Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative

Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.Board of Regents, University of Texas Syste

Medical benefits for workmen under social insurance in Japan

Japan was the first Asian country to introduce social insurance measures and she has expanded them during the last few decades. The first social insurance law was passed in 1922 dealing with worker's health insurance in general. It was followed by many schemes of social insurance. National Health Insurance in 1938, Seamen's Insurance in 1939, Employees' Pension Insurance in 1941 and so forth. After World War II the new Constitution was enacted by which the Japanese Government was made responsible for the provision of medical care services for the whole nation. At present approximately the whole population is covered by either one or more of the various social insurance schemes. The main social insurance programs are shown in Figure 1 and Table 1. Most of these insurance schemes are compulsory under Japanese law. Since it would be too difficult and complicated to explain all of these forms of social insurance in detail, we will discuss only about two schemes directly related to medical care services for the workers; namely, the Health Insurance Scheme for non. occupational diseases and disorders (sickness or injury off the job) and Workmen's Compensation Insurance for occupational diseases and disorders (sickness or injury on the job).</p

CHARACTERIZING DISEASES AND DISORDERS IN GAY USERS’ TWEETS

A lack of information exists about the health issues of lesbian, gay, bisexual, transgender, and queer (LGBTQ) people who are often excluded from national demographic assessments, health studies, and clinical trials. As a result, medical experts and researchers lack holistic understanding of the health disparities facing these populations. Fortunately, publicly available social media data such as Twitter data can be utilized to support the decisions of public health policy makers and managers with respect to LGBTQ people. This research employs a computational approach to collect tweets from gay users on healthrelated topics and model these topics. To determine the nature of health-related information shared by men who have sex with men on Twitter, we collected thousands of tweets from 177 active users. We sampled these tweets using a framework that can be applied to other LGBTQ sub-populations in future research. We found 11 diseases in 7 categories based on ICD 10 that are in line with the published studies and official reports

Never events in gastrointestinal nursing

Gastrointestinal diseases and disorders frequently require interventions that can lead to serious consequences for patients when an organization has not put in place the correct systems and processes to prevent incidents from happening, procedures have not been followed (generally due to poor observation), or when an individual disregards protocol (generally due to lack of judgment). It has been identified that over 400,000 patients suffer potentially preventable harmful events each year (Emslie, 2002). In this article, Carol Cox describes the types of risks that can lead to never events and factors that increase the potential for error

Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells

The pathogenesis of neurological diseases and disorders remains mostly unknown. Neuroinflammation has been proposed as a causative factor for neurological diseases. The confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) of mammals has tremendous implications for our understanding of the physio- and pathology of the nervous system. The generation of newborn neuronal cells in the adult brain is modulated in neurological diseases and during inflammation. This suggests that adult neurogenesis is involved in the pathogenesis of neurological diseases and disorders, particularly during neuroinflammation. In this manuscript, we will review the modulation of adult neurogenesis in neurological diseases and during neuroinflammation. We will discuss the role and contribution of neuroinflammation and adult neurogenesis to neurological diseases and disorders, and for the therapeutic potential of adult NSCs

Incidences and veterinary clinical management of postpartum diseases among domestic cows and does in Klang Valley, Malaysia

The postpartum period is a time that is characterised by an increased risk of developing parturition related diseases and disorders by the dam. These may affect production in affected animals. Thee objective of this study was to determine the incidences and methods of clinical management of postpartum diseases among farm animals within the Klang Valley in Selangor, Malaysia. Primary data were obtained from a four-year (January 2013 to December 2017) farm record from sixteen (16) cattle and goats mixed farms. Postpartum diseases and disorders made up 3.4% (53/1550) of total diseases and disorders recorded for cows and does. Out of the 53 cases of postpartum diseases and disorders recorded, the followings were observed; metritis (24.5%), vaginal prolapse (22.6%), pyometra (20.8%), retained placenta (15.1%), uterine prolapse (9.4%), endometritis (5.7%) and uterine tears (1.9%). Most of the recorded postpartum cases were seen in cattle (83.0%) than in goat (17.0%) populations. More postpartum diseases and disorders were seen in younger cows (56.8%) as compared to older cows (43.2%). Similarly, more cases were seen in older does (66.6%) as compared to younger does (33.4%). Furthermore, a higher frequency of postpartum diseases was observed in animals during their rst parturition (77.4%) than in animals during their second (17.0%) or third parturition (5.6%). Flunixin meglumine and oxytetracyclines administered via the uterus were frequently used in clinical management of postpartum diseases. However, a detailed and strict follow up of the cases were lacking (52.8%). This study shows that postpartum diseases are quite common in primipara ruminants in the Klang Valley. Although conventional methods of managing postpartum cases in the Klang valley yielded satisfactory outcomes, there is need for compliance on detailed follow up therapy to avoid cases of treatment failures in affected animals

Effects of chlorhexidine gluconate oral care on hospital mortality : a hospital-wide, observational cohort study

Chlorhexidine oral care is widely used in critically and non-critically ill hospitalized patients to maintain oral health. We investigated the effect of chlorhexidine oral care on mortality in a general hospitalized population. In this single-center, retrospective, hospital-wide, observational cohort study we included adult hospitalized patients (2012-2014). Mortality associated with chlorhexidine oral care was assessed by logistic regression analysis. A threshold cumulative dose of 300 mg served as a dichotomic proxy for chlorhexidine exposure. We adjusted for demographics, diagnostic category, and risk of mortality expressed in four categories (minor, moderate, major, and extreme). The study cohort included 82,274 patients of which 11,133 (14%) received chlorhexidine oral care. Low-level exposure to chlorhexidine oral care (ae 300 mg) was associated with increased risk of death [odds ratio (OR) 2.61; 95% confidence interval (CI) 2.32-2.92]. This association was stronger among patients with a lower risk of death: OR 5.50 (95% CI 4.51-6.71) with minor/moderate risk, OR 2.33 (95% CI 1.96-2.78) with a major risk, and a not significant OR 1.13 (95% CI 0.90-1.41) with an extreme risk of mortality. Similar observations were made for high-level exposure (> 300 mg). No harmful effect was observed in ventilated and non-ventilated ICU patients. Increased risk of death was observed in patients who did not receive mechanical ventilation and were not admitted to ICUs. The adjusted number of patients needed to be exposed to result in one additional fatality case was 47.1 (95% CI 45.2-49.1). These data argue against the indiscriminate widespread use of chlorhexidine oral care in hospitalized patients, in the absence of proven benefit in specific populations

Public Media Coverage of Rare Diseases and Disorders:The Case of Spanish Public Broadcasting Corporation

Rare diseases and disorders are, as the names suggest, a strange or unusual health condition, and so the coverage given by the media is not as extensive as it could be. However, researchers point out that this situation is changing little by little, and there is now more information about those who suffer from these conditions, and their experience. It is quite interesting to see how the public media, especially in the case of Spain, are making a great effort to give a voice and space to people affected by such diseases. In the case of public media, there are many other aspects to be considered. Firstly, the Spanish Broadcasting Corporation, Radio Televisión Española (RTVE) is not tied to private finance. Secondly, these channels are expected to be more independent and, subsequently, there may be no additional pressure to reach high audience share or obtain external funding from private media companies. This is especially interesting in the case of radio broadcasting, as it tends to be a medium with a high level of credibility, and closeness to the audience.2020-2

Rethinking paradigms for studying mechanisms of action of plant bioactives

Many foods in our diets such as berries, tea, chocolate and wine contain flavonoids, which are natural components of plants. A substantial body of evidence supports the role of flavonoids in providing protection against cardio-metabolic diseases and disorders. Despite the nearly exponential growth in flavonoid research in the past 20 years, limited progress has been made in understanding how these dietary components work. Research initially focused on their antioxidant activity without taking into account their metabolism, which now appears extensive. This has provided a new research impetus to understand the biological activity of the flavonoid metabolites. Here, we outline recent research, which suggests a highly complex interplay between metabolism, intestinal microflora, the immune system and various tissues of our body