What's a brain: neuroanatomy and neurochemistry of anxiety disorders in dogs

This review deals with the neurocircuitry of fear and anxiety disorders, with the focus on neuroanatomy and neurochemistry. This knowledge is required to correctly diagnose and treat dogs with anxiety-related behavioral disorders. Research to date has shown the involvement of the frontal cortex, the amygdala, the thalamus and the hippocampus as core regions in regulating fear. Imbalances (hyper- or hypoactivation) in this fear circuitry can trigger inappropriate fear responses, i.e. anxiety disorders. Serotonin, dopamine and norepinephrine are the main neurotransmitters of emotion in the brain, but gamma-aminobutyric acid (GABA), glutamate, and the hypothalamic-pituitary-adrenal (HPA) axis producing glucocorticoids are also important in the neurochemistry of anxiety

The role of the cerebellum in unconsciuos and conscious processing of emotions: a review

Studies from the past three decades have demonstrated that there is cerebellar involvement in the emotional domain. Emotional processing in humans requires both unconscious and conscious mechanisms. A significant amount of evidence indicates that the cerebellum is one of the cerebral structures that subserve emotional processing, although conflicting data have been reported on its function in unconscious and conscious mechanisms. This review discusses the available clinical, neuroimaging and neurophysiological data on this issue. We also propose a model in which the cerebellum acts as a mediator between the internal state and external environment for the unconscious and conscious levels of emotional processing

Psychological and Biological Foundations of Time Preference: Evidence from a Day Reconstruction Study with Biological Tracking

This paper considers the relationship between the economic concept of time preference and relevant concepts from psychology and biology. Using novel data from a time diary study conducted in Ireland that combined detailed psychometric testing with medical testing and real-time bio-tracking, we examine the distribution of a number of psychometric measures linked to the economic concept of time preferences and test the extent to which these measures form coherent clusters and the degree to which these clusters are related to underlying biological substrates. The paper finds that financial discounting is related to a range of psychological variables including consideration of future consequences, self-control, conscientiousness, extraversion, and experiential avoidance as well as being predicted by heart rate variability and blood pressure.time preferences, day reconstruction study, economics and psychology, economics and biology

Are Large Physiological Reactions to Acute Psychological Stress Always Bad for Health?

How we react physiologically to stress has long been considered to have implications for our health. There is now persuasive evidence that individuals who show large cardiovascular reactions to stress are at increased risk of developing cardiovascular disease, particularly hypertension. By implication, low reactivity is protective or benign. However, there is recent evidence that low reactivity may predict elevated risk for a range of adverse health outcomes, such as depression, obesity, poor self-reported health, and compromised immunity. In addition, low cortisol and cardiovascular reactivity may be a characteristic of individuals with addictions to tobacco and alcohol, as well as those at risk of addiction and those who relapse from abstinence. Our ideas about reactivity may have to be revised in the light of such findings

Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis

Objective We investigated the nature and neural foundations of pathologic tearfulness in a uniquely large cohort of patients who had presented with autoimmune limbic encephalitis (aLE). Methods We recruited 38 patients (26 men, 12 women; median age 63.06 years; interquartile range [IQR] 16.06 years) in the postacute phase of aLE who completed questionnaires probing emotion regulation. All patients underwent structural/functional MRI postacutely, along with 67 age- and sex-matched healthy controls (40 men, 27 women; median age 64.70 years; IQR 19.87 years). We investigated correlations of questionnaire scores with demographic, clinical, neuropsychological, and brain imaging data across patients. We also compared patients diagnosed with pathologic tearfulness and those without, along with healthy controls, on gray matter volume, resting-state functional connectivity, and activity. Results Pathologic tearfulness was reported by 50% of the patients, while no patient reported pathologic laughing. It was not associated with depression, impulsiveness, memory impairment, executive dysfunction in the postacute phase, or amygdalar abnormalities in the acute phase. It correlated with changes in specific emotional brain networks: volume reduction in the right anterior hippocampus, left fusiform gyrus, and cerebellum, abnormal hippocampal resting-state functional connectivity with the posteromedial cortex and right middle frontal gyrus, and abnormal hemodynamic activity in the left fusiform gyrus, right inferior parietal lobule, and ventral pons. Conclusions Pathologic tearfulness is common following aLE, is not a manifestation of other neuropsychiatric features, and reflects abnormalities in networks of emotion regulation beyond the acute hippocampal focus. The condition, which may also be present in other neurologic disorders, provides novel insights into the neural basis of affective control and its dysfunction in disease

Psychological and Biological Foundations of Time Preference: Evidence from a Day Reconstruction Study with Biological Tracking

This paper considers the relationship between the economic concept of time preference and relevant concepts from psychology and biology. Using novel data from a time diary study conducted in Ireland that combined detailed psychometric testing with medical testing and realtime bio-tracking, we examine the distribution of a number of psychometric measures linked to the economic concept of time preferences and test the extent to which these measures form coherent clusters and the degree to which these clusters are related to underlying biological substrates. The paper finds that financial discounting is related to a range of psychological variables including consideration of future consequences, self-control, conscientiousness, extraversion, and experiential avoidance as well as being predicted by heart rate variability and blood pressure.

Psychopathology and neuropsychological functioning among male and female prisoners in England and Wales

PhDGender differences in the presentation and psychological function of prisoners is an increasingly prominent issue in day to day management, treatment outcome, and risk reduction. However, research in this area is not well developed, and little is known about the gender-specific associations between psychopathy, personality disorder (PD) and criminal histories, or differences in neuropsychological function between male and female prisoners. This is an important area to evaluate when considering recent government initiatives to develop services for individuals with dangerous and severe personality disorder (DSPD), where male and female offenders are seen as having an equivalent level of risk and need. For intervention and management strategies to be most responsive to the needs of these individuals, we need to know more about the gender-specific differences in psychopathology and neuropsychological functioning. This study explored psychopathy, PD, criminality, and neurocognitive performance in a large cohort sample of 620 serious male and female prisoners incarcerated in penal establishments across England and Wales. It examined prevalence and performance rates and the associations between these measures, paying particular interest to gender-specific relationships. Multivariate regression analysis demonstrated divergent relationships between facets of psychopathy, features of PD, criminality, and neuropsychological functioning among male and female prisoners. Female prisoners scoring highly on antisocial features of psychopathy were more antisocial than their male equivalents regarding Antisocial PD and lifetime robbery offences. Affective features of psychopathy were associated with a higher degree of Borderline PD traits and violent history in women specifically. Additionally, deficient emotional processing among female prisoners was further impaired by high rates of Borderline PD. In contrast, risky decision-making in men was specifically linked to affective features of psychopathy and antisocial behavioural traits. These results are discussed in terms of gender-specific interventions and treatment efficacy, which may help inform needs analysis for treatment providers

Psychological and Biological Foundations of Time Preference - Evidence from a Day Reconstruction Study with Biological Tracking

This paper considers the relationship between the economic concept of time preference and relevant concepts from psychology and biology. Using novel data from a time diary study conducted in Ireland that combined detailed psychometric testing with medical testing and real-time bio-tracking, we examine the distribution of a number of psychometric measures linked to the economic concept of time preferences and test the extent to which these measures form coherent clusters and the degree to which these clusters are related to underlying biological substrates. The paper finds that financial discounting is related to a range of psychological variables including consideration of future consequences, self-control, conscientiousness, extraversion, and experiential avoidance as well as being predicted by heart rate variability and blood pressure.

Brain responses in aggression-prone individuals: A systematic review and meta-analysis of functional magnetic resonance imaging (fMRI) studies of anger- and aggression-eliciting tasks

Reactive aggression in response to perceived threat or provocation is part of humans' adaptive behavioral repertoire. However, high levels of aggression can lead to the violation of social and legal norms. Understanding brain function in individuals with high levels of aggression as they process anger- and aggression-eliciting stimuli is critical for refining explanatory models of aggression and thereby improving interventions. Three neurobiological models of reactive aggression - the limbic hyperactivity, prefrontal hypoactivity, and dysregulated limbic-prefrontal connectivity models - have been proposed. However, these models are based on neuroimaging studies involving mainly non-aggressive individuals, leaving it unclear which model best describes brain function in those with a history of aggression. We conducted a systematic literature search (PubMed and Psycinfo) and Multilevel Kernel Density meta-analysis (MKDA) of nine functional magnetic resonance imaging (fMRI) studies (eight included in the between-group analysis [i.e., aggression vs. control groups], five in the within-group analysis). Studies examined brain responses to tasks putatively eliciting anger and aggression in individuals with a history of aggression alone and relative to controls. Individuals with a history of aggression exhibited greater activity in the superior temporal gyrus and in regions comprising the cognitive control and default mode networks (right posterior cingulate cortex, precentral gyrus, precuneus, right inferior frontal gyrus) during reactive aggression relative to baseline conditions. Compared to controls, individuals with a history of aggression exhibited increased activity in limbic regions (left hippocampus, left amygdala, left parahippocampal gyrus) and temporal regions (superior, middle, inferior temporal gyrus), and reduced activity in occipital regions (left occipital cortex, left calcarine cortex). These findings lend support to the limbic hyperactivity model in individuals with a history of aggression, and further indicate altered temporal and occipital activity in anger- and aggression-eliciting conditions involving face and speech processing

The role of sex, gender role, and extraversion-introversion in explaining the experience, expression and control of anger

Anger is a frequently experienced emotion that has been shown to influence perceptions, beliefs, ideas, reasoning, and ultimately choices and actions. It has the potential to become a serious problem if it reaches dysfunctional levels. This study examines the role of biological sex, gender role, and extraversion-introversion in the expression, experience and control of anger. A sample of 110 persons drawn from the Australian community were administered the Staxi-2, EPQ-R and the BSRI. Results showed that extraversion-introversion accounted for most variance associated with anger expression, while gender role accounted for most variance associated with anger control. Biological sex was not significant in accounting for anger variance. This research has highlighted factors that correlate with different aspects of anger, and provides for a better understanding of anger as both an emotional and socially constructed force. The results are consistent with the view that biological factors probably best explain the expression of anger, but that socially constructed factors such as gender role may best explain the control of anger. Sustained research in this area will provide for improved understanding of how biological and social determinants interact in the expression and control of anger