1,934 research outputs found

    Functional magnetic resonance imaging : an intermediary between behavior and neural activity

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    Blood oxygen level dependent (BOLD) functional magnetic resonance imaging is a non-invasive technique used to trace changes in neural dynamics in reaction to mental activity caused by perceptual, motor or cognitive tasks. The BOLD response is a complex signal, a consequence of a series of physiological events regulated by increased neural activity. A method to infer from the BOLD signal onto underlying neuronal activity (hemodynamic inverse problem) is proposed in Chapter 2 under the assumption of a previously proposed mathematical model on the transduction of neural activity to the BOLD signal. Also, in this chapter we clarify the meaning of the neural activity function used as the input for an intrinsic dynamic system which can be viewed as an advanced substitute for the impulse response function. Chapter 3 describes an approach for recovering neural timing information (mental chronometry) in an object interaction decision task via solving the hemodynamic inverse problem. In contrast to the hemodynamic level, at the neural level, we were able to determine statistically significant latencies in activation between functional units in the model used. In Chapter 4, two approaches for regularization parameter tuning in a regularized-regression analysis are compared in an attempt to find the optimal amount of smoothing to be imposed on fMRI data in determining an empirical hemodynamic response function. We found that the noise autocorrelation structure can be improved by tuning the regularization parameter but the whitening-based criterion provides too much smoothing when compared to cross-validation. Chapter~5 illustrates that the smoothing techniques proposed in Chapter 4 can be useful in the issue of correlating behavioral and hemodynamic characteristics. Specifically, Chapter 5, based on the smoothing techniques from Chapter 4, seeks to correlate several parameters characterizing the hemodynamic response in Broca's area to behavioral measures in a naming task. In particular, a condition for independence between two routes of converting print to speech in a dual route cognitive model was verified in terms of hemodynamic parameters

    Advancing functional connectivity research from association to causation

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    Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods ('effective connectivity') is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures

    On-line apnea-bradycardia detection using hidden semi-Markov models.

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    International audienceIn this work, we propose a detection method that exploits not only the instantaneous values, but also the intrinsic dynamics of the RR series, for the detection of apnea-bradycardia episodes in preterm infants. A hidden semi-Markov model is proposed to represent and characterize the temporal evolution of observed RR series and different pre-processing methods of these series are investigated. This approach is quantitatively evaluated through synthetic and real signals, the latter being acquired in neonatal intensive care units (NICU). Compared to two conventional detectors used in NICU our best detector shows an improvement of around 13% in sensitivity and 7% in specificity. Furthermore, a reduced detection delay of approximately 3 seconds is obtained with respect to conventional detectors

    Bits from Biology for Computational Intelligence

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    Computational intelligence is broadly defined as biologically-inspired computing. Usually, inspiration is drawn from neural systems. This article shows how to analyze neural systems using information theory to obtain constraints that help identify the algorithms run by such systems and the information they represent. Algorithms and representations identified information-theoretically may then guide the design of biologically inspired computing systems (BICS). The material covered includes the necessary introduction to information theory and the estimation of information theoretic quantities from neural data. We then show how to analyze the information encoded in a system about its environment, and also discuss recent methodological developments on the question of how much information each agent carries about the environment either uniquely, or redundantly or synergistically together with others. Last, we introduce the framework of local information dynamics, where information processing is decomposed into component processes of information storage, transfer, and modification -- locally in space and time. We close by discussing example applications of these measures to neural data and other complex systems

    Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD

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    Understanding the underlying mechanisms of the human brain in health and disease will require models with necessary and sufficient details to explain how function emerges from the underlying anatomy and is shaped by neuromodulation. Here, we provide such a detailed causal explanation using a whole-brain model integrating multimodal imaging in healthy human participants undergoing manipulation of the serotonin system. Specifically, we combined anatomical data from diffusion magnetic resonance imaging (dMRI) and functional magnetic resonance imaging (fMRI) with neurotransmitter data obtained with positron emission tomography (PET) of the detailed serotonin 2A receptor (5-HT2AR) density map. This allowed us to model the resting state (with and without concurrent music listening) and mechanistically explain the functional effects of 5-HT2AR stimulation with lysergic acid diethylamide (LSD) on healthy participants. The whole-brain model used a dynamical mean-field quantitative description of populations of excitatory and inhibitory neurons as well as the associated synaptic dynamics, where the neuronal gain function of the model is modulated by the 5-HT2AR density. The model identified the causative mechanisms for the non-linear interactions between the neuronal and neurotransmitter system, which are uniquely linked to (1) the underlying anatomical connectivity, (2) the modulation by the specific brainwide distribution of neurotransmitter receptor density, and (3) the non-linear interactions between the two. Taking neuromodulatory activity into account when modeling global brain dynamics will lead to novel insights into human brain function in health and disease and opens exciting possibilities for drug discovery and design in neuropsychiatric disorders.ERC Advanced Grant DYSTRUCTURE (295129), the Spanish Research ProjectPSI2016-75688-P, and the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). ERC Consolidator Grant: CAREGIVING (615539) and Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). Alex Mosley Charitable Trust, and the study that yielded the empirical LSD data was carried out as part of a Beckley-Imperial research collaboration. J. Cabral is supported under the project NORTE-01-0145-FEDER-000023 from the Northern Portugal Regional Operational Program (NORTE 2020) under the Portugal 2020 Partnership Agreement through the European Regional Development Fund (FEDER). Cimbi database were supported by a centre grant from the Lundbeck Foundation (2010-5364

    The Human Connectome Project's neuroimaging approach

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    Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease
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