An Unsupervised Method for Suspicious Regions Detection in Mammogram Images

Over the past years many researchers proposed biomedical imaging methods for computer-aided detection and classification of suspicious regions in mammograms. Mammogram interpretation is performed by radiologists by visual inspection. The large volume of mammograms to be analyzed makes such readings labour intensive and often inaccurate. For this purpose, in this paper we propose a new unsupervised method to automatically detect suspicious regions in mammogram images. The method consists mainly of two steps: preprocessing; feature extraction and selection. Preprocessing steps allow to separate background region from the breast profile region. In greater detail, gray levels mapping transform and histogram specifications are used to enhance the visual representation of mammogram details. Then, local keypoints and descriptors such as SURF have been extracted in breast profile region. The extracted keypoints are filtered by proper parameters tuning to detect suspicious regions. The results, in terms of sensitivity and confidence interval are very encouraging

COMPUTER AIDED SYSTEM FOR BREAST CANCER DIAGNOSIS USING CURVELET TRANSFORM

Breast cancer is a leading cause of death among women worldwide. Early detection is the key for improving breast cancer prognosis. Digital mammography remains one of the most suitable tools for early detection of breast cancer. Hence, there are strong needs for the development of computer aided diagnosis (CAD) systems which have the capability to help radiologists in decision making. The main goal is to increase the diagnostic accuracy rate. In this thesis we developed a computer aided system for the diagnosis and detection of breast cancer using curvelet transform. Curvelet is a multiscale transform which possess directionality and anisotropy, and it breaks some inherent limitations of wavelet in representing edges in images. We started this study by developing a diagnosis system. Five feature extraction methods were developed with curvelet and wavelet coefficients to differentiate between different breast cancer classes. The results with curvelet and wavelet were compared. The experimental results show a high performance of the proposed methods and classification accuracy rate achieved 97.30%. The thesis then provides an automatic system for breast cancer detection. An automatic thresholding algorithm was used to separate the area composed of the breast and the pectoral muscle from the background of the image. Subsequently, a region growing algorithm was used to locate the pectoral muscle and suppress it from the breast. Then, the work concentrates on the segmentation of region of interest (ROI). Two methods are suggested to accomplish the segmentation stage: an adaptive thresholding method and a pattern matching method. Once the ROI has been identified, an automatic cropping is performed to extract it from the original mammogram. Subsequently, the suggested feature extraction methods were applied to the segmented ROIs. Finally, the K-Nearest Neighbor (KNN) and Support Vector Machine (SVM) classifiers were used to determine whether the region is abnormal or normal. At this level, the study focuses on two abnormality types (mammographic masses and architectural distortion). Experimental results show that the introduced methods have very high detection accuracies. The effectiveness of the proposed methods has been tested with Mammographic Image Analysis Society (MIAS) dataset. Throughout the thesis all proposed methods and algorithms have been applied with both curvelet and wavelet for comparison and statistical tests were also performed. The overall results show that curvelet transform performs better than wavelet and the difference is statistically significant

Improvement of mammographic mass characterization using spiculation measures and morphological features

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135119/1/mp1548.pd

Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Breast Mass Segmentation Using a Semi-automatic Procedure Based on Fuzzy C-means Clustering

Mammography is the primary modality that helped in the early detection and diagnosis of women breast diseases. Further, the process of extracting the masses in mammogram represents a challenging task facing the radiologists, due to problems such as fuzzy or speculated borders, low contrast and the presence of intensity inhomogeneities. Aims to help the radiologists in the diagnosis of breast cancer, many approaches have been conducted to automatically segment the masses in mammograms. Towards this aim, in this paper, we present a new approach for extraction of tumors from region-of-interest (ROI) using the algorithm of Fuzzy C-Means (FCM) setting two clusters for semi-automated segmentation. The proposed method meant to select as input data the set of pixels that enable to get the meaningful information required to segment the masses with high accuracy. This could be accomplished through eliminating unnecessary pixels, which influence on this process through separating it outside of the input data using an optimal threshold given by monitoring the change of clusters rate during the process of threshold decrementing. The proposed methodology has successfully segmented the masses, with an average sensitivity of 82.02% and specificity of 98.23%

Artificial neural network and its applications in quality process control, document recognition and biomedical imaging

In computer-vision based system a digital image obtained by a digital camera would usually have 24-bit color image. The analysis of an image with that many levels might require complicated image processing techniques and higher computational costs. But in real-time application, where a part has to be inspected within a few milliseconds, either we have to reduce the image to a more manageable number of gray levels, usually two levels (binary image), and at the same time retain all necessary features of the original image or develop a complicated technique. A binary image can be obtained by thresholding the original image into two levels. Therefore, thresholding of a given image into binary image is a necessary step for most image analysis and recognition techniques. In this thesis, we have studied the effectiveness of using artificial neural network (ANN) in pharmaceutical, document recognition and biomedical imaging applications for image thresholding and classification purposes. Finally, we have developed edge-based, ANN-based and region-growing based image thresholding techniques to extract low contrast objects of interest and classify them into respective classes in those applications. Real-time quality inspection of gelatin capsules in pharmaceutical applications is an important issue from the point of view of industry\u27s productivity and competitiveness. Computer vision-based automatic quality inspection and controller system is one of the solutions to this problem. Machine vision systems provide quality control and real-time feedback for industrial processes, overcoming physical limitations and subjective judgment of humans. In this thesis, we have developed an image processing system using edge-based image thresholding techniques for quality inspection that satisfy the industrial requirements in pharmaceutical applications to pass the accepted and rejected capsules. In document recognition application, success of OCR mostly depends on the quality of the thresholded image. Non-uniform illumination, low contrast and complex background make it challenging in this application. In this thesis, optimal parameters for ANN-based local thresholding approach for gray scale composite document image with non-uniform background is proposed. An exhaustive search was conducted to select the optimal features and found that pixel value, mean and entropy are the most significant features at window size 3x3 in this application. For other applications, it might be different, but the procedure to find the optimal parameters is same. The average recognition rate 99.25% shows that the proposed 3 features at window size 3x3 are optimal in terms of recognition rate and PSNR compare to the ANN-based thresholding technique with different parameters presented in the literature. In biomedical imaging application, breast cancer continues to be a public health problem. In this thesis we presented a computer aided diagnosis (CAD) system for mass detection and classification in digitized mammograms, which performs mass detection on regions of interest (ROI) followed by the benign-malignant classification on detected masses. Three layers ANN with seven features is proposed for classifying the marked regions into benign and malignant and 90.91% sensitivity and 83.87% specificity is achieved that is very much promising compare to the radiologist\u27s sensitivity 75%

Design and evaluation of an external filter technique for exposure equalization in mammography

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134768/1/mp8659.pd