575 research outputs found
Framework for a low-cost intra-operative image-guided neuronavigator including brain shift compensation
In this paper we present a methodology to address the problem of brain tissue
deformation referred to as 'brain-shift'. This deformation occurs throughout a
neurosurgery intervention and strongly alters the accuracy of the
neuronavigation systems used to date in clinical routine which rely solely on
pre-operative patient imaging to locate the surgical target, such as a tumour
or a functional area. After a general description of the framework of our
intra-operative image-guided system, we describe a procedure to generate
patient specific finite element meshes of the brain and propose a biomechanical
model which can take into account tissue deformations and surgical procedures
that modify the brain structure, like tumour or tissue resection
Automatic finite elements mesh generation from planar contours of the brain: an image driven 'blobby' approach
In this paper, we address the problem of automatic mesh generation for finite elements modeling of anatomical organs for which a volumetric data set is available. In the first step a set of characteristic outlines of the organ is defined manually or automatically within the volume. The outlines define the "key frames" that will guide the procedure of surface reconstruction. Then, based on this information, and along with organ surface curvature information extracted from the volume data, a 3D scalar field is generated. This field allows a 3D reconstruction of the organ: as an iso-surface model, using a marching cubes algorithm; or as a 3D mesh, using a grid "immersion" technique, the field value being used as the outside/inside test. The final reconstruction respects the various topological changes that occur within the organ, such as holes and branching elements
Registration of 3D fetal neurosonography and MRI.
We propose a method for registration of 3D fetal brain ultrasound with a reconstructed magnetic resonance fetal brain volume. This method, for the first time, allows the alignment of models of the fetal brain built from magnetic resonance images with 3D fetal brain ultrasound, opening possibilities to develop new, prior information based image analysis methods for 3D fetal neurosonography. The reconstructed magnetic resonance volume is first segmented using a probabilistic atlas and a pseudo ultrasound image volume is simulated from the segmentation. This pseudo ultrasound image is then affinely aligned with clinical ultrasound fetal brain volumes using a robust block-matching approach that can deal with intensity artefacts and missing features in the ultrasound images. A qualitative and quantitative evaluation demonstrates good performance of the method for our application, in comparison with other tested approaches. The intensity average of 27 ultrasound images co-aligned with the pseudo ultrasound template shows good correlation with anatomy of the fetal brain as seen in the reconstructed magnetic resonance image
A Multi-modal Brain Image Registration Framework for US-guided Neuronavigation Systems - Integrating MR and US for Minimally Invasive Neuroimaging
US-guided neuronavigation exploits the simplicity of use and minimal invasiveness of Ultrasound (US) imaging and the high tissue resolution and signal-to-noise ratio of Magnetic Resonance Imaging (MRI) to guide brain surgeries. More specifically, the intra-operative 3D US images are combined with pre-operative MR images to accurately localise the course of instruments in the operative field with minimal invasiveness. Multi-modal image registration of 3D US and MR images is an essential part of such system. In this paper, we present a complete software framework that enables the registration US and MR brain scans based on a multi resolution deformable transform, tackling elastic deformations (i.e. brain shifts) possibly occurring during the surgical procedure. The framework supports also simpler and faster registration techniques, based on rigid or affine transforms, and enables the interactive visualisation and rendering of the overlaid US and MRI volumes. The registration was experimentally validated on a public dataset of realistic brain phantom images, at different levels of artificially induced deformations
Registration of ultrasound and computed tomography for guidance of laparoscopic liver surgery
Laparoscopic Ultrasound (LUS) imaging is a standard tool used for image-guidance during laparoscopic liver resection, as it provides real-time information on the internal structure of the liver. However, LUS probes are di cult to handle and their resulting images hard to interpret. Additionally, some anatomical targets such as tumours are not always visible, making the LUS guidance less e ective. To solve this problem, registration between the LUS images and a pre-operative Computed Tomography (CT) scan using information from blood vessels has been previously proposed. By merging these two modalities, the relative position between the LUS images and the anatomy of CT is obtained and both can be used to guide the surgeon. The problem of LUS to CT registration is specially challenging, as besides being a multi-modal registration, the eld of view of LUS is signi cantly smaller than that of CT. Therefore, this problem becomes poorly constrained and typically an accurate initialisation is needed. Also, the liver is highly deformed during laparoscopy, complicating the problem further. So far, the methods presented in the literature are not clinically feasible as they depend on manually set correspondences between both images. In this thesis, a solution for this registration problem that may be more transferable to the clinic is proposed. Firstly, traditional registration approaches comprised of manual initialisation and optimisation of a cost function are studied. Secondly, it is demonstrated that a globally optimal registration without a manual initialisation is possible. Finally, a new globally optimal solution that does not require commonly used tracking technologies is proposed and validated. The resulting approach provides clinical value as it does not require manual interaction in the operating room or tracking devices. Furthermore, the proposed method could potentially be applied to other image-guidance problems that require registration between ultrasound and a pre-operative scan
Image guidance in neurosurgical procedures, the "Visages" point of view.
This paper gives an overview of the evolution of clinical
neuroinformatics in the domain of neurosurgery. It shows how
image guided neurosurgery (IGNS) is evolving according to the integration of new imaging modalities before, during and after the surgical procedure and how this acts as the premise of the Operative Room of the future. These different issues, as addressed by the VisAGeS INRIA/INSERM U746 research team (http://www.irisa.fr/visages), are presented and discussed in order to exhibit the benefits of an integrated work between physicians (radiologists, neurologists and neurosurgeons) and computer scientists to give adequate answers toward a more effective use of
images in IGNS
A Feature-Driven Active Framework for Ultrasound-Based Brain Shift Compensation
A reliable Ultrasound (US)-to-US registration method to compensate for brain
shift would substantially improve Image-Guided Neurological Surgery. Developing
such a registration method is very challenging, due to factors such as missing
correspondence in images, the complexity of brain pathology and the demand for
fast computation. We propose a novel feature-driven active framework. Here,
landmarks and their displacement are first estimated from a pair of US images
using corresponding local image features. Subsequently, a Gaussian Process (GP)
model is used to interpolate a dense deformation field from the sparse
landmarks. Kernels of the GP are estimated by using variograms and a discrete
grid search method. If necessary, the user can actively add new landmarks based
on the image context and visualization of the uncertainty measure provided by
the GP to further improve the result. We retrospectively demonstrate our
registration framework as a robust and accurate brain shift compensation
solution on clinical data acquired during neurosurgery
Vessel-based brain-shift compensation using elastic registration driven by a patient-specific finite element model
International audienceDuring brain tumor surgery, planning and guidance are based on pre-operative images which do not account for brain-shift.However, this shift is a major source of error in neuro-navigation systems and affects the accuracy of the procedure. The vascular tree is extracted from pre-operative Magnetic Resonance Angiography and from intra-operative Doppler ultrasound images, which provides sparse information on brain deformations.The pre-operative images are then updated based on an elastic registration of the blood vessels, driven by a patient-specific biomechanical model.This biomechanical model is used to extrapolate the deformation to the surrounding soft tissues.Quantitative results on a single surgical case are provided, with an evaluation of the execution time for each processing step.Our method is proved to be efficient to compensate for brain deformation while being compatible with a surgical process
Neurosurgery and brain shift: review of the state of the art and main contributions of robotics
Este artĂculo presenta una revisiĂłn acerca de la neurocirugĂa, los asistentes robĂłticos en este tipo de procedimiento, y el tratamiento que se le da al problema del desplazamiento que sufre el tejido cerebral, incluyendo las tĂ©cnicas para la obtenciĂłn de imágenes mĂ©dicas. Se abarca de manera especial el fenĂłmeno del desplazamiento cerebral, comĂşnmente conocido como brain shift, el cual causa pĂ©rdida de referencia entre las imágenes preoperatorias y los volĂşmenes a tratar durante la cirugĂa guiada por imágenes mĂ©dicas. HipotĂ©ticamente, con la predicciĂłn y correcciĂłn del brain shift sobre el sistema de neuronavegaciĂłn, se podrĂan planear y seguir trayectorias de mĂnima invasiĂłn, lo que conllevarĂa a minimizar el daño a los tejidos funcionales y posiblemente a reducir la morbilidad y mortalidad en estos delicados y exigentes procedimientos mĂ©dicos, como por ejemplo, en la extirpaciĂłn de un tumor cerebral. Se mencionan tambiĂ©n otros inconvenientes asociados a la neurocirugĂa y se muestra cĂłmo los sistemas robotizados han ayudado a solventar esta problemática. Finalmente se ponen en relieve las perspectivas futuras de esta rama de la medicina, la cual desde muchas disciplinas busca tratar las dolencias del principal Ăłrgano del ser humano.This paper presents a review about neurosurgery, robotic assistants in this type of procedure, and the approach to the problem of brain tissue displacement, including techniques for obtaining medical images. It is especially focused on the phenomenon of brain displacement, commonly known as brain shift, which causes a loss of reference between the preoperative images and the volumes to be treated during image-guided surgery. Hypothetically, with brain shift prediction and correction for the neuronavigation system, minimal invasion trajectories could be planned and shortened. This would reduce damage to functional tissues and possibly lower the morbidity and mortality in delicate and demanding medical procedures such as the removal of a brain tumor. This paper also mentions other issues associated with neurosurgery and shows the way robotized systems have helped solve these problems. Finally, it highlights the future perspectives of neurosurgery, a branch of medicine that seeks to treat the ailments of the main organ of the human body from the perspective of many disciplines
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