Alzheimer's Disease: A Survey

Alzheimer's Diseases (AD) is one of the type of dementia. This is one of the harmful disease which can lead to death and yet there is no treatment. There is no current technique which is 100% accurate for the treatment of this disease. In recent years, Neuroimaging combined with machine learning techniques have been used for detection of Alzheimer's disease. Based on our survey we came across many methods like Convolution Neural Network (CNN) where in each brain area is been split into small three dimensional patches which acts as input samples for CNN. The other method used was Deep Neural Networks (DNN) where the brain MRI images are segmented to extract the brain chambers and then features are extracted from the segmented area. There are many such methods which can be used for detection of Alzheimer’s Disease

Alzheimer Disease Detection Techniques and Methods: A Review

Brain pathological changes linked with Alzheimer's disease (AD) can be measured with Neuroimaging. In the past few years, these measures are rapidly integrated into the signatures of Alzheimer disease (AD) with the help of classification frameworks which are offering tools for diagnosis and prognosis. Here is the review study of Alzheimer's disease based on Neuroimaging and cognitive impairment classification. This work is a systematic review for the published work in the field of AD especially the computer-aided diagnosis. The imaging modalities include 1) Magnetic resonance imaging (MRI) 2) Functional MRI (fMRI) 3) Diffusion tensor imaging 4) Positron emission tomography (PET) and 5) amyloid-PET. The study revealed that the classification criterion based on the features shows promising results to diagnose the disease and helps in clinical progression. The most widely used machine learning classifiers for AD diagnosis include Support Vector Machine, Bayesian Classifiers, Linear Discriminant Analysis, and K-Nearest Neighbor along with Deep learning. The study revealed that the deep learning techniques and support vector machine give higher accuracies in the identification of Alzheimer’s disease. The possible challenges along with future directions are also discussed in the paper

DEEP-AD: The deep learning model for diagnostic classification and prognostic prediction of alzheimer's disease

In terms of context, the aim of this dissertation is to aid neuroradiologists in their clinical judgment regarding the early detection of AD by using DL. To that aim, the system design research methodology is suggested in this dissertation for achieving three goals. The first goal is to investigate the DL models that have performed well at identifying patterns associated with AD, as well as the accuracy so far attained, limitations, and gaps. A systematic review of the literature (SLR) revealed a shortage of empirical studies on the early identification of AD through DL. In this regard, thirteen empirical studies were identified and examined. We concluded that three-dimensional (3D) DL models have been generated far less often and that their performance is also inadequate to qualify them for clinical trials. The second goal is to provide the neuroradiologist with the computer-interpretable information they need to analyze neuroimaging biomarkers. Given this context, the next step in this dissertation is to find the optimum DL model to analyze neuroimaging biomarkers. It has been achieved in two steps. In the first step, eight state-of-the-art DL models have been implemented by training from scratch using end-to-end learning (E2EL) for two binary classification tasks (AD vs. CN and AD vs. stable MCI) and compared by utilizing MRI scans from the publicly accessible datasets of neuroimaging biomarkers. Comparative analysis is carried out by utilizing efficiency-effects graphs, comprehensive indicators, and ranking mechanisms. For the training of the AD vs. sMCI task, the EfficientNet-B0 model gets the highest value for the comprehensive indicator and has the fewest parameters. DenseNet264 performed better than the others in terms of evaluation matrices, but since it has the most parameters, it costs more to train. For the AD vs. CN task by DenseNet264, we achieved 100% accuracy for training and 99.56% accuracy for testing. However, the classification accuracy was still only 82.5% for the AD vs. sMCI task. In the second step, fusion of transfer learning (TL) with E2EL is applied to train the EfficientNet-B0 for the AD vs. sMCI task, which achieved 95.29% accuracy for training and 93.10% accuracy for testing. Additionally, we have also implemented EfficientNet-B0 for the multiclass AD vs. CN vs. sMCI classification task with E2EL to be used in ensemble of models and achieved 85.66% training accuracy and 87.38% testing accuracy. To evaluate the model’s robustness, neuroradiologists must validate the implemented model. As a result, the third goal of this dissertation is to create a tool that neuroradiologists may use at their convenience. To achieve this objective, this dissertation proposes a web-based application (DEEP-AD) that has been created by making an ensemble of Efficient-Net B0 and DenseNet 264 (based on the contribution of goal 2). The accuracy of a DEEP-AD prototype has undergone repeated evaluation and improvement. First, we validated 41 subjects of Spanish MRI datasets (acquired from HT Medica, Madrid, Spain), achieving an accuracy of 82.90%, which was later verified by neuroradiologists. The results of these evaluation studies showed the accomplishment of such goals and relevant directions for future research in applied DL for the early detection of AD in clinical settings.En términos de contexto, el objetivo de esta tesis es ayudar a los neurorradiólogos en su juicio clínico sobre la detección precoz de la AD mediante el uso de DL. Para ello, en esta tesis se propone la metodología de investigación de diseño de sistemas para lograr tres objetivos. El segundo objetivo es proporcionar al neurorradiólogo la información interpretable por ordenador que necesita para analizar los biomarcadores de neuroimagen. Dado este contexto, el siguiente paso en esta tesis es encontrar el modelo DL óptimo para analizar biomarcadores de neuroimagen. Esto se ha logrado en dos pasos. En el primer paso, se han implementado ocho modelos DL de última generación mediante entrenamiento desde cero utilizando aprendizaje de extremo a extremo (E2EL) para dos tareas de clasificación binarias (AD vs. CN y AD vs. MCI estable) y se han comparado utilizando escaneos MRI de los conjuntos de datos de biomarcadores de neuroimagen de acceso público. El análisis comparativo se lleva a cabo utilizando gráficos de efecto-eficacia, indicadores exhaustivos y mecanismos de clasificación. Para el entrenamiento de la tarea AD vs. sMCI, el modelo EfficientNet-B0 obtiene el valor más alto para el indicador exhaustivo y tiene el menor número de parámetros. DenseNet264 obtuvo mejores resultados que los demás en términos de matrices de evaluación, pero al ser el que tiene más parámetros, su entrenamiento es más costoso. Para la tarea AD vs. CN de DenseNet264, conseguimos una accuracy del 100% en el entrenamiento y del 99,56% en las pruebas. Sin embargo, la accuracy de la clasificación fue sólo del 82,5% para la tarea AD vs. sMCI. En el segundo paso, se aplica la fusión del aprendizaje por transferencia (TL) con E2EL para entrenar la EfficientNet-B0 para la tarea AD vs. sMCI, que alcanzó una accuracy del 95,29% en el entrenamiento y del 93,10% en las pruebas. Además, también hemos implementado EfficientNet-B0 para la tarea de clasificación multiclase AD vs. CN vs. sMCI con E2EL para su uso en conjuntos de modelos y hemos obtenido una accuracy de entrenamiento del 85,66% y una precisión de prueba del 87,38%. Para evaluar la solidez del modelo, los neurorradiólogos deben validar el modelo implementado. Como resultado, el tercer objetivo de esta disertación es crear una herramienta que los neurorradiólogos puedan utilizar a su conveniencia. Para lograr este objetivo, esta disertación propone una aplicación basada en web (DEEP-AD) que ha sido creada haciendo un ensemble de Efficient-Net B0 y DenseNet 264 (basado en la contribución del objetivo 2). La accuracy del prototipo DEEP-AD ha sido sometida a repetidas evaluaciones y mejoras. En primer lugar, validamos 41 sujetos de conjuntos de datos de MRI españoles (adquiridos de HT Medica, Madrid, España), logrando una accuracy del 82,90%, que posteriormente fue verificada por neurorradiólogos. Los resultados de estos estudios de evaluación mostraron el cumplimiento de dichos objetivos y las direcciones relevantes para futuras investigaciones en DL, aplicada en la detección precoz de la AD en entornos clínicos.Escuela de DoctoradoDoctorado en Tecnologías de la Información y las Telecomunicacione

A transfer learning based approach for brain tumor classification

In order to improve patient outcomes, brain tumors—which are notorious for their catastrophic effects and short life expectancy, particularly in higher grades—need to be diagnosed accurately and treated with care. Patient survival chances may be hampered by incorrect medical procedures brought on by a brain tumor misdiagnosis. CNNs and computer-aided tumor detection systems have demonstrated promise in revolutionizing brain tumor diagnostics through the application of ML techniques. One issue in the field of brain tumor detection and classification is the dearth of non-invasive indication support systems, which is compounded by data scarcity. Conventional neural networks may cause problems such as overfitting and gradient vanishing when they use uniform filters in different visual settings. Moreover, these methods incur time and computational complexity as they train the model from scratch and extract the pertinent characteristics. This paper presents an InceptionV4 neural network architecture-based Transfer Learning-based methodology to address the shortcomings in brain tumor classification methods. The goal is to deliver precise diagnostic assistance while minimizing calculation time and improving accuracy. The model makes use of a dataset that contains 7022 MRI images that were obtained from figshare, the SARTAJ dataset, and Br35H, among other sites. The suggested InceptionV4 architecture improves its ability to categorize brain tumors into three groups and normal brain images by utilizing transfer learning approaches. The suggested InceptionV4 model achieves an accuracy rate of 98.7% in brain tumor classification, indicating the model’s remarkable performance. This suggests a noteworthy progression in the precision of diagnosis and computational effectiveness to support practitioners making decisions

Novel Deep Learning Models for Medical Imaging Analysis

abstract: Deep learning is a sub-field of machine learning in which models are developed to imitate the workings of the human brain in processing data and creating patterns for decision making. This dissertation is focused on developing deep learning models for medical imaging analysis of different modalities for different tasks including detection, segmentation and classification. Imaging modalities including digital mammography (DM), magnetic resonance imaging (MRI), positron emission tomography (PET) and computed tomography (CT) are studied in the dissertation for various medical applications. The first phase of the research is to develop a novel shallow-deep convolutional neural network (SD-CNN) model for improved breast cancer diagnosis. This model takes one type of medical image as input and synthesizes different modalities for additional feature sources; both original image and synthetic image are used for feature generation. This proposed architecture is validated in the application of breast cancer diagnosis and proved to be outperforming the competing models. Motivated by the success from the first phase, the second phase focuses on improving medical imaging synthesis performance with advanced deep learning architecture. A new architecture named deep residual inception encoder-decoder network (RIED-Net) is proposed. RIED-Net has the advantages of preserving pixel-level information and cross-modality feature transferring. The applicability of RIED-Net is validated in breast cancer diagnosis and Alzheimer’s disease (AD) staging. Recognizing medical imaging research often has multiples inter-related tasks, namely, detection, segmentation and classification, my third phase of the research is to develop a multi-task deep learning model. Specifically, a feature transfer enabled multi-task deep learning model (FT-MTL-Net) is proposed to transfer high-resolution features from segmentation task to low-resolution feature-based classification task. The application of FT-MTL-Net on breast cancer detection, segmentation and classification using DM images is studied. As a continuing effort on exploring the transfer learning in deep models for medical application, the last phase is to develop a deep learning model for both feature transfer and knowledge from pre-training age prediction task to new domain of Mild cognitive impairment (MCI) to AD conversion prediction task. It is validated in the application of predicting MCI patients’ conversion to AD with 3D MRI images.Dissertation/ThesisDoctoral Dissertation Industrial Engineering 201

3D Deep Learning on Medical Images: A Review

The rapid advancements in machine learning, graphics processing technologies and availability of medical imaging data has led to a rapid increase in use of deep learning models in the medical domain. This was exacerbated by the rapid advancements in convolutional neural network (CNN) based architectures, which were adopted by the medical imaging community to assist clinicians in disease diagnosis. Since the grand success of AlexNet in 2012, CNNs have been increasingly used in medical image analysis to improve the efficiency of human clinicians. In recent years, three-dimensional (3D) CNNs have been employed for analysis of medical images. In this paper, we trace the history of how the 3D CNN was developed from its machine learning roots, give a brief mathematical description of 3D CNN and the preprocessing steps required for medical images before feeding them to 3D CNNs. We review the significant research in the field of 3D medical imaging analysis using 3D CNNs (and its variants) in different medical areas such as classification, segmentation, detection, and localization. We conclude by discussing the challenges associated with the use of 3D CNNs in the medical imaging domain (and the use of deep learning models, in general) and possible future trends in the field.Comment: 13 pages, 4 figures, 2 table

Security Issues of Big Data in the Banking Sector and Analytical Approach

This study highlights the banking sector as a rich source of data that includes customer data, financial transactions and economic indicators. The main focus is on effectively applying and training machine learning techniques using this abundance of data. In particular, it aims to determine which model gives better results by examining various machine learning models for risk detection in the mentioned data set

Machine Learning Methods for Depression Detection Using SMRI and RS-FMRI Images

Major Depression Disorder (MDD) is a common disease throughout the world that negatively influences people’s lives. Early diagnosis of MDD is beneficial, so detecting practical biomarkers would aid clinicians in the diagnosis of MDD. Having an automated method to find biomarkers for MDD is helpful even though it is difficult. The main aim of this research is to generate a method for detecting discriminative features for MDD diagnosis based on Magnetic Resonance Imaging (MRI) data. In this research, representational similarity analysis provides a framework to compare distributed patterns and obtain the similarity/dissimilarity of brain regions. Regions are obtained by either data-driven or model-driven methods such as cubes and atlases respectively. For structural MRI (sMRI) similarity of voxels of spatial cubes (data-driven) are explored. For resting-state fMRI (rs-fMRI) images, the similarity of the time series of both cubes (data-driven) and atlases (model-driven) are examined. Moreover, the similarity method of the inverse of Minimum Covariant Determinant is applied that excludes outliers from patterns and finds conditionally independent regions given the rest of regions. Next, a statistical test that is robust to outliers, identifies discriminative similarity features between two groups of MDDs and controls. Therefore, the key contribution is the way to get discriminative features that include obtaining similarity of voxel’s cubes/time series using the inverse of robust covariance along with the statistical test. The experimental results show that obtaining these features along with the Bernoulli Naïve Bayes classifier achieves superior performance compared with other methods. The performance of our method is verified by applying it to three imbalanced datasets. Moreover, the similarity-based methods are compared with deep learning and regional-based approaches for detecting MDD using either sMRI or rs-fMRI. Given that depression is famous to be a connectivity disorder problem, investigating the similarity of the brain’s regions is valuable to understand the behavior of the brain. The combinations of structural and functional brain similarities are explored to investigate the brain’s structural and functional properties together. Moreover, the combination of data-driven (cube) and model-driven (atlas) similarities of rs-fMRI are looked over to evaluate how they affect the performance of the classifier. Besides, discriminative similarities are visualized for both sMRI and rs-fMRI. Also, to measure the informativeness of a cube, the relationship of atlas regions with overlapping cubes and vise versa (cubes with overlapping regions) are explored and visualized. Furthermore, the relationship between brain structure and function has been probed through common similarities between structural and resting-state functional networks