42,584 research outputs found
Robust semi-automated path extraction for visualising stenosis of the coronary arteries
Computed tomography angiography (CTA) is useful for diagnosing and planning treatment of heart disease. However, contrast agent in surrounding structures (such as the aorta and left ventricle) makes 3-D visualisation of the coronary arteries difficult. This paper presents a composite method employing segmentation and volume rendering to overcome this issue. A key contribution is a novel Fast Marching minimal path cost function for vessel centreline extraction. The resultant centreline is used to compute a measure of vessel lumen, which indicates the degree of stenosis (narrowing of a vessel). Two volume visualisation techniques are presented which utilise the segmented arteries and lumen measure. The system is evaluated and demonstrated using synthetic and clinically obtained datasets
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
Magnetic-Visual Sensor Fusion-based Dense 3D Reconstruction and Localization for Endoscopic Capsule Robots
Reliable and real-time 3D reconstruction and localization functionality is a
crucial prerequisite for the navigation of actively controlled capsule
endoscopic robots as an emerging, minimally invasive diagnostic and therapeutic
technology for use in the gastrointestinal (GI) tract. In this study, we
propose a fully dense, non-rigidly deformable, strictly real-time,
intraoperative map fusion approach for actively controlled endoscopic capsule
robot applications which combines magnetic and vision-based localization, with
non-rigid deformations based frame-to-model map fusion. The performance of the
proposed method is demonstrated using four different ex-vivo porcine stomach
models. Across different trajectories of varying speed and complexity, and four
different endoscopic cameras, the root mean square surface reconstruction
errors 1.58 to 2.17 cm.Comment: submitted to IROS 201
Vessel tractography using an intensity based tensor model with branch detection
In this paper, we present a tubular structure seg- mentation method that utilizes a second order tensor constructed from directional intensity measurements, which is inspired from diffusion tensor image (DTI) modeling. The constructed anisotropic tensor which is fit inside a vessel drives the segmen- tation analogously to a tractography approach in DTI. Our model is initialized at a single seed point and is capable of capturing whole vessel trees by an automatic branch detection algorithm developed in the same framework. The centerline of the vessel as well as its thickness is extracted. Performance results within the Rotterdam Coronary Artery Algorithm Evaluation framework are provided for comparison with existing techniques. 96.4% average overlap with ground truth delineated by experts is obtained in addition to other measures reported in the paper. Moreover, we demonstrate further quantitative results over synthetic vascular datasets, and we provide quantitative experiments for branch detection on patient Computed Tomography Angiography (CTA) volumes, as well as qualitative evaluations on the same CTA datasets, from visual scores by a cardiologist expert
Left-invariant evolutions of wavelet transforms on the Similitude Group
Enhancement of multiple-scale elongated structures in noisy image data is
relevant for many biomedical applications but commonly used PDE-based
enhancement techniques often fail at crossings in an image. To get an overview
of how an image is composed of local multiple-scale elongated structures we
construct a multiple scale orientation score, which is a continuous wavelet
transform on the similitude group, SIM(2). Our unitary transform maps the space
of images onto a reproducing kernel space defined on SIM(2), allowing us to
robustly relate Euclidean (and scaling) invariant operators on images to
left-invariant operators on the corresponding continuous wavelet transform.
Rather than often used wavelet (soft-)thresholding techniques, we employ the
group structure in the wavelet domain to arrive at left-invariant evolutions
and flows (diffusion), for contextual crossing preserving enhancement of
multiple scale elongated structures in noisy images. We present experiments
that display benefits of our work compared to recent PDE techniques acting
directly on the images and to our previous work on left-invariant diffusions on
orientation scores defined on Euclidean motion group.Comment: 40 page
Simulation of the influence of hydrophones used for the characterization of pressure field distribution in low frequency, high power ultrasonic reactor vessels
This paper describes the use of a finite element (FE) modeling approach to investigate the influence of different hydrophone designs in laboratory scale reactor vessels. In addition to conventional PVDF membrane and piezoceramic hydrophone, the performance of a conceptual array hydrophone, comprising a 2D matrix of PVDF array elements, will be simulated. The FE modeling concentrates on two issues: the disturbance to the field through the introduction of each hydrophone configuration; and their suitability and response to measuring non-linear effects. To simplify the model the ultrasonic transducer is not directly represented. Here, a pressure loading function is used as the excitation technique, with a sawtooth waveform applied for the simulation of the non-linear detection capability of each hydrophone configuration. The results from the simulation programme demonstrate that the dynamics of the reactor vessel are critical to optimize the performance of the ultrasonic system. In addition, the introduction of a hydrophone alters the wave propagation, and hence the field distribution beyond a given probe location. Nevertheless, the spatial pressure distribution at the active area remains reasonably accurate if within the useable bandwidth of the device. Accordingly, the broadband nature of the membrane device is suited to operation in both the linear and non-linear regimes, with the PVDF array membrane device offering a fast, convenient measurement of the pressure field distribution for industrial applications
- …