484 research outputs found

    Low power/low voltage techniques for analog CMOS circuits

    Get PDF

    Integrated interface electronics for capacitive MEMS inertial sensors

    Get PDF
    This thesis is composed of 13 publications and an overview of the research topic, which also summarizes the work. The research presented in this thesis concentrates on integrated circuits for the realization of interface electronics for capacitive MEMS (micro-electro-mechanical system) inertial sensors, i.e. accelerometers and gyroscopes. The research focuses on circuit techniques for capacitive detection and actuation and on high-voltage and clock generation within the sensor interface. Characteristics of capacitive accelerometers and gyroscopes and the electronic circuits for accessing the capacitive information in open- and closed-loop configurations are introduced in the thesis. One part of the experimental work, an accelerometer, is realized as a continuous-time closed-loop sensor, and is capable of achieving sub-micro-g resolution. The interface electronics is implemented in a 0.7-ยตm high-voltage technology. It consists of a force feedback loop, clock generation circuits, and a digitizer. Another part of the experimental work, an analog 2-axis gyroscope, is optimized not only for noise, but predominantly for low power consumption and a small chip area. The implementation includes a pseudo-continuous-time sense readout, analog continuous-time drive loop, phase-locked loop (PLL) for clock generation, and high-voltage circuits for electrostatic excitation and high-voltage detection. The interface is implemented in a 0.35-ยตm high-voltage technology within an active area of 2.5 mmยฒ. The gyroscope achieves a spot noise of 0.015 ยฐ/s/โˆšHฬ…zฬ… for the x-axis and 0.041 ยฐ/s/โˆšHฬ…zฬ… for the y-axis. Coherent demodulation and discrete-time signal processing are often an important part of the sensors and also typical examples that require clock signals. Thus, clock generation within the sensor interfaces is also reviewed. The related experimental work includes two integrated charge pump PLLs, which are optimized for compact realization but also considered with regard to their noise performance. Finally, this thesis discusses fully integrated high-voltage generation, which allows a higher electrostatic force and signal current in capacitive sensors. Open- and closed-loop Dickson charge pumps and high-voltage amplifiers have been realized fully on-chip, with the focus being on optimizing the chip area and on generating precise spurious free high-voltage signals up to 27 V

    ๊ณ ์† ์‹œ๋ฆฌ์–ผ ๋งํฌ๋ฅผ ์œ„ํ•œ ๊ณ ๋ฆฌ ๋ฐœ์ง„๊ธฐ๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ ํ•˜๋Š” ์ฃผํŒŒ์ˆ˜ ํ•ฉ์„ฑ๊ธฐ

    Get PDF
    ํ•™์œ„๋…ผ๋ฌธ(๋ฐ•์‚ฌ) -- ์„œ์šธ๋Œ€ํ•™๊ต๋Œ€ํ•™์› : ๊ณต๊ณผ๋Œ€ํ•™ ์ „๊ธฐยท์ •๋ณด๊ณตํ•™๋ถ€, 2022. 8. ์ •๋•๊ท .In this dissertation, major concerns in the clocking of modern serial links are discussed. As sub-rate, multi-standard architectures are becoming predominant, the conventional clocking methodology seems to necessitate innovation in terms of low-cost implementation. Frequency synthesis with active, inductor-less oscillators replacing LC counterparts are reviewed, and solutions for two major drawbacks are proposed. Each solution is verified by prototype chip design, giving a possibility that the inductor-less oscillator may become a proper candidate for future high-speed serial links. To mitigate the high flicker noise of a high-frequency ring oscillator (RO), a reference multiplication technique that effectively extends the bandwidth of the following all-digital phase-locked loop (ADPLL) is proposed. The technique avoids any jitter accumulation, generating a clean mid-frequency clock, overall achieving high jitter performance in conjunction with the ADPLL. Timing constraint for the proper reference multiplication is first analyzed to determine the calibration points that may correct the existent phase errors. The weight for each calibration point is updated by the proposed a priori probability-based least-mean-square (LMS) algorithm. To minimize the time required for the calibration, each gain for the weight update is adaptively varied by deducing a posteriori which error source dominates the others. The prototype chip is fabricated in a 40-nm CMOS technology, and its measurement results verify the low-jitter, high-frequency clock generation with fast calibration settling. The presented work achieves an rms jitter of 177/223 fs at 8/16-GHz output, consuming 12.1/17-mW power. As the second embodiment, an RO-based ADPLL with an analog technique that addresses the high supply sensitivity of the RO is presented. Unlike prior arts, the circuit for the proposed technique does not extort the RO voltage headroom, allowing high-frequency oscillation. Further, the performance given from the technique is robust over process, voltage, and temperature (PVT) variations, avoiding the use of additional calibration hardware. Lastly, a comprehensive analysis of phase noise contribution is conducted for the overall ADPLL, followed by circuit optimizations, to retain the low-jitter output. Implemented in a 40-nm CMOS technology, the frequency synthesizer achieves an rms jitter of 289 fs at 8 GHz output without any injected supply noise. Under a 20-mVrms white supply noise, the ADPLL suppresses supply-noise-induced jitter by -23.8 dB.๋ณธ ๋…ผ๋ฌธ์€ ํ˜„๋Œ€ ์‹œ๋ฆฌ์–ผ ๋งํฌ์˜ ํด๋ฝํ‚น์— ๊ด€์—ฌ๋˜๋Š” ์ฃผ์š”ํ•œ ๋ฌธ์ œ๋“ค์— ๋Œ€ํ•˜์—ฌ ๊ธฐ์ˆ ํ•œ๋‹ค. ์ค€์†๋„, ๋‹ค์ค‘ ํ‘œ์ค€ ๊ตฌ์กฐ๋“ค์ด ์ฑ„ํƒ๋˜๊ณ  ์žˆ๋Š” ์ถ”์„ธ์— ๋”ฐ๋ผ, ๊ธฐ์กด์˜ ํด๋ผํ‚น ๋ฐฉ๋ฒ•์€ ๋‚ฎ์€ ๋น„์šฉ์˜ ๊ตฌํ˜„์˜ ๊ด€์ ์—์„œ ์ƒˆ๋กœ์šด ํ˜์‹ ์„ ํ•„์š”๋กœ ํ•œ๋‹ค. LC ๊ณต์ง„๊ธฐ๋ฅผ ๋Œ€์‹ ํ•˜์—ฌ ๋Šฅ๋™ ์†Œ์ž ๋ฐœ์ง„๊ธฐ๋ฅผ ์‚ฌ์šฉํ•œ ์ฃผํŒŒ์ˆ˜ ํ•ฉ์„ฑ์— ๋Œ€ํ•˜์—ฌ ์•Œ์•„๋ณด๊ณ , ์ด์— ๋ฐœ์ƒํ•˜๋Š” ๋‘๊ฐ€์ง€ ์ฃผ์š” ๋ฌธ์ œ์ ๊ณผ ๊ฐ๊ฐ์— ๋Œ€ํ•œ ํ•ด๊ฒฐ ๋ฐฉ์•ˆ์„ ํƒ์ƒ‰ํ•œ๋‹ค. ๊ฐ ์ œ์•ˆ ๋ฐฉ๋ฒ•์„ ํ”„๋กœํ† ํƒ€์ž… ์นฉ์„ ํ†ตํ•ด ๊ทธ ํšจ์šฉ์„ฑ์„ ๊ฒ€์ฆํ•˜๊ณ , ์ด์–ด์„œ ๋Šฅ๋™ ์†Œ์ž ๋ฐœ์ง„๊ธฐ๊ฐ€ ๋ฏธ๋ž˜์˜ ๊ณ ์† ์‹œ๋ฆฌ์–ผ ๋งํฌ์˜ ํด๋ฝํ‚น์— ์‚ฌ์šฉ๋  ๊ฐ€๋Šฅ์„ฑ์— ๋Œ€ํ•ด ๊ฒ€ํ† ํ•œ๋‹ค. ์ฒซ๋ฒˆ์งธ ์‹œ์—ฐ์œผ๋กœ์จ, ๊ณ ์ฃผํŒŒ ๊ณ ๋ฆฌ ๋ฐœ์ง„๊ธฐ์˜ ๋†’์€ ํ”Œ๋ฆฌ์ปค ์žก์Œ์„ ์™„ํ™”์‹œํ‚ค๊ธฐ ์œ„ํ•ด ๊ธฐ์ค€ ์‹ ํ˜ธ๋ฅผ ๋ฐฐ์ˆ˜ํ™”ํ•˜์—ฌ ๋’ท๋‹จ์˜ ์œ„์ƒ ๊ณ ์ • ๋ฃจํ”„์˜ ๋Œ€์—ญํญ์„ ํšจ๊ณผ์ ์œผ๋กœ ๊ทน๋Œ€ํ™” ์‹œํ‚ค๋Š” ํšŒ๋กœ ๊ธฐ์ˆ ์„ ์ œ์•ˆํ•œ๋‹ค. ๋ณธ ๊ธฐ์ˆ ์€ ์ง€ํ„ฐ๋ฅผ ๋ˆ„์  ์‹œํ‚ค์ง€ ์•Š์œผ๋ฉฐ ๋”ฐ๋ผ์„œ ๊นจ๋—ํ•œ ์ค‘๊ฐ„ ์ฃผํŒŒ์ˆ˜ ํด๋ฝ์„ ์ƒ์„ฑ์‹œ์ผœ ์œ„์ƒ ๊ณ ์ • ๋ฃจํ”„์™€ ํ•จ๊ป˜ ๋†’์€ ์„ฑ๋Šฅ์˜ ๊ณ ์ฃผํŒŒ ํด๋ฝ์„ ํ•ฉ์„ฑํ•œ๋‹ค. ๊ธฐ์ค€ ์‹ ํ˜ธ๋ฅผ ์„ฑ๊ณต์ ์œผ๋กœ ๋ฐฐ์ˆ˜ํ™”ํ•˜๊ธฐ ์œ„ํ•œ ํƒ€์ด๋ฐ ์กฐ๊ฑด๋“ค์„ ๋จผ์ € ๋ถ„์„ํ•˜์—ฌ ํƒ€์ด๋ฐ ์˜ค๋ฅ˜๋ฅผ ์ œ๊ฑฐํ•˜๊ธฐ ์œ„ํ•œ ๋ฐฉ๋ฒ•๋ก ์„ ํŒŒ์•…ํ•œ๋‹ค. ๊ฐ ๊ต์ • ์ค‘๋Ÿ‰์€ ์—ฐ์—ญ์  ํ™•๋ฅ ์„ ๊ธฐ๋ฐ˜์œผ๋กœํ•œ LMS ์•Œ๊ณ ๋ฆฌ์ฆ˜์„ ํ†ตํ•ด ๊ฐฑ์‹ ๋˜๋„๋ก ์„ค๊ณ„๋œ๋‹ค. ๊ต์ •์— ํ•„์š”ํ•œ ์‹œ๊ฐ„์„ ์ตœ์†Œํ™” ํ•˜๊ธฐ ์œ„ํ•˜์—ฌ, ๊ฐ ๊ต์ • ์ด๋“์€ ํƒ€์ด๋ฐ ์˜ค๋ฅ˜ ๊ทผ์›๋“ค์˜ ํฌ๊ธฐ๋ฅผ ๊ท€๋‚ฉ์ ์œผ๋กœ ์ถ”๋ก ํ•œ ๊ฐ’์„ ๋ฐ”ํƒ•์œผ๋กœ ์ง€์†์ ์œผ๋กœ ์ œ์–ด๋œ๋‹ค. 40-nm CMOS ๊ณต์ •์œผ๋กœ ๊ตฌํ˜„๋œ ํ”„๋กœํ† ํƒ€์ž… ์นฉ์˜ ์ธก์ •์„ ํ†ตํ•ด ์ €์†Œ์Œ, ๊ณ ์ฃผํŒŒ ํด๋ฝ์„ ๋น ๋ฅธ ๊ต์ • ์‹œ๊ฐ„์•ˆ์— ํ•ฉ์„ฑํ•ด ๋ƒ„์„ ํ™•์ธํ•˜์˜€๋‹ค. ์ด๋Š” 177/223 fs์˜ rms ์ง€ํ„ฐ๋ฅผ ๊ฐ€์ง€๋Š” 8/16 GHz์˜ ํด๋ฝ์„ ์ถœ๋ ฅํ•œ๋‹ค. ๋‘๋ฒˆ์งธ ์‹œ์—ฐ์œผ๋กœ์จ, ๊ณ ๋ฆฌ ๋ฐœ์ง„๊ธฐ์˜ ๋†’์€ ์ „์› ๋…ธ์ด์ฆˆ ์˜์กด์„ฑ์„ ์™„ํ™”์‹œํ‚ค๋Š” ๊ธฐ์ˆ ์ด ํฌํ•จ๋œ ์ฃผํŒŒ์ˆ˜ ํ•ฉ์„ฑ๊ธฐ๊ฐ€ ์„ค๊ณ„๋˜์—ˆ๋‹ค. ์ด๋Š” ๊ณ ๋ฆฌ ๋ฐœ์ง„๊ธฐ์˜ ์ „์•• ํ—ค๋“œ๋ฃธ์„ ๋ณด์กดํ•จ์œผ๋กœ์„œ ๊ณ ์ฃผํŒŒ ๋ฐœ์ง„์„ ๊ฐ€๋Šฅํ•˜๊ฒŒ ํ•œ๋‹ค. ๋‚˜์•„๊ฐ€, ์ „์› ๋…ธ์ด์ฆˆ ๊ฐ์†Œ ์„ฑ๋Šฅ์€ ๊ณต์ •, ์ „์••, ์˜จ๋„ ๋ณ€๋™์— ๋Œ€ํ•˜์—ฌ ๋ฏผ๊ฐํ•˜์ง€ ์•Š์œผ๋ฉฐ, ๋”ฐ๋ผ์„œ ์ถ”๊ฐ€์ ์ธ ๊ต์ • ํšŒ๋กœ๋ฅผ ํ•„์š”๋กœ ํ•˜์ง€ ์•Š๋Š”๋‹ค. ๋งˆ์ง€๋ง‰์œผ๋กœ, ์œ„์ƒ ๋…ธ์ด์ฆˆ์— ๋Œ€ํ•œ ํฌ๊ด„์  ๋ถ„์„๊ณผ ํšŒ๋กœ ์ตœ์ ํ™”๋ฅผ ํ†ตํ•˜์—ฌ ์ฃผํŒŒ์ˆ˜ ํ•ฉ์„ฑ๊ธฐ์˜ ์ €์žก์Œ ์ถœ๋ ฅ์„ ๋ฐฉํ•ดํ•˜์ง€ ์•Š๋Š” ๋ฐฉ๋ฒ•์„ ๊ณ ์•ˆํ•˜์˜€๋‹ค. ํ•ด๋‹น ํ”„๋กœํ† ํƒ€์ž… ์นฉ์€ 40-nm CMOS ๊ณต์ •์œผ๋กœ ๊ตฌํ˜„๋˜์—ˆ์œผ๋ฉฐ, ์ „์› ๋…ธ์ด์ฆˆ๊ฐ€ ์ธ๊ฐ€๋˜์ง€ ์•Š์€ ์ƒํƒœ์—์„œ 289 fs์˜ rms ์ง€ํ„ฐ๋ฅผ ๊ฐ€์ง€๋Š” 8 GHz์˜ ํด๋ฝ์„ ์ถœ๋ ฅํ•œ๋‹ค. ๋˜ํ•œ, 20 mVrms์˜ ์ „์› ๋…ธ์ด์ฆˆ๊ฐ€ ์ธ๊ฐ€๋˜์—ˆ์„ ๋•Œ์— ์œ ๋„๋˜๋Š” ์ง€ํ„ฐ์˜ ์–‘์„ -23.8 dB ๋งŒํผ ์ค„์ด๋Š” ๊ฒƒ์„ ํ™•์ธํ•˜์˜€๋‹ค.1 Introduction 1 1.1 Motivation 3 1.1.1 Clocking in High-Speed Serial Links 4 1.1.2 Multi-Phase, High-Frequency Clock Conversion 8 1.2 Dissertation Objectives 10 2 RO-Based High-Frequency Synthesis 12 2.1 Phase-Locked Loop Fundamentals 12 2.2 Toward All-Digital Regime 15 2.3 RO Design Challenges 21 2.3.1 Oscillator Phase Noise 21 2.3.2 Challenge 1: High Flicker Noise 23 2.3.3 Challenge 2: High Supply Noise Sensitivity 26 3 Filtering RO Noise 28 3.1 Introduction 28 3.2 Proposed Reference Octupler 34 3.2.1 Delay Constraint 34 3.2.2 Phase Error Calibration 38 3.2.3 Circuit Implementation 51 3.3 IL-ADPLL Implementation 55 3.4 Measurement Results 59 3.5 Summary 63 4 RO Supply Noise Compensation 69 4.1 Introduction 69 4.2 Proposed Analog Closed Loop for Supply Noise Compensation 72 4.2.1 Circuit Implementation 73 4.2.2 Frequency-Domain Analysis 76 4.2.3 Circuit Optimization 81 4.3 ADPLL Implementation 87 4.4 Measurement Results 90 4.5 Summary 98 5 Conclusions 99 A Notes on the 8REF 102 B Notes on the ACSC 105๋ฐ•

    LASER Tech Briefs, September 1993

    Get PDF
    This edition of LASER Tech briefs contains a feature on photonics. The other topics include: Electronic Components and Circuits. Electronic Systems, Physical Sciences, Materials, Computer Programs, Mechanics, Machinery, Fabrication Technology, Mathematics and Information Sciences, Life Sciences and books and reports

    Digital enhancement techniques for fractional-N frequency synthesizers

    Get PDF
    Meeting the demand for unprecedented connectivity in the era of internet-of-things (IoT) requires extremely energy efficient operation of IoT nodes to extend battery life. Managing the data traffic generated by trillions of such nodes also puts severe energy constraints on the data centers. Clock generators that are essential elements in these systems consume significant power and therefore must be optimized for low power and high performance. The focus of this thesis is on improving the energy efficiency of frequency synthesizers and clocking modules by exploring design techniques at both the architectural and circuit levels. In the first part of this work, a digital fractional-N phase locked loop (FNPLL) that employs a high resolution time-to-digital converter (TDC) and a truly ฮ”ฮฃ fractional divider to achieve low in-band noise with a wide bandwidth is presented. The fractional divider employs a digital-to-time converter (DTC) to cancel out ฮ”ฮฃ quantization noise in time domain, thus alleviating TDC dynamic range requirements. The proposed digital architecture adopts a narrow range low-power time-amplifier based TDC (TA-TDC) to achieve sub 1ps resolution. Fabricated in 65nm CMOS process, the prototype PLL achieves better than -106dBc/Hz in-band noise and 3MHz PLL bandwidth at 4.5GHz output frequency using 50MHz reference. The PLL achieves excellent jitter performance of 490fsrms, while consumes only 3.7mW. This translates to the best reported jitter-power figure-of-merit (FoM) of -240.5dB among previously reported FNPLLs. Phase noise performance of ring oscillator based digital FNPLLs is severely compromised by conflicting bandwidth requirements to simultaneously suppress oscillator phase and quantization noise introduced by the TDC, ฮ”ฮฃ fractional divider, and digital-to-analog converter (DAC). As a consequence, their FoM that quantifies the power-jitter tradeoff is at least 25dB worse than their LC-oscillator based FNPLL counterparts. In the second part of this thesis, we seek to close this performance gap by extending PLL bandwidth using quantization noise cancellation techniques and by employing a dual-path digital loop filter to suppress the detrimental impact of DAC quantization noise. A prototype was implemented in a 65nm CMOS process operating over a wide frequency range of 2.0GHz-5.5GHz using a modified extended range multi-modulus divider with seamless switching. The proposed digital FNPLL achieves 1.9psrms integrated jitter while consuming only 4mW at 5GHz output. The measured in-band phase noise is better than -96 dBc/Hz at 1MHz offset. The proposed FNPLL achieves wide bandwidth up to 6MHz using a 50 MHz reference and its FoM is -228.5dB, which is at about 20dB better than previously reported ring-based digital FNPLLs. In the third part, we propose a new multi-output clock generator architecture using open loop fractional dividers for system-on-chip (SoC) platforms. Modern multi-core processors use per core clocking, where each core runs at its own speed. The core frequency can be changed dynamically to optimize for performance or power dissipation using a dynamic frequency scaling (DFS) technique. Fast frequency switching is highly desirable as long as it does not interrupt code execution; therefore it requires smooth frequency transitions with no undershoots. The second main requirement in processor clocking is the capability of spread spectrum frequency modulation. By spreading the clock energy across a wide bandwidth, the electromagnetic interference (EMI) is dramatically reduced. A conventional PLL clock generation approach suffers from a slow frequency settling and limited spread spectrum modulation capabilities. The proposed open loop fractional divider architecture overcomes the bandwidth limitation in fractional-N PLLs. The fractional divider switches the output frequency instantaneously and provides an excellent spread spectrum performance, where precise and programmable modulation depth and frequency can be applied to satisfy different EMI requirements. The fractional divider has unlimited modulation bandwidth resulting in spread spectrum modulation with no filtering, unlike fractional-N PLL; consequently it achieves higher EMI reduction. A prototype fractional divider was implemented in a 65nm CMOS process, where the measured peak-to-peak jitter is less than 27ps over a wide frequency range from 20MHz to 1GHz. The total power consumption is about 3.2mW for 1GHz output frequency. The all-digital implementation of the divider occupies the smallest area of 0.017mm2 compared to state-of-the-art designs. As the data rate of serial links goes higher, the jitter requirements of the clock generator become more stringent. Improving the jitter performance of conventional PLLs to less than (200fsrms) always comes with a large power penalty (tens of mWs). This is due to the PLL coupled noise bandwidth trade-off, which imposes stringent noise requirements on the oscillator and/or loop components. Alternatively, an injection-locked clock multiplier (ILCM) provides many advantages in terms of phase noise, power, and area compared to classical PLLs, but they suffer from a narrow lock-in range and a high sensitivity to PVT variations especially at a large multiplication factor (N). In the fourth part of this thesis, a low-jitter, low-power LC-based ILCM with a digital frequency-tracking loop (FTL) is presented. The proposed FTL relies on a new pulse gating technique to continuously tune the oscillator's free-running frequency. The FTL ensures robust operation across PVT variations and resolves the race condition existing in injection locked PLLs by decoupling frequency tuning from the injection path. As a result, the phase locking condition is only determined by the injection path. This work also introduces an accurate theoretical large-signal analysis for phase domain response (PDR) of injection locked oscillators (ILOs). The proposed PDR analysis captures the asymmetric nature of ILO's lock-in range, and the impact of frequency error on injection strength and phase noise performance. The proposed architecture and analysis are demonstrated by a prototype fabricated in 65 nm CMOS process with active area of 0.25mm2. The prototype ILCM multiplies the reference frequency by 64 to generate an output clock in the range of 6.75GHz-8.25GHz. A superior jitter performance of 190fsrms is achieved, while consuming only 2.25mW power. This translates to a best FoM of -251dB. Unlike conventional PLLs, ILCMs have been fundamentally limited to only integer-N operation and cannot synthesize fractional-N frequencies. In the last part of this thesis, we extend the merits of ILCMs to fractional-N and overcome this fundamental limitation. We employ DTC-based QNC techniques in order to align injected pulses to the oscillator's zero crossings, which enables it to pull the oscillator toward phase lock, thus realizing a fractional-N ILCM. Fabricated in 65nm CMOS process, a prototype 20-bit fractional-N ILCM with an output range of 6.75GHz-8.25GHz consumes only 3.25mW. It achieves excellent jitter performance of 110fsrms and 175fsrms in integer- and fractional-N modes respectively, which translates to the best-reported FoM in both integer- (-255dB) and fractional-N (-252dB) modes. The proposed fractional-N ILCM also features the first-reported rapid on/off capability, where the transient absolute jitter performance at wake-up is bounded below 4ps after less than 4ns. This demonstrates almost instantaneous phase settling. This unique capability enables tremendous energy saving by turning on the clock multiplier only when needed. This energy proportional operation leverages idle times to save power at the system-level of wireline and wireless transceivers

    Design, Construction, and Applications of a High-Resolution Terahertz Time-Domain Spectrometer

    Get PDF
    This thesis reports on the design, construction, and initial applications of a high-resolution terahertz time-domain ASOPS spectrometer. The instrument employs asynchronous optical sampling (ASOPS) between two Ti:sapphire ultrafast lasers operating at a repetition rate of approximately 80 MHz, and we thus demonstrate a THz frequency resolution approaching the limit of that repetition rate. This is an order of magnitude improvement in resolution over typical THz time-domain spectrometers. The improved resolution is important for our primary effort of collecting THz spectra for far-infrared astronomy. We report on various spectroscopic applications including the THz rotational spectrum of water, where we achieve a mean frequency error, relative to established line centers, of 27.0 MHz. We also demonstrate application of the THz system to the long-duration observation of a coherent magnon mode in a anti-ferromagnetic yttrium iron oxide (YFeO3) crystal. Furthermore, we apply the all-optical virtual delay line of ASOPS to a transient thermoreflectance experiment for quickly measuring the thermal conductivity of semiconductors

    Space programs summary no. 37-45, volume IV FOR the period April 1, 1967 to May 31, 1967. Supporting research and advanced development

    Get PDF
    Space exploration projects on systems, guidance and control, environmental simulation, space sciences, propulsion, telecommunications, and engineering mechanic

    Thermal unfolding dynamics of proteins probed by nonlinear infrared spectroscopy

    Get PDF
    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2007.Vita.Includes bibliographical references.This thesis presents spectroscopic approaches to study the thermal unfolding dynamics of proteins. The spectroscopic tool is nonlinear infrared (IR) spectroscopy of the protein amide I band. Among various nonlinear IR techniques, two-dimensional infrared (2D IR) spectroscopy, which is an IR analogue of 2D NMR, is the most informative. A 2D IR spectrum is obtained from a double Fourier transform of the heterodyned third-order nonlinear signal, which is generated by three consecutive interactions between femtosecond IR pulses and the vibrations of the system. This technique is sensitive to the presence of P-sheet structure in proteins through the formation of cross peaks between the two characteristic vibrational modes of 0-sheets. In this work, 2D IR spectroscopy is used to measure equilibrium thermal unfolding of ribonuclease A and ubiquitin. For transient unfolding studies, the temperature of the solution is rapidly raised by a nanosecond temperature jump (T-jump) laser, which is followed by probing structural changes of proteins with dispersed vibrational echo (DVE) spectroscopy or 2D IR spectroscopy.(cont.) DVE spectroscopy is a homodyne measurement of the third-order signal, in which the spectrum is related to a projection of a complex 2D IR spectrum onto one of the frequency axes (03). In spite of its reduced dimension measurement, DVE spectroscopy is sensitive enough to be utilized in transient probing with less experimental challenges. From transient thermal unfolding studies of ubiquitin probed by DVE spectroscopy, complicated non-exponential relaxations are observed on the microsecond timescale, which are followed by ms unfolding. Non-exponential relaxation is interpreted as downhill unfolding of a transient species populated around the top of a barrier (transition state) due to the barrier shift caused by a rapid T-jump. Variations in the unfolding transition state of ubiquitin are further investigated with temperature-dependent T-jump experiments and mutation studies. Experimental conclusions are supported by calculations of the unfolding free energy surfaces using statistical mechanical modeling. T-jump 2D IR spectroscopy is also performed to remove ambiguities in the projected domain of DVE spectroscopy and provide a new spectroscopic measure for transient unfolding through line-broadening analysis.by Hoi Sung Chung.Ph.D
    • โ€ฆ
    corecore