Historical Analyses of Disordered Handwriting

Handwritten texts carry significant information, extending beyond the meaning of their words. Modern neurology, for example, benefits from the interpretation of the graphic features of writing and drawing for the diagnosis and monitoring of diseases and disorders. This article examines how handwriting analysis can be used, and has been used historically, as a methodological tool for the assessment of medical conditions and how this enhances our understanding of historical contexts of writing. We analyze handwritten material, writing tests and letters, from patients in an early 20th-century psychiatric hospital in southern Germany (Irsee/Kaufbeuren). In this institution, early psychiatrists assessed handwriting features, providing us novel insights into the earliest practices of psychiatric handwriting analysis, which can be connected to Berkenkotter’s research on medical admission records. We finally consider the degree to which historical handwriting bears semiotic potential to explain the psychological state and personality of a writer, and how future research in written communication should approach these sources

an experimental protocol to support cognitive impairment diagnosis by using handwriting analysis

Abstract Nowadays diseases involving cognitive impairments affect millions of people worldwide, with Alzheimer's and Parkinson's diseases being the most common ones. Because of the worldwide average lifespan increment, it is expected that their incidence will increase in the next few decades. Among the daily activities, handwriting is one of the first affected by cognitive impairments. For this reasons, researchers have also been investigating the analysis of handwriting alterations as diagnostic signs for this kind of diseases. In this paper we present an experimental protocol that we developed for the analysis of the handwriting dynamics of patients affected by cognitive impairments. The aim of this protocol is to build a large database that would allow to effectively train different classifier systems. We also detail the most common and effective features previously used in the literature to represent handwriting dynamics of the subjects affected by cognitive impairments

Graphonomics and your Brain on Art, Creativity and Innovation : Proceedings of the 19th International Graphonomics Conference (IGS 2019 – Your Brain on Art)

[Italiano]: “Grafonomia e cervello su arte, creatività e innovazione”. Un forum internazionale per discutere sui recenti progressi nell'interazione tra arti creative, neuroscienze, ingegneria, comunicazione, tecnologia, industria, istruzione, design, applicazioni forensi e mediche. I contributi hanno esaminato lo stato dell'arte, identificando sfide e opportunità, e hanno delineato le possibili linee di sviluppo di questo settore di ricerca. I temi affrontati includono: strategie integrate per la comprensione dei sistemi neurali, affettivi e cognitivi in ambienti realistici e complessi; individualità e differenziazione dal punto di vista neurale e comportamentale; neuroaesthetics (uso delle neuroscienze per spiegare e comprendere le esperienze estetiche a livello neurologico); creatività e innovazione; neuro-ingegneria e arte ispirata dal cervello, creatività e uso di dispositivi di mobile brain-body imaging (MoBI) indossabili; terapia basata su arte creativa; apprendimento informale; formazione; applicazioni forensi. / [English]: “Graphonomics and your brain on art, creativity and innovation”. A single track, international forum for discussion on recent advances at the intersection of the creative arts, neuroscience, engineering, media, technology, industry, education, design, forensics, and medicine. The contributions reviewed the state of the art, identified challenges and opportunities and created a roadmap for the field of graphonomics and your brain on art. The topics addressed include: integrative strategies for understanding neural, affective and cognitive systems in realistic, complex environments; neural and behavioral individuality and variation; neuroaesthetics (the use of neuroscience to explain and understand the aesthetic experiences at the neurological level); creativity and innovation; neuroengineering and brain-inspired art, creative concepts and wearable mobile brain-body imaging (MoBI) designs; creative art therapy; informal learning; education; forensics

Automatic Analysis of Archimedes’ Spiral for Characterization of Genetic Essential Tremor Based on Shannon’s Entropy and Fractal Dimension

Among neural disorders related to movement, essential tremor has the highest prevalence; in fact, it is twenty times more common than Parkinson's disease. The drawing of the Archimedes' spiral is the gold standard test to distinguish between both pathologies. The aim of this paper is to select non-linear biomarkers based on the analysis of digital drawings. It belongs to a larger cross study for early diagnosis of essential tremor that also includes genetic information. The proposed automatic analysis system consists in a hybrid solution: Machine Learning paradigms and automatic selection of features based on statistical tests using medical criteria. Moreover, the selected biomarkers comprise not only commonly used linear features (static and dynamic), but also other non-linear ones: Shannon entropy and Fractal Dimension. The results are hopeful, and the developed tool can easily be adapted to users; and taking into account social and economic points of view, it could be very helpful in real complex environments.This research was partially funded by the Basque Goverment, the University of the Basque Country by the IT1115-16 project-ELEKIN, Diputacion Foral de Gipuzkoa, University of Vic-Central University of Catalonia under the research grant R0947, and the Spanish Ministry of Science and Innovation TEC2016-77791-C04-R

Handwriting Biometrics: Applications and Future Trends in e-Security and e-Health

Online handwritten analysis presents many applications in e-security, signature biometrics being the most popular but not the only one. Handwriting analysis also has an important set of applications in e-health. Both kinds of applications (e-security and e-health) have some unsolved questions and relations among them that should be addressed in the next years. We summarize the state of the art and applications based on handwriting signals. Later on, we focus on the main achievements and challenges that should be addressed by the scientific community, providing a guide for future research. Among all the points discussed in this article, we remark the importance of considering security, health, and metadata from a joint perspective. This is especially critical due to the risks inherent when using these behavioral signals

Biometric data and machine learning methods in the diagnosis and monitoring of neurodegenerative diseases: a review

Представлен обзор неинвазивных биометрических методов выявления и прогнозирования развития нейродегенеративных заболеваний. Дан анализ различных модальностей, используемых для диагностики и мониторинга. Рассмотрены такие модальности, как рукописные данные, электроэнцефалограмма, речь, походка, движение глаз, а также использование композиций данных модальностей. Проведен подробный анализ современных методов и систем принятия решений, основанных на машинном обучении. Представлены наборы данных, методы предобработки, модели машинного обучения, оценки точности при диагностике заболеваний. В заключении рассмотрены текущие открытые проблемы и будущие перспективы исследований в данном направлении.Работа выполнена при поддержке Российского на-учного фонда (проект № 22-21-00021)

Derivation and Analysis of Dynamic Handwriting Features as Clinical Markers of Parkinson’s Disease

Parkinson’s Disease (PD) is a complex neurodegenerative disorder that is challenging to diagnose. Recent research has demonstrated predictive value in the analysis of dynamic handwriting features for detecting PD, however, consensus on clinically-useful features is yet to be reached. Here we explore and evaluate secondary kinematic handwriting features hypothesized to be diagnostically relevant to Parkinson’s Disease using a publicly-available Spiral Drawing Test PD dataset. Univariate and multivariate analysis was performed on derived features. Classification outcome was determined using logistic regression models with 10-fold cross validation. Feature correlation was based on model specificity and sensitivity. Variations in grip angle, instantaneous acceleration and pressure indices were found to have high predictive potential as clinical markers of PD, with combined classification accuracy of above 90%. Our results show that the significance of secondary handwriting features and recommend the feature expansion step for hypothesis generation, comparative evaluation of test types and improved classification accuracy

Gait Analysis for Early Neurodegenerative Diseases Classification through the Kinematic Theory of Rapid Human Movements

Neurodegenerative diseases are particular diseases whose decline can partially or completely compromise the normal course of life of a human being. In order to increase the quality of patient's life, a timely diagnosis plays a major role. The analysis of neurodegenerative diseases, and their stage, is also carried out by means of gait analysis. Performing early stage neurodegenerative disease assessment is still an open problem. In this paper, the focus is on modeling the human gait movement pattern by using the kinematic theory of rapid human movements and its sigma-lognormal model. The hypothesis is that the kinematic theory of rapid human movements, originally developed to describe handwriting patterns, and used in conjunction with other spatio-temporal features, can discriminate neurodegenerative diseases patterns, especially in early stages, while analyzing human gait with 2D cameras. The thesis empirically demonstrates its effectiveness in describing neurodegenerative patterns, when used in conjunction with state-of-the-art pose estimation and feature extraction techniques. The solution developed achieved 99.1% of accuracy using velocity-based, angle-based and sigma-lognormal features and left walk orientation

Feature Selection as a Tool to Support the Diagnosis of Cognitive Impairments Through Handwriting Analysis

Cognitive Impairments are cognitive deficits that are greater than expected for a person of a given age and level of education, but which do not significantly interfere with the daily life of the people affected. They range from mild to severe and are seen as a risk factor for Alzheimer's disease, currently the most common neurodegenerative brain disorder worldwide. In a previous study, we presented an experimental protocol comprising different handwriting tasks to be carried out by patients and a healthy control group: the aim was to investigate whether the analysis of the handwriting could be used as a tool to support the diagnosis of this kind of impairment. In the study presented here, we used a well-known and widely-used feature selection approach to determine the most effective features for predicting the symptoms related to cognitive impairments via handwriting analysis. Our intention is to deepen the knowledge about the different cognitive functions affected by the onset of these diseases, as well as to improve the performance of the tools developed to support their diagnosis. The results showed that different sets of highly discriminant features, closely related to the cognitive skills impaired, were selected for the handwriting tasks making up the protocol, thus supporting our hypothesis that their use can be very helpful to support the diagnosis of cognitive impairment

attentional pattern classification for automatic dementia detection

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