and enhances information quality. Implications: Semantic technologies coupled with social media and end-user involvement can instigate innovative influence with wide organisational implications that can benefit a considerable range of industries. The scalable and sustainable business models of social computing and the collective intelligence of organisational social media can be resourcefully paired with internal research and knowledge from interoperable information repositories, back-end databases and legacy systems. Semantified information assets can free human resources so that they can be used to better serve business development, support innovation and increase productivity