9,837 research outputs found
Cost-efficient vaccination protocols for network epidemiology
We investigate methods to vaccinate contact networks -- i.e. removing nodes
in such a way that disease spreading is hindered as much as possible -- with
respect to their cost-efficiency. Any real implementation of such protocols
would come with costs related both to the vaccination itself, and gathering of
information about the network. Disregarding this, we argue, would lead to
erroneous evaluation of vaccination protocols. We use the
susceptible-infected-recovered model -- the generic model for diseases making
patients immune upon recovery -- as our disease-spreading scenario, and analyze
outbreaks on both empirical and model networks. For different relative costs,
different protocols dominate. For high vaccination costs and low costs of
gathering information, the so-called acquaintance vaccination is the most cost
efficient. For other parameter values, protocols designed for query-efficient
identification of the network's largest degrees are most efficient
Controlling nosocomial infection based on structure of hospital social networks
Nosocomial infection raises a serious public health problem, as implied by
the existence of pathogens characteristic to healthcare and hospital-mediated
outbreaks of influenza and SARS. We simulate stochastic SIR dynamics on social
networks, which are based on observations in a hospital in Tokyo, to explore
effective containment strategies against nosocomial infection. The observed
networks have hierarchical and modular structure. We show that healthcare
workers, particularly medical doctors, are main vectors of diseases on these
networks. Intervention methods that restrict interaction between medical
doctors and their visits to different wards shrink the final epidemic size more
than intervention methods that directly protect patients, such as isolating
patients in single rooms. By the same token, vaccinating doctors with priority
rather than patients or nurses is more effective. Finally, vaccinating
individuals with large betweenness centrality is superior to vaccinating ones
with large connectedness to others or randomly chosen individuals, as suggested
by previous model studies. [The abstract of the manuscript has more
information.]Comment: 12 figures, 2 table
Modelling the economic efficiency of using different strategies to control Porcine Reproductive & Respiratory Syndrome at herd level
PRRS is among the diseases with the highest economic impact in pig production worldwide. Different strategies have been developed and applied to combat PRRS at farm level. The broad variety of available intervention strategies makes it difficult to decide on the most cost-efficient strategy for a given farm situation, as it depends on many farm-individual factors like disease severity, prices or farm structure. Aim of this study was to create a simulation tool to estimate the cost-efficiency of different control strategies at individual farm level. Baseline is a model that estimates the costs of PRRS, based on changes in health and productivity, in a specific farm setting (e.g. farm type, herd size, type of batch farrowing).
The model evaluates different intervention scenarios: depopulation/repopulation (D/R), close & roll-over (C&R), mass vaccination of sows (MS), mass vaccination of sows and vaccination of piglets (MS + piglets), improvements in internal biosecurity (BSM), and combinations of vaccinations with BSM. Data on improvement in health and productivity parameters for each intervention were obtained through literature review and from expert opinions. The economic efficiency of the different strategies was assessed over 5 years through investment appraisals: the resulting expected value (EV) indicated the most cost-effective strategy. Calculations were performed for 5 example scenarios with varying farm type (farrow-to-finish – breeding herd), disease severity (slightly – moderately – severely affected) and PRRSV detection (yes – no). The assumed herd size was 1000 sows with farm and price structure as commonly found in Germany. In a moderately affected (moderate deviations in health and productivity parameters from what could be expected in an average negative herd), unstable farrow-to-finish herd, the most cost-efficient strategies according to their median EV were C&R (€1′126′807) and MS + piglets (€ 1′114′649). In a slightly affected farrow-to-finish herd, no virus detected, the highest median EV was for MS + piglets (€ 721′745) and MS (€ 664′111). Results indicate that the expected benefits of interventions and the most efficient strategy depend on the individual farm situation, e.g. disease severity. The model provides new insights regarding the cost-efficiency of various PRRSV intervention strategies at farm level. It is a valuable tool for farmers and veterinarians to estimate expected economic consequences of an intervention for a specific farm setting and thus enables a better informed decision
Immunization strategies for epidemic processes in time-varying contact networks
Spreading processes represent a very efficient tool to investigate the
structural properties of networks and the relative importance of their
constituents, and have been widely used to this aim in static networks. Here we
consider simple disease spreading processes on empirical time-varying networks
of contacts between individuals, and compare the effect of several immunization
strategies on these processes. An immunization strategy is defined as the
choice of a set of nodes (individuals) who cannot catch nor transmit the
disease. This choice is performed according to a certain ranking of the nodes
of the contact network. We consider various ranking strategies, focusing in
particular on the role of the training window during which the nodes'
properties are measured in the time-varying network: longer training windows
correspond to a larger amount of information collected and could be expected to
result in better performances of the immunization strategies. We find instead
an unexpected saturation in the efficiency of strategies based on nodes'
characteristics when the length of the training window is increased, showing
that a limited amount of information on the contact patterns is sufficient to
design efficient immunization strategies. This finding is balanced by the large
variations of the contact patterns, which strongly alter the importance of
nodes from one period to the next and therefore significantly limit the
efficiency of any strategy based on an importance ranking of nodes. We also
observe that the efficiency of strategies that include an element of randomness
and are based on temporally local information do not perform as well but are
largely independent on the amount of information available
Integrated Serologic Surveillance of Population Immunity and Disease Transmission.
Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus, but broader testing of existing serologic surveys with multiplex antibody assays would create new opportunities for integrated surveillance. In this perspective, we highlight multiple areas for potential synergy where integrated surveillance could add more value to public health efforts than the current trend of independent disease monitoring through vertical programs. We describe innovations in laboratory and data science that should accelerate integration and identify remaining challenges with respect to specimen collection, testing, and analysis. Throughout, we illustrate how information generated through integrated surveillance platforms can create new opportunities to more quickly and precisely identify global health program gaps that range from undervaccination to emerging pathogens to multilayered health disparities that span diverse communicable diseases
Evaluation of the cost of cervical cancer at the National Institute of Oncology, Rabat
Introduction: The Cervical Cancer (CC) is one of the heavy and costly diseases for the population and the health system. We want to know through this study, the first in Morocco, the annual cost of the treatment of this disease at the National Institute of Oncology (NIO) in Rabat, we also want to explore the possibility of flat-rate management of this disease in order to standardize medical practices and improve reimbursement by health insurance funds. Methods: 550 patients were treated for their cervical cancer in the Rabat's NIO. Data of all of medical and surgical services offered to patients were collected from the NIO registry. The cost of care was assessed using the method of micro-costing. We will focus to the total direct cost of all the services lavished to patients in NIO. Results: The global cost was about US 2,599 ± US$ 839. Radiotherapy accounts for 55% of total costs, followed by brachytherapy (27%) and surgery (7%). This three services plus chemotherapy influence the overall cost of care (p <0.001). Other services (radiology, laboratory tests and consultations) represent only 10%. The overall cost is influenced by the stage of the disease, this cost decreased significantly evolving in the stage of CC (p <0.001). Conclusion: The standardization of medical practices is essential to the equity and efficiency in access to care. The flat-rate or lump sum by stage of disease is possible and interesting for standardizing medical practices and improving the services of the health insurance plan.Pan African Medical Journal 2016; 2
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