Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction with voxel-based morphometry were used to determine the success of the measures as an adjunct to diagnosis and to explore the neural basis of apraxia of speech in nfvPPA. Forty-one patients (21 lvPPA, 20 nfvPPA) were recruited from a consecutive sample with suspected frontotemporal dementia. Patients were diagnosed using the current gold-standard of expert perceptual judgment, based on presence/absence of particular speech features during speaking tasks. Seventeen healthy age-matched adults served as controls. MRI scans were available for 11 control and 37 PPA cases; 23 of the PPA cases underwent amyloid ligand PET imaging. Measures, corresponding to perceptual features of apraxia of speech, were periods of silence during reading and relative vowel duration and intensity in polysyllable word repetition. Discriminant function analyses revealed that a measure of relative vowel duration differentiated nfvPPA cases from both control and lvPPA cases (r2 = 0.47) with 88% agreement with expert judgment of presence of apraxia of speech in nfvPPA cases. VBM analysis showed that relative vowel duration covaried with grey matter intensity in areas critical for speech motor planning and programming: precentral gyrus, supplementary motor area and inferior frontal gyrus bilaterally, only affected in the nfvPPA group. This bilateral involvement of frontal speech networks in nfvPPA potentially affects access to compensatory mechanisms involving right hemisphere homologues. Measures of silences during reading also discriminated the PPA and control groups, but did not increase predictive accuracy. Findings suggest that a measure of relative vowel duration from of a polysyllable word repetition task may be sufficient for detecting most cases of apraxia of speech and distinguishing between nfvPPA and lvPPA

Effects of prosodically modulated sub-phonetic variation on lexical competition

Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., Put the cap next to the square) or utterance-final position (e.g., Now click on the cap). Displays consisted of the target picture (e.g., a cap), a monosyllabic competitor picture (e.g., a cat), a polysyllabic competitor picture (e.g., a captain) and a distractor (e.g., a beaker). The relative proportion of fixations to the two types of competitor pictures changed as a function of the position of the target word in the utterance, demonstrating that lexical competition is modulated by prosodically conditioned phonetic variation

Lexical segmentation and word recognition in fluent aphasia

The current thesis reports a psycholinguistic study of lexical segmentation and word recognition in fluent aphasia.When listening to normal running speech we must identify individual words from a continuous stream before we can extract a linguistic message from it. Normal listeners are able to resolve the segmentation problem without any noticeable difficulty. In this thesis I consider how fluent aphasic listeners perform the process of lexical segmentation and whether any of their impaired comprehension of spoken language has its provenance in the failure to segment speech normally.The investigation was composed of a series of 5 experiments which examined the processing of both explicit acoustic and prosodic cues to word juncture and features which affect listeners' segmentation of the speech stream implicitly, through inter-lexical competition of potential word matchesThe data collected show that lexical segmentation of continuous speech is compromised in fluent aphasia. Word hypotheses do not always accrue appropriate activational information from all of the available sources within the time frame in which segmentation problem is normally resolved. The fluent aphasic performance, although quantitatively impaired compared to normal, reflects an underlying normal competence; their processing seldom displays a totally qualitatively different processing profile to normal. They are able to engage frequency, morphological structure, and imageability as modulators of activation. Word class, a feature found to be influential in the normal resolution of segmentation is not used by the fluent aphasic studied. In those cases of occasional failure to adequately resolve segmentation by automatic frequency mediated activation, fluent aphasics invoke the metalinguistic influence of real world plausibility of alternative parses

Sensitivity to speech rhythm explains individual differences in reading ability independently of phonological awareness

This study considered whether sensitivity to speech rhythm can predict concurrent variance in reading attainment after individual differences in age, vocabulary and phonological awareness have been controlled. Five to six-year-old English-speaking children completed a battery of phonological processing assessments and reading assessments, along with a simple word stress manipulation task. The results showed that performance on the stress manipulation measure predicted a significant amount of variance in reading attainment after age, vocabulary, and phonological processing had been taken into account. These results suggest that stress sensitivity is an important, yet neglected aspect of English-speaking children?s phonological representations, which needs to be incorporated into theoretical accounts of reading development

Syllabic effects in Italian lexical access

Two cross-modal priming experiments tested whether lexical access is constrained by syllabic structure in Italian. Results extend the available Italian data on the processing of stressed syllables showing that syllabic information restricts the set of candidates to those structurally consistent with the intended word (Experiment 1). Lexical access, however, takes place as soon as possible and it is not delayed till the incoming input corresponds to the first syllable of the word. And, the initial activated set includes candidates whose syllabic structure does not match the intended word (Experiment 2). The present data challenge the early hypothesis that in Romance languages syllables are the units for lexical access during spoken word recognition. The implications of the results for our understanding of the role of syllabic information in language processing are discussed

Comparison of Word Intelligibility in Spoken and Sung Phrases

Twenty listeners were exposed to spoken and sung passages in English produced by three trained vocalists. Passages included representative words extracted from a large database of vocal lyrics, including both popular and classical repertoires. Target words were set within spoken or sung carrier phrases. Sung carrier phrases were selected from classical vocal melodies. Roughly a quarter of all words sung by an unaccompanied soloist were misheard. Sung passages showed a seven-fold decrease in intelligibility compared with their spoken counterparts. The perceptual mistakes occurring with vowels replicate previous studies showing the centralization of vowels. Significant confusions are also evident for consonants, especially voiced stops and nasals

Lexical stress and lexical access: effects in read and spontaneous speech

This thesis examines three issues which are of importance in the study of auditory word recognition: the phonological unit which is used to access representations in the mental lexicon; the extent to which hearers can rely on words being identified before their acoustic offsets; and the role of context in auditory word recognition. Three hypotheses which are based on the predictions of the Cohort Model (Marslen-Wilson and Tyler 1980) are tested experimentally using the gating paradigm. First, the phonological access hypothesis claims that word onsets, rather than any other part of the word, are used to access representations in the mental lexicon. An alternative candidate which has been proposed as the initiator of lexical access is the stressed syllable. Second, the early recognition hypothesis states that polysyllabic words, and the majority of words heard in context, will be recognised before their acoustic offsets. Finally, the context-free hypothesis predicts that during the initial stages of the processing of words, no effects of context will be discernible.Experiment 1 tests all three predictions by manipulating aspects of carefully articulated, read speech. First, examination of the gating responses from three context conditions offers no support for the context-free hypothesis. Second, the high number of words which are identified before their acoustic offsets is consistent with the early recognition hypothesis. Finally, the phonological access hypothesis is tested by manipulation of the stress patterns of stimuli. The dependent variables which are examined relate to the processes of lexical access and lexical retrieval; stress differences are found on access measures but not on those relating to retrieval. When the experiment is replicated with a group of subjects whose level of literacy is lower than that of the undergraduates who took part in the original experiment, differences are found in measures relating to contextual processing.Experiment 2 continues to examine the phonological access hypothesis, by manipulating speech style (read versus conversational) as well as stress pattern. Gated words, excised from the speech of six speakers, are presented in isolation. Words excised from read speech and words stressed on the first syllable elicit a greater number of responses which match the stimuli than conversational tokens and words with unstressed initial syllables. Intelligibility differences among the four conditions are also reported.Experiment 3 aims to investigate the processing of read and spontaneous tokens heard in context, while maintaining the manipulation of stress pattern. A subset of the words from Experiment 2 are presented in their original sentence contexts: the test words themselves, plus up to three subsequent words, are gated. Although the presence of preceding context generally enhances intelligibility, some words remain unrecognised by the end of the third subsequent word. An interaction between stress and speech style may be explained in terms of the unintelligibility of the preceding context.Several issues arising from Experiments 1, 2 and 3 are considered further. The characteristics of words which fail to be recognised before their offsets are examined using the statistical technique of regression; the contributions of phonetic and phonological aspects of stressed syllables are assessed; and a further experiment is reported which explores top-down processing in spontaneous speech, and which offers support for the interpretation of the results of Experiment 3 offered earlier

Where is the length effect? A cross-linguistic study.

Many models of speech production assume that one cannot begin to articulate a word before all its segmental units are inserted into the articulatory plan. Moreover, some of these models assume that segments are serially inserted from left to right. As a consequence, latencies to name words should increase with word length. In a series of five experiments, however, we showed that the time to name a picture or retrieve a word associated with a symbol is not affected by the length of the word. Experiments 1 and 2 used French materials and participants, while Experiments 3, 4 and 5 were conducted with English materials and participants. These results are discussed in relation to current models of speech production, and previous reports of length effects are reevaluated in light of these findings. We conclude that if words are encoded serially, then articulation can start before an entire phonological word has been encoded