B-spline based sharp feature preserving shape reconstruction approach for electrical impedance tomography

This paper presents a B-spline based shape reconstruction approach for electrical impedance tomography (EIT). In the proposed approach, the conductivity distribution to be reconstructed is assumed to be piecewise constant. The geometry of the inclusions is parameterized using B-spline curves, and the EIT forward solver is modified as a set of control points representing the inclusions’ boundary to the data on the domain boundary. The low order representation decreases the computational demand and reduces the ill-posedness of the EIT reconstruction problem. The performance of the proposed B-spline based approach is tested with simulations which demonstrate the most popular biomedical application of EIT: lung imaging. The approach is experimentally validated using water tank data. In addition, robustness studies of the proposed approach considering varying initial guesses, inaccurately known contact impedances, differing numbers of control points, and degree of B-spline are performed. The simulation and experimental results show that the B-spline based approach offers improvements in image quality in comparison to the traditional Fourier series based reconstruction approach, as measured by quantitative metrics such as relative size coverage ratio and relative contrast. Inasmuch, the proposed approach is demonstrated to offer clear improvement in the ability to preserve the sharp properties of the inclusions to be imaged

Shape reconstruction using Boolean operations in electrical impedance tomography

In this work, we propose a new shape reconstruction framework rooted in the concept of Boolean operations for electrical impedance tomography (EIT). Within the framework, the evolution of inclusion shapes and topologies are simultaneously estimated through an explicit boundary description. For this, we use B-spline curves as basic shape primitives for shape reconstruction and topology optimization. The effectiveness of the proposed approach is demonstrated using simulated and experimentally-obtained data (testing EIT lung imaging). In the study, improved preservation of sharp features is observed when employing the proposed approach relative to the recently developed moving morphable components-based approach. In addition, robustness studies of the proposed approach considering background inhomogeneity and differing numbers of B-spline curve control points are performed. It is found that the proposed approach is tolerant to modeling errors caused by background inhomogeneity and is also quite robust to the selection of control points

Less is often more : applied inverse problems using hp-forward models

To solve an applied inverse problem, a numerical forward model for the problem’s physics is required. Commonly, the finite element method is employed with discretizations consisting of elements with variable size h and polynomial degree p. Solutions to hp-forward models are known to converge exponentially by simultaneously decreasing h and increasing p. On the other hand, applied inverse problems are often ill-posed and their minimization rate exhibits uncertainty. Presently, the behavior of applied inverse problems incorporating hp elements of differing p, h, and geometry is not fully understood. Nonetheless, recent research suggests that employing increasingly higher-order hp-forward models (increasing mesh density and p) decreases reconstruction errors compared to inverse regimes using lower-order hp-forward models (coarser meshes and lower p). However, an affirmative or negative answer to following question has not been provided, “Does the use of higher order hp-forward models in applied inverse problems always result in lower error reconstructions than approaches using lower order hp-forward models?” In this article we aim to reduce the current knowledge gap and answer the open question by conducting extensive numerical investigations in the context of two contemporary applied inverse problems: elasticity imaging and hydraulic tomography – nonlinear inverse problems with a PDE describing the underlying physics. Our results support a negative answer to the question – i.e. decreasing h (increasing mesh density), increasing p, or simultaneously decreasing h and increasing p does not guarantee lower error reconstructions in applied inverse problems. Rather, there is complex balance between the accuracy of the hp-forward model, noise, prior knowledge (regularization), Jacobian accuracy, and ill-conditioning of the Jacobian matrix which ultimately contribute to reconstruction errors. As demonstrated herein, it is often more advantageous to use lower-order hp-forward models than higherorder hp-forward models in applied inverse problems. These realizations and other counterintuitive behavior of applied inverse problems using hp-forward models are described in detail herein

Visualisation of multi-dimensional medical images with application to brain electrical impedance tomography

Medical imaging plays an important role in modem medicine. With the increasing complexity and information presented by medical images, visualisation is vital for medical research and clinical applications to interpret the information presented in these images. The aim of this research is to investigate improvements to medical image visualisation, particularly for multi-dimensional medical image datasets. A recently developed medical imaging technique known as Electrical Impedance Tomography (EIT) is presented as a demonstration. To fulfil the aim, three main efforts are included in this work. First, a novel scheme for the processmg of brain EIT data with SPM (Statistical Parametric Mapping) to detect ROI (Regions of Interest) in the data is proposed based on a theoretical analysis. To evaluate the feasibility of this scheme, two types of experiments are carried out: one is implemented with simulated EIT data, and the other is performed with human brain EIT data under visual stimulation. The experimental results demonstrate that: SPM is able to localise the expected ROI in EIT data correctly; and it is reasonable to use the balloon hemodynamic change model to simulate the impedance change during brain function activity. Secondly, to deal with the absence of human morphology information in EIT visualisation, an innovative landmark-based registration scheme is developed to register brain EIT image with a standard anatomical brain atlas. Finally, a new task typology model is derived for task exploration in medical image visualisation, and a task-based system development methodology is proposed for the visualisation of multi-dimensional medical images. As a case study, a prototype visualisation system, named EIT5DVis, has been developed, following this methodology. to visualise five-dimensional brain EIT data. The EIT5DVis system is able to accept visualisation tasks through a graphical user interface; apply appropriate methods to analyse tasks, which include the ROI detection approach and registration scheme mentioned in the preceding paragraphs; and produce various visualisations

Mobile Wound Assessment and 3D Modeling from a Single Image

The prevalence of camera-enabled mobile phones have made mobile wound assessment a viable treatment option for millions of previously difficult to reach patients. We have designed a complete mobile wound assessment platform to ameliorate the many challenges related to chronic wound care. Chronic wounds and infections are the most severe, costly and fatal types of wounds, placing them at the center of mobile wound assessment. Wound physicians assess thousands of single-view wound images from all over the world, and it may be difficult to determine the location of the wound on the body, for example, if the wound is taken at close range. In our solution, end-users capture an image of the wound by taking a picture with their mobile camera. The wound image is segmented and classified using modern convolution neural networks, and is stored securely in the cloud for remote tracking. We use an interactive semi-automated approach to allow users to specify the location of the wound on the body. To accomplish this we have created, to the best our knowledge, the first 3D human surface anatomy labeling system, based off the current NYU and Anatomy Mapper labeling systems. To interactively view wounds in 3D, we have presented an efficient projective texture mapping algorithm for texturing wounds onto a 3D human anatomy model. In so doing, we have demonstrated an approach to 3D wound reconstruction that works even for a single wound image