Design and development of a novel Invasive Blood Pressure simulator for patient's monitor testing

This paper presents a newly-designed and realized Invasive Blood Pressure (IBP) device for the simulation on patient’s monitors. This device shows improvements and presents extended features with respect to a first prototype presented by the authors and similar systems available in the state-of-the-art. A peculiarity of the presented device is that all implemented features can be customized from the developer and from the point of view of the end user. The realized device has been tested, and its performances in terms of accuracy and of the back-loop measurement of the output for the blood pressure regulation utilization have been described. In particular, an accuracy of ±1 mmHg at 25 °C, on a range from −30 to 300 mmHg, was evaluated under different test conditions. The designed device is an ideal tool for testing IBP modules, for zero setting, and for calibrations. The implemented extended features, like the generation of custom waveforms and the Universal Serial Bus (USB) connectivity, allow use of this device in a wide range of applications, from research to equipment maintenance in clinical environments to educational purposes. Moreover, the presented device represents an innovation, both in terms of technology and methodologies: It allows quick and efficient tests to verify the proper functioning of IBP module of patients’ monitors. With this innovative device, tests can be performed directly in the field and faster procedures can be implemented by the clinical maintenance personnel. This device is an open source project and all materials, hardware, and software are fully available for interested developers or researchers.Web of Science201art. no. 25

A Novel Iterative Structure for Online Calibration of M-Channel Time-Interleaved ADCs

published_or_final_versio

Simple quadrature oscillator for BIST

A simple quadrature oscillator for the built-in self-test (BIST) of integrated analogue filters is proposed. A new hardware-efficient approach for amplitude control is described, the main assets being: (i) the technique requires little hardware, which makes it very useful for BIST; (ii) the oscillation amplitude is well defined, and (iii) the distortion-level introduced by the amplitude control loop is under the control of the designer

New iterative framework for frequency response mismatch correction in time-interleaved ADCs: Design and performance analysis

This paper proposes a new iterative framework for the correction of frequency response mismatch in time-interleaved analog-to-digital converters. Based on a general time-varying linear system model for the mismatch, we treat the reconstruction problem as a linear inverse problem and establish a flexible iterative framework for practical implementation. It encumbrances a number of efficient iterative correction algorithms and simplifies their design, implementation, and performance analysis. In particular, an efficient Gauss-Seidel iteration is studied in detail to illustrate how the correction problem can be solved iteratively and how the proposed structure can be efficiently implemented using Farrow-based variable digital filters with few general-purpose multipliers. We also study important issues, such as the sufficient convergence condition and reconstructed signal spectrum, derive new lower bound of signal-to-distortion-and-noise ratio in order to ensure stable operation, and predict the performance of the proposed structure. Furthermore, we propose an extended iterative structure, which is able to cope with systems involving more than one type of mismatches. Finally, the theoretical results and the effectiveness of the proposed approach are validated by means of computer simulations. © 2011 IEEE.published_or_final_versio

Enabling hybrid process metrology in roll-to-roll nanomanufacturing: design of a tip-based tool for topographic sampling on flexible substrates

This work seeks to demonstrate the efficacy of a novel approach for topography measurement of nano-scale structures fabricated on a flexible substrate in a roll-to-roll (R2R) fashion. R2R manufactured products can be extremely cost competitive compared to more traditional, silicon wafer or glass panel based nanofabrication solutions, in addition to the unique and often desirable mechanical properties inherent to flexible substrates. As such, flexible nanomanufacturing is an area of immense research interest. However, despite the significant potential of these products for a variety of applications, developing manufacturing systems from lab-scale prototypes to pilot- or high volume manufacturing (HVM) has often proven both difficult and infeasibly expensive as research investment and achievable process yield limit advancement. One of the most significant capability gaps in current art, and roadblocks on the path towards adoption of R2R nanomanufacturing, is the lack of high-throughput, nanometer-scale metrology for process development, real-time control, and yield enhancement. This dissertation presents the design of a tip-based measurement tool implementing atomic force microscope (AFM) probes manufactured with a micro-electro-mechanical system (MEMS) approach to the challenge of sub-micron topography measurement which is also compatible with R2R manufacturing on flexible substrates. A proof-of-concept prototype tool with subsystems to regulate a flexible web, isolate and position the atomic force microscope probe, and measure features on the substrate, all coordinated by a real-time embedded control system, was designed and fabricated. The positioning subsystem was evaluated dynamically to ensure initial design requirements were met, and stationery, step-and-scan results were presented. However, to wholly meet this extent need for in-line R2R metrology, a system capable of atomic force microscope scanning despite a continuous, non-zero substrate velocity is required - any regular stoppage of the web in a R2R process all but dooms economically viable production throughput. Refinement and redesign of the proof-of-concept tool was driven by new system requirements to meet this goal, in addition to lessons learned from the initial prototype. Improvements focused on upgrading the web handling spindle design and mechatronics, tool power electronics, moving structures, and control algorithms used for high-speed synchronous positioning of the atomic force microscope and web. The culmination of this work will serve to introduce a new measurement framework which may be used to accelerate and enable future research in R2R manufacturing of nanofeatured products.Mechanical Engineerin

Accelerator Design for the CHESS-U Upgrade

During the summer and fall of 2018 the Cornell High Energy Synchrotron Source (CHESS) is undergoing an upgrade to increase high-energy flux for x-ray users. The upgrade requires replacing one-sixth of the Cornell Electron Storage Ring (CESR), inverting the polarity of half of the CHESS beam lines, and switching to single-beam on-axis operation. The new sextant is comprised of six double-bend achromats (DBAs) with combined-function dipole-quadrupoles. Although the DBA design is widely utilized and well understood, the constraints for the CESR modifications make the CHESS-U lattice unique. This paper describes the design objectives, constraints, and implementation for the CESR accelerator upgrade for CHESS-U

A simplified implementation of the stationary liquid mass balance method for on-line OUR monitoring in animal cell cultures

This is the peer reviewed version of the following article: [Fontova, A. , Lecina, M. , López‐Repullo, J. , Martínez‐Monge, I. , Comas, P. , Bragós, R. and Cairó, J. J. (2018), A simplified implementation of the stationary liquid mass balance method for on‐line OUR monitoring in animal cell cultures. J. Chem. Technol. Biotechnol. doi:10.1002/jctb.5551], which has been published in final form at [doi:10.1002/jctb.5551]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.BACKGROUND: Compared with other methods, the stationary liquid mass balance method for oxygen uptake rate (OUR) determination offers advantages in terms of estimation accuracy and reduction of stress. However, the need for sophisticated instrumentation, like mass flow controllers and gas analysers, has historically limited wider implementation of such a method. In this paper, a new simplified method based on inexpensive valves for the continuous estimation of OUR in animal cell cultures is evaluated. The determination of OUR values is based on accurate operation of the dissolved oxygen (DO) control loop and monitoring of its internal variables. RESULTS: The method developed was tested empirically in 2¿L bioreactor HEK293 batch cultures. OUR profiles obtained by a dynamic method, global mass balance method and the developed simplified method were monitored and compared. The results show how OUR profile obtained with the proposed method better follows the off-line cell density determination. The OUR estimation frequency was also increased, improving the method capabilities and applications. The theoretical rationale of the method was extended to the sensitivity analysis which was analytically and numerically approached. CONCLUSIONS: The results showed the proposed method to be not only cheap, but also a reliable alternative to monitor the metabolic activity in bioreactors in many biotechnological processes, being a useful tool for high cell density culture strategies implementation based on OUR monitoring.Peer ReviewedPostprint (published version

Disturbance Observer-based Robust Control and Its Applications: 35th Anniversary Overview

Disturbance Observer has been one of the most widely used robust control tools since it was proposed in 1983. This paper introduces the origins of Disturbance Observer and presents a survey of the major results on Disturbance Observer-based robust control in the last thirty-five years. Furthermore, it explains the analysis and synthesis techniques of Disturbance Observer-based robust control for linear and nonlinear systems by using a unified framework. In the last section, this paper presents concluding remarks on Disturbance Observer-based robust control and its engineering applications.Comment: 12 pages, 4 figure

Speech Transmission Index from running speech : a neural network approach

Speech Transmission Index (STI) is an important objective parameter concerning speech intelligibility for sound transmission channels. It is normally measured with specific test signals to ensure high accuracy and good repeatability. Measurement with running speech was previously proposed, but accuracy is compromised and hence applications limited. A new approach that uses artificial neural networks to accurately extract the STI from received running speech is developed in this paper. Neural networks are trained on a large set of transmitted speech examples with prior knowledge of the transmission channels' STIs. The networks perform complicated nonlinear function mappings and spectral feature memorization to enable accurate objective parameter extraction from transmitted speech. Validations via simulations demonstrate the feasibility of this new method on a one-net-one-speech extract basis. In this case, accuracy is comparable with normal measurement methods. This provides an alternative to standard measurement techniques, and it is intended that the neural network method can facilitate occupied room acoustic measurements