Radio Sources Segmentation and Classification with Deep Learning

Modern large radio continuum surveys have high sensitivity and resolution, and can resolve previously undetected extended and diffuse emissions, which brings great challenges for the detection and morphological classification of extended sources. We present HeTu-v2, a deep learning-based source detector that uses the combined networks of Mask Region-based Convolutional Neural Networks (Mask R-CNN) and a Transformer block to achieve high-quality radio sources segmentation and classification. The sources are classified into 5 categories: Compact or point-like sources (CS), Fanaroff-Riley Type I (FRI), Fanaroff-Riley Type II (FRII), Head-Tail (HT), and Core-Jet (CJ) sources. HeTu-v2 has been trained and validated with the data from the Faint Images of the Radio Sky at Twenty-one centimeters (FIRST). We found that HeTu-v2 has a high accuracy with a mean average precision ($AP_{\rm @50:5:95}$) of 77.8%, which is 15.6 points and 11.3 points higher than that of HeTu-v1 and the original Mask R-CNN respectively. We produced a FIRST morphological catalog (FIRST-HeTu) using HeTu-v2, which contains 835,435 sources and achieves 98.6% of completeness and up to 98.5% of accuracy compared to the latest 2014 data release of the FIRST survey. HeTu-v2 could also be employed for other astronomical tasks like building sky models, associating radio components, and classifying radio galaxies

Toward Flare-Free Images: A Survey

Lens flare is a common image artifact that can significantly degrade image quality and affect the performance of computer vision systems due to a strong light source pointing at the camera. This survey provides a comprehensive overview of the multifaceted domain of lens flare, encompassing its underlying physics, influencing factors, types, and characteristics. It delves into the complex optics of flare formation, arising from factors like internal reflection, scattering, diffraction, and dispersion within the camera lens system. The diverse categories of flare are explored, including scattering, reflective, glare, orb, and starburst types. Key properties such as shape, color, and localization are analyzed. The numerous factors impacting flare appearance are discussed, spanning light source attributes, lens features, camera settings, and scene content. The survey extensively covers the wide range of methods proposed for flare removal, including hardware optimization strategies, classical image processing techniques, and learning-based methods using deep learning. It not only describes pioneering flare datasets created for training and evaluation purposes but also how they were created. Commonly employed performance metrics such as PSNR, SSIM, and LPIPS are explored. Challenges posed by flare's complex and data-dependent characteristics are highlighted. The survey provides insights into best practices, limitations, and promising future directions for flare removal research. Reviewing the state-of-the-art enables an in-depth understanding of the inherent complexities of the flare phenomenon and the capabilities of existing solutions. This can inform and inspire new innovations for handling lens flare artifacts and improving visual quality across various applications

Object detection and sim-to-real 6D pose estimation

Deep Learning has led to significant advances in computer vision, making perception an important component in many fields such as robotics, medicine, agriculture, remote sensing, etc. Object detection has been a major part of computer vision research that has led to further enhancements like object pose, grasp, and depth estimation. However, even object detectors suffer from a lack of data, which requires a well-defined data pipeline that first labels and then augments data. Based on the conducted review, no available labeling tool supports the benchmark (COCO) export functionality for multi-label ground truth, and no augmentation library supports transformations for the combination of polygon segmentation, bounding boxes, and key points. Having determined the need for an updated data pipeline, in this project, a novel approach is presented that spans from labeling to augmentation and includes data visualization, manipulation, and cleaning. In addition, this work majorly focuses on the usage of object detectors in an industrial use case and further uses multitask learning to develop a state-of-the-art multitask architecture. This pipeline and the architecture are further utilized to infer industrial object pose in the world coordinate frame. Finally, after comparison among multiple object detectors and pose estimators, a multitask architecture with pose estimation methodology is considered better for the industrial use case

Cell Nuclear Morphology Analysis Using 3D Shape Modeling, Machine Learning and Visual Analytics

Quantitative analysis of morphological changes in a cell nucleus is important for the understanding of nuclear architecture and its relationship with cell differentiation, development, proliferation, and disease. Changes in the nuclear form are associated with reorganization of chromatin architecture related to altered functional properties such as gene regulation and expression. Understanding these processes through quantitative analysis of morphological changes is important not only for investigating nuclear organization, but also has clinical implications, for example, in detection and treatment of pathological conditions such as cancer. While efforts have been made to characterize nuclear shapes in two or pseudo-three dimensions, several studies have demonstrated that three dimensional (3D) representations provide better nuclear shape description, in part due to the high variability of nuclear morphologies. 3D shape descriptors that permit robust morphological analysis and facilitate human interpretation are still under active investigation. A few methods have been proposed to classify nuclear morphologies in 3D, however, there is a lack of publicly available 3D data for the evaluation and comparison of such algorithms. There is a compelling need for robust 3D nuclear morphometric techniques to carry out population-wide analyses. In this work, we address a number of these existing limitations. First, we present a largest publicly available, to-date, 3D microscopy imaging dataset for cell nuclear morphology analysis and classification. We provide a detailed description of the image analysis protocol, from segmentation to baseline evaluation of a number of popular classification algorithms using 2D and 3D voxel-based morphometric measures. We proposed a specific cross-validation scheme that accounts for possible batch effects in data. Second, we propose a new technique that combines mathematical modeling, machine learning, and interpretation of morphometric characteristics of cell nuclei and nucleoli in 3D. Employing robust and smooth surface reconstruction methods to accurately approximate 3D object boundary enables the establishment of homologies between different biological shapes. Then, we compute geometric morphological measures characterizing the form of cell nuclei and nucleoli. We combine these methods into a highly parallel computational pipeline workflow for automated morphological analysis of thousands of nuclei and nucleoli in 3D. We also describe the use of visual analytics and deep learning techniques for the analysis of nuclear morphology data. Third, we evaluate proposed methods for 3D surface morphometric analysis of our data. We improved the performance of morphological classification between epithelial vs mesenchymal human prostate cancer cells compared to the previously reported results due to the more accurate shape representation and the use of combined nuclear and nucleolar morphometry. We confirmed previously reported relevant morphological characteristics, and also reported new features that can provide insight in the underlying biological mechanisms of pathology of prostate cancer. We also assessed nuclear morphology changes associated with chromatin remodeling in drug-induced cellular reprogramming. We computed temporal trajectories reflecting morphological differences in astroglial cell sub-populations administered with 2 different treatments vs controls. We described specific changes in nuclear morphology that are characteristic of chromatin re-organization under each treatment, which previously has been only tentatively hypothesized in literature. Our approach demonstrated high classification performance on each of 3 different cell lines and reported the most salient morphometric characteristics. We conclude with the discussion of the potential impact of method development in nuclear morphology analysis on clinical decision-making and fundamental investigation of 3D nuclear architecture. We consider some open problems and future trends in this field.PHDBioinformaticsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/147598/1/akalinin_1.pd

Anatomical Modeling of Cerebral Microvascular Structures: Application to Identify Biomarkers of Microstrokes

Les réseaux microvasculaires corticaux sont responsables du transport de l’oxygène et des substrats énergétiques vers les neurones. Ces réseaux réagissent dynamiquement aux demandes énergétiques lors d’une activation neuronale par le biais du couplage neurovasculaire. Afin d’élucider le rôle de la composante microvasculaire dans ce processus de couplage, l’utilisation de la modélisation in-formatique pourrait se révéler un élément clé. Cependant, la manque de méthodologies de calcul appropriées et entièrement automatisées pour modéliser et caractériser les réseaux microvasculaires reste l’un des principaux obstacles. Le développement d’une solution entièrement automatisée est donc important pour des explorations plus avancées, notamment pour quantifier l’impact des mal-formations vasculaires associées à de nombreuses maladies cérébrovasculaires. Une observation courante dans l’ensemble des troubles neurovasculaires est la formation de micro-blocages vascu-laires cérébraux (mAVC) dans les artérioles pénétrantes de la surface piale. De récents travaux ont démontré l’impact de ces événements microscopiques sur la fonction cérébrale. Par conséquent, il est d’une importance vitale de développer une approche non invasive et comparative pour identifier leur présence dans un cadre clinique. Dans cette thèse,un pipeline de traitement entièrement automatisé est proposé pour aborder le prob-lème de la modélisation anatomique microvasculaire. La méthode de modélisation consiste en un réseau de neurones entièrement convolutif pour segmenter les capillaires sanguins, un générateur de modèle de surface 3D et un algorithme de contraction de la géométrie pour produire des mod-èles graphiques vasculaires ne comportant pas de connections multiples. Une amélioration de ce pipeline est développée plus tard pour alléger l’exigence de maillage lors de la phase de représen-tation graphique. Un nouveau schéma permettant de générer un modèle de graphe est développé avec des exigences d’entrée assouplies et permettant de retenir les informations sur les rayons des vaisseaux. Il est inspiré de graphes géométriques déformants construits en respectant les morpholo-gies vasculaires au lieu de maillages de surface. Un mécanisme pour supprimer la structure initiale du graphe à chaque exécution est implémenté avec un critère de convergence pour arrêter le pro-cessus. Une phase de raffinement est introduite pour obtenir des modèles vasculaires finaux. La modélisation informatique développée est ensuite appliquée pour simuler les signatures IRM po-tentielles de mAVC, combinant le marquage de spin artériel (ASL) et l’imagerie multidirectionnelle pondérée en diffusion (DWI). L’hypothèse est basée sur des observations récentes démontrant une réorientation radiale de la microvascularisation dans la périphérie du mAVC lors de la récupéra-tion chez la souris. Des lits capillaires synthétiques, orientés aléatoirement et radialement, et des angiogrammes de tomographie par cohérence optique (OCT), acquis dans le cortex de souris (n = 5) avant et après l’induction d’une photothrombose ciblée, sont analysés. Les graphes vasculaires informatiques sont exploités dans un simulateur 3D Monte-Carlo pour caractériser la réponse par résonance magnétique (MR), tout en considérant les effets des perturbations du champ magnétique causées par la désoxyhémoglobine, et l’advection et la diffusion des spins nucléaires. Le pipeline graphique proposé est validé sur des angiographies synthétiques et réelles acquises avec différentes modalités d’imagerie. Comparé à d’autres méthodes effectuées dans le milieu de la recherche, les expériences indiquent que le schéma proposé produit des taux d’erreur géométriques et topologiques amoindris sur divers angiogrammes. L’évaluation confirme également l’efficacité de la méthode proposée en fournissant des modèles représentatifs qui capturent tous les aspects anatomiques des structures vasculaires. Ensuite, afin de trouver des signatures de mAVC basées sur le signal IRM, la modélisation vasculaire proposée est exploitée pour quantifier le rapport de perte de signal intravoxel minimal lors de l’application de plusieurs directions de gradient, à des paramètres de séquence variables avec et sans ASL. Avec l’ASL, les résultats démontrent une dif-férence significative (p <0,05) entre le signal calculé avant et 3 semaines après la photothrombose. La puissance statistique a encore augmenté (p <0,005) en utilisant des angiogrammes capturés à la semaine suivante. Sans ASL, aucun changement de signal significatif n’est trouvé. Des rapports plus élevés sont obtenus à des intensités de champ magnétique plus faibles (par exemple, B0 = 3) et une lecture TE plus courte (<16 ms). Cette étude suggère que les mAVC pourraient être carac-térisés par des séquences ASL-DWI, et fournirait les informations nécessaires pour les validations expérimentales postérieures et les futurs essais comparatifs.----------ABSTRACT Cortical microvascular networks are responsible for carrying the necessary oxygen and energy substrates to our neurons. These networks react to the dynamic energy demands during neuronal activation through the process of neurovascular coupling. A key element in elucidating the role of the microvascular component in the brain is through computational modeling. However, the lack of fully-automated computational frameworks to model and characterize these microvascular net-works remains one of the main obstacles. Developing a fully-automated solution is thus substantial for further explorations, especially to quantify the impact of cerebrovascular malformations associ-ated with many cerebrovascular diseases. A common pathogenic outcome in a set of neurovascular disorders is the formation of microstrokes, i.e., micro occlusions in penetrating arterioles descend-ing from the pial surface. Recent experiments have demonstrated the impact of these microscopic events on brain function. Hence, it is of vital importance to develop a non-invasive and translatable approach to identify their presence in a clinical setting. In this thesis, a fully automatic processing pipeline to address the problem of microvascular anatom-ical modeling is proposed. The modeling scheme consists of a fully-convolutional neural network to segment microvessels, a 3D surface model generator and a geometry contraction algorithm to produce vascular graphical models with a single connected component. An improvement on this pipeline is developed later to alleviate the requirement of water-tight surface meshes as inputs to the graphing phase. The novel graphing scheme works with relaxed input requirements and intrin-sically captures vessel radii information, based on deforming geometric graphs constructed within vascular boundaries instead of surface meshes. A mechanism to decimate the initial graph struc-ture at each run is formulated with a convergence criterion to stop the process. A refinement phase is introduced to obtain final vascular models. The developed computational modeling is then ap-plied to simulate potential MRI signatures of microstrokes, combining arterial spin labeling (ASL) and multi-directional diffusion-weighted imaging (DWI). The hypothesis is driven based on recent observations demonstrating a radial reorientation of microvasculature around the micro-infarction locus during recovery in mice. Synthetic capillary beds, randomly- and radially oriented, and op-tical coherence tomography (OCT) angiograms, acquired in the barrel cortex of mice (n=5) before and after inducing targeted photothrombosis, are analyzed. The computational vascular graphs are exploited within a 3D Monte-Carlo simulator to characterize the magnetic resonance (MR) re-sponse, encompassing the effects of magnetic field perturbations caused by deoxyhemoglobin, and the advection and diffusion of the nuclear spins. The proposed graphing pipeline is validated on both synthetic and real angiograms acquired with different imaging modalities. Compared to other efficient and state-of-the-art graphing schemes, the experiments indicate that the proposed scheme produces the lowest geometric and topological error rates on various angiograms. The evaluation also confirms the efficiency of the proposed scheme in providing representative models that capture all anatomical aspects of vascular struc-tures. Next, searching for MRI-based signatures of microstokes, the proposed vascular modeling is exploited to quantify the minimal intravoxel signal loss ratio when applying multiple gradient di-rections, at varying sequence parameters with and without ASL. With ASL, the results demonstrate a significant difference (p<0.05) between the signal-ratios computed at baseline and 3 weeks after photothrombosis. The statistical power further increased (p<0.005) using angiograms captured at week 4. Without ASL, no reliable signal change is found. Higher ratios with improved significance are achieved at low magnetic field strengths (e.g., at 3 Tesla) and shorter readout TE (<16 ms). This study suggests that microstrokes might be characterized through ASL-DWI sequences, and provides necessary insights for posterior experimental validations, and ultimately, future transla-tional trials

Exploiting Spatio-Temporal Coherence for Video Object Detection in Robotics

This paper proposes a method to enhance video object detection for indoor environments in robotics. Concretely, it exploits knowledge about the camera motion between frames to propagate previously detected objects to successive frames. The proposal is rooted in the concepts of planar homography to propose regions of interest where to find objects, and recursive Bayesian filtering to integrate observations over time. The proposal is evaluated on six virtual, indoor environments, accounting for the detection of nine object classes over a total of ∼ 7k frames. Results show that our proposal improves the recall and the F1-score by a factor of 1.41 and 1.27, respectively, as well as it achieves a significant reduction of the object categorization entropy (58.8%) when compared to a two-stage video object detection method used as baseline, at the cost of small time overheads (120 ms) and precision loss (0.92).</p

Scalable exploration of 3D massive models

Programa Oficial de Doutoramento en Tecnoloxías da Información e as Comunicacións. 5032V01[Resumo] Esta tese presenta unha serie técnicas escalables que avanzan o estado da arte da creación e exploración de grandes modelos tridimensionaies. No ámbito da xeración destes modelos, preséntanse métodos para mellorar a adquisición e procesado de escenas reais, grazas a unha implementación eficiente dun sistema out- of- core de xestión de nubes de puntos, e unha nova metodoloxía escalable de fusión de datos de xeometría e cor para adquisicións con oclusións. No ámbito da visualización de grandes conxuntos de datos, que é o núcleo principal desta tese, preséntanse dous novos métodos. O primeiro é unha técnica adaptabile out-of-core que aproveita o hardware de rasterización da GPU e as occlusion queries para crear lotes coherentes de traballo, que serán procesados por kernels de trazado de raios codificados en shaders, permitindo out-of-core ray-tracing con sombreado e iluminación global. O segundo é un método de compresión agresivo que aproveita a redundancia xeométrica que se adoita atopar en grandes modelos 3D para comprimir os datos de forma que caiban, nun formato totalmente renderizable, na memoria da GPU. O método está deseñado para representacións voxelizadas de escenas 3D, que son amplamente utilizadas para diversos cálculos como para acelerar as consultas de visibilidade na GPU. A compresión lógrase fusionando subárbores idénticas a través dunha transformación de similitude, e aproveitando a distribución non homoxénea de referencias a nodos compartidos para almacenar punteiros aos nodos fillo, e utilizando unha codificación de bits variable. A capacidade e o rendemento de todos os métodos avalíanse utilizando diversos casos de uso do mundo real de diversos ámbitos e sectores, incluídos o patrimonio cultural, a enxeñería e os videoxogos.[Resumen] En esta tesis se presentan una serie técnicas escalables que avanzan el estado del arte de la creación y exploración de grandes modelos tridimensionales. En el ámbito de la generación de estos modelos, se presentan métodos para mejorar la adquisición y procesado de escenas reales, gracias a una implementación eficiente de un sistema out-of-core de gestión de nubes de puntos, y una nueva metodología escalable de fusión de datos de geometría y color para adquisiciones con oclusiones. Para la visualización de grandes conjuntos de datos, que constituye el núcleo principal de esta tesis, se presentan dos nuevos métodos. El primero de ellos es una técnica adaptable out-of-core que aprovecha el hardware de rasterización de la GPU y las occlusion queries, para crear lotes coherentes de trabajo, que serán procesados por kernels de trazado de rayos codificados en shaders, permitiendo renders out-of-core avanzados con sombreado e iluminación global. El segundo es un método de compresión agresivo, que aprovecha la redundancia geométrica que se suele encontrar en grandes modelos 3D para comprimir los datos de forma que quepan, en un formato totalmente renderizable, en la memoria de la GPU. El método está diseñado para representaciones voxelizadas de escenas 3D, que son ampliamente utilizadas para diversos cálculos como la aceleración las consultas de visibilidad en la GPU o el trazado de sombras. La compresión se logra fusionando subárboles idénticos a través de una transformación de similitud, y aprovechando la distribución no homogénea de referencias a nodos compartidos para almacenar punteros a los nodos hijo, utilizando una codificación de bits variable. La capacidad y el rendimiento de todos los métodos se evalúan utilizando diversos casos de uso del mundo real de diversos ámbitos y sectores, incluidos el patrimonio cultural, la ingeniería y los videojuegos.[Abstract] This thesis introduces scalable techniques that advance the state-of-the-art in massive model creation and exploration. Concerning model creation, we present methods for improving reality-based scene acquisition and processing, introducing an efficient implementation of scalable out-of-core point clouds and a data-fusion approach for creating detailed colored models from cluttered scene acquisitions. The core of this thesis concerns enabling technology for the exploration of general large datasets. Two novel solutions are introduced. The first is an adaptive out-of-core technique exploiting the GPU rasterization pipeline and hardware occlusion queries in order to create coherent batches of work for localized shader-based ray tracing kernels, opening the door to out-of-core ray tracing with shadowing and global illumination. The second is an aggressive compression method that exploits redundancy in large models to compress data so that it fits, in fully renderable format, in GPU memory. The method is targeted to voxelized representations of 3D scenes, which are widely used to accelerate visibility queries on the GPU. Compression is achieved by merging subtrees that are identical through a similarity transform and by exploiting the skewed distribution of references to shared nodes to store child pointers using a variable bitrate encoding The capability and performance of all methods are evaluated on many very massive real-world scenes from several domains, including cultural heritage, engineering, and gaming

An objective comparison of detection and segmentation algorithms for artefacts in clinical endoscopy

We present a comprehensive analysis of the submissions to the first edition of the Endoscopy Artefact Detection challenge (EAD). Using crowd-sourcing, this initiative is a step towards understanding the limitations of existing state-of-the-art computer vision methods applied to endoscopy and promoting the development of new approaches suitable for clinical translation. Endoscopy is a routine imaging technique for the detection, diagnosis and treatment of diseases in hollow-organs; the esophagus, stomach, colon, uterus and the bladder. However the nature of these organs prevent imaged tissues to be free of imaging artefacts such as bubbles, pixel saturation, organ specularity and debris, all of which pose substantial challenges for any quantitative analysis. Consequently, the potential for improved clinical outcomes through quantitative assessment of abnormal mucosal surface observed in endoscopy videos is presently not realized accurately. The EAD challenge promotes awareness of and addresses this key bottleneck problem by investigating methods that can accurately classify, localize and segment artefacts in endoscopy frames as critical prerequisite tasks. Using a diverse curated multi-institutional, multi-modality, multi-organ dataset of video frames, the accuracy and performance of 23 algorithms were objectively ranked for artefact detection and segmentation. The ability of methods to generalize to unseen datasets was also evaluated. The best performing methods (top 15%) propose deep learning strategies to reconcile variabilities in artefact appearance with respect to size, modality, occurrence and organ type. However, no single method outperformed across all tasks. Detailed analyses reveal the shortcomings of current training strategies and highlight the need for developing new optimal metrics to accurately quantify the clinical applicability of methods

Automatic image analysis of C-arm Computed Tomography images for ankle joint surgeries

Open reduction and internal fixation is a standard procedure in ankle surgery for treating a fractured fibula. Since fibula fractures are often accompanied by an injury of the syndesmosis complex, it is essential to restore the correct relative pose of the fibula relative to the adjoining tibia for the ligaments to heal. Otherwise, the patient might experience instability of the ankle leading to arthritis and ankle pain and ultimately revision surgery. Incorrect positioning referred to as malreduction of the fibula is assumed to be one of the major causes of unsuccessful ankle surgery. 3D C-arm imaging is the current standard procedure for revealing malreduction of fractures in the operating room. However, intra-operative visual inspection of the reduction result is complicated due to high inter-individual variation of the ankle anatomy and rather based on the subjective experience of the surgeon. A contralateral side comparison with the patient’s uninjured ankle is recommended but has not been integrated into clinical routine due to the high level of radiation exposure it incurs. This thesis presents the first approach towards a computer-assisted intra-operative contralateral side comparison of the ankle joint. The focus of this thesis was the design, development and validation of a software-based prototype for a fully automatic intra-operative assistance system for orthopedic surgeons. The implementation does not require an additional 3D C-arm scan of the uninjured ankle, thus reducing time consumption and cumulative radiation dose. A 3D statistical shape model (SSM) is used to reconstruct a 3D surface model from three 2D fluoroscopic projections representing the uninjured ankle. To this end, a 3D SSM segmentation is performed on the 3D image of the injured ankle to gain prior knowledge of the ankle. A 3D convolutional neural network (CNN) based initialization method was developed and its outcome was incorporated into the SSM adaption step. Segmentation quality was shown to be improved in terms of accuracy and robustness compared to the pure intensity-based SSM. This allows us to overcome the limitations of the previously proposed methods, namely inaccuracy due to metal artifacts and the lack of device-to-patient orientation of the C-arm. A 2D-CNN is employed to extract semantic knowledge from all fluoroscopic projection images. This step of the pipeline both creates features for the subsequent reconstruction and also helps to pre-initialize the 3D-SSM without user interaction. A 2D-3D multi-bone reconstruction method has been developed which uses distance maps of the 2D features for fast and accurate correspondence optimization and SSM adaption. This is the central and most crucial component of the workflow. This is the first time that a bone reconstruction method has been applied to the complex ankle joint and the first reconstruction method using CNN based segmentations as features. The reconstructed 3D-SSM of the uninjured ankle can be back-projected and visualized in a workflow-oriented manner to procure clear visualization of the region of interest, which is essential for the evaluation of the reduction result. The surgeon can thus directly compare an overlay of the contralateral ankle with the injured ankle. The developed methods were evaluated individually using data sets acquired during a cadaver study and representative clinical data acquired during fibular reduction. A hierarchical evaluation was designed to assess the inaccuracies of the system on different levels and to identify major sources of error. The overall evaluation performed on eleven challenging clinical datasets acquired for manual contralateral side comparison showed that the system is capable of accurately reconstructing 3D surface models of the uninjured ankle solely using three projection images. A mean Hausdorff distance of 1.72 mm was measured when comparing the reconstruction result to the ground truth segmentation and almost achieved the high required clinical accuracy of 1-2 mm. The overall error of the pipeline was mainly attributed to inaccuracies in the 2D-CNN segmentation. The consistency of these results requires further validation on a larger dataset. The workflow proposed in this thesis establishes the first approach to enable automatic computer-assisted contralateral side comparison in ankle surgery. The feasibility of the proposed approach was proven on a limited amount of clinical cases and has already yielded good results. The next important step is to alleviate the identified bottlenecks in the approach by providing more training data in order to further improve the accuracy. In conclusion, the new approach presented gives the chance to guide the surgeon during the reduction process, improve the surgical outcome while avoiding additional radiation exposure and reduce the number of revision surgeries in the long term