18,993 research outputs found
MammoApplet: an interactive Java applet tool for manual annotation in medical imaging
Web-based applications in computational medicine have become increasingly important during the last years. The rapid growth of the World Wide Web supposes a new paradigm in the telemedicine and eHealth areas in order to assist and enhance the prevention, diagnosis and treatment of patients. Furthermore, training of radiologists and management of medical databases are also becoming increasingly important issues in the field. In this paper, we present MammoApplet , an interactive Java applet interface designed as a web-based tool. It aims to facilitate the diagnosis of new mammographic cases by providing a set of image processing tools that allow a better visualization of the images, and a set of drawing tools, used to annotate the suspicious regions. Each annotation allows including the attributes considered by the experts when issuing the final diagnosis. The overall set of overlays is stored in a database as XML files associated with the original images. The final goal is to obtain a database of already diagnosed cases for training and enhancing the performance of novice radiologistsPeer ReviewedPostprint (author's final draft
A Deep Dive into Understanding Tumor Foci Classification using Multiparametric MRI Based on Convolutional Neural Network
Deep learning models have had a great success in disease classifications
using large data pools of skin cancer images or lung X-rays. However, data
scarcity has been the roadblock of applying deep learning models directly on
prostate multiparametric MRI (mpMRI). Although model interpretation has been
heavily studied for natural images for the past few years, there has been a
lack of interpretation of deep learning models trained on medical images. This
work designs a customized workflow for the small and imbalanced data set of
prostate mpMRI where features were extracted from a deep learning model and
then analyzed by a traditional machine learning classifier. In addition, this
work contributes to revealing how deep learning models interpret mpMRI for
prostate cancer patients stratification
A surgical system for automatic registration, stiffness mapping and dynamic image overlay
In this paper we develop a surgical system using the da Vinci research kit
(dVRK) that is capable of autonomously searching for tumors and dynamically
displaying the tumor location using augmented reality. Such a system has the
potential to quickly reveal the location and shape of tumors and visually
overlay that information to reduce the cognitive overload of the surgeon. We
believe that our approach is one of the first to incorporate state-of-the-art
methods in registration, force sensing and tumor localization into a unified
surgical system. First, the preoperative model is registered to the
intra-operative scene using a Bingham distribution-based filtering approach. An
active level set estimation is then used to find the location and the shape of
the tumors. We use a recently developed miniature force sensor to perform the
palpation. The estimated stiffness map is then dynamically overlaid onto the
registered preoperative model of the organ. We demonstrate the efficacy of our
system by performing experiments on phantom prostate models with embedded stiff
inclusions.Comment: International Symposium on Medical Robotics (ISMR 2018
Optical techniques for 3D surface reconstruction in computer-assisted laparoscopic surgery
One of the main challenges for computer-assisted surgery (CAS) is to determine the intra-opera- tive morphology and motion of soft-tissues. This information is prerequisite to the registration of multi-modal patient-specific data for enhancing the surgeon’s navigation capabilites by observ- ing beyond exposed tissue surfaces and for providing intelligent control of robotic-assisted in- struments. In minimally invasive surgery (MIS), optical techniques are an increasingly attractive approach for in vivo 3D reconstruction of the soft-tissue surface geometry. This paper reviews the state-of-the-art methods for optical intra-operative 3D reconstruction in laparoscopic surgery and discusses the technical challenges and future perspectives towards clinical translation. With the recent paradigm shift of surgical practice towards MIS and new developments in 3D opti- cal imaging, this is a timely discussion about technologies that could facilitate complex CAS procedures in dynamic and deformable anatomical regions
InferenceMAP: Mapping of Single-Molecule Dynamics with Bayesian Inference
Single-particle tracking (SPT) grants unprecedented insight into cellular
function at the molecular scale [1]. Throughout the cell, the movement of
single-molecules is generally heterogeneous and complex. Hence, there is an
imperative to understand the multi-scale nature of single-molecule dynamics in
biological systems. We have previously shown that with high-density SPT,
spatial maps of the parameters that dictate molecule motion can be generated to
intricately describe cellular environments [2,3,4]. To date, however, there
exist no publically available tools that reconcile trajectory data to generate
the aforementioned maps. We address this void in the SPT community with
InferenceMAP: an interactive software package that uses a powerful Bayesian
method to map the dynamic cellular space experienced by individual
biomolecules.Comment: 56 page
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