Assessing the Technical Specifications of Predictive Maintenance: A Case Study of Centrifugal Compressor

Dependability analyses in the design phase are common in IEC 60300 standards to assess the reliability, risk, maintainability, and maintenance supportability of specific physical assets. Reliability and risk assessment uses well-known methods such as failure modes, effects, and criticality analysis (FMECA), fault tree analysis (FTA), and event tree analysis (ETA)to identify critical components and failure modes based on failure rate, severity, and detectability. Monitoring technology has evolved over time, and a new method of failure mode and symptom analysis (FMSA) was introduced in ISO 13379-1 to identify the critical symptoms and descriptors of failure mechanisms. FMSA is used to estimate monitoring priority, and this helps to determine the critical monitoring specifications. However, FMSA cannot determine the effectiveness of technical specifications that are essential for predictive maintenance, such as detection techniques (capability and coverage), diagnosis (fault type, location, and severity), or prognosis (precision and predictive horizon). The paper proposes a novel predictive maintenance (PdM) assessment matrix to overcome these problems, which is tested using a case study of a centrifugal compressor and validated using empirical data provided by the case study company. The paper also demonstrates the possible enhancements introduced by Industry 4.0 technologies.publishedVersio

Monitoring of the central blood pressure waveform via a conformal ultrasonic device.

Continuous monitoring of the central-blood-pressure waveform from deeply embedded vessels, such as the carotid artery and jugular vein, has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep-tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood-pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments

Digital CMOS ISFET architectures and algorithmic methods for point-of-care diagnostics

Over the past decade, the surge of infectious diseases outbreaks across the globe is redefining how healthcare is provided and delivered to patients, with a clear trend towards distributed diagnosis at the Point-of-Care (PoC). In this context, Ion-Sensitive Field Effect Transistors (ISFETs) fabricated on standard CMOS technology have emerged as a promising solution to achieve a precise, deliverable and inexpensive platform that could be deployed worldwide to provide a rapid diagnosis of infectious diseases. This thesis presents advancements for the future of ISFET-based PoC diagnostic platforms, proposing and implementing a set of hardware and software methodologies to overcome its main challenges and enhance its sensing capabilities. The first part of this thesis focuses on novel hardware architectures that enable direct integration with computational capabilities while providing pixel programmability and adaptability required to overcome pressing challenges on ISFET-based PoC platforms. This section explores oscillator-based ISFET architectures, a set of sensing front-ends that encodes the chemical information on the duty cycle of a PWM signal. Two initial architectures are proposed and fabricated in AMS 0.35um, confirming multiple degrees of programmability and potential for multi-sensing. One of these architectures is optimised to create a dual-sensing pixel capable of sensing both temperature and chemical information on the same spatial point while modulating this information simultaneously on a single waveform. This dual-sensing capability, verified in silico using TSMC 0.18um process, is vital for DNA-based diagnosis where protocols such as LAMP or PCR require precise thermal control. The COVID-19 pandemic highlighted the need for a deliverable diagnosis that perform nucleic acid amplification tests at the PoC, requiring minimal footprint by integrating sensing and computational capabilities. In response to this challenge, a paradigm shift is proposed, advocating for integrating all elements of the portable diagnostic platform under a single piece of silicon, realising a ``Diagnosis-on-a-Chip". This approach is enabled by a novel Digital ISFET Pixel that integrates both ADC and memory with sensing elements on each pixel, enhancing its parallelism. Furthermore, this architecture removes the need for external instrumentation or memories and facilitates its integration with computational capabilities on-chip, such as the proposed ARM Cortex M3 system. These computational capabilities need to be complemented with software methods that enable sensing enhancement and new applications using ISFET arrays. The second part of this thesis is devoted to these methods. Leveraging the programmability capabilities available on oscillator-based architectures, various digital signal processing algorithms are implemented to overcome the most urgent ISFET non-idealities, such as trapped charge, drift and chemical noise. These methods enable fast trapped charge cancellation and enhanced dynamic range through real-time drift compensation, achieving over 36 hours of continuous monitoring without pixel saturation. Furthermore, the recent development of data-driven models and software methods open a wide range of opportunities for ISFET sensing and beyond. In the last section of this thesis, two examples of these opportunities are explored: the optimisation of image compression algorithms on chemical images generated by an ultra-high frame-rate ISFET array; and a proposed paradigm shift on surface Electromyography (sEMG) signals, moving from data-harvesting to information-focused sensing. These examples represent an initial step forward on a journey towards a new generation of miniaturised, precise and efficient sensors for PoC diagnostics.Open Acces

EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound - Part 1: Examination Techniques and Normal Findings (Long version).

Abstract ▼ In October 2014 the European Federation of Societies for Ultrasound in Medicine and Biology formed a Gastrointestinal Ultrasound (GIUS) task force group to promote the use of GIUS in a clinical setting. One of the main objectives of the task force group was to develop clinical recommendations and guidelines for the use of GIUS under the auspices of EFSUMB. The first part, gives an overview of the examination techniques for GIUS recommended by experts in the field. It also presents the current evidence for the interpretation of normal sonoanatomical and physiological features as examined with different ultrasound modalities

Vibro-acoustic Analysis of Reciprocating Compressor in the Context of Fault Diagnosis

This project assessed the behaviour of a positive displacement type of compressor utilising airborne acoustic signatures. The study concentrated on finding an improved method based on airborne sound that can be suitable for diagnosing some common faults in reciprocating compressor (RC). Being a critical component of the industry, the condition monitoring of reciprocating compressor is very much needed to avoid any failure of its machine parts that can cause a sudden breakdown of RC. The compressor acoustic signal is a result of various mechanical forces related to the varied cylinder pressure, valve movement, turbulence air flow which in terms contribute to the periodic excitation along with the non-linearity caused by the valve fluttering, hence making the airborne signal complex and non-stationary in nature. The transient response due to the periodic impact of the valves, modulation effect due to the fluid-mechanical interaction and low signal to noise ratio (SNR) are the challenging aspects of this study. To demonstrate the vibro-acoustic property of the reciprocating compressor, first a model was developed. The leakages in valve and intercooler are very common in RC. The second most common fault which is often neglected is a clogged filter. Hence, taking into consideration, filter blockage fault is introduced for the first time in the existing test set up. Three faults (discharge valve leakage, intercooler leakage and filter blockage) are simulated, and corresponding acoustic responses are recorded for further study of the signal-nature. The model is then validated by the actual data from RC test bed. Along with the modelling of compressor acoustics, various signal processing techniques like Minimum Entropy Deconvolution (MED), Teager Energy Operator (TEO) are used on the test data to detect abnormalities present. MED in this case, is proved to be effective in finding the transient responses whereas, TEO serves as an energy detection tool for tracking the total mechanical energy. Still both methods find it difficult to come up with the best possible diagnosis results as they fail to take all the major characteristics of the RC acoustics into consideration. To overcome this challenge, higher order spectral analysis as a form of Modulation Signal Bi-Spectrum (MSB) is used to find out the most effective modulating components by enhancing the modulating characteristics and suppressing the noise. Moreover, the quadratic phase coupling allows MSB to handle the non-linearity that might be present in RC due to the valve fluttering. The proposed MSB based method not only provides a more consistent and accurate diagnosis of compressor faults but also shows that airborne acoustics has a good aspect in fault identification of RC by validating both model and test results. Recognizing that there is perpetual room for improvement, the performance of the proposed RC fault diagnosis method can be enhanced by incorporating a denoising technique developed using the Variational Mode Decomposition (VMD) associated with Kalman filtering method. The future study must also consider several other individual and compound faults that can be incorporated in the study for understanding vibro-acoustic phenomena of RC

A new fault diagnosis method using deep belief network and compressive sensing

Compressive sensing provides a new idea for machinery monitoring, which greatly reduces the burden on data transmission. After that, the compressed signal will be used for fault diagnosis by feature extraction and fault classification. However, traditional fault diagnosis heavily depends on the prior knowledge and requires a signal reconstruction which will cost great time consumption. For this problem, a deep belief network (DBN) is used here for fault detection directly on compressed signal. This is the first time DBN is combined with the compressive sensing. The PCA analysis shows that DBN has successfully separated different features. The DBN method which is tested on compressed gearbox signal, achieves 92.5 % accuracy for 25 % compressed signal. We compare the DBN on both compressed and reconstructed signal, and find that the DBN using compressed signal not only achieves better accuracies, but also costs less time when compression ratio is less than 0.35. Moreover, the results have been compared with other classification methods

Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation

Ultrasonically probing optical absorption, photoacoustic tomography (PAT) combines rich optical contrast with high ultrasonic resolution at depths beyond the optical diffusion limit. With consistent optical absorption contrast at different scales and highly scalable spatial resolution and penetration depth, PAT holds great promise as an important tool for both fundamental research and clinical application. Despite tremendous progress, PAT still encounters certain limitations that prevent it from becoming readily adopted in the clinical settings. This dissertation aims to advance both the technical development and application of PAT towards its clinical translation. The first part of this dissertation describes the development of photoacoustic elastography techniques, which complement PAT with the capability to image the elastic properties of biological tissue and detect pathological conditions associated with its alterations. First, I demonstrated vascular-elastic PAT (VE-PAT), capable of quantifying blood vessel compliance changes due to thrombosis and occlusions. Then, I developed photoacoustic elastography to noninvasively map the elasticity distribution in biological tissue. Third, I further enhanced its performance by combing conventional photoacoustic elastography with a stress sensor having known stress–strain behavior to achieve quantitative photoacoustic elastography (QPAE). QPAE can quantify the Young’s modulus of biological tissues on an absolute scale. The second part of this dissertation introduces technical improvements of photoacoustic microscopy (PAM). First, by employing near-infrared (NIR) light for illumination, a greater imaging depth and finer lateral resolution were achieved by near-infrared optical-resolution PAM (NIR-OR-PAM). In addition, NIR-OR-PAM was capable of imaging other tissue components, including lipid and melanin. Second, I upgraded a high-speed functional OR-PAM (HF-OR-PAM) system and applied it to image neurovascular coupling during epileptic seizure propagation in mouse brains in vivo with high spatio-temporal resolution. Last, I developed a single-cell metabolic PAM (SCM-PAM) system, which improves the current single-cell oxygen consumption rate (OCR) measurement throughput from ~30 cells over 15 minutes to ~3000 cells over 15 minutes. This throughput enhancement of two orders of magnitude achieves modeling of single-cell OCR distribution with a statistically meaningful cell count. SCM-PAM enables imaging of intratumoral metabolic heterogeneity with single-cell resolution. The third part of this dissertation introduces the application of linear-array-based PAT (LA-PAT) in label-free high-throughput imaging of melanoma circulating tumor cells (CTCs) in patients in vivo. Taking advantage of the strong optical absorption of melanin and the unique capability of PAT to image optical absorption, with 100% relative sensitivity, at depths with high ultrasonic spatial resolution, LA-PAT is inherently suitable for melanoma CTC imaging. First, with a center ultrasonic frequency of 21 MHz, the LA-PAT system was able to detect melanoma CTCs clusters and quantify their sizes based on the contrast-to-noise ratio (CNR). Second, I developed an LA-PAT system with a center ultrasonic frequency of 40 MHz and imaged melanoma CTCs in patients in vivo with a CNR greater than 12. We successfully imaged 16 melanoma patients and detected melanoma CTCs in 3 of them. Among the CTC-positive patients, 67% had disease progression despite systemic therapy. In contrast, only 23% of the CTC-negative patients showed disease progression. This study lays a solid foundation for translating CTC detection to bedside for clinical care and decision-making