Report on using the GPPS to assess trends in EQ-5D scores for people with long-term conditions

Background: Estimating the extent to which NHS services are contributing to improving the health-related quality of life (HRQoL) of people with long-term conditions is an important (if challenging) objective. Its importance is reflected in domain 2 of the NHS Outcomes Framework. Understanding whether this goal is being achieved requires methods which help the interpretation of the role of services on observed trends in HRQoL. Controlling for the influence of external factors, such as the severity of the underlying condition – or ‘need’ – on quality of life, is particularly crucial because NHS and care activity levels increase with need-related factors (NRFs), but otherwise NRFs are strongly associated with worse HRQoL. Failing to control for NRFs makes it therefore very difficult to interpret observed changes in quality of life, and in particular to appraise the role that NHS and care services might play in improving the well-being of people with long-term conditions. This report aims to develop a methodology which is easy to implement and which standardises for changes in NRFs when investigating changes through time in the HRQoL of people with long-term conditions

Statistical Inferences for Polarity Identification in Natural Language

Information forms the basis for all human behavior, including the ubiquitous decision-making that people constantly perform in their every day lives. It is thus the mission of researchers to understand how humans process information to reach decisions. In order to facilitate this task, this work proposes a novel method of studying the reception of granular expressions in natural language. The approach utilizes LASSO regularization as a statistical tool to extract decisive words from textual content and draw statistical inferences based on the correspondence between the occurrences of words and an exogenous response variable. Accordingly, the method immediately suggests significant implications for social sciences and Information Systems research: everyone can now identify text segments and word choices that are statistically relevant to authors or readers and, based on this knowledge, test hypotheses from behavioral research. We demonstrate the contribution of our method by examining how authors communicate subjective information through narrative materials. This allows us to answer the question of which words to choose when communicating negative information. On the other hand, we show that investors trade not only upon facts in financial disclosures but are distracted by filler words and non-informative language. Practitioners - for example those in the fields of investor communications or marketing - can exploit our insights to enhance their writings based on the true perception of word choice

Empirical Evaluation of Mutation-based Test Prioritization Techniques

We propose a new test case prioritization technique that combines both mutation-based and diversity-based approaches. Our diversity-aware mutation-based technique relies on the notion of mutant distinguishment, which aims to distinguish one mutant's behavior from another, rather than from the original program. We empirically investigate the relative cost and effectiveness of the mutation-based prioritization techniques (i.e., using both the traditional mutant kill and the proposed mutant distinguishment) with 352 real faults and 553,477 developer-written test cases. The empirical evaluation considers both the traditional and the diversity-aware mutation criteria in various settings: single-objective greedy, hybrid, and multi-objective optimization. The results show that there is no single dominant technique across all the studied faults. To this end, \rev{we we show when and the reason why each one of the mutation-based prioritization criteria performs poorly, using a graphical model called Mutant Distinguishment Graph (MDG) that demonstrates the distribution of the fault detecting test cases with respect to mutant kills and distinguishment

Are providers prepared for genomic medicine: interpretation of Direct-to-Consumer genetic testing (DTC-GT) results and genetic self-efficacy by medical professionals.

BACKGROUND:Precision medicine is set to deliver a rich new data set of genomic information. However, the number of certified specialists in the United States is small, with only 4244 genetic counselors and 1302 clinical geneticists. We conducted a national survey of 264 medical professionals to evaluate how they interpret genetic test results, determine their confidence and self-efficacy of interpreting genetic test results with patients, and capture their opinions and experiences with direct-to-consumer genetic tests (DTC-GT). METHODS:Participants were grouped into two categories, genetic specialists (genetic counselors and clinical geneticists) and medical providers (primary care, internists, physicians assistants, advanced nurse practitioners, etc.). The survey (full instrument can be found in the Additional file 1) presented three genetic test report scenarios for interpretation: a genetic risk for diabetes, genomic sequencing for symptoms report implicating a potential HMN7B: distal hereditary motor neuropathy VIIB diagnosis, and a statin-induced myopathy risk. Participants were also asked about their opinions on DTC-GT results and rank their own perceived level of preparedness to review genetic test results with patients. RESULTS:The rates of correctly interpreting results were relatively high (74.4% for the providers compared to the specialist's 83.4%) and age, prior genetic test consultation experience, and level of trust assigned to the reports were associated with higher correct interpretation rates. The self-selected efficacy and the level of preparedness to consult on a patient's genetic results were higher for the specialists than the provider group. CONCLUSION:Specialists remain the best group to assist patients with DTC-GT, however, primary care providers may still provide accurate interpretation of test results when specialists are unavailable