Estimating the Amount of Information Conveyed by a Population of Neurons

Recent advances in electrophysiological recording technology have allowed for the collection of data from large populations of neurons simultaneously. Yet despite these advances, methods for the estimation of the amount of information conveyed by multiple neurons have been stymied by the “curse of dimensionality”–as the number of included neurons increases, so too does the dimensionality of the data necessary for such measurements, leading to an exponential and, therefore, intractible increase in the amounts of data required for valid measurements. Here we put forth a novel method for the estimation of the amount of information transmitted by the discharge of a large population of neurons, a method which exploits the little-known fact that (under certain constraints) the Fourier coefficients of variables such as neural spike trains follow a Gaussian distribution. This fact enables an accurate measure of information even with limited data. The method, which we call the Fourier Method, is presented in detail, tested for robustness, and its application is demonstrated with both simulated and real spike trains. ii

Scalable and perceptual audio compression

This thesis deals with scalable perceptual audio compression. Two scalable perceptual solutions as well as a scalable to lossless solution are proposed and investigated. One of the scalable perceptual solutions is built around sinusoidal modelling of the audio signal whilst the other is built on a transform coding paradigm. The scalable coders are shown to scale both in a waveform matching manner as well as a psychoacoustic manner. In order to measure the psychoacoustic scalability of the systems investigated in this thesis, the similarity between the original signal\u27s psychoacoustic parameters and that of the synthesized signal are compared. The psychoacoustic parameters used are loudness, sharpness, tonahty and roughness. This analysis technique is a novel method used in this thesis and it allows an insight into the perceptual distortion that has been introduced by any coder analyzed in this manner

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Secure steganography, compression and diagnoses of electrocardiograms in wireless body sensor networks

Submission of this completed form results in your thesis/project being lodged online at the RMIT Research Repository. Further information about the RMIT Research Repository is available at http://researchbank.rmit.edu.au Please complete abstract and keywords below for cataloguing and indexing your thesis/project. Abstract (Minimum 200 words, maximum 500 words) The usage of e-health applications is increasing in the modern era. Remote cardiac patients monitoring application is an important example of these e-health applications. Diagnosing cardiac disease in time is of crucial importance to save many patients lives. More than 3.5 million Australians suffer from long-term cardiac diseases. Therefore, in an ideal situation, a continuous cardiac monitoring system should be provided for this large number of patients. However, health-care providers lack the technology required to achieve this objective. Cloud services can be utilized to fill the technology gap for health-care providers. However, three main problems prevent health-care providers from using cloud services. Privacy, performance and accuracy of diagnoses. In this thesis we are addressing these three problems. To provide strong privacy protection services, two steganography techniques are proposed. Both techniques could achieve promising results in terms of security and distortion measurement. The differences between original and resultant watermarked ECG signals were less then 1%. Accordingly, the resultant ECG signal can be still used for diagnoses purposes, and only authorized persons who have the required security information, can extract the hidden secret data in the ECG signal. Consequently, to solve the performance problem of storing huge amount of data concerning ECG into the cloud, two types of compression techniques are introduced: Fractal based lossy compression technique and Gaussian based lossless compression technique. This thesis proves that, fractal models can be efficiently used in ECG lossy compression. Moreover, the proposed fractal technique is a multi-processing ready technique that is suitable to be implemented inside a cloud to make use of its multi processing capability. A high compression ratio could be achieved with low distortion effects. The Gaussian lossless compression technique is proposed to provide a high compression ratio. Moreover, because the compressed files are stored in the cloud, its services should be able to provide automatic diagnosis capability. Therefore, cloud services should be able to diagnose compressed ECG files without undergoing a decompression stage to reduce additional processing overhead. Accordingly, the proposed Gaussian compression provides the ability to diagnose the resultant compressed file. Subsequently, to make use of this homomorphic feature of the proposed Gaussian compression algorithm, in this thesis we have introduced a new diagnoses technique that can be used to detect life-threatening cardiac diseases such as Ventricular Tachycardia and Ventricular Fibrillation. The proposed technique is applied directly to the compressed ECG files without going through the decompression stage. The proposed technique could achieve high accuracy results near to 100% for detecting Ventricular Arrhythmia and 96% for detecting Left Bundle Branch Block. Finally, we believe that in this thesis, the first steps towards encouraging health-care providers to use cloud services have been taken. However, this journey is still long

P Wave Detection in Pathological ECG Signals

Důležitou součástí hodnocení elektrokardiogramu (EKG) a následné detekce srdečních patologií, zejména v dlouhodobém monitorování, je detekce vln P. Výsledky detekce vln P umožňují získat ze záznamu EKG více informací o srdeční činnosti. Podle správně detekovaných pozic vln P je možné detekovat a odlišit patologie, které současné programy používané v medicínské praxi identifikovat neumožňují (např. atrioventrikulární blok 1., 2. a 3. stupně, cestující pacemaker, Wolffův-Parkinsonův-Whiteův syndrom). Tato dizertační práce představuje novou metodu detekce vln P v záznamech EKG během fyziologické a zejména patologické srdeční činnosti. Metoda je založena na fázorové transformaci, inovativních pravidlech detekce a identifikaci možných patologií zpřesňující detekci vln P. Dalším důležitým výsledkem práce je vytvoření dvou veřejně dostupných databází záznamů EKG s obsahem patologií a anotovanými vlnami P. Dizertační práce je rozdělena na teoretickou část a soubor publikací představující příspěvek autora v oblasti detekce vlny P.Accurate software for the P wave detection, mainly in long-term monitoring, is an important part of electrocardiogram (ECG) evaluation and subsequent cardiac pathological events detection. The results of P wave detection allow us to obtain more information from the ECG records. According to the correct P wave detection, it is possible to detect and distinguish cardiac pathologies which are nowadays automatically undetectable by commonly used software in medical practice (events e.g. atrioventricular block 1st, 2nd and 3rd degree, WPW syndrome, wandering pacemaker, etc.). This thesis introduces a new method for P wave detection in ECG signals during both physiological and pathological heart function. This novel method is based on a phasor transform, innovative rules, and identification of possible pathologies that improve P wave detection. An equally important part of the work is the creation of two publicly available databases of physiological and pathological ECG records with annotated P waves. The dissertation is divided into theoretical analysis and a set of publications representing the contribution of the author in the area of P wave detection.

Lossless and low-cost integer-based lifting wavelet transform

Discrete wavelet transform (DWT) is a powerful tool for analyzing real-time signals, including aperiodic, irregular, noisy, and transient data, because of its capability to explore signals in both the frequency- and time-domain in different resolutions. For this reason, they are used extensively in a wide number of applications in image and signal processing. Despite the wide usage, the implementation of the wavelet transform is usually lossy or computationally complex, and it requires expensive hardware. However, in many applications, such as medical diagnosis, reversible data-hiding, and critical satellite data, lossless implementation of the wavelet transform is desirable. It is also important to have more hardware-friendly implementations due to its recent inclusion in signal processing modules in system-on-chips (SoCs). To address the need, this research work provides a generalized implementation of a wavelet transform using an integer-based lifting method to produce lossless and low-cost architecture while maintaining the performance close to the original wavelets. In order to achieve a general implementation method for all orthogonal and biorthogonal wavelets, the Daubechies wavelet family has been utilized at first since it is one of the most widely used wavelets and based on a systematic method of construction of compact support orthogonal wavelets. Though the first two phases of this work are for Daubechies wavelets, they can be generalized in order to apply to other wavelets as well. Subsequently, some techniques used in the primary works have been adopted and the critical issues for achieving general lossless implementation have solved to propose a general lossless method. The research work presented here can be divided into several phases. In the first phase, low-cost architectures of the Daubechies-4 (D4) and Daubechies-6 (D6) wavelets have been derived by applying the integer-polynomial mapping. A lifting architecture has been used which reduces the cost by a half compared to the conventional convolution-based approach. The application of integer-polynomial mapping (IPM) of the polynomial filter coefficient with a floating-point value further decreases the complexity and reduces the loss in signal reconstruction. Also, the “resource sharing” between lifting steps results in a further reduction in implementation costs and near-lossless data reconstruction. In the second phase, a completely lossless or error-free architecture has been proposed for the Daubechies-8 (D8) wavelet. Several lifting variants have been derived for the same wavelet, the integer mapping has been applied, and the best variant is determined in terms of performance, using entropy and transform coding gain. Then a theory has been derived regarding the impact of scaling steps on the transform coding gain (GT). The approach results in the lowest cost lossless architecture of the D8 in the literature, to the best of our knowledge. The proposed approach may be applied to other orthogonal wavelets, including biorthogonal ones to achieve higher performance. In the final phase, a general algorithm has been proposed to implement the original filter coefficients expressed by a polyphase matrix into a more efficient lifting structure. This is done by using modified factorization, so that the factorized polyphase matrix does not include the lossy scaling step like the conventional lifting method. This general technique has been applied on some widely used orthogonal and biorthogonal wavelets and its advantages have been discussed. Since the discrete wavelet transform is used in a vast number of applications, the proposed algorithms can be utilized in those cases to achieve lossless, low-cost, and hardware-friendly architectures

AI Enabled Drug Design and Side Effect Prediction Powered by Multi-Objective Evolutionary Algorithms & Transformer Models

Due to the large search space and conflicting objectives, drug design and discovery is a difficult problem for which new machine learning (ML) approaches are required. Here, the problem is to invent a method by which new, therapeutically useful, compounds can be discovered; and to simultaneously avoid compounds which will fail clinical trials or pass unwanted effects onto the end patient. By extending current technologies as well as adding new ones, more design criteria can be included, and more promising novel drugs can be discovered. This work advances the field of computational drug design by (1) developing MOEA-DT, a non-deep learning application for multi-objective molecular optimization, which generates new molecules with high performance in a variety of design criteria; and (2) developing SEMTL-BERT, a side effect prediction algorithm which leverages the latest ML techniques and datasets to accomplish its task. Experiments performed show that MOEA-DT either matches or outperforms other similar methods, and that SEMTL-BERT can enhance predictive ability

Entropy in Image Analysis II

Image analysis is a fundamental task for any application where extracting information from images is required. The analysis requires highly sophisticated numerical and analytical methods, particularly for those applications in medicine, security, and other fields where the results of the processing consist of data of vital importance. This fact is evident from all the articles composing the Special Issue "Entropy in Image Analysis II", in which the authors used widely tested methods to verify their results. In the process of reading the present volume, the reader will appreciate the richness of their methods and applications, in particular for medical imaging and image security, and a remarkable cross-fertilization among the proposed research areas