Computational Intelligence in Healthcare

This book is a printed edition of the Special Issue Computational Intelligence in Healthcare that was published in Electronic

Computational Intelligence in Healthcare

The number of patient health data has been estimated to have reached 2314 exabytes by 2020. Traditional data analysis techniques are unsuitable to extract useful information from such a vast quantity of data. Thus, intelligent data analysis methods combining human expertise and computational models for accurate and in-depth data analysis are necessary. The technological revolution and medical advances made by combining vast quantities of available data, cloud computing services, and AI-based solutions can provide expert insight and analysis on a mass scale and at a relatively low cost. Computational intelligence (CI) methods, such as fuzzy models, artificial neural networks, evolutionary algorithms, and probabilistic methods, have recently emerged as promising tools for the development and application of intelligent systems in healthcare practice. CI-based systems can learn from data and evolve according to changes in the environments by taking into account the uncertainty characterizing health data, including omics data, clinical data, sensor, and imaging data. The use of CI in healthcare can improve the processing of such data to develop intelligent solutions for prevention, diagnosis, treatment, and follow-up, as well as for the analysis of administrative processes. The present Special Issue on computational intelligence for healthcare is intended to show the potential and the practical impacts of CI techniques in challenging healthcare applications

Neuropathy Classification of Corneal Nerve Images Using Artificial Intelligence

Nerve variations in the human cornea have been associated with alterations in the neuropathy state of a patient suffering from chronic diseases. For some diseases, such as diabetes, detection of neuropathy prior to visible symptoms is important, whereas for others, such as multiple sclerosis, early prediction of disease worsening is crucial. As current methods fail to provide early diagnosis of neuropathy, in vivo corneal confocal microscopy enables very early insight into the nerve damage by illuminating and magnifying the human cornea. This non-invasive method captures a sequence of images from the corneal sub-basal nerve plexus. Current practices of manual nerve tracing and classification impede the advancement of medical research in this domain. Since corneal nerve analysis for neuropathy is in its initial stages, there is a dire need for process automation. To address this limitation, we seek to automate the two stages of this process: nerve segmentation and neuropathy classification of images. For nerve segmentation, we compare the performance of two existing solutions on multiple datasets to select the appropriate method and proceed to the classification stage. Consequently, we approach neuropathy classification of the images through artificial intelligence using Adaptive Neuro-Fuzzy Inference System, Support Vector Machines, Naïve Bayes and k-nearest neighbors. We further compare the performance of machine learning classifiers with deep learning. We ascertained that nerve segmentation using convolutional neural networks provided a significant improvement in sensitivity and false negative rate by at least 5% over the state-of-the-art software. For classification, ANFIS yielded the best classification accuracy of 93.7% compared to other classifiers. Furthermore, for this problem, machine learning approaches performed better in terms of classification accuracy than deep learning

Probabilistic Modeling and Inference for Obfuscated Network Attack Sequences

Prevalent computing devices with networking capabilities have become critical network infrastructure for government, industry, academia and every-day life. As their value rises, the motivation driving network attacks on this infrastructure has shifted from the pursuit of notoriety to the pursuit of profit or political gains, leading to network attack on various scales. Facing diverse network attack strategies and overwhelming alters, much work has been devoted to correlate observed malicious events to pre-defined scenarios, attempting to deduce the attack plans based on expert models of how network attacks may transpire. We started the exploration of characterizing network attacks by investigating how temporal and spatial features of attack sequence can be used to describe different types of attack sources in real data set. Attack sequence models were built from real data set to describe different attack strategies. Based on the probabilistic attack sequence model, attack predictions were made to actively predict next possible actions. Experiments through attack predictions have revealed that sophisticated attackers can employ a number of obfuscation techniques to confuse the alert correlation engine or classifier. Unfortunately, most exiting work treats attack obfuscations by developing ad-hoc fixes to specific obfuscation technique. To this end, we developed an attack modeling framework that enables a systematical analysis of obfuscations. The proposed framework represents network attack strategies as general finite order Markov models and integrates it with different attack obfuscation models to form probabilistic graphical model models. A set of algorithms is developed to inference the network attack strategies given the models and the observed sequences, which are likely to be obfuscated. The algorithms enable an efficient analysis of the impact of different obfuscation techniques and attack strategies, by determining the expected classification accuracy of the obfuscated sequences. The algorithms are developed by integrating the recursion concept in dynamic programming and the Monte-Carlo method. The primary contributions of this work include the development of the formal framework and the algorithms to evaluate the impact of attack obfuscations. Several knowledge-driven attack obfuscation models are developed and analyzed to demonstrate the impact of different types of commonly used obfuscation techniques. The framework and algorithms developed in this work can also be applied to other contexts beyond network security. Any behavior sequences that might suffer from noise and require matching to pre-defined models can use this work to recover the most likely original sequence or evaluate quantitatively the expected classification accuracy one can achieve to separate the sequences

ISBIS 2016: Meeting on Statistics in Business and Industry

This Book includes the abstracts of the talks presented at the 2016 International Symposium on Business and Industrial Statistics, held at Barcelona, June 8-10, 2016, hosted at the Universitat Politècnica de Catalunya - Barcelona TECH, by the Department of Statistics and Operations Research. The location of the meeting was at ETSEIB Building (Escola Tecnica Superior d'Enginyeria Industrial) at Avda Diagonal 647. The meeting organizers celebrated the continued success of ISBIS and ENBIS society, and the meeting draw together the international community of statisticians, both academics and industry professionals, who share the goal of making statistics the foundation for decision making in business and related applications. The Scientific Program Committee was constituted by: David Banks, Duke University Amílcar Oliveira, DCeT - Universidade Aberta and CEAUL Teresa A. Oliveira, DCeT - Universidade Aberta and CEAUL Nalini Ravishankar, University of Connecticut Xavier Tort Martorell, Universitat Politécnica de Catalunya, Barcelona TECH Martina Vandebroek, KU Leuven Vincenzo Esposito Vinzi, ESSEC Business Schoo

Data Mining

Data mining is a branch of computer science that is used to automatically extract meaningful, useful knowledge and previously unknown, hidden, interesting patterns from a large amount of data to support the decision-making process. This book presents recent theoretical and practical advances in the field of data mining. It discusses a number of data mining methods, including classification, clustering, and association rule mining. This book brings together many different successful data mining studies in various areas such as health, banking, education, software engineering, animal science, and the environment

Preparation of Silver Decorated Reduced Graphene Oxide Nanohybrid for Effective Photocatalytic Degradation of Indigo Carmine Dye

Background: Even though silver decorated reduced graphene oxide (Ag-rGO) shows max- imum absorptivity in the UV region, most of the research on the degradation of dyes using Ag-rGO is in the visible region. Therefore the present work focused on the photocatalytic degradation of indigo carmine (IC) dye in the presence of Ag-rGO as a catalyst by UV light irradiation. Methods: In this context, silver-decorated reduced graphene oxide hybrid material was fabricated and explored its potential for the photocatalytic degradation of aqueous IC solution in the UV region. The decoration of Ag nanoparticles on the surface of the rGO nanosheets is evidenced by TEM analysis. The extent of mineralization of the dye was measured by estimating chemical oxygen demand (COD) values before and after irradiation. Results: The synthesized Ag-rGO binary composites displayed excellent photocatalytic activity in 2 Χ 10-5 M IC concentration and 5mg catalyst loading. The optical absorption spectrum of Ag-rGO showed that the energy band-gap was found to be 2.27 eV, which is significantly smaller compared to the band-gap of GO. 5 mg of Ag-rGO was found to be an optimum quantity for the effective degrada- tion of IC dye. The degradation rate increases with the decrease in the concentration of the dye at al- kaline pH conditions. The photocatalytic efficiency was 92% for the second time. Conclusion: The impact of the enhanced reactive species generation was consistent with higher pho- tocatalytic dye degradation. The photocatalytic mechanism has been proposed and the hydroxyl radi- cal was found to be the reactive species responsible for the degradation of dye. The feasibility of reus- ing the photocatalyst showed that the photocatalytic efficiency was very effective for the second tim

Speech data analysis for semantic indexing of video of simulated medical crises.

The Simulation for Pediatric Assessment, Resuscitation, and Communication (SPARC) group within the Department of Pediatrics at the University of Louisville, was established to enhance the care of children by using simulation based educational methodologies to improve patient safety and strengthen clinician-patient interactions. After each simulation session, the physician must manually review and annotate the recordings and then debrief the trainees. The physician responsible for the simulation has recorded 100s of videos, and is seeking solutions that can automate the process. This dissertation introduces our developed system for efficient segmentation and semantic indexing of videos of medical simulations using machine learning methods. It provides the physician with automated tools to review important sections of the simulation by identifying who spoke, when and what was his/her emotion. Only audio information is extracted and analyzed because the quality of the image recording is low and the visual environment is static for most parts. Our proposed system includes four main components: preprocessing, speaker segmentation, speaker identification, and emotion recognition. The preprocessing consists of first extracting the audio component from the video recording. Then, extracting various low-level audio features to detect and remove silence segments. We investigate and compare two different approaches for this task. The first one is threshold-based and the second one is classification-based. The second main component of the proposed system consists of detecting speaker changing points for the purpose of segmenting the audio stream. We propose two fusion methods for this task. The speaker identification and emotion recognition components of our system are designed to provide users the capability to browse the video and retrieve shots that identify ”who spoke, when, and the speaker’s emotion” for further analysis. For this component, we propose two feature representation methods that map audio segments of arbitary length to a feature vector with fixed dimensions. The first one is based on soft bag-of-word (BoW) feature representations. In particular, we define three types of BoW that are based on crisp, fuzzy, and possibilistic voting. The second feature representation is a generalization of the BoW and is based on Fisher Vector (FV). FV uses the Fisher Kernel principle and combines the benefits of generative and discriminative approaches. The proposed feature representations are used within two learning frameworks. The first one is supervised learning and assumes that a large collection of labeled training data is available. Within this framework, we use standard classifiers including K-nearest neighbor (K-NN), support vector machine (SVM), and Naive Bayes. The second framework is based on semi-supervised learning where only a limited amount of labeled training samples are available. We use an approach that is based on label propagation. Our proposed algorithms were evaluated using 15 medical simulation sessions. The results were analyzed and compared to those obtained using state-of-the-art algorithms. We show that our proposed speech segmentation fusion algorithms and feature mappings outperform existing methods. We also integrated all proposed algorithms and developed a GUI prototype system for subjective evaluation. This prototype processes medical simulation video and provides the user with a visual summary of the different speech segments. It also allows the user to browse videos and retrieve scenes that provide answers to semantic queries such as: who spoke and when; who interrupted who? and what was the emotion of the speaker? The GUI prototype can also provide summary statistics of each simulation video. Examples include: for how long did each person spoke? What is the longest uninterrupted speech segment? Is there an unusual large number of pauses within the speech segment of a given speaker

Enhanced Prediction of Network Attacks Using Incomplete Data

For years, intrusion detection has been considered a key component of many organizations’ network defense capabilities. Although a number of approaches to intrusion detection have been tried, few have been capable of providing security personnel responsible for the protection of a network with sufficient information to make adjustments and respond to attacks in real-time. Because intrusion detection systems rarely have complete information, false negatives and false positives are extremely common, and thus valuable resources are wasted responding to irrelevant events. In order to provide better actionable information for security personnel, a mechanism for quantifying the confidence level in predictions is needed. This work presents an approach which seeks to combine a primary prediction model with a novel secondary confidence level model which provides a measurement of the confidence in a given attack prediction being made. The ability to accurately identify an attack and quantify the confidence level in the prediction could serve as the basis for a new generation of intrusion detection devices, devices that provide earlier and better alerts for administrators and allow more proactive response to events as they are occurring