Relationship between serum calcium and CA 19-9 levels in colorectal cancer

AIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above. RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. CONCLUSION: Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer

CORRELATION STUDY OF SERUM CALCIUM LEVELS AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS IN RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA

  Objective: This study was designed is to determine the correlation between serum calcium level and serum cartilage oligomeric matrix protein (COMP) level in Indonesian patients with rheumatoid arthritis (RA).Subjects and Methods: The subjects are patients who visit the rheumatology clinic at a government hospital in Bandung, Indonesia. Serum calcium level was determined by a complexometric method, and the serum COMP level was determined by enzyme-linked immunosorbent assay. Statistical analysis was performed with R software.Results: The serum calcium level was 82.24±44.82 mg/mL in RA patients and 99.04±60.56 mg/mL in normal controls. The serum COMP level was 843.80±35.79 ng/ml in RA patients and 830.00±48.92 ng/ml in normal controls.Conclusion: There is no correlation between serum calcium level and serum COMP levels in RA patients (p=0.967 and rho=0.006)

Pengaruh Kendali Glukosa terhadap Kadar Kalsium Serum pada Penderita DM Tipe 2 di Malang Raya

Introduction : Diabetes mellitus (DM) is a glucose metabolism disorder that is able to cause organ damage if the patient has inadequate glycemic control. Organ damage in patient with DM leads to micronutrient metabolism disorder includes calcium. Decreased serum calcium level in DM patient could reduce the insulin sensitivity. The effect of glycemic control in type 2 DM on calcium serum level in Indonesia has never been studied. Therefore, further research is needed, especially in Malang City.Method : : A cross sectional study with control group post-test-only design was conducted using purposive non-random sampling. Total subject was 40 patients consist of 15 patients with good glycemic control and 25 with poor glycemic control. Each group examined for serum calcium level using Atomic Absorption Spectrophotometry (AAS). Data were analyzed by using Independent T-Test followed by Pearson correlation test with a significance level of p <0.05Results : Calcium level in type 2 DM patients with good glycemic control (4,25±1,54 mg/dL) were higher than poor glycemic control (3,32±1,43 mg/dL) with signifikasi p=0,404. Glycemic control is moderately correlated on serum calcium with correlation level r=-0,358 and signification level p=0,03.Conclusion : Glycemic control in type 2 diabetes mellitus moderate correlated with serum calcium level.Keywords: Glycemic control in type 2 DM is moderately correlated with serum calcium level

Calcium supplementation amongst postmenopausal women: effect on serum calcium, phosphorus and magnesium level

This study assessed the effect of calcium supplementation towards the change in serum calcium, phosphorus and magnesium level. We carried out a randomized controlled trial of calcium supplementation in 113 postmenopausal women for 24 months period study. Subjects were randomly assigned into two groups. Subjects in Calcium Supplemented Group (CSG) were to take calcium supplement (1200 mg/day) while the Control Group were not given any placebo and advised to continue with their regular diet. The study showed that calcium supplementation helps to increased daily intake of calcium amongst the subject which in results helping to maintain the serum calcium level within normal range. The serum magnesium and phosphorus level in this study were kept at a normal range although there is a slight decrease in serum phosphorus levels may be due to a reduction in the daily intake of the mineral

Corrected Serum Calcium and Serum Albumin in predicting the Severity and Short Term Functional Outcome in patients with Acute Ischemic Stroke

BACKGROUND: Stroke has now become the second leading cause of death worldwide. Identification of predictors of mortality is very vital so that we can institute many prompt therapeutic measures to improve outcome. AIMS AND OBJECTIVES: To assess the role of corrected serum calcium and serum albumin in predicting the severity and short term functional outcome in acute ischemic stroke using NIHSS and modified rankin scale. METHODS: An observational study was done with 70 patients admitted with acute ischemic stroke. Stroke severity was assessed using NIHSS and one week outcome using modified rankin scale. Serum calcium and serum albumin level were estimated. RESULTS: There was significant association between corrected serum calcium and serum albumin with NIHSS and modified rankin scale. The association was independent. CONCLUSION: The stroke severity is more at low calcium and low albumin level than at higher calcium and albumin level and also functional outcome in them is better when the levels of calcium and albumin are higher. This shows that corrected serum calcium and serum albumin can be used as an indicator of severity and for predicting prognosis in acute ischemic stroke

Association of serum calcium with level of blood pressure in type 2 diabetic patients

Introduction: Hypertension and diabetes are two common diseases and they affect the same major target organs. Objectives: In this study, we sought to investigate the probable association of serum calcium with levels of systolic and blood pressure in a group of type 2 diabetic (T2D) patients. Patients and Methods: A total of 60 patients with T2D were enrolled to the study. To determine serum creatinine, calcium and hemoglobin A1c (HbA1c), venous blood samples were obtained in the fasting state. Results: Among 60 participants, 56.7 were female. Mean of ages was 57±8.3 years. Mean of systolic and diastolic blood pressure were 133±13 mmHg and 84±7.4 mmHg, respectively. Mean of serum calcium was 9.0±0.4 mg/dl. In this study, there was no significant difference of serum calcium and HbA1c between males and females. A significant inverse correlation of serum calcium with level of diastolic blood pressure (r=-0.261, p=0.046) was seen (adjusted for duration of diabetes). Moreover, a negative correlation of systolic blood pressure with level of serum calcium was existed, however, this correlation was not significant (r=-0.232, p=0.080) adjusted for duration of diabetes. Conclusions: We found a significant inverse correlation of serum calcium with level of diastolic blood pressure. We propose to more attention to serum calcium during the treatment of hypertension in diabetic patients. © 2013, Society of Diabetic Nephropathy Prevention. All rights reserved

Vitamin D Supplementation in Tuberculosis Patients: A Cross Sectional Study

Previous studies have not been able to show with certainty the effect of vitamin D supplementation in tuberculosis patients. The objective of this study is to determine whether vitamin D supplementation to patients with tuberculosis could influence 25-hydroxyvitamin D (25(OH)D) and calcium serum levels. The results, after 28 days, the vitamin D supplementation showed significant increase of 25(OH)D serum level at the end point (p=0.001), but not for the calcium serum level (p=0.3). The Conclusions is supplementation with 1,000 IU vitamin D per day increased the 25(OH)D serum level but there was no association with the calcium serum level

A study of maternal serum calcium and serum magnesium levels in pre-eclamptic and normotensive pregnancies

Background: Hypertensive disorders are major factors responsible for morbidity and mortality in pregnancy and pre-eclampsia is the leading cause. The etiopathology of pre-eclampsia is not known even after significant research done on it. A strong strategy in its management is to try to reduce the incidence and severity by predicting its occurrence. In this study, the effect of serum calcium and serum magnesium levels is being investigated with occurrence pre-eclampsia.Methods: Total 120 pregnant patients attending Tirath Ram Shah Hospital were included in the study. They were divided into two groups namely normotensive and hypertensive of 60 each. The serum calcium and serum magnesium levels were estimated and the correlation of these levels was studied with the pre-eclampsia related factors. The data was analysed by application of statistical test of significance.Results: Mean serum calcium level in the normotensive group was 10.119±1.27 mg/dl while mean serum calcium level in the hypertensive group was 9.461±1.164. Mean serum magnesium level in the normotensive women in the study was 1.979±0.405 mg/dl. In the hypertensive women, mean serum magnesium level was 1.723±0.414 mg/dl.Conclusions: This study shows that low levels of calcium and magnesium are found in serum of pre-eclampsia patients as compared to normotensive cases of the study population. The severity of pre-eclampsia is inversely proportional to the levels of serum calcium and magnesium

Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria

Background: Calcium and magnesium are two micronutrients whose role in the development of preeclampsia has been investigated over the years. There is paucity of studies on the role of serum levels of calcium and magnesium in the development of preeclampsia in south-south Nigeria. Objective: Our study evaluated the serum level of calcium and magnesium in preeclamptic and non preeclamptic women in a Tertiary Hospital in southsouth Nigeria. Methodology: We carried out a comparative study in which 52 preeclamptic and 52 non preeclamptic women, who satisfied the eligibility criteria, were enrolled for the study. Data entry and statistical analysis was done using statistical software (IBM SPSS® for windows version 21.0). Data were analyzed for mean and standard deviation. Comparison of serum levels of elements between the two groups was performed by student t-test, and P value &lt; 0.05 was considered as statistically significant. Results: The serum calcium level was statistically lower in the women who developed preeclampsia compared to those who did not (8.37±0.91 mg/dl vs 9.33±1.15mg/dl, p&lt;0.001). The serum magnesium level was not statistically different between women who had preeclampsia and those who did not (1.79±0.24mg/dl vs 1.88±0.37mg/dl, p = 0.102). The systolic and diastolic blood pressure showed a significant negative correlation with serum calcium level, unlike serum magnesiun level in those that had preeclampsia. Conclusion: This study showed that women who developed preeclampsia demonstrated reduced serum calcium level and no reduction in serum magnesium level. This study support the hypothesis that hypocalcaemia, unlike hypomagnecaemia, is a possible aetiology of preeclampsia