Egocentric and allocentric spatial reference frames in aging: A systematic review

Abstract Aging affects many aspects of everyday living, such as autonomy, security and quality of life. Among all, spatial memory and spatial navigation show a gradual but noticeable decline, as a result of both neurobiological changes and the general slowing down of cognitive functioning. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to identify studies that specifically investigated the role of allocentric and egocentric frames in healthy aging. Concerning spatial navigation, our results showed a preservation of egocentric strategies, along with specific impairments in the use of allocentric and switching abilities. Regarding spatial memory, instead, outcomes were more divergent and not frame-specific. With this perspective, spatial impairments were discussed considering the cognitive profile of mild cognitive impairment (MCI) and Alzheimer's Disease (AD)

Enhancing allocentric spatial recall in pre-schoolers through navigational training programme

Unlike for other abilities, children do not receive systematic spatial orientation training at school, even though navigational training during adulthood improves spatial skills. We investigated whether navigational training programme (NTP) improved spatial orientation skills in pre-schoolers. We administered 12-week NTP to seventeen 4- to 5-year-old children (training group, TG). The TG children and 17 age-matched children (control group, CG) who underwent standard didactics were tested twice before (T0) and after (T1) the NTP using tasks that tap into landmark, route and survey representations. We determined that the TG participants significantly improved their performances in the most demanding navigational task, which is the task that taps into survey representation. This improvement was significantly higher than that observed in the CG, suggesting that NTP fostered the acquisition of survey representation. Such representation is typically achieved by age seven. This finding suggests that NTP improves performance on higher-level navigational tasks in pre-schooler

How do we get there? Effects of cognitive aging on route memory

© 2017 The Author(s) Research into the effects of cognitive aging on route navigation usually focuses on differences in learning performance. In contrast, we investigated age-related differences in route knowledge after successful route learning. One young and two groups of older adults categorized using different cut-off scores on the Montreal Cognitive Assessment (MoCA), were trained until they could correctly recall short routes. During the test phase, they were asked to recall the sequence in which landmarks were encountered (Landmark Sequence Task), the sequence of turns (Direction Sequence Task), the direction of turn at each landmark (Landmark Direction Task), and to identify the learned routes from a map perspective (Perspective Taking Task). Comparing the young participant group with the older group that scored high on the MoCA, we found effects of typical aging in learning performance and in the Direction Sequence Task. Comparing the two older groups, we found effects of early signs of atypical aging in the Landmark Direction and the Perspective Taking Tasks. We found no differences between groups in the Landmark Sequence Task. Given that participants were able to recall routes after training, these results suggest that typical and early signs of atypical aging result in differential memory deficits for aspects of route knowledge

Measurement of allocentric processing in mild cognitive impairment and early Alzheimer’s disease using a virtual reality object location paradigm

Aim: Mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) are major contributors to disability in old age and defined in the early stages by spatial memory deficits associated with hippocampal (HC) and entorhinal (EC) atrophy. Currently diagnosis occurs late in the process which limits efficacy of interventions. This study investigated the neural correlates of a novel object location task (OLT) in immersive virtual reality (iVR). Methods: Twenty amnestic MCI (aMCI) patients and twenty two healthy controls were tested on the iVR OLT, underwent neuropsychological testing and structural MRI scanning. OLT performance and HC, EC subfield volumetric data were compared between groups, and correlational analyses of HC/EC volumes and performance were conducted. Results: Participants with aMCI were significantly impaired in object location recall and object recognition compared to controls. They had significantly smaller total HC, subiculum, CA1, EC and perirhinal volumes. There was a significant interaction of group in analysis of neural correlates: OLT performance was strongly predicted by total HC and subiculum volumes in patients only. EC subfields were not significant predictors of performance. Conclusion: Performance on the novel OLT in immersive VR is a good indicator of HC integrity in older adults with amnestic MCI and can improve the diagnostic process for people with MCI and AD in the future

The impact of 3D virtual environments with different levels of realism on route learning: a focus on age-based differences

With technological advancements, it has become notably easier to create virtual environments (VEs) depicting the real world with high fidelity and realism. These VEs offer some attractive use cases for navigation studies looking into spatial cognition. However, such photorealistic VEs, while attractive, may complicate the route learning process as they may overwhelm users with the amount of information they contain. Understanding how much and what kind of photorealistic information is relevant to people at which point on their route and while they are learning a route can help define how to design virtual environments that better support spatial learning. Among the users who may be overwhelmed by too much information, older adults represent a special interest group for two key reasons: 1) The number of people over 65 years old is expected to increase to 1.5 billion by 2050 (World Health Organization, 2011); 2) cognitive abilities decline as people age (Park et al., 2002). The ability to independently navigate in the real world is an important aspect of human well-being. This fact has many socio-economic implications, yet age-related cognitive decline creates difficulties for older people in learning their routes in unfamiliar environments, limiting their independence. This thesis takes a user-centered approach to the design of visualizations for assisting all people, and specifically older adults, in learning routes while navigating in a VE. Specifically, the objectives of this thesis are threefold, addressing the basic dimensions of: ❖ Visualization type as expressed by different levels of realism: Evaluate how much and what kind of photorealistic information should be depicted and where it should be represented within a VE in a navigational context. It proposes visualization design guidelines for the design of VEs that assist users in effectively encoding visuospatial information. ❖ Use context as expressed by route recall in short- and long-term: Identify the implications that different information types (visual, spatial, and visuospatial) have over short- and long-term route recall with the use of 3D VE designs varying in levels of realism. ❖ User characteristics as expressed by group differences related to aging, spatial abilities, and memory capacity: Better understand how visuospatial information is encoded and decoded by people in different age groups, and of different spatial and memory abilities, particularly while learning a route in 3D VE designs varying in levels of realism. In this project, the methodology used for investigating the topics outlined above was a set of controlled lab experiments nested within one. Within this experiment, participants’ recall accuracy for various visual, spatial, and visuospatial elements on the route was evaluated using three visualization types that varied in their amount of photorealism. These included an Abstract, a Realistic, and a Mixed VE (see Figure 2), for a number of route recall tasks relevant to navigation. The Mixed VE is termed “mixed” because it includes elements from both the Abstract and the Realistic VEs, balancing the amount of realism in a deliberate manner (elaborated in Section 3.5.2). This feature is developed within this thesis. The tested recall tasks were differentiated based on the type of information being assessed: visual, spatial, and visuospatial (elaborated in Section 3.6.1). These tasks were performed by the participants both immediately after experiencing a drive-through of a route in the three VEs and a week after that; thus, addressing short- and long-term memory, respectively. Participants were counterbalanced for their age, gender, and expertise while their spatial abilities and visuospatial memory capacity were controlled with standardized psychological tests. The results of the experiments highlight the importance of all three investigated dimensions for successful route learning with VEs. More specifically, statistically significant differences in participants’ recall accuracy were observed for: 1) the visualization type, highlighting the value of balancing the amount of photorealistic information presented in VEs while also demonstrating the positive and negative effects of abstraction and realism in VEs on route learning; 2) the recall type, highlighting nuances and peculiarities across the recall of visual, spatial, and visuospatial information in the short- and long-term; and, 3) the user characteristics, as expressed by age differences, but also by spatial abilities and visuospatial memory capacity, highlighting the importance of considering the user type, i.e., for whom the visualization is customized. The original and unique results identified from this work advance the knowledge in GIScience, particularly in geovisualization, from the perspective of the “cognitive design” of visualizations in two distinct ways: (i) understanding the effects that visual realism has—as presented in VEs—on route learning, specifically for people of different age groups and with different spatial abilities and memory capacity, and (ii) proposing empirically validated visualization design guidelines for the use of photorealism in VEs for efficient recall of visuospatial information during route learning, not only for shortterm but also for long-term recall in younger and older adults

Cognitive Aging

Given the global demographic shift towards an aging population, there is a pressing need to understand how aging affects cognition. This collection of articles, from across the globe, represents some of the diverse aspects of cognitive aging. These articles investigate the fundamental processes and mechanisms underlying the neural and cognitive changes associated with normal and pathological aging. They describe the many facets of cognition, memory, language and thinking that are affected by the aging process. The articles will hopefully fascinate readers, and entice them to learn more about how such research is conducted, as well as serving as avenues for exploration to compensate for deficits in cognitive function. The studies are cutting edge and offer insight into the development of the theories that best account for the changes in brain and behaviour that affect us all

Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities

(Dis)orientation and Design Preferences Within an Unfamiliar Care Environment: A Content Analysis of Older Adults’ Qualitative Reports After Route Learning

© The Author(s) 2020. Ensuring that environments are designed to cater for those with decreasing orientation, perceptual and mobility skills, is an example of how environments are being changed to become more age and dementia friendly. However, environmental design should directly involve potential users of the environment to ensure that their views are accounted for. Four open-ended questions, focusing on orientation strategies, reasons for disorientation, and design preferences, were given to 32 older adults after they had completed a route learning task through an unfamiliar environment. A Content Analysis found a strong focus on participants’ ability to memorize routes based on verbally encoding the route and on their ability to remember landmarks, with the reports linking closely to cognitive theories of navigation. Design suggestions included the importance of a homely and welcoming environment, memorable features, and access to the outdoors. The findings can be used inform age and dementia friendly design principles